检索结果-南通市图书馆

Evaluating Anti-SmDl-amino-acid 83-119 Peptide Reactivity in Children with Systemic Lupus Erythematosus and Other Immunological Diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2016年第23期129卷 2840-2844页

作者： Hai-Ou Yang Xiao-qing Zhang qi-hua fu Department of Laboratory Medicine Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Background： SmD1-amino-acid 83-119 peptide （SmD183-119） is the major epitope of Smith （Sm） antigen, which is specific for adult systemic lupus erythematosus （SLE）. The anti-SmD183-119 antibody has exhibited higher sensitivity and specificity than anti-Sm antibody in diagnosing adult SLE. However, the utility of anti-SmD183-119 antibodies remains unclear in children with SLE （cSLE）. This study aimed to assess the characteristics of anti-StuD 183-119 antibody in the diagnosis of cSLE. Methods： Samples from 242 children with different rheumatological and immunological disorders, including autoimmune diseases （SLE [n = 46] and ankylosing spondylitis [AS, n = 11]）, nonautoimmune diseases （Henoch-Schonlein purpura [HSP, n = 60], idiopathic thrombocytopenia purpura [n = 27], hematuria [n = 59], and arthralgia [n = 39]） were collected from Shanghai Children＇s Medical Center from March 6, 2012 to February 27, 2014. Seventy age- and sex-matched patients were enrolled in this study as the negative controls. All the patients＇ sera were analyzed for the anti-SmD 183-119, anti-Sm, anti-U 1-nRNP, anti-double-stranded DNA （dsDNA）, anti-nucleosome, anti-SSA/Ro60, anti-SSA/Ro52, anti-SSB, anti-Scl-70, and anti-histone antibodies using the immunoblotting assay. The differences in sensitivity and specificity between anti-SmD183-119 and anti-Sm antibodies were compared by Chi-square test. The correlations between anti-SmD183-119 and other auto-antibodies were analyzed using the Spearman＇s correlation analysis. A value of P 〈 0.05 was considered statistically significant. Results： Thirty-six out of 46 patients with cSLE were found to be positive for anti-SmD183-119, while 12 patients from the cSLE cohort were found to be positive for anti-Sm. Compared to cSLE, it has been shown that anti-SmD183-119 was only detected in 27.3% of patients with AS and 16.7% of patients with HSP. In comparison with anti-Sm, it has been demonstrated that anti-StuD 183-119 had a higher sensitivity （78.3% vs. 2

关键词： Autoantibodies Children Diagnosis StuD 1-amino-acid 83-119 Peptide Systemic Lupus Erythematosus

Synthesis,Structure and Properties of α-Keggin-type of K_(6)H_(3)[ZnW_(11)O_(40)Al]·9.5H_(2)O

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 1997年第4期13卷 14-18页

作者： YANG qi hua, fu qiang, LIU Jing fu ** (Department of Chemistry, Northeast Normal University, Changchun, 130024) XING Yan, LIN Yong hua and JIA Heng qing (Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022)

A new heteropolycomplex, K 6H 3[ZnW 11 O 40 Al]·9 5H 2O was prepared and characterized by means of elemental analysis, IR, UV spectroscopy, 27 Al NMR , electrochemistry and X ray crystallography. The crystal of K 6H 3[ZnW 11 O 40 Al]·9 5H 2O is cubic, space group Fm 3m , with lattice constants a=b=c =2 144 8(2) nm, V =9 866(2) nm 3, Mo radiation, R =0 057 8 for 497 independent data with [ I>2δ(I) ]. The anion is of α type Keggin structure with C s symmetry.

关键词： Lacunary Keggin structure Synthesis 27 Al NMR

缺失数据下线性模型中回归参数的经验似然置信区域

在线全文

学校读者我要写书评

暂无评论

数学的实践与认识 2009年第11期39卷 74-78页

作者：齐化富秦永松青岛港湾职业技术学院基础部山东青岛266404 广西师范大学数学科学学院广西桂林541004

在缺失样本下,构造了线性模型中参数的调整的经验似然置信域,数值模拟表明调整的经验似然置信域有较好的覆盖率和精度.

关键词：线性模型回归补足经验似然

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai fu Geping Yin Liguang Wang Yongmin Wu hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

随机设计下部分线性模型经验欧氏似然比置信域

在线全文

学校读者我要写书评

暂无评论

桂林航天工业高等专科学校学报 2008年第1期13卷 98-100页

作者：齐化富王炜青岛港湾职业技术学院数力教研室山东青岛266404

在随机设计下本文构造了部分线性模型的经验欧氏似然比统计量,并由它的极限分布构造了部分线形模型参数的渐进置信域。

关键词：部分线性模型经验似然经验欧氏似然

基于回归模型下的中国对外进出口数额的预测研究

在线全文

学校读者我要写书评

暂无评论

中小企业管理与科技 2020年第10期4卷 176-177页

作者：齐化富于潇青岛港湾职业技术学院山东青岛266404

论文建立了中国对外进出口总额和部分中国宏观经济数据的多元线性规划预测模型,成功实现了对进出口总额的预测,此预测数据能有效指导管理层及时调配市场资源,达到市场资源利用最优化。

关键词：进出口总额线性规划模型最优化

动脉导管未闭患儿TFAP-2B基因突变的研究

在线全文

学校读者我要写书评

暂无评论

中华儿科杂志 2010年第12期48卷 900-904页

作者：陈轶维赵武李奋吉炜傅启华张志芳王剑上海交通大学医学院附属上海儿童医学中心心血管内科 200127 上海交通大学医学院附属上海儿童医学中心检验科 200127 蚌埠医学院附属第一医院儿科

目的发现我国动脉导管未闭（patent ductus arteriosus,PDA）患儿分子遗传方面缺陷,为PDA早期预防及遗传咨询提供支持.方法收集100例单纯性PDA患儿的临床资料和外周静脉血样本,以100名健康儿童为对照.应用聚合酶链式反应（polymerase ... 详细信息

目的发现我国动脉导管未闭（patent ductus arteriosus,PDA）患儿分子遗传方面缺陷,为PDA早期预防及遗传咨询提供支持.方法收集100例单纯性PDA患儿的临床资料和外周静脉血样本,以100名健康儿童为对照.应用聚合酶链式反应（polymerase chain reaction,PCR）扩增TFAP-2B基因的全部外显子和外显子两侧部分内含子,并对扩增片段进行双向测序.应用BLAST程序将所测TFAP-2B基因序列与GeneBank中的已知序列进行对比以检测基因突变.采用逆转录聚合酶链式反应（reverse transcription polymerase chain reaction,RT-PCR）对1例家族史阳性患儿及其家属共16人TFAP-2B部分cDNA片段进行扩增,扩增产物直接进行双向序列测定.结果基因分析显示,在1例家族史阳性患儿及其患病亲属中,TFAP-2B第3内含子剪接位点＋5位发生突变[intron3（＋5）G＞A],患儿TFAP-2B基因部分cDNA巢式PCR扩增结果提示3号外显子完全缺失.此外,还发现了一个新的单核苷酸多态性,即转录起始点上游第34位的鸟嘌呤变为腺嘌呤,这个多态在PDA患者和健康对照组的频率分布差异有统计学意义（Z=-2.513,P=0.012）.结论 TFAP-2B基因突变能够导致家族型PDA.

关键词：动脉导管未闭转录因子AP-2 突变

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng fu Key Laboratory for Soft Chemistry and functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK