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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

第十一届全国化学生物学学术会议

作者： qi-pin qin Zhen-Feng Wang Xiao-Ling Huang Ming-Xiong Tan Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology College of Chemistry and Food ScienceYulin Normal University

The jatrorrhizine was the major bioactive alkaloids isolated from Tinospora capillipes Gagnep. It was important compounds because of their wide range of pharmacological activities including antifungal,anti-tumor and antibacterial activities. However,no jatrorrhizine metal complexes have been ***,a new Pt(II) complex,[Pt(J-TFA)Cl]Cl(Pt1) with jatrorrhizine derivatives(J-TFA) was first prepared as desirable luminescent agents for cellular applications and potent telomerase inhibitors,which can induce bladder T-24 tumor cell apoptosis by targeting telomerase,together with induction of mitochondrial dysfunction,telomere DNA damage and cell-cycle ***,jatrorrhizine Pt1 complex may have the potential to be further developed into safe and effective Pt-based anticancer agents.

关键词： Platinum complex jatrorrhizine telomerase mitochondrial dysfunction

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

Antitumor mechanism of a platinum(Ⅱ) complex with liriodenine from traditional Chinese medicine

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Antitumor mechanism of a platinum(Ⅱ) complex with liriodeni...

8-羟基喹啉及其衍生物金属配合物抗肿瘤和抗菌活性研究进展

第八届全国化学生物学学术会议

作者： Yu-Lan Li qi-pin qin Yan-Cheng Liu Ke-Bin Huang 陈振锋 Hong Liang State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry & Pharmacy of Guangxi Normal University

Liriodenine(L),an active component isolated from the traditional Chinese medicine(TCM),was selected as an bioactive ligand to afford the corresponding platinum(II) complex, cis-[PtCl(L)(DMSO)](1),whose crystal structure was shown in *** antitumor mechanism of complex 1 towards the liver tumor cell line BEL-7404 was studied aiming to the cell cycle

关键词： liriodenine platinum complex antitumor mechanism apoptosis

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中国科学：化学 2017年第2期47卷 172-182页

作者：覃姣兰曹倩倩覃其品梁宏陈振锋省部共建药用资源化学与分子工程国家重点实验室广西师范大学化学与药学学院桂林541004 广西百色职业学院百色533000

铂类抗癌药物在临床上的成功应用,极大推动了金属药物化学的发展.寻找新型作用机制金属药物已成为药物化学研究领域的热点之一.本文就8-羟基喹啉及其衍生物金属配合物在抗肿瘤和抗菌方面的研究进展进行综述,从金属配合物的合成、结构、... 详细信息

铂类抗癌药物在临床上的成功应用,极大推动了金属药物化学的发展.寻找新型作用机制金属药物已成为药物化学研究领域的热点之一.本文就8-羟基喹啉及其衍生物金属配合物在抗肿瘤和抗菌方面的研究进展进行综述,从金属配合物的合成、结构、活性、作用机制、构效关系等总结了8-羟基喹啉及其衍生物金属抗肿瘤配合物的最新研究进展.对8-羟基喹啉及其衍生物金属抗菌配合物的研究也进行了总结,从中发现了一些活性基团及卤代效应的趋势,为设计和开发具有应用前景的8-羟基喹啉及其衍生物金属抗肿瘤、抗菌药物提供了重要的参考.

关键词： 8-羟基喹啉衍生物金属配合物抗肿瘤抗菌

An infrared study of Be stars based on ISO SWS01 spectra

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Research in Astronomy and Astrophysics 2009年第7期9卷 770-776页

作者： pin Zhang Zai-qi Fu Cosmic Ray Institute Yunnan University Kunming 650091 China Department of Physics Zhaotong Teachers College Zhaotong 657000 China

The Infrared Space Observatory （ISO） Short-Wavelength Spectrometer （SWS） spectra of 10 Be stars are presented. It can be seen that the Be stars show a diversity in their ISO SWS01 spectral classifications by Kraemer et al., from naked stars, stars associated with dust, stars with warm dust shells, stars with cool dust shells to very red sources. In addition, the Brα/HI（14-6） line flux ratio derived for the sample stars is compared with that of P Cyg, and it is found that the line ratio of Be stars which were investigated show not only lower values as suggested by Waters et al., but also larger values. Therefore, the line ratio cannot be used to judge whether a star is a Be star or not.

