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Clinical evaluation of sintilimab in conjunction with bevacizumab for advanced colorectal cancer with microsatellite stable-type after failure of first-line therapy

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3277-3287页

作者： Liang Wang Yong-Zhi Diao Xin-Fu Ma Yu-Shuang Luo qi-jing guo Xiao-qian Chen Department of Gastrointestinal Oncology Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Gastroenterology The First People’s Hospital of XiningXining 810000Qinghai ProvinceChina Department of Medical Oncology Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

BACKGROUND At present,immune checkpoint inhibitors(ICIs)remain the 1st-line therapy me-thod for patients suffering from high microsatellite instability/deficient misma-tch repair metastatic colorectal cancer(mCRC).However,ICI treatments demon-strate minimal therapeutic efficacy against microsatellite stable(MSS)/proficient mismatch repair(pMMR)*** is mainly because this type of tumor is a“cold tumor”with almost no lymphocyte ***-angiogenic drugs have been found to improve the immune microenvironment by promoting many immune cells to enter the immune microenvironment,thereby exerting anti-tumor *** To investigate the effects of ICIs combined with bevacizumab monoclonal anti-body on tumor immune cells in MSS/pMMR advanced CRC patients with first-line treatment *** A total of 110 MSS/pMMR patients with advanced CRC after first-line treatment failure in the Affiliated Hospital of qinghai University were enrolled for a ran-domized controlled *** short,patients in the experimental group(n=60)were given sintilimab plus bevacizumab for 4 cycles,and those in the control group(n=50)patients were treated with FOLFIRI combined with bevacizumab for 4 *** expression levels of cluster of differentiation(CD)8(+)T cells,tumor-associated macrophages(TAMs),and cancer-associated fibroblasts(CAFs)were comprehensively evaluated to assess the effects of sintilimab combined with bevacizumab on MSS/pMMR advanced CRC sufferers following failure of 1st-line *** The positive expression rates of CD8(+)T lymphocytes(30%vs 50%),TAMs(23.30%vs 60%),and CAFs(23.30%vs 50%)before and after treatment in both groups exhibited statistical significance(P<0.05).Additionally,the therapeutic effects of both groups(partial remission:26.67%vs 10%;objective response rate:26.70%vs 10%)were significantly different(P<0.05).Although the experimental group showed a higher progression-free survival,median progression-free survival,and disease control rate

关键词： Immune checkpoint inhibitors Bevacizumab Colorectal cancer Cytotoxic T lymphocytes Tumor-associated macrophages Cancer-associated fibroblasts

Practical approach for detecting k-nonseparability of multipartite quantum states

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 32-48页

作者： Jie guo Jinchuan Hou Xiaofei qi Kan He College of Mathematics Taiyuan University of Technology School of Mathematics and Statistics Shanxi University Key Laboratory of Complex Systems and Data Science of Ministry of Education Shanxi University

The instantaneous detection of entanglement in quantum states poses a significant challenge in the fields of quantum computation and quantum information, and there are no practical methods or tools to complete this task satisfactorily so far. We propose a sufficient and necessary criterion of k-nonseparability for any n-partite finite or infinite dimensional systems, 2 ≤ k ≤ n. This criterion serves as the foundation for a practical scheme designed to detect entanglement and k-nonseparability across multipartite finite-dimensional systems. To exemplify the application of our scheme, we have developed a software tool that facilitates swift and precise identification of entanglement, k-nonseparability, and genuine entanglement within n-qubit systems, specifically tailored for systems with 2 ≤ n ≤ 4.

关键词： multipartite systems entanglement states entanglement witnesses ${\bm~k}$-nonseparability

过表达VHA-c4和VHA-c5基因对拟南芥根长的影响

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植物科学学报 2016年第5期34卷 765-774页

作者：苏杰郭荣起李国婧王瑞刚内蒙古农业大学职业技术学院内蒙古土右旗014109 内蒙古农业大学生命科学学院呼和浩特010018 内蒙古呼伦贝尔市农业科学研究所内蒙古牙克石162650

为研究液泡H+-ATPase c亚基VHA-c4和VHA-c5基因在植物生长发育过程中的作用,本研究构建了拟南芥VHA-c4和VHA-c5过表达载体并转化野生型拟南芥,分别获得9个和7个T2代转基因纯合体株系。采用半定量RT-PCR方法对过表达VHA-c4和VHA-c5的转... 详细信息

为研究液泡H+-ATPase c亚基VHA-c4和VHA-c5基因在植物生长发育过程中的作用,本研究构建了拟南芥VHA-c4和VHA-c5过表达载体并转化野生型拟南芥,分别获得9个和7个T2代转基因纯合体株系。采用半定量RT-PCR方法对过表达VHA-c4和VHA-c5的转基因纯合体进行阳性鉴定,发现其mRNA表达量均高于对照。对转基因纯合体进行暗培养和正常光照培养,结果显示,黑暗条件下,所有VHA-c4转基因株系的主根变短,而在正常光照下,所有VHA-c5转基因株系的主根变短,推测VHA-c4和VHA-c5分别在黑暗和光照条件下影响植物根的生长。用ABA和糖(葡萄糖和蔗糖)处理转基因纯合体,结果显示它们与野生型的表型无明显差异,表明VHA-c4和VHA-c5基因的过表达没有影响拟南芥对ABA和糖的响应。

