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Effect of ulinastatin combined with anti-infective therapy on systemic inflammatory response and oxidative stress response in patients with acute severe pneumonia

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Journal of Hainan Medical University 2017年第16期23卷 13-16页

作者： Jie Peng Na An jun-qi ma Emergency Department Traditional Chinese Medicine Hospital of Xinjiang Medical UniversityUrumchiXinjiang830000

Objective: To study the effect of ulinastatin combined with anti-infective therapy on systemic inflammatory response and oxidative stress response in patients with acute severe pneumonia. Methods: A total of 50 patients with acute severe pneumonia who were treated in the hospital between September 2014 and December 2016 were collected and divided into control group and observation group according to the random number table method, 25 cases in each group. Control group received conventional therapy, and the observation group received ulinastatin combined with conventional therapy. The differences in inflammatory response and oxidative stress response in serum were measured before treatment and 10 d after treatment. Results:Before treatment, differences in serum levels of inflammatory response indexes and oxidative stress indexes were not statistically significant between the two groups. After treatment, serum IL-2, IL-6, PCT, HMGB1, CRP, IL-4, IL-10, IL-13, MDA, AOPP and ROS levels of both groups of patients were lower than those before treatment while SOD, T-AOC, GSH-Px and LHP levels were higher than those before treatment, and serum IL-2, IL-6, PCT, HMGB1, CRP, IL-4, IL-10, IL-13, MDA, AOPP and ROS levels of observation group were lower than those of control group while SOD, T-AOC, GSH-Px and LHP levels were higher than those of control group. Conclusion: Ulinastatin combined with anti-infective therapy can effectively reduce the systemic inflammatory response and oxidative stress response and optimize the overall condition in patients with acute severe pneumonia.

关键词： Acute severe pneumonia Ulinastatin Inflammatory response Oxidative stress

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The MdABI5 transcription factor interacts with the MdNRT1.5/MdNPF7.3 promoter to fine-tune nitrate transport from roots to shoots in apple

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Horticulture Research 2021年第1期8卷 3131-3143页

作者： Ya-Jing Liu Ning Gao qi-jun ma Jiu-Cheng Zhang Xun Wang Jing Lu Yu-Jin Hao Xiao-Fei Wang Chun-Xiang You State Key Laboratory of Crop Biology Shandong Collaborative Innovation Center of Fruit&Vegetable Quality and Efficient ProductionCollege of Horticulture Science and EngineeringShandong Agricultural UniversityTai-AnShandong 271018China

Nitrate is a major nitrogen resource for plant growth and development and acts as both a crucial nutrient and a signaling molecule for plants;hence,understanding nitrate signaling is important for crop *** acid(ABA)has been demonstrated to be involved in nitrate signaling,but the underlying mechanism is largely unknown in *** this study,we found that exogenous ABA inhibited the transport of nitrate from roots to shoots in apple,and the transcription of the nitrate transporter MdNRT1.5/MdNPF7.3 was noticeably reduced at the transcriptional level by ABA,which inhibited the transport of nitrate from roots to ***,it was found that the ABA-responsive transcription factor MdABI5 bound directly to the ABRE recognition site of the MdNRT1.5 promoter and suppressed its *** of MdABI5 inhibited ABA-mediated transport of nitrate from roots to ***,these results demonstrate that MdABI5 regulates the transport of nitrate from roots to shoots partially by mediating the expression of MdNRT1.5,illuminating the molecular mechanism by which ABA regulates nitrate transport in apple.

