检索结果-南通市图书馆

Application of 3D-printed prosthesis in revision surgery with large inflammatory pseudotumour and extensive bone defect: A case report

引用

World Journal of Clinical Cases 2022年第36期10卷 13388-13395页

作者： Hong-Ping Wang Ming-You Wang Yu-Ping Lan Zhuo-Dong Tang qi-feng tao Chun-Yu Chen Department of Orthopaedics Panzhihua Municipal Central HospitalPanzhihua 617000Sichuan ProvinceChina Department of Clinical Medicine Dali UniversityDali 671000Yunnan ProvinceChina

BACKGROUND Hip revision surgery is the final treatment option for the failure of artificial hip joints, but it is more difficult than the initial operation. For patients with hip joint loosening around the prosthesis combined with large inflammatory pseudotumours and large segment bone defects, hip revision is even more difficult, and clinical reports are *** SUMMARY Male, 59 years old. The patient underwent left hip replacement 35 years ago and was now admitted to hospital due to massive masses in the left thigh, shortening of the left lower extremity, and pain and lameness of the left hip joint. X-ray, computed tomography and magnetic resonance imaging revealed prosthesis loosening, left acetabular bone defect(Parprosky IIIB type), and a bone defect of the left proximal femur(Parprosky IIIA type). Inflammatory pseudotumours were seen in the left hip and left thigh. Hip revision surgery was performed using a 3Dprinted custom acetabular prosthesis was used for hip revision surgery, which was produced by Arcam Electron Beam Melting system with Electron Beam Melting technology. The operation was successful, and the patient was followed up regularly after the operation. The custom-made acetabular prosthesis was well matched, the inflammatory pseudotumour was completely removed, the postoperative hip prosthesis was stable, and the old greater trochanter fracture was well reduced and fixed. The patient was partially weight-bearing with crutches 3 mo after the operation and walked with full weight-bearing after 6 mo. The hip prosthesis was stable, and there was no recurrence of inflammatory pseudotumours at the last follow-up. The Visual Analogue Scale was 3, and the Harris hip score was *** The use of 3D-printed personalized custom prostheses for complex hip revision surgery has satisfactory surgical results and has great clinical application value.

关键词： 3D printing Inflammatory pseudotumour Electron Beam Melting technology Hip revision Bone defect Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

传统支气管针吸活检术在基层医院诊断原发性肺癌中的运用价值

引用

中国基层医药 2016年第24期23卷 3709-3712页

作者：张齐陶峰嘉兴市第一医院呼吸内科浙江省嘉兴314201

目的：探讨传统支气管针吸活检术（C-TBNA）在基层医院诊断原发性肺癌中的运用价值。方法回顾性分析嘉兴市第一医院呼吸科2013年1月至2014年12月经 C-TBNA 病理诊断的原发性肺癌患者118例临床资料，其中包括淋巴结的穿刺和肺内肿块的穿... 详细信息

目的：探讨传统支气管针吸活检术（C-TBNA）在基层医院诊断原发性肺癌中的运用价值。方法回顾性分析嘉兴市第一医院呼吸科2013年1月至2014年12月经 C-TBNA 病理诊断的原发性肺癌患者118例临床资料，其中包括淋巴结的穿刺和肺内肿块的穿刺，同时所有患者均行胸部 CT 检查。结果通过对118例 C-TBNA 阳性患者的病理分析，其中腺癌45例（38．1％）、鳞癌28例（23．7％）、小细胞癌17例（14．4％）。联合 TNBA 淋巴结与胸部 CT 比较，C-TBNA 淋巴结穿刺在肺癌诊断及分期中明显优于胸部 CT，并减少胸部 CT 淋巴结的假阴性率。C-TBNA 淋巴结的阳性率与穿刺区域无关，118例患者取得淋巴结穿刺标本289份，其中阳性标本194份，分三个区域（上纵隔区，下纵隔区，10～14区），对三个区域进行组间率比较，差异无统计学意义（P ＝0．407），所有患者检查耐受性良好，均无相关并发症。结论 C-TBNA 作为肺门、纵隔淋巴结及肺内肿块病理评估手段，明显提高肺癌的诊断阳性率，其穿刺阳性率与穿刺区域无关。气管镜在肺癌诊断的应用中安全、有效、可行。

关键词：肺肿瘤淋巴结活组织检查,针吸体层摄影术,X线计算机

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu feng Su Tian Jiang Shao-Yuan Zhang Lu Lv tao Long Hui-Wen Pan Jun-qing qi qiang Zhou Wei-feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

C-X3-C基序趋化因子配体1/C-X3-C基序趋化因子受体1通路参与失血性休克/复苏大鼠记忆功能恢复

引用

解剖学报 2024年第2期55卷 158-166页

作者：吴小军王日兴林芳崇吕有凯冯奇桃云天奇海南医学院第二附属医院急诊科海口570311

目的探讨C-X3-C基序趋化因子配体1(CX3CL1)/C-X3-C基序趋化因子受体1(CX3CR1)通路调控的小胶质细胞活化对失血性休克/复苏大鼠记忆功能的影响。方法实验分为2部分。第1部分,将大鼠随机分为假手术组,模型-0.5 h组,模型-1.5 h组,模型-3 h... 详细信息

