检索结果-南通市图书馆

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

在线全文

学校读者我要写书评

暂无评论

我国渔业水域环境保护与管理的法律制度评析

上海海洋大学学报 2011年第6期20卷 910-915页

作者：齐奇唐议上海海洋大学海洋科学学院上海201306

我国渔业水域环境保护与管理的基本法律制度初步形成于20世纪80年代,90年代以来有所调整和加强,在综合性水环境保护和管理制度基础上,初步形成了渔业水域环境监测和评价制度、渔业水质标准制度、渔业污染事故调查处理和赔偿制度、渔业... 详细信息

我国渔业水域环境保护与管理的基本法律制度初步形成于20世纪80年代,90年代以来有所调整和加强,在综合性水环境保护和管理制度基础上,初步形成了渔业水域环境监测和评价制度、渔业水质标准制度、渔业污染事故调查处理和赔偿制度、渔业水域生态环境损害预防、补救和赔偿制度等专门的渔业水域环境保护与管理制度,法律制度建设初见成效,但仍存在一定的问题:(1)与《海洋环境保护法》、《水污染防治法》、《渔业法》中有关基本法律规定相配套的法规不完整,致使法律制度的可执行性较差。(2)部分重要的法律规定不明确,存在执行上的困难或无法执行。(3)现有法律制度未能严格执行。(4)一些重要的法律制度不健全。建议应进行渔业水域环境保护与管理的综合性专项立法;尽快修改或重新制定《渔业法》、《水污染防治法》的实施细则或实施条例;严格执行现有的法律制度;积极探索公众参与渔业水域环境保护和监管的制度与机制。

关键词：渔业水域环境保护与管理法律制度中国

Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong tang Zhetuo qi Haiyang Xie Shusen Zheng qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

关键词：

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie qi Tian tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren Ying tang qi Yang Tian-Tian Meng Song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

掺杂单层MoS_(2)电子结构与光催化性质的第一性原理计算

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

原子与分子物理学报 2025年第1期42卷 35-40页

作者：徐启远高朋刘正堂九江学院机械与智能制造学院九江332005 西北工业大学材料学院西安710072

为了提高MoS_(2)的光催化能力,本研究基于第一性原理平面波赝势方法,对Cr、W、Fe、Co、Ni替换单层MoS_(2)晶格中的Mo进行研究.结果表明:W的替换能为正值,Cr、Fe、Co、Ni的替换能为负值.Cr、W掺杂晶格产生畸变主要是杂质原子的共价半径... 详细信息

为了提高MoS_(2)的光催化能力,本研究基于第一性原理平面波赝势方法,对Cr、W、Fe、Co、Ni替换单层MoS_(2)晶格中的Mo进行研究.结果表明:W的替换能为正值,Cr、Fe、Co、Ni的替换能为负值.Cr、W掺杂晶格产生畸变主要是杂质原子的共价半径引起的;Fe、Co、Ni掺杂晶格产生畸变主要是掺杂原子的自旋导致的.Cr、W、Fe、Co、Ni掺杂单层MoS_(2)带隙类型没有发生改变,仍然为直接带隙,但禁带宽度变小,吸收带红移,尤其Fe、Co、Ni掺杂,导带下方有杂质能级使费米能级向高能方向移动,可以作为捕获电子陷阱,增加电子密度,减少光激发电子-空穴对的复合,有利于提升光催化能力.

关键词：掺杂单层二硫化钼光催化电子结构

维普期刊数据库博看期刊

Lipid metabolism and diseases

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2016年第19期61卷 1471-1472页

作者： qi-Qun tang Key Laboratory of Metabolism and Molecular Medicine Ministry of Education Department of Biochemistry and Molecular Biology Fudan University Shanghai Medical College

Lipids are a large and diverse class of biomolecules that exert multiple biochemical functions,such as fueling energy production,and building blocks for plasma membrane and chemical signals during cellular communication.

关键词：冠状动脉疾病脂代谢代谢性疾病能源生产脂肪组织脂质代谢睡眠呼吸暂停能量平衡

Enabling Efficient Batch Updating Verification for Multi-versioned Data in Cloud Storage

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2019年第2期28卷 377-385页

作者： qi Yining tang Xin HUANG Yongfeng Department of Electronic Engineering Tsinghua University Tsinghua National Laboratory for Information Science and Technology

Existing dynamic data possession verification schemes not only suffer from low efficiency of rebalancing its Merkle Hash tree(MHT) when executing data updating, but also lack effective mechanism to verify multi-version files. Aiming at these problems, this paper propose a new data structure called Rank-based multi-version Merkle AVL tree(RBMV-MAT) to achieve efficient batch updating verification for multi-version ***-MAT uses a special lock and relaxed balance to decrease the frequency of rebalacing operations. The experimental results show that our efficient scheme has better efficiency than those of existing methods.

关键词： Cloud storage Data integrity Provable data possession(PDP) Data dynamics Cloud computing

On Characteristic Functions of De Bruijn Sequences

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2016年第2期25卷 304-311页

作者： tang Zhenwei qi Wenfeng TIAN Tian Department of Applied Mathematics Zhengzhou Information Science and Technology Institute

In 1982, H. Fredricksen presented the upper and lower bounds of the number of ones in the truth table of characteristic functions of de Bruijn sequences. In this paper, the distribution of ones in the truth table of characteristic functions of de Bruijn sequences is further studied. We provide the upper and lower bounds of the number of ones in the partial truth table of characteristic functions of de Bruijn sequences. Furthermore, the two bounds are tight.

关键词： Nonlinear feedback shift registers De Bruijn sequences Weight of the truth table