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Advances in Manufacturing 2023年第4期11卷 587-600页

作者： Da-Wei zhang Wen-long Gao-zhang qi zhang Xi’an Key Laboratory of Intelligent Equipment and Control School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an710049People’s Republic of China

Distortion during the forging or machining processes of a blade causes problems in subsequent manufacturing. This paper proposes an alternative multipoint correction method integrated with blade measurement, determination of correcting parameters, and adjustment of the correcting die. An iterative algorithm for determining the correcting parameters is proposed. Measuring equipment combining a laser displacement sensor with multipoint flexible support is manufactured to measure the blade shape. Multipoint correcting equipment with an adaptive lower die and rapid adjustment is manufactured, and software is developed for data analysis and equipment control. The correction experiment for a rough-machined steam-turbine blade indicates that the correcting parameters can be determined after one modification based on numerical simulation, and that a rough blade that meets the allowance for finish machining can be obtained using the determined correction parameters.

关键词： Blade Surface measurement Numerical simulation Multipoint correction

Anti-sintering behavior and combustion process of aluminum nano particles coated with PTFE:A molecular dynamics study

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Defence Technology（防务技术） 2023年第6期24卷 46-57页

作者： Jun-peng Liu Hao-rui zhang qi-long Yan Science and Technology on Combustion Internal Flow and Thermostructure LaboratoryNorthwestern Polytechnical UniversityXi'an 710071China

The characteristic of easy sintering of aluminum nanoparticle(ANP)limits its application in solid propellants.Coating ANP with fluoropolymer could effectively improve its combustion performance.To find out how the coating layer inhibits sintering and promotes complete combustion of particles from an atomic view,a comparative study has been done for bare ANP and PTFE coated ANP by using reactive molecular dynamics simulations.The sintering process is quantified by shrinkage ratio and gyration radius.Our results show that,at the same heating rate and combustion temperatures,bare ANPs are sintered together after the temperature exceeds the melting point of aluminum but the decomposition of PTFE coating layer pushes particles away and increases reaction surface area by producing small Al-F clusters.The sintering of ANPs which are heated in PTFE is alleviated compared with particles heated in oxygen,but particles still sinter together due to the lack of intimate contact between PTFE and alumina surface.The effect of temperature on the combustion of PTFE coated ANPs is also studied from 1000 to3500 K.The number density analysis shows the particles will not be sintered at any temperature.Aluminum fluoride prefers diffusing to the external space and the remained particles are mainly composed of Al,C and O.Fast ignition simulations are performed by adopting micro canonical ensemble.With the expansion of aluminum core and the melting of alumina shell,bare ANPs are sintered into a liquid particle directly.For PTFE coated ANPs,the volatilization of gaseous aluminum fluoride products continually endows particles opposite momentum.

关键词： Aluminum nanoparticle Sintering Combustion Molecular dynamics simulation

PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy

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Cancer Biology & Medicine 2018年第2期15卷 116-123页

作者： long Jia qi zhang Rongxin zhang Laboratory of Immunology and Inflammation Department of Immunology and Research Center of Basic Medical SciencesKey Laboratory of Immune Microenvironments and Diseases of Educational MinistryTianjin Medical University Institute of Integrative Medicines for Acute Abdominal Diseases Tianjin Nankai Hospital Guangdong Province Key Laboratory for Biotechnology Drug Candidates School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical University

Cancer immunotherapy has greatly advanced in recent years,and PD-1/PD-L1 blocking therapy has become a major pillar of immunotherapy.Successful clinical trials of PD-1/PD-L1 blocking therapies in cancer treatments have benefited many patients,which promoted the Food and Drug Administration(FDA)approval of PD-1/PD-L1 blocking drugs.In this review,we provide a detailed introduction of five PD-1/PD-L1 blocking drugs,with indications and studies,as a valuable reference for doctors and medical investigators.Moreover,the characteristics of PD-1/PD-L1 blocking therapies,including their universality and sustainability,are discussed in this review.Furthermore,we also discuss and predict the possibility of PD-L1 as an indication marker of PD-1/PD-L1 blocking therapy for pan-cancer treatment,and the current status of combination therapies.

关键词：癌症治疗免疫疗法封锁小径管理局参考书药品食物

Electro-mechanical coupling properties of band gaps in an with periodically attached “spring-mass” resonators

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Applied Mathematics(A Journal of Chinese Universities) 2023年第3期38卷 429-443页

作者： zhang Jian qiAN Deng-hui REN long WANG qi School of Naval Architecture&Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China China Nanhu Academy of Electronics and Information Technology Jiaxing 314000China

The model of a locally resonant (LR) epoxy/PZT-4 phononic crystal (PC)nanobeam with “spring-mass” resonators periodically attached to epoxy is proposed. The corresponding band structures are calculated by coupling Euler beam theory, nonlocal piezoelectricity theory and plane wave expansion (PWE) method. Three complete band gaps with the widest total width less than 10GHz can be formed in the proposed nanobeam by comprehensively comparing the band structures of three kinds of LR PC nanobeams with resonators attached or not. Furthermore, influencing rules of the coupling fields between electricity and mechanics,“spring-mass” resonator, nonlocal effect and different geometric parameters on the first three band gaps are discussed and summarized. All the investigations are expected to be applied to realize the active control of vibration in the region of ultrahigh frequency.

关键词： phononic crystal nanobeam electro-mechanical coupling effect nonlocal effect locally resonant mechanism

Modulation of Conformational Transition of Polypeptides under Slightly Acidic Environment

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Chinese Journal of Chemistry 2022年第24期40卷 2981-2987,I0002页

作者： Jie Li Jiajie zhang qi long Weisheng Guo Menghua Xiong Guangzhou First People's Hospital School of Biomedical Sciences and EngineeringSouth China University of TechnologyGuangzhou International CampusGuangzhouGuangdong511442 China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouGuangdong510006 China Translational Medicine Center Key Laboratory of Molecular TargetClinical PharmacologySchool of Pharmaceutical SciencesThe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong510260 China Key Laboratory of Biomedical Engineering of Guangdong Province and Innovation Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhouGuangdong510006 China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhouGuangdong510006 China

Controlling the conformational transition of polypeptides under slightly acidic environment is challenging.Herein,we report a class of pH-responsive helix-to-coil conformationally transitionable polypeptides(pCTPs)by simply conjugating tertiary amine groups(TAs)to polylysine.Their conformation is highly dependent on the charge state of TAs,showing a helical structure when most TAs are deprotonated and a non-helical structure when majority of TAs are protonated.The conformational transition pH can be modulated by tuning the hydrophobicity of TAs and the incorporation of hydrophobic monomers at a pH range of 7.2 to 6.0.Such pCTP showed a vesicle-to-micelle transition when their conformation transformed from helix to coil,facilitating controlled drug release.Our study provided an approach to control the conformational transition of polypeptides under slightly acidic condition.

关键词： Peptides Conformational transition Helical structures pH responsiveness Drug delivery

Efficacy of qihuang decoction(芪黄煎剂) on enteric nervous system in rats after gastrectomy

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Journal of Traditional Chinese Medicine 2022年第4期42卷 556-564页

作者： zhang qi ZHENG Zhou HUANG long PENG Hui YU qingsheng WANG Laiyong Department of General Surgery First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China Institute of Chinese Medicine Surgery Anhui Academy of Traditional Chinese MedicineHefei 230031China