关键词： stars circumstellar matter - infrared stars - stars emission-line Be

microRNA-455-5p alleviates neuroinflammation in cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第8期17卷 1769-1775页

作者： Jian-Song Zhang pin-pin Hou Shuai Shao Anatol Manaenko Zhi-Peng Xiao Yan Chen Bing Zhao Feng Jia Xiao-Hua Zhang qi-Yong Mei qin Hu Central Laboratory Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurosurgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Medical Genetics Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurosurgery Changzheng Hospitalthe Second Military Medical UniversityShanghaiChina

Neuroinflammation is a major pathophysiological factor that results in the development of brain injury after cerebral ischemia/*** of microRNA(miR)-455-5p after ischemic stroke has been considered a potential biomarker and therapeutic target for neuronal injury after ***,the role of miR-455-5p in the post-ischemia/reperfusion inflammatory response and the underlying mechanism have not been *** this study,mouse models of cerebral ischemia/reperfusion injury were established by transient occlusion of the middle cerebral artery for 1 hour followed by ***-455-5p,antagomir-455-5p,and their negative controls were injected intracerebroventricularly 2 hours before or 0 and 1 hour after middle cerebral artery occlusion(MCAO).The results showed that cerebral ischemia/reperfusion decreased miR-455-5p expression in the brain tissue and the peripheral ***-455-5p pretreatment increased miR-455-5p expression in the brain tissue,reduced the cerebral infarct volume,and improved neurological ***,primary cultured microglia were exposed to oxygen-glucose deprivation for 3 hours followed by 21 hours of reoxygenation to mimic cerebral ischemia/***-455-5p reduced C-C chemokine receptor type 5 mRNA and protein levels,inhibited microglia activation,and reduced the production of the inflammatory factors tumor necrosis factor-αand interleukin-1β.These results suggest that miR-455-5p is a potential biomarker and therapeutic target for the treatment of cerebral ischemia/reperfusion injury and that it alleviates cerebral ischemia/reperfusion injury by inhibiting C-C chemokine receptor type 5 expression and reducing the neuroinflammatory response.

关键词： agomiR-455-5p biomarker blood-brain barrier C-C chemokine receptor type 5 ischemia/reperfusion injury ischemic stroke microglia microRNA-455-5p neuroinflammation pretreatment

Thermodynamics and microstructures of Euler–Heisenberg black hole in a cavity

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Communications in Theoretical Physics 2023年第9期75卷 91-103页

作者： qin Yu qi Xu Jun Tao Center for Theoretical Physics College of PhysicsSichuan UniversityChengdu610065China

Euler–Heisenberg black holes with quantum electrodynamics(QED) correction are embraced by a cavity in this paper, which serves as a boundary of the black hole spacetime and contributes to the equilibrium of the system. We explore the thermodynamic properties of the black hole, including the phase transitions and phase structures. The small/large black hole phase transition occurs for a negative QED parameter, while the reentrant phase transition can be observed for a small positive QED parameter. Then the thermodynamic geometry is investigated to diagnose microscopic interactions of black hole thermodynamic systems. For the reentrant phase transition, the small black holes are dominated by repulsion for the first-order coexistence curve, while the interaction between the small black hole molecules could be attractive or repulsive for the small/large black hole phase transition.

关键词： black hole thermodynamics phase transition microstructure

Construction and applications of DNA-based nanomaterials in cancer therapy

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Chinese Chemical Letters 2022年第3期33卷 1131-1140页

作者： Hedong qi Yuwei Xu pin Hu Chi Yao Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China

As a biologically active macromolecule, deoxyribonucleic acid(DNA) has the advantages of sequence programmability and structure controllability and can accurately transmit sequence information to specific biological functions. Facing the complex internal microenvironment and heterogeneity in tumor treatment, the construction and applications of DNA-based nanomaterials have become a focus point of research. In particular, the hybridization of DNA molecules with other materials endows DNA-based nanomaterials with multiple functions such as targeting, stimulus responsiveness and regulations of biological activities, making DNA nanostructures great potential in the treatment of major human *** this review, the construction and characteristics of DNA-based nanomaterials are introduced. Then,the functions and applications of DNA-based nanomaterials in the delivery of chemotherapy drugs and gene drugs, stimulus-responsive release and regulation of cell homeostasis are reviewed. Finally, the future development and challenges of DNA-based nanomaterials are prospected. We envision that DNAbased nanomaterials can enrich the nanomaterial system by rational design and synthesis and address the growing demands on biological and biomedical applications in the real world.

关键词： DNA nanomaterials DNA nanotechnology Drug delivery Cancer therapy