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Chinese Journal of Polymer Science 2018年第2期36卷 207-213页

作者： Yan-Ning Zeng qi-feng xing Yan-Ping Ma Wen-Hua Sun Laboratory of Engineering Plastics Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences

5,6,7-Trihydroquinolin-8-one was condensed with the corresponding benzidine to give N,N′-bis（5,6,7-trihydroquinolin-8-ylidene）-[1,1′-biphenyl]-4,4′-diamine derivatives（L1–L3）. The ligands were reacted with two equivalents of Ni Cl2·6H2O in a mixture of Et OH and CH2Cl2 to afford the corresponding dinickel（II） chloride complexes（Ni1-Ni3）. The organic compounds were completely characterized, whilst the bi-metallic complexes were characterized by FTIR spectra and elemental analysis. These nickel complexes exhibited high activities towards ethylene polymerization in the presence of either MAO or Me2AlCl, maintaining a high activity over a prolonged period. The obtained polyethylenes were confirmed as having low molecular weights by GPC analysis.

关键词： Dinuclear nickel complexes Ethylene polymerization Molecular weight Molecular weight distribution

Trichlorozirconium η~2-Hydrazonides： Synthesis, Characterization and Their Catalytic Behavior toward Ethylene Polymerization

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Chinese Journal of Polymer Science 2016年第3期34卷 390-398页

作者： Xin-e Duan qi-feng xing Zhen-ming Dong Jian-bin Chao Sheng-di Bai 刘滇生孙文华 Institute of Applied Chemistry Shanxi Untverstty Taiyuan 030006 China School of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

The trichlorozirconium η~2-hydrazonides（R=H, A; R=CH_3, B） were synthesized through the finely controlled stoichiometrical reactions of anhydrous zirconium tetrachloride with the lithium salt of either 1-（furan-2-ylmethylene）-2-phenylhydrazonide or 1-（furan-2-ylethylidene）-2-phenyl hydrazonide in the solvent tetrahydrofuran（THF）, respectively. These complexes were highly sensitive to air and moisture due to solely using less bulky ligand of hydrazonides. The molecular structures of the title complexes, determined by means of single crystal X-ray diffraction, were found to be the distorted pentagonal bipyramid geometry around zirconium atom, with three chlorides and the hydrazonato ligand acting as the η~2-coordination mode as well as two incorporated THF molecules. Upon activation with either methylaluminoxane（MAO） or modified methylaluminoxane（MMAO）, both complexes A and B exhibited catalytic activities toward ethylene polymerization, producing polyethylenes with ultra-high molecular weights.

关键词： Titanium complexes Phenylhydrazonide Ethylene polymerization Ultra-high molecular weight polyethylene

Evaluation of Thermal Hazard of Composite Modified Double-base Propellant by Microcalorimetery Method

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Chemical Research in Chinese Universities 2010年第4期26卷 626-629页

作者： XUE Liang ZHAO feng-qi xing Xiao-ling XU Si-yu PEI qing GAO Yin HU Rong-zu Xi ＇an Modern Chemistry Research Institute Xi ＇an 710065 P. R. China

The thermal decomposition behavior of composite modified double-base（CMDB） propellant containing cyclotrimethylene trinitramine（RDX） was studied via a Calvet microcalorimeter at five different heating rates. The activation energy（E） and the pre-exponential factor（A） of two obvious exothermic processes were obtained by Kissinger＇s method and Ozawa＇s method. The entropy of activation（△S^≠）, the enthalpy of activation（△H^≠）, and the free energy of activation（△G^≠） of the first stage were calculated. To evaluate the thermal hazard of the RDX-CMDB propellant, the critical temperature of thermal explosion（Tb）, the self acceleration decomposition temperature（Tsgox）, the adiabatic decomposition temperature increment（ATad） and the time-to-explosion of adiabatic system（t） were presented as 145.3 ℃, 138.15 ℃, 1634 K and 583.71 s（n=0） and 586.28 s（n=1）, respectively.