OBJECTIVE:To investigate the influence of qihuang decoction(芪黄煎剂)on enteric nervous system after gastrectomy in rats.METHODS:The morphology,distribution and number of intestinal neurons in enteric nervous system(ENS)were observed by immunofluorescence labeling and confocal laser scanning microscopy.Reverse transcriptionpolymerase chain reaction and Western blot were used to detect the mRNA and protein expression of intestinal neurotransmitters and corresponding receptors in ENS.RESULTS:The morphology and distribution of enteric neurons in ENS were changed after gastrectomy,and these neurons in qihuang decoction group were similar with that of sham operation group.The number of ACh and SP positive neurons,mRNA and protein expression of excitatory neurotransmitters(ACh E,SP)and receptors(M3R,NK1R)were decreased after gastrectomy.And the intervention of qihuang decoction could increase the number of ACh and SP positive neurons and promote the expression of their mRNA and protein.For vasoactive intestinal peptide(VIP)and nitric oxide synthase(NOS),the number of neurons and mRNA and protein expression of inhibitory neurotransmitters(VIP and NOS)and receptors(VIP2R)were increased after gastrectomy.And these rising indexes fall back after the intervention of qihuang decoction.Besides,the intestinal propulsion rate in QH group was significantly increased than that in SEN and IEN group.CONCLUSIONS:These experimental results showed that after gastrectomy,early intervention with qihuang decoction in small intestine will contribute to the postoperative recovery of enteric nervous system and intestinal propulsion rate,and consequently enhance gastrointestinal motility.

关键词： Gastrectomy gastrointestinal motility enteric nervous system neurotransmitter agents receptors,neurotransmitter qihuang decoction

Dynamic Behavior of Gravity Retaining Walls with Coral Sand Backfill Under Earthquakes:Shaking Table Tests

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China Ocean Engineering 2022年第6期36卷 839-848页

作者： zhang Yan-ling WANG Cheng-long DING Xuan-ming WU qi College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of New Technology for Construction of Cities in Mountain Area School of Civil EngineeringChongqing UniversityChongqing 400045China

The retaining walls in coral sand sites are inevitably threatened by earthquakes. A series of shaking table tests were carried out to study the seismic stability of gravity retaining walls with coral sand backfill. Parallel tests with quartz sand were performed to compare and discuss the special dynamic properties of coral sand sites. The results show that the acceleration difference between the retaining wall and the coral sand backfill is 76%-92% that of the quartz sand,which corresponds to the larger liquefaction resistance of coral sand compared with the quartz sand. However, the horizontal displacement of the retaining walls with coral sand backfill reaches 79% of its own width under 0.4g vibration intensity. The risk of instability and damage of the retaining walls with coral sand backfill under strong earthquakes needs attention.

关键词： coral sand seismic response liquefaction shaking table test gravity retaining walls

Experimental Study on the Resistance and Splash Performances of Water Collecting Devices for Mechanical Draft Cooling Towers

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Fluid Dynamics & Materials Processing 2023年第7期19卷 1789-1801页

作者： Guoqing long Guogang zhang qi zhang Cuilin Zhao Suoying He Fengzhong Sun China Energy Engineering Group Guangdong Electric Power Design Institute Co. Ltd.Guangzhou510663China School of Energy and Power Engineering Shandong UniversityJinan250061China

In recent years,water collecting systems,with the associated advantages of energy saving and noise reduction,have become the foundation for the development of a scheme to optimize the structure of cooling towers.To explore the feasibility of this approach for mechanical draft cooling towers,a small-scale experimental device has been built to study the resistance and splash performances of three U-type water collecting devices(WCDs)for different water flow rates and wind speeds.The experimental results show that within the considered ranges of wind speed and water flow rate,the pressure drop of the different WCDs can vary significantly.The resistance and local splash performances can also be remarkably different.Some recommendations about the most suitable system are provided.Moreover,a regression analysis of the experimental data is conducted,and the resulting fitting formulas for resistance and splash performance of WCD are reported.

关键词： Mechanical draft cooling towers water collecting device resistance performance splash performance fitting formulas

Enhancing Li cycling coulombic efficiency while mitigating “shuttle effect” of Li-S battery through sustained release of LiNO_(3)

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Journal of Energy Chemistry 2023年第9期84卷 22-29页

作者： qi Jin Kaixin Zhao Lili Wu Lu Li long Kong Xitian zhang Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina Frontiers Science Center for Flexible Electronics and Xi’an Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710129ShaanxiChina

In practical lithium-sulfur batteries(LSBs),the shuttle effect and Li cycling coulombic efficiency(CE) are strongly affected by the physicochemical properties of solid electrolyte interphase(SEI).LiNO_(3) is widely used as an additive in electrolytes to build a high-quality SEI,but its self-sacrificial nature limits the ability to mitigate the shuttle effect and stabilize Li anode during long-term cycling.To counteract LiNO_(3) consumption during long-term cycling without using a high initial concentration,inspired by sustainedrelease drugs,we encapsulated LiNO_(3) in lithiated Nafion polymer and added an electrolyte co-solvent(1,1,2,2-tetrafluoroethylene 2,2,2-trifluoromethyl ether) with poor LiNO_(3) solubility to construct highquality and durable F-and N-rich SEI.Theoretical calculations,experiments,multiphysics simulations,and in-situ observations confirmed that the F-and N-rich SEI can modulate lithium deposition behavior and allow persistent repair of SEI during prolonged cycling.Hence,the F-and N-rich SEI improves the Li anode cycling CE to 99.63% and alleviates the shuttle effect during long-term cycling.The lithium anode with sustainable F-and N-rich SEI shows a stable Li plating/stripping over 2000 h at 1 mA cm^(-2).As expected,Li‖S full cells with this SEI achieved a long lifespan of 250 cycles,far exceeding cells with a routine SEI.The Li‖S pouch cell based on F-and N-rich SEI also can achieve a high energy density of about300 Wh kg^(-1) at initial cycles.This strategy provides a novel design for high-quality and durable SEls in LSBs and may also be extendable to other alkali metal batteries.

关键词： Lithium-sulfur battery Solid electrolyte interphase LiNO_(3) Coulombic efficiency Shuttle effect

Highly luminescent zero-dimensional lead-free manganese halides forβ-ray scintillation

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Nano Research 2022年第9期15卷 8486-8492页

作者： Linyuan Lian Wei qi Huaiyi Ding Hao Tian qi Ye Yong-Biao Zhao long Zhao Jianbo Gao Daoli zhang Jianbing zhang School of Optical and Electronic Information Huazhong University of Science and Technology1037 Luoyu RoadWuhan 430074China Hubei Key Laboratory of Bioinorganic Chemistry&Materia Medica School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Yunnan Provincial Higher Education Institutions for Optoelectronics Device Engineering School of Physics and AstronomyYunnan UniversityKunming 650504China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China Department of Physics and Astronomy Ultrafast Photophysics of Quantum Devices LaboratoryClemson UniversityClemsonSC 29634USA Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518057China

Because of their moderate penetration power,β-rays(high-energy electrons)are a useful signal for evaluating the surface contamination of nuclear radiation.However,the development ofβ-ray scintillators,which convert the absorbed high-energy electrons into visible photons,is hindered by the limitations of materials selection.Herein,we report two highly luminescent zerodimensional(0D)organic-inorganic lead-free metal halide hybrids,(C_(13)H_(30)N)_(2)MnBr_(4)and(C_(19)H_(34)N)_(2)MnBr_(4),as scintillators exhibiting efficientβ-ray scintillation.These hybrid scintillators combine the superior properties of organic and inorganic components.For example,organic components that contain light elements C,H,and N enhance the capturing efficiency ofβparticles;isolated inorganic[MnBr_(4)]2−tetrahedrons serve as highly localized emitting centers to emit intense radioluminescence(RL)underβ-ray excitation.Both hybrids show a narrow-band green emission peaked at 518 nm with photoluminescence quantum efficiencies(PLQEs)of 81.3%for(C_(13)H_(30)N)_(2)MnBr_(4)and 86.4%for(C_(19)H_(34)N)_(2)MnBr_(4),respectively.To enable the solution processing of this promising metal halide hybrid,we successfully synthesized(C_(13)H_(30)N)_(2)MnBr_(4)colloidal nanocrystals for the first time.Being excited byβ-rays,(C_(13)H_(30)N)_(2)MnBr_(4)scintillators show a linear response toβ-ray dose rate over a broad range from 400 to 2,800 Gy·s^(−1),and also display robust radiation resistance that 80%of the initial RL intensity can be maintained after an ultrahigh accumulated radiation dose of 240 kGy.This work will open up a new route for the development ofβ-ray scintillators.

关键词： zero-dimensional metal halide hybrids radiation sterilization β-ray scintillation nanocrystals