关键词： ABI5 nitrate roots

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye jun-Ji ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie qi Tian Tang Yunfan Zhang Zhiyuan ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 ma cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

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Controllable optical bistability in a Fabry-Pérot cavity with a nonlinear three-dimensional Dirac semimetal

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Chinese Physics B 2024年第3期33卷 441-446页

作者：袁红霞李佳雪马奇军田海山叶云洋罗文昕吴杏华蒋乐勇 School of Physics and Electronics Hunan Normal UniversityChangsha 410081China School of Intelligent manufacturing and Electronic Engineering Wenzhou University of TechnologyWenzhou 325035China Key Laboratory for Microstructural Functional materials of Jiangxi Province College of ScienceJiujiang UniversityJiujiang 332005China

Optical bistability(OB)is capable of rapidly and reversibly transforming a parameter of an optical signal from one state to another,and homologous nonlinear optical bistable devices are core components of high-speed all-optical communication and all-optical *** this paper,we theoretically investigated the controllable OB from a Fabry-Pérot(FP)cavity with a nonlinear three-dimensional Dirac semimetal(3D DSM)in the terahertz *** OB stems from the third-order nonlinear bulk conductivity of the 3D DSM and the resonance mode has a positive effect on the generation of *** FP cavity structure is able to tune the OB because the transmittance and the reflectance can be modulated by the Fermi energy of the 3D *** believe that this FP cavity configuration could provide a reference concept for realizing tunable bistable devices.

关键词： optical bistability Dirac semimetal Fabry-Pérot cavity

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Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao Gao Xingzhao Zhang Dacheng ma Chuanlei Zhu jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han jun Xiao Jian-Feng ma Wen ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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1341.4nmNd∶YAP激光内镜下治疗消化道疾病45例报告

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中国激光 2001年第11期28卷 1054-1056页

作者：贾方王修齐马军忠河南省人民医院消化内科激光室郑州450003

可经光导纤维传输的 134 1.4nm激光有着良好的组织凝固、气化功能 ,且肌体组织穿透力较 10 6 4nm激光小得多 ,因而安全性能显著提高。 45例内镜下消化道增生性疾病的治疗结果表明 :134 1.

关键词： Nd:YAP激光器消化道增生性疾病激光内镜治疗

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Immersive Virtual Product Development

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厦门大学学报（自然科学版） 2002年第S1期41卷 143-页

作者： BAO Jin-song, JIN Ye, GU Ming-qiang, YAN jun-qi, ma Deng -ze (Industrial VR Lab of CIM Institute, Shanghai Jiaotong University, Shan ghai 200030, China)

Immersive virtual product development is a new desi gn , developing and evaluation method of integrated product and processing tragedie s, which using VR, multi-discipline simulation and scientific visualization tec hnologies. Users may have the experiences of being part of a cyberspace environm ent with the ability to navigate and manipulate objects which have properties an d behaviors that correspond to those of the real world objects. We present a fra mework and prototype system of an immerse VPD (IVPD) which enables users to navi gate and interact with 3D peripherals with the display system. The framework of IVPD which we have defined can meet these requirements. In the immersive virtual environment, design will include four main parts: 3D CAD/modeler, multidiscipli ne simulations, CAM and discrete system simulation. 3D CAD/modeler can create 3D geometric objects and import models from other commercial softwares such as UG, CATIA etc. It can also store all kinds of models into databases with hierarchy which will provide geometric models with simulations and evaluations in later pr ocedures. Multidiscipline simulations can integrate many simulations such as FEA , CFD, Noisy and etc. Each kind of these simulation softwares will reflect a cer tain aspect of product or component’s performances. CAM, as a successor of prod uct development, mainly simulates the manufacturing procedures in the computer. Discrete system simulation will able to see the layout problems for a factory. I t is very useful for production management. Participants may actively view the v irtual world revolving around them while others control navigation and simul ations, and may interact with other members such as pass an object from one embo died manikin to another.

关键词： virtual reality immersive VPD virtual environme nt multi-discipline simulation

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用降级法及计算机辅助进行平面三级或四级机构的运动分析——绣花机摆针调节机构的运动分析

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陕西科技大学学报 1986年第4期 11-19页

作者：詹启贤马俊慧

本文提出了用降级法及计算机辅助进行平面三级或四级机构的运动分析,并对一种典型实用的复杂平面凸轮连杆机构——GIXX—X型工业用绣花机的摆针调节机构进行了完整的运动分析。

关键词：运动分析降级法计算机辅助机助绣花机刺绣机

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