关键词：拟南芥 VHA-c4 VHA-c5 黑暗正常光照 ABA 糖

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan jing guo qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

泡沫铝/石蜡PCM对锂电池组峰值温度的影响

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电源技术 2018年第8期42卷 1136-1139页

作者：安治国刘奇郭敬谊丁玉章重庆交通大学机电与车辆工程学院重庆400074 重庆交通大学外国语学院重庆400074

泡沫铝/石蜡由于兼具较高相变潜热以及导热率,被认为是一种很有发展前景的散热材料。建立了电动汽车锂离子电池的三维热仿真模型,在仿真研究的基础上对电池组散热系统的电池排布与泡沫铝孔隙率进行了有交互作用的正交实验。用极差分析... 详细信息

泡沫铝/石蜡由于兼具较高相变潜热以及导热率,被认为是一种很有发展前景的散热材料。建立了电动汽车锂离子电池的三维热仿真模型,在仿真研究的基础上对电池组散热系统的电池排布与泡沫铝孔隙率进行了有交互作用的正交实验。用极差分析法和方差分析法得出这些参数及相应交互作用对电池组峰值温度的影响,确定了电池组散热系统的最优参数,仿真后的结果表明优化后的电池组散热性能良好。

关键词：锂电池组相变材料散热系统峰值温度

The low-latitude sodium layer:comparative data from lidar observations at Hainan,China and São Paulo,Brazil

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Earth and Planetary Physics 2025年第1期9卷 39-53页

作者： Fang Wu jing Jiao guoTao Yang LiFang Du ZhengKuan Liu HaoRan Zheng JiXin guo ShaoHua Gong YaJun Zhu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China China-Brazil Joint Laboratory for Space Weather NSSC/INPESão Josédos Campos 12227-010Brazil School of Physics and Electronics Engineering Hainan Normal UniversityHaikou 571158China

Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude *** sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s *** paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the *** low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in ***,maximal Na density over Brazil is greater than that over *** variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before *** variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain *** suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WACCM-Na model.

关键词： metallic sodium layer seasonal variation nocturnal variation lidar

CALRoads模式在上海市典型道路CO扩散预测中的应用

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环境监测管理与技术 2006年第4期18卷 7-11,20页

作者：李莉陈长虹黄成景启国潘汉生黄海英上海市环境科学研究院上海200233

根据上海市市区、郊区典型主干道的气象条件、车流量、车型比例,以及CO小时质量浓度的监测资料,采用CALRoads模式中CALINE4和CAL3QHC模块,对郊区主干道和市区典型路口的适用条件分别进行了验证。结果表明,在稳定的气象条件下,CALINE4模... 详细信息

根据上海市市区、郊区典型主干道的气象条件、车流量、车型比例,以及CO小时质量浓度的监测资料,采用CALRoads模式中CALINE4和CAL3QHC模块,对郊区主干道和市区典型路口的适用条件分别进行了验证。结果表明,在稳定的气象条件下,CALINE4模式在模拟周围相对空旷主干道附近的CO质量浓度时,具有较好的结果,将CAL3QHC模式应用于市区典型交叉口,可以得到同监测值相对吻合的模拟结果,但准确性低于郊区。应用CALRoads模型对未来城郊典型道路附近CO高峰小时质量浓度的发展趋势进行了预测,并基于情景分析给出了减少交通污染的对策建议。

关键词： CO 大气扩散线源模式 CALRoads 预测上海

A NEW WELL TEST MODEL FOR A TWO-ZONE LINEAR COMPOSITE RESERVOIR WITH VARIED THICKNESSES

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Journal of Hydrodynamics 2010年第6期22卷 804-809页

作者： ZHANG Lie-hui guo jing-jing LIU qi-guo State Key Laboratory of Reservoir Geology and Exploitation Southwest Petroleum University Chengdu 610500China

This article presents a new well test model for two-zone linear composite reservoirs, where the rock and fluid properties as well as the formation thicknesses on both sides of the discontinuity are distinctly different. An analytical solution of pressure-transient behavior for a line-source, constant-rate well in this type of reservoir configuration is obtained with Fourier space transformation and Laplace transformation. By applying Duhamel principle, the wellbore storage and skins effects can easily be included. A set of type curves are generated and the sensitivities of the relevant parameters are discussed. A new correlating parameter MhDl√ηD is proposed to identify the pressure response in the pressure derivative curve. The model as well as the corresponding type curves are quite general that they are useful in predicting the production performance or analyzing the production data from this type of well-reservoir systems.

关键词： non-uniform thickness linear composite well test model type curve

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao jing-Dong J.Han qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening