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Transcriptomic analysis reveals the regulation network of BmKruppel homolog 1 in the oocyte development of Bombyx mori

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Insect Science 2021年第1期28卷 47-62页

作者： Zi-Dan Zhu qi-hao hu Chun-Mei Tong Hong-Guang Yang Si-Chun Zheng qi-Li Feng hui-Min Deng Guangdong Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and Technology&School of Life SciencesSouth China Normal UniversityGuangzhouChina

Kriippel homolog 1(Kr-hl),a zinc finger transcription factor,is involved in the metamorphosis and adult reproduction of ***,the role of Kr-hl in reproduction of holometabolic insects remains to be *** regulation network of 7-associated genes in the reproduction in Bombyx mori was investigated in this *** higher expression level of BmKr-hl in the ovaries was detected during the late pupal stage and *** interference(RNAi)-mediated depletion of BmKr-hl in the female at day 6 of pupae resulted in abnormal oocytes at 48 h post-double-stranded RNA treatment,which showed less yolk protein deposition and partially transparent ***-seq and subsequent differentially expressed transcripts analysis showed that knockdown of BmKr-hl caused a decrease in the expression of 2882 genes and an increase in the expression of 2565 genes in the oocytes at day 8 of ***,27 genes coding for transcription factors were down-regulated,while six genes coding for other transcription factors were ***-hl bound to the Kr-hl binding site of the transcription factors AP-1(activating protein-1)and FOXG1 to increase their messenger RNA tran・scripts in the BmN cells,*** Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses of that positively co-expressed with AP-1 and FOXG1 transcripts showed mainly enrichment in the metabolic-related pathways,the nu・tri ent absorption and the yolk protein absorption *** data suggested that BmKr-h 1 might directly regulate the metabolic-related pathways,the nutrient absorption and the yolk protein absorption processes or probably through AP-1 and/or FOXG1 to regulate oocyte development.

关键词： Kriippel homolog 1 oocyte development regulatory network RNA interference transcriptomics

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han Tang Jianian hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan hu Yue Li hua Zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-Zhao Xiao hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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A PRECONDITIONER FOR COUPLING SYSTEM OF NATURAL BOUNDARY ELEMENT AND COMPOSITE GRID FINITE ELEMENT

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Journal of Computational Mathematics 2002年第2期20卷 165-174页

作者： qi-ya hu De-hao Yu Chinese Acad Sci Acad Math & Syst Sci ICMSEC LSEC Beijing 100080 Peoples R China

Discusses a coupling boundary element methods with finite element method for the Dirichlet exterior problems. Information on the natural boundary reduction; Discussion on the composite grid discretization; Details on ... 详细信息

关键词： natural boundary reduction composite grid error estimate preconditioner condition number

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吸附除氟材料研究新进展

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化工新型材料 2018年第3期46卷 37-41页

作者：林皓齐小宝胡家朋刘瑞来饶瑞晔武夷学院生态与资源工程学院福建省生态产业绿色技术重点实验室武夷山354300 福建师范大学材料科学与工程学院福建省高分子材料与工程重点实验室福州350007

氟是人体内重要的微量元素之一,但在水中如果其浓度过高,将会对人体和环境造成很大危害。如何去除水中的氟备受科研工作者的关注。在众多方法中,吸附法可以简单、有效地去除饮用水中的氟离子,因此得到广泛应用。新型除氟材料成为当前研... 详细信息

氟是人体内重要的微量元素之一,但在水中如果其浓度过高,将会对人体和环境造成很大危害。如何去除水中的氟备受科研工作者的关注。在众多方法中,吸附法可以简单、有效地去除饮用水中的氟离子,因此得到广泛应用。新型除氟材料成为当前研究的热点。综述了近年来国内外关于除氟材料的最新研究进展,包括天然矿物、金属氧化物、生物材料、类水滑石、树脂类和废弃物等材料,并探讨了各种除氟材料的除氟机理。通过对国内外研究成果的总结与分析,展望了除氟材料进一步研究的发展方向。

关键词：除氟材料水处理吸附综述

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Inhibition Performance of Enhanced-Mo Inhibitor for Carbon Steel in 55% LiBr Solution

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Journal of Iron and Steel Research International 2008年第1期15卷 49-54页

作者： LIANG Cheng-hao hu Xian-qi Electromechanics and Materials Engineering College Dalian Maritime University Dalian 116026 Liaoning China School of Chemical Engineering Dalian University of Technology Dalian 116012 Liaoning China

The inhibition performance of enhanced-Mo inhibitor for carbon steel in 55% LiBr solution was measured by means of chemical immersion,electrochemical measurements,and physical detection *** indicated that enhanced-Mo inhibitor showed excellent inhibition performance of carbon steel in 55% LiBr solution,especially at high *** increasing the temperature of solution from 160 ℃ to 240 ℃,the corrosion rates of carbon steel increased from 17.67 μm/a to 33.07 μm/***-Mo inhibitor might improve the anodic polarization performance of carbon steel and widen the passive potential region of carbon steel in 55% LiBr ***-Mo inhibitor belongs to anodic *** 55% LiBr solution,the relationship between corrosion current density icorr and corrosion potential Ecorr of carbon steel accorded with the equation lgicorr=-2.66-3.54Ecorr,and the value of cathodic Tafel constant βc for the H2 reaction was 282 *** 55% LiBr solution contained enhanced-Mo inhibitor,a passive film comprising Fe3O4 and MoO2 was formed on the carbon steel surface by electrochemical *** corrosion of carbon steel might be retarded by this protective film,and the anticorrosion performance of carbon steel in 55% LiBr solution might be improved by enhanced-Mo inhibitor.

关键词： corrosion enhanced-Mo inhibitor carbon steel

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A rate-based method for dynamic analysis and optimal design of reactive extraction: n-Hexyl acetate esterification as an example

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Chinese Journal of Chemical Engineering 2020年第1期28卷 76-83页

作者： Xutao hu hao qin Biao hu Hongye Cheng Lifang Chen Zhiwen qi Max Planck Partner Group at the State Key Laboratory of Chemical Engineering School of Chemical Engineering East China University of Science and Technology

The dynamic analysis and optimal design of reactive extraction are challenging due to high nonlinearity of model equations and tough decision of judging criteria. In this work, a dynamic rate-based method is developed on g PROMS platform to get easy access to the solutions of reactive extraction with phase splitting. Based on rigorous criteria, dynamic analysis from initial state to final equilibrium(e.g., evolution of phase composition, mass transfer rate and reaction rate) and optimal design of operating conditions(e.g., extractant dosage and feed molar ratio) are achieved. To illustrate the method, the esterification of n-hexyl acetate is taken as an example. The approach proves to be reliable in the analysis and optimization of the exemplified system, which provides instructive reference for further process design and simulation of reactive extraction.

关键词： Reactive extraction Dynamic rate-based method Optimal design Process simulation n-Hexyl acetate esterification

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新型浆锚连接方钢管混凝土拼接柱抗震性能试验研究

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土木与环境工程学报（中英文） 2025年第1期47卷 152-166页

作者：郑立文李智赵亮胡少伟李景浩齐浩重庆大学土木工程学院重庆400045 郑州大学水利与交通工程学院郑州450001 中国电子科技集团公司第二十九研究所成都610036

为进一步提高用于钢-混凝土组合结构的柱构件的装配效率,并改善其抗震性能,降低生产成本,提出一种新型浆锚连接方钢管混凝土拼接柱设计方法。通过对缩尺比例为2的5个拼接柱构件和1个整浇柱构件开展拟静力试验,获得不同配筋率、配筋形式... 详细信息

为进一步提高用于钢-混凝土组合结构的柱构件的装配效率,并改善其抗震性能,降低生产成本,提出一种新型浆锚连接方钢管混凝土拼接柱设计方法。通过对缩尺比例为2的5个拼接柱构件和1个整浇柱构件开展拟静力试验,获得不同配筋率、配筋形式和柱-柱节点拼接部位的新型拼接柱的抗震性能。试验结果表明:新型拼接柱构件在低周期反复荷载下的破坏过程及其形态与整浇柱构件相似,其滞回曲线饱满,耗能能力、抗承载力退化和抵抗变形(刚度)能力均比整浇柱构件更加优良,特别是将柱-柱节点拼接部位设于柱间反弯点区域的P类型构件变形能力最佳,证明了该新型拼接柱设计方法的科学性,并对提高钢-混凝土组合框架结构的整体抗震性能具有应用潜力。

关键词：钢管混凝土柱浆锚连接拼接部位拟静力试验抗震性能

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Anticorrosion Performance of Carbon Steel in 55% LiBr Solution Containing PMA/SbBr_3 Inhibitor

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Journal of Iron and Steel Research International 2006年第4期13卷 56-60页

作者： hu Xian-qi LIANG Cheng-hao huANG Nai-bao School of Chemical Engineering Dalian University of Technology Dalian 116012 Liaoning China Electromechanics and Materials Engineering College Dalian Maritime University Dalian 116026 Liaoning China

The anticorrosion performance of carbon steel in 55 % LiBr solution containing PMA/SbBr3 inhibitor was studied by weight-loss tests, electrochemical measurements and surface analysis. In 55 %LiBr＋PMA/SbBr3 solution, corrosion rates of carbon steel at 145 ℃, 175℃, 190℃ and 240℃ are 18.32μm·a^-1 , 27.68μm·a^-1, 53.58μm·a^-1 and 73. 78μm·a^-1 , respectively. PMA/SbBr3 inhibitor may inhibit the corrosion of carbon steel in 55% LiBr solution effectively. Especially, it shows an excellent corrosion inhibition performance at high temperature. Both anodic and cathodic reactions of carbon steel may be inhibited by PMA/SbBr3 inhibitor, so it may be classified as mixed inhibitor. In 55%LiBr＋PMA/SbBr3 solution, the apparent activation energy of the corrosion reaction of carbon steel is 29. 61 kJ·mol^-1. The corrosion inhibition mechanism of PMA/SbBr3 is suggested as follows： PMA has the effect of inhibiting hydrogen evolution and a strong oxidizing property; Sb^3＋ also exhibits oxidizing properties, and can exist stably with PMA in LiBr solutions; the passive film comprising Fe2O3 and antimony formed on carbon steel surface may prevent Brfrom diffusing into the metal surface due to the synergistic effect of PMA and Sb^3＋ ; As a result, the anticorrosion performance of carbon steel may be improved by PMA/SbBr3 inhibitor in 55% LiBr solution.

关键词： carbon steel lithium bromide corrosion inhibitor

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Facile Synthesis of Polyisothioureas via Alternating Copolymerization of Aziridines and Isothiocayanates

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Chinese Journal of Polymer Science 2024年第3期42卷 292-298,I0005页

作者： hao-Tian Zhang Ming-Xin Niu qi Zhang Chen-Yang hu Xuan Pang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Materials Science and Engineering Jilin UniversityChangchun 130025China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Isothiourea is an important class of sulfur-containing molecules showing unique catalytic and biological activities. As such,polyisothiourea is envisioned to be an interesting type of polymer that potentially exhibits a number of interesting properties. However, there is no access to synthesizing well-defined polyisothiourea, and currently isothiourea-containing polymers are mainly prepared by immobilizing onto other polymer's side chain. Herein, we report the first facile synthesis of polyisothioureas via alternating copolymerization of aziridines and isothiocayanates. Mediated by the catalytic system of phosphazene superbases/alcohol, a broad scope of aziridines and isothiocayanates could be transformed into polyisothioureas with adjustable substitutions(11 examples). The structures of obtained polyisothioureas were fully characterized with ^(1)H-NMR, ^(13)C-NMR, and ^(1)H-^(13)C HMBC NMR. Moreover, the polyisothioureas show tunable thermal properties depending on substitutions on the isothiourea linkages. The novel structure of these polyisothioureas will enable a powerful platform for the discovery of nextgeneration functional plastics.

关键词： Polyisothioureas Alternative copolymer Aziridines Isothiocayanates

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