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Donor-derived infections among Chinese donation after cardiac death liver recipients

World Journal of Gastroenterology 2017年第31期23卷 5809-5816页

作者： qi-Fa Ye Wei Zhou qi-quan wan Department of Transplant Surgery the Third Xiangya Hospital of Central South University Department of Transplant Surgery Zhongnan Hospital of Wuhan University

AIM To investigate blood cultures of deceased donors and report the confirmed transmission of bacterial infection from donors to liver *** We retrospectively studied the results of blood cultures among our donation after cardiac death(DCD) donors and calculated the donor-derived bacterial infection rates among liver recipients. Study participants underwent liver transplantation between January 1, 2010 and February 1, 2017. The study involved a total of 67 recipients of liver grafts from 67 DCD donors. We extracted the data of donors' and patients' characteristics, culture results and clinical outcomes, especially the post-transplant complications in liver recipients, from electronic medical records. We analyzed the characteristics of the donors and the corresponding liver recipients with emphasis put on donor-derived *** Head trauma was the most common origin of death among our 67 DCD donors(46.3%). Blood taken prior to the procurement operation was cultured for 53 of the donors, with 17 episodes of bloodstream infections developing from 13 donors. The predominant organism isolated from the blood of donors was Gram-positive bacteria(70.6%). Only three(4.5%) of 67 liver recipients developed confirmed donor-derived bacterial infections,with two isolates of multidrug-resistant Klebsiella pneumoniae and one isolate of multidrug-resistant Enterobacter aerogenes. The liver recipients with donorderived infections showed relation to higher crude mortality and graft loss rates(33.3% each) within 3 mo post transplantation, as compared to those without donor-derived infections(9.4% and 4.7%, respectively). All three liver recipients received appropriate antimicrobial *** Liver recipients have high occurrence of donor-derived infections. The liver recipients with donor-derived multidrug-resistant Enterobacteriaceae infections can have good outcome if appropriate antimicrobial therapy is given.

关键词： Liver transplant Donation after cardiac death donor Infection Multidrug resistant Bacteria Transmission

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Klebsiella pneumoniae infections after liver transplantation:Drug resistance and distribution of pathogens,risk factors,and influence on outcomes

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World Journal of Hepatology 2024年第4期16卷 612-624页

作者： Long Guo Peng Peng Wei-Ting Peng Jie Zhao qi-quan wan Department of Respiratory and Critical Care Medicine The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Clinical Laboratory Medicine Center Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 421007Hunan ProvinceChina The Second Affiliated Hospital Class Xiangya School of MedicineCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China Department of Transplant Surgery The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Engineering and Technology Research Center for Transplantation Medicine of National Health Commission The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina

BACKGROUND Liver transplantation(LT)is the only curative treatment for end-stage liver ***,LT recipients are susceptible to infection,which is the leading cause of early mortality after *** pneumoniae infections(KPIs)in the bloodstream are common in LT *** hypothesized that KPIs and carbapenemresistant Klebsiella pneumoniae(CRKP)infections may affect the outcomes of LT *** To assess KPI incidence,timing,distribution,drug resistance,and risk factors following LT and its association with *** This retrospective study included 406 patients undergoing LT at The Third Xiangya Hospital of Central South University,a tertiary hospital,from January 2015 to January *** investigated the risk factors for KPIs and assessed the impact of KPIs and CRKP infections on the prognosis of LT recipients using logistic regression *** KPI incidence was 7.9%(n=32),with lung/thoracic cavity the most frequent site of infection;the median time from LT to KPI onset was 7.5 *** 44 Klebsiella pneumoniae isolates,43(97.7%)and 34(77.3%)were susceptible to polymyxin B or ceftazidime/avibactam and tigecycline,respectively;>70%were resistant to piperacillin/tazobactam,ceftazidime,cefepime,aztreonam,meropenem,and *** sex[odds ratio(OR)=2.827,95%confidence interval(CI):1.256-6.364;P=0.012],pre-LT diabetes(OR=2.794,95%CI:1.070-7.294;P=0.036),day 1 post-LT alanine aminotransferase(ALT)levels≥1500 U/L(OR=3.645,95%CI:1.671-7.950;P=0.001),and post-LT urethral catheter duration over 4 d(OR=2.266,95%CI:1.016-5.054;P=0.046)were risk factors for *** infections,but not KPIs,were risk factors for 6-month all-cause mortality *** KPIs occur frequently and rapidly after *** factors include female sex,pre-LT diabetes,increased post-LT ALT levels,and urethral catheter *** infections,and not KPIs,affect mortality.

关键词： Liver transplantation Klebsiella pneumoniae infections Carbapenem-resistant Klebsiella pneumoniae Risk factors Outcomes

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Nomogram to predict gas-related complications during transoral endoscopic resection of upper gastrointestinal submucosal lesions:Clinical significance

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World Journal of Gastrointestinal Endoscopy 2024年第1期16卷 5-10页

作者： Xu-Peng Wen qi-quan wan Department of Critical Care Medicine Zhongshan HospitalFudan UniversityShanghai 200030China Department of Transplant Surgery The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina

Transoral endoscopic resections in treating upper gastrointestinal submucosal lesions have the advantages of maintaining the integrity of the gastrointestinal lumen,avoiding perforation and reducing gastrointestinal *** are becoming more widely used in clinical practice,but,they may also present a variety of ***-related complications are one of the most common,which can be left untreated if the symptoms are mild,but in severe cases,they can lead to rapid changes in the respiratory and circulatory systems in a short period,which can be ***,it is important to predict the occurrence of gas-related complications early and take preventive measures *** on the authors'results in the prepublication of the article“Nomogram to predict gas-related complications during transoral endoscopic resection of upper gastrointestinal submucosal lesions,”and in conjunction with our evaluation and additions to the relevant content,radiographs may help screen patients at high risk for gas-related *** blood glucose levels,shortening the duration of surgery,and choosing the most appropriate surgical resection may positively impact the prognosis of patients at high risk for gas-related complications during transoral endoscopic resection of upper gastrointestinal submucosal lesions.

关键词： Complications Endoscopy Upper gastrointestinal tract Nomogram Clinical significance

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相似原理应用于混响室缩比模型的验证分析

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电波科学学报 2011年第1期26卷 180-185页

作者：齐万泉汪宗福马蔚宇杨于杰北京无线电计量测试研究所北京100143 中国三江航天集团设计所湖北武汉430035

为了能够将缩比模型应用于混响室设计中,对电磁场相似原理在混响室金属谐振腔体中的适用性问题进行了验证。分析计算了混响室缩比前后的模式数目,证明其符合相似原理;对构造的模型进行了仿真分析,表明缩比前后混响室金属腔体中观察点的... 详细信息

为了能够将缩比模型应用于混响室设计中,对电磁场相似原理在混响室金属谐振腔体中的适用性问题进行了验证。分析计算了混响室缩比前后的模式数目,证明其符合相似原理;对构造的模型进行了仿真分析,表明缩比前后混响室金属腔体中观察点的电场值具有相似性;通过混响室实物的场均匀性测试数据验证了仿真分析方法的正确性。理论推导和仿真分析结果均说明电磁场相似原理可应用于混响室缩比模型中。

关键词：混响室缩比模型相似原理

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获取吸波结构电磁参数的FEM/GA方法

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微波学报 2008年第3期24卷 1-4页

作者：齐万泉苏东林张伟北京航空航天大学电子信息工程学院北京100083

提出了利用有限元计算模型和改进的遗传进化算法获取吸波结构中未知参数层电磁参数的方法。根据电磁参数与多角度入射吸波结构反射率的关系建立有限元正向计算模型,根据自由空间方法搭建的测试系统测量得到相应入射角度下的反射率,并利... 详细信息

提出了利用有限元计算模型和改进的遗传进化算法获取吸波结构中未知参数层电磁参数的方法。根据电磁参数与多角度入射吸波结构反射率的关系建立有限元正向计算模型,根据自由空间方法搭建的测试系统测量得到相应入射角度下的反射率,并利用遗传优化得到吸波结构中未知参数层的电磁参数。优化过程中采用高斯随机数代替基本遗传算法的均匀平均数,避免陷入局部最优点。与传统的网络参数法相比较,本文提出的方法避免了厚度谐振和多值性问题。

关键词：有限元反射率电磁参数吸波结构

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基于混响室的电场探头校准方法研究

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宇航计测技术 2018年第1期38卷 23-26页

作者：王淞宇齐万泉北京无线电计量测试研究所北京100039

针对电场探头在高场强下的校准需求,本文提出了利用混响室开展电场探头校准,介绍了基于混响室的电场探头校准原理和校准方法,解决了200V/m以上高场强环境下电场探头的校准问题,并与微波场强标准中的测量结果进行了对比分析。两组测量结... 详细信息

针对电场探头在高场强下的校准需求,本文提出了利用混响室开展电场探头校准,介绍了基于混响室的电场探头校准原理和校准方法,解决了200V/m以上高场强环境下电场探头的校准问题,并与微波场强标准中的测量结果进行了对比分析。两组测量结果具有较好的一致性。

关键词：混响室电场探头校准

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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen wan Fangqi Li Weiwei Lin Zhihua Han Beijie qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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基于电光调制技术的脉冲场强校准方法

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宇航计测技术 2023年第1期43卷 17-21页

作者：彭博王淞宇齐万泉何巍北京无线电计量测试研究所北京100039 计量与校准技术重点实验室北京100039

研究脉冲场强的校准方法,分析S频段脉冲场强产生原理和校准装置组成。通过基于电光调制技术的铌酸锂光波导传感器法对脉冲功率产生的峰值场强进行测量,峰值场强(1~3)kV/m,脉宽(10~100)μs,占空比1%~10%,上升/下降时间小于100ns,场强幅... 详细信息

研究脉冲场强的校准方法,分析S频段脉冲场强产生原理和校准装置组成。通过基于电光调制技术的铌酸锂光波导传感器法对脉冲功率产生的峰值场强进行测量,峰值场强(1~3)kV/m,脉宽(10~100)μs,占空比1%~10%,上升/下降时间小于100ns,场强幅值测量偏差小于1dB。通过分析不确定度来源对测量不确定度进行了评定,扩展不确定度1.7dB。最后采用接收天线法对光波导传感器法的脉冲场强校准结果进行了验证。

关键词：脉冲调制场铌酸锂光波导传感器场强测量

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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基于双因素方差分析的混响室搅拌器优化研究

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宇航计测技术 2010年第1期30卷 33-37页

作者：汪宗福杨于杰齐万泉单涛中国三江航天集团设计所武汉430035 北京无线电计量测试研究所北京100039

针对混响室搅拌器的优化问题,建立了混响室仿真模型,分析了搅拌器叶片不同夹角和不同边长比对混响室场均匀性的影响,得到了叶片较优夹角和较优边长比。通过对仿真数据进行双因素方差分析,得到搅拌器叶片夹角和边长比对场均匀性影响的权... 详细信息

针对混响室搅拌器的优化问题,建立了混响室仿真模型,分析了搅拌器叶片不同夹角和不同边长比对混响室场均匀性的影响,得到了叶片较优夹角和较优边长比。通过对仿真数据进行双因素方差分析,得到搅拌器叶片夹角和边长比对场均匀性影响的权重关系。该结论为混响室搅拌器的优化设计提供了指导依据。

关键词：混响室 +双因素方差分析场均匀性 +搅拌器优化

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