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Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： qi-hong zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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New thiopyran-4-spiro-2′-(1,3-dithiolane):Formation mechanism and crystal structure

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Chinese Chemical Letters 2011年第3期22卷 280-283页

作者： hong qi Li zhong Bao Zhang Lin Li Key Laboratory of Science & Technology of Eco-Textile Ministry of Education College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China

Ethylene trithiocarbonate reacted with dimethyl acetylenedicarboxylate to furnish tetramethyl thiopyran-4-spiro-2＇-（1,3- dithiolane）-2,3,5,6-tetracarboxylate,a new thiopyran-4-spiro-2＇-（1,3-dithiolane） heterocyclic compound,as the minor product together with the major product dimethyl 2-thioxo-1,3-dithiole-4,*** new heterocycle was probably formed through a[2 ＋ 2]cycloaddition between ethylene trithiocarbonate and dimethyl acetylenedicarboxylate followed by a 1,3-dipolar cycloaddition or[4 ＋ 2]*** structure of the new compound revealed that the thiopyran ring and 1,3-dithiolane moiety were perpendicular to each other.

关键词： Thiopyran-4-spiro-2'-(1 3-dithiolane) Cycloaddition Mechanism Crystal structure

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Comprehensively evaluate the short outcome of small bowel obstruction:A novel medical-economic score system

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World Journal of Gastroenterology 2023年第9期29卷 1509-1522页

作者： Wei-Xuan Xu qi-hong zhong Yong Cai Can-hong Zhan Shuai Chen Hui Wang Peng-Sheng Tu Wen-Xuan Chen Xian-qiang Chen Jun-Rong Zhang Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350122Fujian ProvinceChina Department of General Surgery(Emergency Surgery) Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND Small bowel obstruction(SBO)still imposes a substantial burden on the health care *** evaluation systems for SBO outcomes only focus on a single *** comprehensive evaluation of outcomes for patients with SBO remains poorly *** intensive clinical care would effectively improve the short-term outcomes for SBO,however,the full spectrum of the potential risk status regarding the high complication-cost burden is *** We aim to construct a novel system for the evaluation of SBO outcomes and the identification of potential risk *** Patients who were diagnosed with SBO were enrolled and stratified into the simple SBO(SiBO)group and the strangulated SBO(StBO)group.A principal component(PC)analysis was applied for data simplification and the extraction of patient characteristics,followed by separation of the high PC score group and the low PC score *** identified independent risk status on admission via a binary logistic regression and then constructed predictive models for worsened management *** operating characteristic curves were drawn,and the areas under the curve(AUCs)were calculated to assess the effectiveness of the predictive *** Of the 281 patients,45 patients(16.0%)were found to have StBO,whereas 236 patients(84.0%)had *** standardized length of stay(LOS),total hospital cost and the presence of severe adverse events(SAEs),a novel principal component was extracted(PC score=0.429×LOS+0.444×total hospital cost+0.291×SAE).In the multivariate analysis,risk statuses related to poor results for SiBO patients,including a low lymphocyte to monocyte ratio(OR=0.656),radiological features of a lack of small bowel feces signs(OR=0.316)and mural thickening(OR=1.338),were identified as risk *** the StBO group,higher BUN levels(OR=1.478)and lower lymphocytes levels(OR=0.071)were *** AUCs of the predictive models for poor outcomes were 0.715(95%CI:0.635-0.795

关键词： Principal component analysis Small bowel obstruction Outcome evaluation system Risk factors Intensive clinical care Radiomics

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轿车悬架弹性橡胶衬套弯曲刚度的工程算法

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机械设计 2007年第1期24卷 60-62页

作者：祁宏钟上海精粹机电科技有限公司上海200331

在线性前提下,根据橡胶衬套径向刚度在线性范围内,找出了求解橡胶衬套弯曲刚度的工程算法,经过试验验证,具有工程使用价值。

关键词：橡胶衬套弯曲刚度工程算法

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The Green Synthesis of the 1,4-Diazabutadienes

The Green Synthesis of the 1,4-Diazabutadienes

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中国化学会第26届学术年会有机化学分会场

作者： Jing-Yu He, qi-Di zhong, hong Yan College of Life Science and Bioengineering Beijing University of Technology, Beijing 100124

＜正＞1,4-Diazabutadienes, as metallic ligands, had extensive applications in organic synthesise, such as copolymerization of olefins[1], aldehyde-olefination[2], epoxidation of olefins[3], and photochemistry [4],

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应用弹性力学的橡胶衬套轴向刚度计算方法

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机械设计 2015年第7期32卷 32-35页

作者：祁宏钟王岩松邢彦锋上海工程技术大学汽车工程学院上海201620

悬架开发初期准确计算衬套刚度特性,可缩短底盘系统开发周期。面对尚无衬套轴向刚度理论计算方法的局面,基于弹性力学,提出一种筒形衬套轴向刚度理论算法。该方法以筒状无开孔弹性橡胶为对象,应用弹性力学和简化边界条件给出了衬套轴向... 详细信息

悬架开发初期准确计算衬套刚度特性,可缩短底盘系统开发周期。面对尚无衬套轴向刚度理论计算方法的局面,基于弹性力学,提出一种筒形衬套轴向刚度理论算法。该方法以筒状无开孔弹性橡胶为对象,应用弹性力学和简化边界条件给出了衬套轴向刚度公式。经理论计算和试验结果对比表明,该算法简单易行,误差在10%以内,满足筒状衬套轴向刚度工程设计需要,也适用于筒状衬套轴向刚度的其他工程应用领域。

关键词：衬套轴向刚度简化边界条件

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基于统计能量分析的车内中高频噪声分析与优化

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机械设计 2014年第9期31卷 66-70页

作者：祁宏钟王岩松王国庆李欣上海工程技术大学汽车工程学院上海201620

为了降低驾驶员头部声腔噪声,基于统计能量分析(Statistical Energy Analysis,SEA)原理,将汽车划分为79个结构子系统和8个声腔子系统。采用导纳法对复杂结构子系统的模态密度进行仿真,利用稳态能量流方法计算得到复杂结构的内损耗因子,... 详细信息

为了降低驾驶员头部声腔噪声,基于统计能量分析(Statistical Energy Analysis,SEA)原理,将汽车划分为79个结构子系统和8个声腔子系统。采用导纳法对复杂结构子系统的模态密度进行仿真,利用稳态能量流方法计算得到复杂结构的内损耗因子,计算了子系统间的耦合损耗因子。试验测量了动力总成振动和路面随机输入对车身的激励,测试了发动机舱声激励,建立了轿车的CFD模型,对车外风激励进行了仿真。在上述研究工作的基础上建立SEA分析模型,分析预测了驾驶员头部的噪声,通过试验对比,验证了统计能量分析模型的准确性。据此提出降低头部声腔噪声的3种措施并对比,得出最有效的噪声控制措施。

关键词：统计能量分析车内噪声内损耗因子耦合损耗因子

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C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu zhong-Shang Dai Guo-zhong Gong Min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(P<0.01).Notably,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

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大采高工作面支架回撤通道围岩变形分析及支护优化研究

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煤炭技术 2020年第12期39卷 4-7页

作者：洪启忠赵伟刘辉枣庄矿业集团新安煤业有限公司山东枣庄277642 中国矿业大学江苏徐州221116

针对大采高工作面支架回撤通道围岩变形强烈、支护困难等问题,基于新安煤业有限公司3313综采工作面地质情况,运用离散元数值模拟分析了预掘回撤通道、采煤机截煤形成回撤通道和分步掘进回撤通道3种掘进方式下回撤通道围岩变形情况,并提... 详细信息

针对大采高工作面支架回撤通道围岩变形强烈、支护困难等问题,基于新安煤业有限公司3313综采工作面地质情况,运用离散元数值模拟分析了预掘回撤通道、采煤机截煤形成回撤通道和分步掘进回撤通道3种掘进方式下回撤通道围岩变形情况,并提出分步掘进回撤通道支护设计方案。模拟和现场监测结果表明:预掘回撤通道受采动影响较大,围岩变形量最大;采煤机截煤和分步掘进形成回撤通道2种方式围岩变形较小,通道稳定性较好,但采煤机截煤形成回撤通道时,顶板锚索梯网支护实施困难,且对施工人员的安全带来极大威胁;分步掘进回撤通道及相应支护设计方案较好控制了回撤通道的变形,保证了工作面液压支架的快速安全回撤。

关键词：大采高回撤通道围岩变形分步掘进支护设计

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A Robust 2D Lidar SLAM Method in Complex Environment

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Photonic Sensors 2022年第4期12卷 51-65页

作者： Shan HUANG hong-zhong HUANG qi ZENG Peng HUANG Center for System Reliability and Safety University of Electronic Science and Technology of ChinaChengdu 611731China EvenTec Co. Ltd.Chengdu 610097China Jiangxi University of Science and Technology Ganzhou 341000China

The two-dimensional(2D)lidar is a ranging optical sensor that can measure the cross-section of the geometric structure of the *** propose a robust 2D lidar simultaneous localization and mapping(SLAM)algorithm working in ambiguous *** improve the front-end scan-matching module’s accuracy and robustness,we propose performing degeneration analysis,line landmark tracking,and environment coverage *** max-clique selection and odometer verification are introduced to increase the stability of the SLAM algorithm in an ambiguous ***,we propose a tightly coupled framework that integrates lidar,wheel odometer,and inertial measurement unit(IMU).The framework achieves the accurate mapping in large-scale environments using a factor graph to model the multi-sensor fusion SLAM *** experimental results demonstrate that the proposed method achieves a highly accurate front-end scan-matching module with an error of 3.8%of the existing *** it can run stably in ambiguous environments where the existing method will be ***,it ccan successfully construct a map with an area of more than 250000 square meters.

关键词： Robotics simultaneous localization and mapping 2D lidar multi-sensor fusion

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