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punicalagin prevents obesity-related cardiac dysfunction through promoting DNA demethylation in mice

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Food Science and Human Wellness 2024年第3期13卷 1465-1474页

作者： Shengjie Pei Run Liu qingqing Ma Peng Jiang Xin He Zhongshi qi Jiacheng Fang Xu Yang Zirui Yao Xiaoqian Liu Xianfeng Jing Lei Chen Duo Li Institute of Nutrition&Health Qingdao UniversityQingdao 266071China School of public Health Qingdao UniversityQingdao 266071China Central Laboratory Guizhou Aerospace HospitalZunyi 563000China Health Centers of Licha Town Qingdao 266071China College of Computer Science and Technology Qingdao UniversityQingdao 266071China

The aim of this study was to investigate whether punicalagin(pu)could prevent obesity-related cardiac dysfunction by promoting DNA demethy lation,and to explore its possible mechanism.C57BL/6J mice were fed with standard diet,high-fat diet(HFD),HFD supplemented with resveratrol,low-dose pu(Lpu)and high-dose pu(Hpu)for 8 *** with HFD group,body weight was significantly lower in pu treatment groups,number of cardionwocytes and the protein level of myosin heavy chain 7B were significantly higher in pu treatment *** of 5-hydroxymethylcytosine and 5-formylcytosine were significantly lower in HFD group than in other *** with the HFD group,the protein level of ten-eleven translocation enzyme(TET)2 was significantly higher in pu treatment groups,p-AMP-activated protein kinase(AMPK)was significantly higher in Lpu *** of total antioxidant capacity and the protein levels of complexesⅡ/Ⅲ/Ⅴ,oxoglutarate dehydrogenase,succinate dehydrogenase B and fumarate hdrolase were significantly lower in HFD group than pu treatment *** ratio of(succinic acid+fumaric acid)/a-ketoglutarate was significantly higher in HFD group than other *** conclusion,pu up-regulated TETs enzyme activities and TET2 protein stability through alleviating mitochondrial dysfunction and activating AMPK,so as to promote DNA demethylation,thus preventing obesity-related cardiac dysfunction.

关键词： DNA demethylation Mitochondrial function Obesity-related cardiac dysfunction punicalagin Ten-eleven translocation family enzymes

Quantum Griffiths singularity in two-dimensional superconducting 4Ha-TaSe_(2) nanodevices

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Nano Research 2023年第10期16卷 12281-12285页

作者： Ying Xing Yiyu Liu pu Yang Jun Ge Longxin Pan Junyan wang Shichao qi Yi Liu Jian wang State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing 102249China International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China College of Chemistry Beijing Normal UniversityBeijing 100875China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials&Micro-nano Devices Renmin University of ChinaBeijing 100872China Collaborative Innovation Center of Quantum Matter Beijing 100871China Hefei National Laboratory Hefei 230088China Beijing Academy of Quantum Information Sciences Beijing 100193China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

The layered transition metal dichalcogenides(TMDs)have raised considerable interest in the past decades for both fundamental physics and low-dimensional nanodevice ***,intriguing phenomena of Ising superconductivity and quantum metallic state have been reported in two-dimensional(2D)4Ha-TaSe2 ***,we report the magnetic field induced superconductor–metal transition(SMT)in mechanical exfoliated 4Ha-TaSe2 nanodevices with thickness down to 2.5 *** observe the quantum Griffiths singularity(QGS)of SMT in thin 4Ha-TaSe2 nanodevices by performing ultralow temperature transport measurements and activated scaling *** increasing the thickness of TaSe2 nanodevice to 10.6 nm,the signature of magnetoresistance crossing region can hardly be detected,revealing the thickness dependence of *** this procedure,the disorder strength plays a dominant *** work enriches the platform for studying QGS and may stimulate further investigations on the correlation between different novel quantum phenomena in the same 2D superconducting system.

关键词： two-dimensional superconductor quantum phase transition quantum Griffiths singularity transition metal dichalcogenides electrical transport property

A recyclable polyurethane with characteristic thermal stiffening behavior via B-N coordination with reversible B-O bonds

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Science China Materials 2024年第10期67卷 3339-3346页

作者： Hui Xiong Linjun Zhang qi Wu Jinrong Wu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Key Laboratory of Composite Materials on Electrical Insulation National Energy AdministrationJiangsu Shemar Electric Co.Ltd.Nantong 226017China

Thermal softening is an inevitable process in the physical ***(pu),a typical commercial material,is constructed by physical networks,which undergoes the serious thermal decay on mechanical properties at high ***,a physically cross-linked pu with a unique thermal stiffening behavior has been developed by incorporating B–N coordination with reversible B–O *** B–N coordination can significantly improve the mechanical properties of the *** reversible B–O bonds(temperature dependent reversible transformation between B–OH and B–O–B)are conducive to constructing more multicoordination macromolecular crosslinking points and more stable B–N coordination bonds at high temperature,endowing the pu with the special thermal stiffening behavior for the first *** thermal stiffening behavior compensates for the bond breakage and the network destruction caused by heat,significantly expands the rubbery plateau and delays the entire chain motion of the thermoplastic *** a result,the terminal flow occurs at a higher temperature up to 200°*** modulus retention ratio of the materials is up to 87%even at 145oC,which is much higher than that of the existing pu elastomer with the physical network and even some covalent cross-link ***,the physical network ensures the recyclability of the pu,and the thermal stiffening behavior is still obtained in recycled *** work provides a simple strategy to impart thermal stiffening behavior to the physically crosslinked pu,thereby significantly extending the operating temperature range of thermoplastic pu,which can potentially expand the scopes of pu in applications under harsh conditions.

关键词： recyclable polyurethane B-N coordination reversible B-O bonds thermal stiffening behavior

早期脑氧利用率对一氧化碳中毒迟发性脑病的预测

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中华劳动卫生职业病杂志 2017年第5期35卷 348-350页

作者：刘倩李伟李娜肖青勉何佳起王维展齐洪娜王璞河北医科大学哈励逊国际和平医院EICU 衡水053000 河北医科大学哈励逊国际和平医院急诊病房衡水053000 河北医科大学哈励逊国际和平医院急救医学部衡水053000

目的探讨急性重度一氧化碳中毒早期阶段脑氧利用率（O2UCc）的动态变化对急性一氧化碳中毒迟发性脑病的预测价值。方法采用前瞻性观察性研究方法，选择2013年11月至2016年3月收治的急性重度一氧化碳中毒患者，记录患者的基线特征及生理... 详细信息

目的探讨急性重度一氧化碳中毒早期阶段脑氧利用率（O2UCc）的动态变化对急性一氧化碳中毒迟发性脑病的预测价值。方法采用前瞻性观察性研究方法，选择2013年11月至2016年3月收治的急性重度一氧化碳中毒患者，记录患者的基线特征及生理学参数，以急性中毒后2月为观察终点，根据是否发生迟发性脑病分为迟发性脑病组21例及无迟发性脑病组64例。连续监测入院时、6、24、48、72 h O2UCc的变化，采用Spearman相关检验对O2UCc与APACHEⅡ评分进行相关性分析，采用受试者工作特征曲线（ROC）评价O2UCc预测迟发性脑病的准确性。结果两组患者入院时O2UC均明显升高，且以迟发性脑病组升高明显，差异有统计学意义（P〈0.05），之后两组均呈现下降趋势，6、24、48 h迟发性脑病组O2UC均高于无迟发性脑病组（迟发性脑病组分别为52.57%±9.30%、47.40%±7.92%、39.38%±8.01%、32.29%±6.31%，无迟发性脑病组分别为41.46±%6.37%、34.51%±7.89%、28.79%±5.4%、27.72%±5.46%），差异有统计学意义（P〈0.05）；入院时、6、24、48 h O2UCc与APACHEⅡ评分呈正相关（r初始、r6 h、r24 h、r48 h分别为0.304、0.398、0.426，0.300，均P〈0.01）；ROC曲线分析结果显示，O2UCc初始、6、24、48 h均对DEACMP有预测价值，以6 h O2UCc预测价值最大，AUC为0.870，95% CI为0.794~0.947（P〈0.05）。结论O2UCc的动态变化对迟发性脑病的早期预检有参考意义，O2UCc可以作为预测迟发性脑病发生的参考指标。

关键词：一氧化碳中毒迟发性脑病脑氧利用率预测

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蜥蜴源黏质沙雷氏菌的分离鉴定与药敏试验

动物医学进展 2024年第1期45卷 126-130页

作者：蒲鹏张锐铮刘寅许信刚张琪西北农林科技大学动物医学院陕西杨凌712100 西北农林科技大学博览园陕西杨凌712100

为弄清西北农林科技大学博览园1只观赏蜥蜴突发全身皮肤化脓溃烂、尾巴坏死脱落的病原,采集患病蜥蜴的坏死病灶及血液病料进行细菌分离纯化、生理生化试验、动物致病性试验、16S rRNA基因测序鉴定。结果显示,从病料中分离并纯化出1株菌... 详细信息

为弄清西北农林科技大学博览园1只观赏蜥蜴突发全身皮肤化脓溃烂、尾巴坏死脱落的病原,采集患病蜥蜴的坏死病灶及血液病料进行细菌分离纯化、生理生化试验、动物致病性试验、16S rRNA基因测序鉴定。结果显示,从病料中分离并纯化出1株菌株,该分离菌株的生理生化特性与黏质沙雷氏菌相符,且该菌对实验小鼠有致病性,其16S rRNA基因序列与NCBI中黏质沙雷氏菌的参考序列同源性为98%。结果表明,所分离到的菌株为黏质沙雷氏菌。药敏试验结果显示,分离菌株对诺氟沙星、丁胺卡那、头孢曲松、氧氟沙星、头孢噻肟等5种抗菌药物高度敏感,对复方新诺明中度敏感,对环丙沙星、头孢噻吩、庆大霉素、头孢氨苄、苯唑西林、多黏菌素B、林可霉素、四环素、氨苄西林等9种抗菌药物耐药。研究结果为筛选有效治疗药物提供了参考依据。

关键词：蜥蜴黏质沙雷氏菌分离鉴定药敏试验

西南生态脆弱区重大建设工程渣场的生态修复技术和策略

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应用与环境生物学报 2024年第4期30卷 848-860页

作者：齐芳丁建林崔嘉琪蒲光兰向双吴彦刘庆中国科学院山地生态恢复与生物资源利用重点实验室生态恢复与生物多样性保育四川省重点实验室中国科学院成都生物研究所成都610213 四川农业大学林学院成都611130 中国科学院茂县山地生态系统定位研究站茂县623299 中国科学院大学北京100049

西南地区是我国长江上游重要的生态屏障区和国家重大建设工程的重要实施区.该区域雨水丰沛、地势陡峭,工程建设产生大量弃渣,不仅占用大面积的临时性和永久性土地,还极易造成水土流失、滑坡泥石流等次生灾害,生态环境极端脆弱.为保障区... 详细信息

西南地区是我国长江上游重要的生态屏障区和国家重大建设工程的重要实施区.该区域雨水丰沛、地势陡峭,工程建设产生大量弃渣,不仅占用大面积的临时性和永久性土地,还极易造成水土流失、滑坡泥石流等次生灾害,生态环境极端脆弱.为保障区域生态安全,亟须进行科学治理.基于西南地区的地质历史、气候条件和人地矛盾等实际,总结西南脆弱生态区渣场生态修复技术的研究进展.目前建设工程产生渣土的来源主要为道路修建、水电站建设、矿山开采和山区城镇基础建设等四大类项目.渣场修复作为一个系统工程,通常按照“土地整理—土壤重构—植被建设—景观再造—生态演替”的序列进行,修复技术主要分为土壤系统构建技术和植物群落构建技术两大板块.土壤系统的构建关键在于坡面整理保持水土,生土熟化和土壤改良,理化、微生物和植物措施修复重金属污染等方面.植物群落构建技术主要由选择先锋物种激发植物存活、群落配置促进持续演替、土壤种子库有效利用、植物配置促进成土等技术组成.针对目前渣场生态修复中存在的修复目标定位不清、土壤修复技术单一、物种适应难、生物入侵、群落演替难以为继等主要问题和难点,提出以区分不同生境梯度、不同生态系统类型和修复目标为核心依据的解决思路.在此基础上,展望了未来渣场修复技术、创新管理模式以及区域差异化治理策略等优化途径.(图2表4参82)

关键词：渣场土壤改良修复目标植物筛选群落配置

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经络诊察研究及应用现状分析

中华中医药杂志 2024年第8期39卷 4391-4394页

作者：赵耀张朴种文强赵娴张宁刘奇吕沛然陕西中医药大学针灸推拿学院咸阳712046 西安市中医医院创伤关节一病区西安710000

经络诊察是通过探索经脉循行体表的病理改变与疾病发生的相关规律,以协助医师诊疗疾病方法。传统经络诊察方法主要有审、切、循、扪、按;诊察内容包括诊脉和诊皮肤。现代经络诊察方法多样,以王居易经络诊察法为主,在人体生殖、运动、消... 详细信息

经络诊察是通过探索经脉循行体表的病理改变与疾病发生的相关规律,以协助医师诊疗疾病方法。传统经络诊察方法主要有审、切、循、扪、按;诊察内容包括诊脉和诊皮肤。现代经络诊察方法多样,以王居易经络诊察法为主,在人体生殖、运动、消化等系统及其他特殊疾病中均有应用。通过经络诊察法可提高医生对疾病的病位、病性、病经、病穴、病期及其相关性的认识,指导针灸临床。文章就经络诊察的研究进展及应用现状进行整理、分析,以期为临床实践提供参考和思路。

关键词：经络诊察研究进展应用现状

Pressure-Tunable Large Anomalous Hall Effect in Ferromagnetic Metal LiMn_(6)Sn_(6)

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Chinese Physics Letters 2024年第5期41卷 69-76页

作者：高玲玲赖俊文陈栋裴翠颖王琦赵毅李昌华曹渭征吴珏霏陈宇林陈星秋孙岩 Claudia Felser 齐彦鹏 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Max Planck Institute for Chemical Physics of Solids Dresden 01187Germany College of Physics Qingdao UniversityQingdao 266071China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUK School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China

Recently, giant intrinsic anomalous Hall effect(AHE) has been observed in the materials with kagome ***, we systematically investigate the influence of high pressure on the AHE in the ferromagnet LiMn_(6)Sn_(6) with clean Mn kagome lattice. Our in situ high-pressure Raman spectroscopy indicates that the crystal structure of LiMn_(6)Sn_(6) maintains a hexagonal phase under high pressures up to 8.51 GPa. The anomalous Hall conductivity(AHC) σ_(xy)^(A) remains around 150 Ω^(-1)·cm^(-1), dominated by the intrinsic mechanism. Combined with theoretical calculations, our results indicate that the stable AHE under pressure in Li Mn_(6)Sn_(6) originates from the robust electronic and magnetic structure.

关键词： structure mechanism intrinsic

Formation and Developmental Characteristics of A- and B-Type Starch Granules in Wheat Endosperm

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Journal of Integrative Agriculture 2012年第1期11卷 73-81页

作者： YIN Yong-an qi Jun-cang LI Wei-hua CAO Lian-pu wang Zi-bu Key Oasis Eco-Agriculture Laboratory of Xinjiang Production and Construction Group/Agricultural Faculty Shihezi UniversityShihezi 832003P.R.China

Wheat grain natural transverse sections of 12 periods were observed and analyzed using scanning electron micrographs technology and Bio-Quant system IV image analyzer in order to detect the developing process of A- and B-type starch granules. In addition, the chemical composition and starch granule-bound proteins （SGPs） of A- and B-type starch granules were tested and analyzed. The results showed that A-type starch granules in wheat began from 3 d post anthesis （DPA） till grain maturing and B-type starch granules occured after 15 DPA till grain maturing. Approximately 98.5% of chemical compositions in both A- and B-type starch granules were amylose and amylopectin, and more than half of which were amylopectin. The amylopectin contents, average chain length, and chain length distribution （degree of polymerization〉 40） of amylopectin in A-type starch granules were significant higher than that of B-type starch granules. SGP-145, SGP-140, and SGP-26 kD were associated with A-type starch formation in wheat grain.

关键词： wheat (Triticum aestivum L.) A- and B-type starch granules formation and developmental characteristics