关键词： CMDB propellant Microcalorimeter Critical temperature of thermal explosion SADT Adiabatic time-to-explosion

Biological artificial vessel graft in distal arterial bypass for treating diabetic lower limb ischemia： a case report

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Chinese Medical Journal 2011年第19期124卷 3185-3188页

作者： GU Yong-quan WU Ying-feng qi Li-xing GUO Lian-ri LI Xue-feng CUI Shi-jun TONG Zhux GUO Jian-ming and ZHANG JianGUO Jian-ming ZHANG Jian Department of Vascular Surgery Xuanwu Hospital Institute of Vascular Surgery Capital Medical University Beijing 100053 China

A 68-year-old female patient was treated for unhealed ulcer in the fourth toe of the left foot. Clinical examinations identified severe stenosis of the proximal segment and occlusion of the distal segment of the left anterior tibial artery, and occlusion of the left posterior tibial artery and the peroneal artery. The proximal stenotic segment of the left anterior tibial artery was dilated, but the distal occlusive part failed to be re-canalized. Left anterior tibial artery to dorsal pedal artery bypass was performed on the patient with an epoxide-crosslinked, special radicals antigen-sealed, porcine-derived biological graft; debridement of the left 4th digiti pedis was also performed. Postoperation course was uneventful. The pulse of the left dorsal pedal artery was strong. The ankle brachial index （ABI） increased from 0.60 to 1.09. Warfarin and two antiplatelet drugs were given after the operation. Six months after operation, computed tomographic angiogram （CTA）identified the patent graft.

关键词： distal arterial bypass xeno epoxide cross-link antigen-sealed biological

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磁悬浮列车系统的随机最优控制

力学季刊 2003年第2期24卷 174-178页

作者：方明霞冯奇马星同济大学固体力学教育部重点实验室上海200092

本文根据磁悬浮列车和车行道的结构特点,将总系统模型按分块原则分成列车、磁执行环节和车行道系统,并在平衡点附近对非线性方程线性化处理,形成未加控制的总系统的状态方程,它是一组考虑外干扰情况下线性时变系统模型。而基于电磁关系... 详细信息

本文根据磁悬浮列车和车行道的结构特点,将总系统模型按分块原则分成列车、磁执行环节和车行道系统,并在平衡点附近对非线性方程线性化处理,形成未加控制的总系统的状态方程,它是一组考虑外干扰情况下线性时变系统模型。而基于电磁关系原则建立的磁悬浮列车系统模型在未加控制状态下是不稳定的,为了保证列车的行驶舒适性、稳定性及可靠性,承重磁铁与导向磁铁必须加以控制。附加控制方程后,就形成了被控制的总系统的状态方程,从而实现车、磁及车行道模型的有机组合。对于实际工程问题,被控制的总系统的动力学性质由于维数较高,直接计算比较困难,本文采用计算机进行数值仿真,利用随机最优控制理论,对系统悬浮气隙和垂向加速度的变化规律进行了研究,并通过实例给出时变系统的仿真结果。

关键词：磁悬浮随机控制仿真

卵巢Sertoli-Leydig细胞瘤超声及MRI表现1例

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中国临床医学影像杂志 2022年第1期33卷 73-74页

作者：冯奇星边雪玲吕铭涛滨州医学院附属医院山东滨州256600

病例女,19岁,因“月经不规律半年,发现盆腔包块3天”就诊入院。体格检查:外阴发育正常;肛诊:子宫平位,正常大小,子宫左后方触及一直径约6 cm包块,边界清,光滑,活动可,无压痛,右侧附件未触及明显异常。实验室检查:睾酮5.1 nmol/L(正常参... 详细信息

病例女,19岁,因“月经不规律半年,发现盆腔包块3天”就诊入院。体格检查:外阴发育正常;肛诊:子宫平位,正常大小,子宫左后方触及一直径约6 cm包块,边界清,光滑,活动可,无压痛,右侧附件未触及明显异常。实验室检查:睾酮5.1 nmol/L(正常参考值0.2~2.86 nmol/L),CEA(癌胚抗原)1.53 ng/mL(0~3.4 ng/mL),CA125(糖类抗原)9.94 U/mL(正常参考值0~35 U/mL)。超声检查:子宫大小正常,右侧卵巢未见明显异常;左侧附件区探及低回声,大小约5.9 cm×5.0 cm×5.5 cm,边界清,内部回声不均匀;CDFI:肿块内部及周边可见中等血流信号(图1a)。MRI:盆腔左侧可见实性为主的类圆形肿块,T1WI呈低信号,T2WI及T2WI-Flair呈稍高信号,边界清,大小约6.6 cm×5.7 cm×5.4 cm,DWI图像为高信号,ADC为低信号(ADC值为0.764×10^(-3) mm^(2)/s),增强扫描,病变呈中度强化(图1b~1d)。

关键词：卵巢肿瘤超声检查,多普勒,彩色磁共振成像

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探索医患纠纷处置新机制:江苏省经验

中国卫生政策研究 2009年第1期2卷 52-53,59页

作者：李少冬戚兴锋江苏省卫生厅江苏南京210008

医患关系在卫生事业发展中有举足轻重的作用。江苏省针对医患关系中的现有问题,建立了医患纠纷人民调解机制,并积极推行医疗责任保险,在制度建设、调解队伍建设、激发相关方积极性、保障实施等方面进行了积极探索,积累了一些经验。

关键词：医患关系机制医患纠纷

中蒙俄经济走廊建设视阈下的内蒙古中小企业国际化研究

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财经理论研究 2016年第6期 18-30页

作者：李瑞峰齐永兴内蒙古财经大学工商管理学院内蒙古呼和浩特010070 内蒙古财经大学研究生院内蒙古呼和浩特010070

中蒙俄经济走廊建设是中国"一带一路"倡议实施的重要组成部分。内蒙古地处中国正北方,与俄罗斯、蒙古接壤,具有不可替代的区位优势,这为内蒙古中小企业国际化发展提供了难得的空间和机遇。本文以内蒙古中小企业国际化发展面临的形势与... 详细信息

中蒙俄经济走廊建设是中国"一带一路"倡议实施的重要组成部分。内蒙古地处中国正北方,与俄罗斯、蒙古接壤,具有不可替代的区位优势,这为内蒙古中小企业国际化发展提供了难得的空间和机遇。本文以内蒙古中小企业国际化发展面临的形势与存在的问题为分析重点,结合中蒙俄经济走廊建设为内蒙古中小企业国际化发展带来的机遇与挑战,最后提出了内蒙古中小企业国际化在新环境下的发展战略。

关键词：中蒙俄经济走廊内蒙古中小企业国际化

原发系统性间变性大细胞淋巴瘤分子分型的病理学研究

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临床与实验病理学杂志 2013年第6期29卷 645-648页

作者：雷军姚丽青吴在增齐兴峰福州总医院第476医院病理科福州350002 南京军区福州总医院病理科福州350025

目的探讨间变性大细胞淋巴瘤(anaplastic large cell lymphoma,ALCL)分子分型及免疫表型特点,为ALCL的分型、诊断、治疗和预后提供依据。方法采用免疫组化EnVision法对40例原发系统性ALCL进行分子分型,以是否表达间变性淋巴瘤激酶(anapl... 详细信息

目的探讨间变性大细胞淋巴瘤(anaplastic large cell lymphoma,ALCL)分子分型及免疫表型特点,为ALCL的分型、诊断、治疗和预后提供依据。方法采用免疫组化EnVision法对40例原发系统性ALCL进行分子分型,以是否表达间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)免疫标记分为ALK+组和ALK-组,分析其临床病理特征及CD30、ALK、T细胞标记、细胞毒相关抗原、EMA、Galectin-3的表达特点。结果 ALCL患者以男性多见,ALK+病例明显多于ALK-,青少年患者多为ALK+,ALK-常见于中老年患者。形态学上ALK+和ALK-较难鉴别,瘤细胞均强表达CD30,两组CD45RO、Galectin-3、CD43、细胞毒相关抗原表达无差异,多为(+)。ALK+者多表达EMA,瘤细胞大部分表达T细胞抗原CD2、CD4、CD45RO,CD5、CD7(-),CD8、CD3常(-);ALK-瘤细胞大部分表达T细胞抗原CD3、CD2、CD4、CD5,少数表达CD8、EMA;EBV+的ALK+组和ALK-组各1例,两者Ki-67增殖指数均>70%,差异无显著性。结论形态学相同的ALCL,通过免疫组化检测ALK蛋白可将其分为ALK+和ALK-两个独立的分子亚型,二者具有不同的临床特点、免疫表型及预后。

关键词：间变性大细胞淋巴瘤 ALK 免疫表型

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis