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针刺联合耳穴压籽治疗后循环缺血性眩晕疗效观察

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辽宁中医药大学学报 2024年第5期26卷 170-174页

作者：王翊梦鲁望杭明辉陆云圻张凯熠洪燕仔上海中医药大学附属龙华医院上海200030 上海中医药大学上海201203 上海第五人民医院上海200240 上海市浦东新区光明中医医院上海201399 上海颛桥社区卫生服务中心上海201108

目的使用经颅多普勒超声(transcranial doppler,TCD)、眩晕障碍量表(dizziness handicap inventory,DHI)、眩晕评估评分量表(dizziness assessment rating scale,DARS)及中医证候量表评价针刺联合耳穴压籽治疗后循环缺血性眩晕的疗效。方法招募上海中医药大学附属龙华医院后循环缺血性眩晕(气血亏虚型)患者67例,随机分为治疗组(针刺+耳穴压籽治疗)34例和对照组(针刺治疗)33例。针刺选穴为百会、风池、肾俞、肝俞、脾俞、足三里。针刺治疗每次20 min,1周3次,12次(4周)为1个疗程。耳穴压籽选穴:枕、皮质下、神门、脾,于每日早晨7:00至晚间7:00嘱患者对穴位进行4次按压,每3 h 1次,每个穴位匀速按压30次。治疗次数:两耳交替压籽,1周3次,12次(4周)为1个疗程。在治疗前、治疗2周、治疗4周时分别对患者进行TCD检测以及DHI、DARS、中医证候积分评分。结果治疗组在治疗2周和4周后对后循环缺血性眩晕(posterior circulation ischemic vertigo,PCIV)患者的DHI和中医证候积分改善较对照组明显(P0.05);两组分别在治疗2周后和治疗4周后对DHI、DARS以及中医证候积分改善较治疗前明显(P0.05);在治疗4周后,两组间差异有统计学意义(P<0.05)。组内比较,两组在治疗2周后和治疗4周后BA、LVA、RVA的收缩峰流速较治疗前差异有统计学意义(P<0.05),并且治疗4周后较治疗2周后差异也有统计学意义(P<0.05)。治疗组总有效率为93.75%,对照组总有效率为74.19%,差异有统计学意义(P<0.05)。结论针刺联合耳穴压籽法和针刺法均可有效加快脑血流速度、改善PCIV患者的眩晕程度,减少PCIV导致的功能障碍,且针刺联合耳穴压籽法的疗效较单纯针刺法更为显著;该试验进行和随访期间不良反应发生率为1.49%,总体安全性良好。

关键词：针刺耳穴压籽后循环缺血眩晕经颅多普勒超声

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Effects of huoxiangzhengqi liquid on enteric mucosal immune responses in mice with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea

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World Journal of Gastroenterology 2006年第45期12卷 7346-7349页

作者： Yin-Hui He Hong-Yan Zhao Zhen-Li Liu Cheng lu Xiao-Jian luo Se-qi Lin Xing-Wen qian Shi-Lin Chen Ai-Ping lu National Pharmaceutical Engineering Research Center Jiangxi University of Traditional Chinese Medicine Nanchang 33000 Jiangxi Province China Institute of Basic Research China Academy of Traditional Chinese Medicine Beijing 100700 China State Key Laboratory of Traditional Chinese Medicine and Molecular Pharmacology Shenzhen 518057 Guangdong Province China E-institute of Shanghai Municipal Education Commission Shanghai Traditional Chinese Medicine University Shanghai China

AIM： To explore effects of huoxiangzhengqi liquid （HXZQ） on enteric mucosal immune responses in mice with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea （BSD）. METHODS： BSD was induced in Balb/c mice by oral administration with Bacillus dysenteriae and Salmonella typhimurium. HXZQ was administrated from the day of diarrhea induction at dosages of 5.21 g/kg and 0.52 g/kg, respectively. The onset of diarrhea and lasting time were recorded. Peyer＇s patches and peripheral lymphocytes were prepared for flow cytometry, and levels of TNF-α in peripheral blood and enteric tissue homogenates were determined with ELISA. Student＇s t test was employed for statistics. RESULTS： Mice in BSD group started showing continuous diarrhea on the day of induction until the fourth day when they were sacrificed. Diarrhea in the mice of HXZQ high and low dose groups lasted for 36 and 54 h, respectively. There were more CD4^＋ and CD8^＋ cells in peripheral blood, fewer CD4^＋ cells in Peyer＇s patches in BSD mice compared to normal mice. Fewer CD4^＋ and CD8^＋ cells was shown in the mice in HXZQ high group compared to BSD mice. In Peyer＇s patch, there were more CD8^＋ cells in mice in HXZQ high and low dose groups and more CD4^＋ in mice in HXZQ high group. Higher levels of TNF-α in peripheral blood and intestinal tissue homogenates in BSD group were observed. Mice in HXZQ high group showed decreased levels of TNF-α in peripheral blood and enteric tissue homogenates. CONCluSION： The immune regulation of CD4^＋ and CD8^＋ cells in Peyer＇s patch and suppression of TNF-α levels in enteric homogenates may partially explain the effect of HXZQ on improvement of BSD.

关键词： Diarrhea Peyer's patches TNF-α Huoxiangzhengqi liquid

基于子空间旋转变换的低复杂度波达角估计算法

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电子与信息学报 2016年第3期38卷 629-634页

作者：闫锋刚齐晓辉刘帅沈毅金铭哈尔滨工业大学哈尔滨150001 哈尔滨工业大学(威海) 威海264209

多重信号分选(MUltiple SIgnal Classification,MUSIC)算法是波达方向(Direction-Of-Arrival,DOA)估计的最重要算法之一,但庞大的计算量使其工程实用性大打折扣。为降低MUSIC的计算量,该文基于子空间旋转(Subspace Rotation Technique,SRT)变换思想提出了一种高效改进算法,即SRT-MUSIC算法。SRT-MUSIC利用秩亏特性对噪声子空间矩阵按行分块并以旋转变换得到降维噪声子空间,进而基于该降维噪声子空间与导向矢量的正交性构造空间谱估计信号DOA。理论分析表明:SRT-MUSIC能有效避免空间谱搜索中的冗余运算,从而成倍降低算法的计算量。对于大阵元、少信号情况,所提算法计算效率优势更为明显。仿真实验证明了SRT-MUSIC的有效性和高效性。

关键词：波达方向估计多重信号分选噪声子空间旋转低复杂度算法

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数字化推拉送丝CO_2焊接系统

焊接学报 2010年第9期31卷 45-48,52页

作者：卢振洋闫思博杨帅刘嘉北京工业大学机械工程及应用电子技术学院北京100124

采用以DSP(数字信号处理器)和CPLD(复杂可编程逻辑器件)为控制核心的数字化电源平台,结合转动惯量小、响应速度快、送丝稳定的交流伺服电机推拉送丝部分,研制了数字化推拉送丝CO2焊接系统.以缓冲器为桥梁,设计了将交流伺服推拉丝与带编... 详细信息

采用以DSP(数字信号处理器)和CPLD(复杂可编程逻辑器件)为控制核心的数字化电源平台,结合转动惯量小、响应速度快、送丝稳定的交流伺服电机推拉送丝部分,研制了数字化推拉送丝CO2焊接系统.以缓冲器为桥梁,设计了将交流伺服推拉丝与带编码器速度反馈的等速送丝融为一体的双电机推拉送丝系统.根据推拉送丝CO2焊接过程的特点,设计了焊丝的运动曲线,并提出了与焊丝运动相对应的电流、电压波形控制方案.通过软件编程的方式实现了推拉送丝CO2焊接工艺.整个熔滴过程均匀一致,焊接飞溅小,焊接热输入量小.

关键词：数字化焊接电源推拉送丝系统 CO2焊接低热输入

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基于WOA-BP算法的持液率预测模型研究

化学工程 2022年第1期50卷 67-73页

作者：肖荣鸽靳帅帅庄琦周鹏冯鑫西安石油大学石油工程学院陕西省油气田特种增产技术重点实验室陕西西安710065 长庆油田分公司油气营销事业部陕西西安710018

湿气管道在运行过程中,不可避免地会在管道低洼处出现积液。积液的存在会诱发很多安全问题,严重时甚至引发事故。因此,对湿气管道持液率进行预测就显得至关重要。文中基于灰色理论,对影响水平管道持液率的6个影响因素进行灰色关联分析,... 详细信息

湿气管道在运行过程中,不可避免地会在管道低洼处出现积液。积液的存在会诱发很多安全问题,严重时甚至引发事故。因此,对湿气管道持液率进行预测就显得至关重要。文中基于灰色理论,对影响水平管道持液率的6个影响因素进行灰色关联分析,选取影响较大的因素作为影响变量;基于鲸鱼算法,建立鲸鱼算法优化BP神经网络的持液率预测模型,并与传统BP算法和遗传算法优化BP神经网络的预测模型进行对比。结果表明:文中预测模型的平均绝对误差为4.50%,均方根误差为0.0121,远低于传统BP预测模型和GA-BP预测模型,具有更高的计算精度,适用范围更广,为湿气管道的持液率预测提供了新思路和新途径。

关键词：湿气管道持液率灰色关联鲸鱼算法 BP神经网络

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丙烯酸酯系水溶性压敏胶的制备及性能研究

中国胶粘剂 2009年第1期18卷 35-39页

作者：吴汝林亓帅青岛科技大学化工学院山东青岛266042

以丙烯酸丁酯(BA)、甲基丙烯酸甲酯(MMA)和丙烯酸(AA)为共聚单体,采用半连续乳液聚合工艺,制取了性能优良的丙烯酸酯系水溶性压敏胶(PSA)。讨论了单体、乳化剂、引发剂、反应温度、反应时间和搅拌速率等对该PSA的固含量、黏度、初粘性... 详细信息

以丙烯酸丁酯(BA)、甲基丙烯酸甲酯(MMA)和丙烯酸(AA)为共聚单体,采用半连续乳液聚合工艺,制取了性能优良的丙烯酸酯系水溶性压敏胶(PSA)。讨论了单体、乳化剂、引发剂、反应温度、反应时间和搅拌速率等对该PSA的固含量、黏度、初粘性、持粘性和水溶性等性能的影响。研究结果表明,丙烯酸酯系水溶性PSA的最佳合成工艺条件是:w(引发剂)=0.7%～0.8%、w(乳化剂)=3.0%,搅拌速率为200r/min,反应温度为85～92℃,反应时间为3.5～4h,保温时间为0.5～1h;在此条件下制取的丙烯酸酯系水溶性PSA具有较好的综合性能。

关键词：水溶性压敏胶丙烯酸酯复合乳化剂乳液聚合

Scutellarin induces apoptosis of colorectal cancer HCT116 cells via Hippo signaling pathway

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中国药理学与毒理学杂志 2021年第10期35卷 775-776页

作者： YANG Han SUN qiang ZENG Sha CHEN Li ZHAO Hui LIU Mao-lun REN Shan MING Tian-qi lu Jin-jian XU Hai-bo State Key Laboratory of Southwestern Chinese Medicine Resources Department of PharmacologyChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Chinese Medical Sciences University of MacaoMacaoChina

OBJECTIVE To investigate the effect of scutellarin on the apoptosis of human colorectal cancer cells via the Hippo signaling pathway in *** MTT colorimetric method was used to detect the influence of scutellarin on the survival rate of HCT116 *** the effect of scutellarin at various concentrations on cell morphology was observed by *** scratch experiment was used to detect the influence of scutellarin on the migration of HCT116 ***33342/PI double staining method was used to detect the effect of scutellarin on the apoptosis of HCT116 *** blotting method was used to assess the action of scutellarin on the expressions of Hippo signaling pathway-related proteins Mst1,Lats1,YAP1,p-YAP(Ser127),TAZ,and its downstream effector proteins c-Myc and cyclin D1,as well as apoptosis-related proteins Bcl-2 and Bax in HCT116 *** Scutellarin significantly affected the morphology of HCT116 cells and reduced the survival rate of HCT116 ***33342/PI double staining showed that scutellarin effectively induced the apoptosis of HCT116 *** blotting analysis showed that the expression levels of Hippo signaling pathway-related proteins Mst1,Lats1,YAP1,TAZ and its downstream effector proteins c-Myc,cyclin D1 were down-regulated in a concentration-dependent manner by scutellarin,and the expression of p-YAP(ser127)was ***,scutellarin substantially lessened the expression level of apoptosis-related protein Bcl-2,and promoted the protein level of *** Scutellarin may inhibit the proliferation and migration of HCT116 cells,while induce its apoptosis,potentially by activation of Hippo signaling pathway.

关键词： scutellarin colorectal cancer HCT116 cells Hippo signaling pathway

Research advances in phytochemistry,pharmacology and toxicology of oleanolic acid

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中国药理学与毒理学杂志 2021年第10期35卷 770-771页

作者： REN Shan SUN qiang CHEN Li ZENG Sha ZHAO Hui LIU Mao-lun YANG Han MING Tian-qi lu Jin-jian XU Hai-bo State Key Laboratory of Southwestern Chinese Medicine Resources Department of PharmacologyChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Chinese Medical Sciences University of MacaoMacaoChina

Oleanolic acid(OA)is a pentacyclic triterpenoid chemical component that exists in natural plants with a molecular formula of C30H48O3 and a molecular weight at 456.71 g·*** is widespread in traditional Chinese herbal medicine(Ligustri lucidi Fructus,Achyranthis Bidentate Radix,Red Sage)and berries(blueberries,grapes).In recent years,because of the extensive pharmacological effects of OA,its advantages in disease treatment have become increasingly prominent and gradually attracted the attention of pharmaceutical *** has effective therapeutic effects on a series of chronic diseases such as inflammation,cancer,diabetes,and cardiovascular diseases through multiple signaling pathways and various *** in cancers,such as colorectal cancer,liver cancer,gastric cancer,lung cancer,breast cancer and other malignancies,OA presents substantial ***,its poor aqueous solubility,needy bioavailability,and unsatisfactory pharmacological activity excessively restrict its clinical *** importantly,the improper utilization of OA can cause adverse reactions,toxic effects and even damage to organs in some specific *** the discovery of various pharmacological effects,the complex action mechanisms of OA,the continuous progress in structural modification of OA,as well as the synthesis of OA derivatives,its application is expanding *** numerous studies,there is a clear indication that OA and its derivatives,if fully developed,may provide an alternative and cheaper treatment for a variety of chronic ***,the specific molecular mechanisms of OA and its derivatives as an alternative therapy and supplementary therapy for cancer,diabetes,cardiovascular disease and other chronic diseases remain to be ***,it is necessary to further study the pharmacokinetics,pharmacological activity,specific targets and related mechanisms of OA to lay a solid foundation for drug development and the application o

关键词： oleanolic acid pharmacology toxicology derivatives review

A Comparative Analysis of the Chloroplast Genomes of Four Salvia Medicinal Plants

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Engineering 2019年第5期5卷 907-915页

作者： Conglian Liang Lei Wang Juan Lei Baozhong Duan Weisi Ma Shuiming Xiao Haijun qi Zhen Wang Yaoqi Liu Xiaofeng Shen shuai Guo Haoyu Hu Jiang Xu Shilin Chen College of Pharmacy Shandong University of Traditional Chinese Medicine(TCM)Jinan 250355China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China State Key Laboratory of Innovative Natural Medicine and TCM Injections Jiangxi Qingfeng Pharmaceutical Co.Ltd.Ganzhou 341000China Beijing Children’s Hospital Capital Medical UniversityNational Center for Children’s HealthBeijing 100045China School of Biological Science The University of QueenslandBrisbaneQLD 4072Australia College of Pharmacy Dali UniversityDali 671000China Institute of Medicinal Plants Yunnan Academy of Agricultural SciencesKunming 650205China

Herbgenomics is an emerging field of traditional Chinese medicine(TCM)research and *** combining TCM research with genomics,herbgenomics can help to establish the scientific validity of TCM and bring it into wider usage within the field of *** Linn.(***.)is a large genus of Labiatae that includes important medicinal *** this herbgenomics study,the complete chloroplast(cp)genomes of two Salvia spp.—namely,*** and ***,which are used as a surrogate for ***—were sequenced and compared with those of two other reported Salvia spp.—namely,*** and *** genome organization,gene number,type,and repeat sequences were *** annotation results showed that both Salvia plants contain 114 unique genes,including 80 protein-coding,30 transfer RNA(tRNA),and four ribosomal RNA(rRNA)*** sequence analysis revealed 21 forward and 22 palindromic sequences in both Salvia cp genomes,and 17 and 21 tandem repeats in *** and ***,respectively.A synteny comparison of the Salvia *** genomes showed a high degree of sequence similarity in the coding regions and a relatively high divergence of the intergenic *** alignment and single-nucleotide polymorphism(SNP)analyses found some candidate fragments to identify Salvia spp.,such as the intergenic region of the trnV–ndhC,trnQ–rps16,atpI–atpH,psbA–ycf3,ycf1,rpoC2,ndhF,matK,rpoB,rpoA,and accD *** of the results—including the repeat sequences and SNP sites,the inverted repeat(IR)region border,and the phylogenetic analysis—showed that *** and *** are extremely similar from a genetic *** cp genome sequences of the two Salvia *** here will pave the way for breeding,species identification,phylogenetic evolution,and cp genetic engineering studies of Salvia medicinal plants.

关键词： Salvia Chloroplast genome Comparative analysis