目的探讨C-X3-C基序趋化因子配体1(CX3CL1)/C-X3-C基序趋化因子受体1(CX3CR1)通路调控的小胶质细胞活化对失血性休克/复苏大鼠记忆功能的影响。方法实验分为2部分。第1部分,将大鼠随机分为假手术组,模型-0.5 h组,模型-1.5 h组,模型-3 h组,每组10只,模型组之间失血性休克时间存在差异。第2部分,大鼠随机分为对照组与CX3CL1组,每组10只。CX3CL1组大鼠脑室注射CX3CL1蛋白,对照组大鼠注射生理盐水。所有大鼠在模型制作前开展Morris水迷宫训练,模型制作后4 d,开展水迷宫测试。完成后,取全脑组织进行HE染色与免疫组织化学染色,取脑脊液检测炎性细胞因子含量,取脑组织进行Real-time PCR检测与Western blotting检测。结果与假手术组相比,模型组大鼠逃避潜伏期增加,穿越平台次数与第Ⅲ象限停留时间减少,且HE染色中显示神经元状态受损。此外,与假手术组相比,模型组大鼠脑组织中离子钙结合衔接分子1(Iba1)表达升高,脑脊液中肿瘤细胞坏死因子α(TNF-α)与白细胞介素(IL)-6含量升高,M1型小胶质细胞标记CD16、TNF-α、IL-1β与诱导性一氧化氮合酶(iNOS)mRNA含量升高。与此同时,与假手术组相比,模型组大鼠脑组织中CX3CL1、CX3CR1蛋白表达降低,磷酸化核因子κB(p-NF-κB)与核苷酸结合寡聚结构域(NOD)样受体蛋白3(NLRP3)蛋白表达升高。然而,与模型组相比,CX3CL1组大鼠逃避潜伏期减少,穿越平台次数与第Ⅲ象限停留时间增加,且神经元状态恢复。此外,与对照组相比,CX3CL1组大鼠脑组织中Iba1表达降低,脑脊液中TNF-α与IL-6含量降低,M1型小胶质细胞标记CD16、TNF-α、IL-1β与iNOS mRNA含量降低,M2型小胶质细胞标记CD206、转化生长因子β(TGF-β)、精氨酸酶1(Arg1)、几丁质酶3样蛋白1(Ym1)mRNA含量升高。结论CX3CL1有助于抑制小胶质细胞过度激活,诱导小胶质细胞向M2型极化,抑制M1型极化,降低炎性细胞因子释放,减轻失血性休克/复苏诱发的记忆功能损伤。

关键词：失血性休克/复苏 C-X3-C基序趋化因子配体1 记忆功能炎症反应小胶质细胞实时定量聚合酶链反应大鼠

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mitophagy is induced by PTEN-induced kinase 1 gene silencing in dopaminergic neurons

Mitophagy is induced by PTEN-induced kinase 1 gene silencing...

引用

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Zhi-feng qi,tao CUI,Li LV,Hua GAO,Hui YANG~* Beijing Institute for Neuroscience,Capital Medical University,Beijing Center for Neural Regeneration & Repair,Key Laboratory for Neurodegenerative Disease of the Ministry of Education,Beijing 100069,China

＜正＞Parkinson’s disease is a common neurodegenerative *** studies indicate that the abnormal autophagy in neurons is the main reason for the generation of ***1（PTEN-induced kinase 1） is one of PD-related genes, which is directly involved in the 1 function of ***,it is not clear that autophagy could be activated by mitochondrial injury induced by PINK1 gene *** study showed that silencing PINK1 may induce autophagy in dopaminegic cell line（MN9D）.We found that the level of LC3II（vacuole membrane associate type）,which has been accepted as marker of autophagy,increased significantly at 48h since PINK1 silencing by Western *** number of vacuoles with mitochondria,which are enclosed by double membrane（mitophagy） was also observed to increase in the group of PINK1 RNA *** of monodansylcadaverine（MDC） and acidotropic orange staining also showed that the level of autophagy was induced significantly by PINK1 gene ***,the level of Beclinl and phosphorylation of Bcl2（p-Bcl2） were increased and the generation of reactive oxygen species（ROS） was also elevated when silencing PINK1 gene in *** conclusion,our study suggests that PINK1 gene silencing may increase the ROS generation and induce mitophagy by activating Beclinl and p-Bcl2 and may provide a clue to find new drugs for the treatment of PD in clinic.

关键词： PINK1 mitophagy Bcl-2 RNA interference Parkinson’s disease.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

引用

World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-qi Zhang Yu-Ying Tan Li Zhang Wen-tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高校创新创业教育多元化复合型师资队伍构建研究

引用

渭南师范学院学报 2018年第14期33卷 5-12页

作者：李亚奇李峰王涛李辉火箭军工程大学作战保障学院西安710025

构建多元化复合型师资队伍是创新创业教育对象和创新创业教育体系的需求,也是提高教师能力素质、推动毕业生更高质量创业就业的需求。创新创业教育师资队伍存在师资数量不足、结构类型单一、胜任创新创业教育能力不强等问题,这主要是由... 详细信息

构建多元化复合型师资队伍是创新创业教育对象和创新创业教育体系的需求,也是提高教师能力素质、推动毕业生更高质量创业就业的需求。创新创业教育师资队伍存在师资数量不足、结构类型单一、胜任创新创业教育能力不强等问题,这主要是由师资队伍的职能定位不准、内培与外引渠道不畅、培训体系与考核评价机制针对性不强等因素所致。高校应遵循系统性、协同性、融合性和多元化原则,构建和加强"专兼协同、分工明确、汇聚合力"的教学创新型专业教师队伍、技术技能型专职教师队伍、创业指导型兼职教师队伍。

关键词：创新创业教育人才培养师资队伍教学能力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

引用

World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-Yuan Hu Ding Ding Yu Song Ya-feng Deng Cheng-Ming Zhang tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

丙戊酸钠在脑肿瘤术后的临床应用

引用

中国新药与临床杂志 2002年第4期21卷 205-207页

作者：邱炳辉欧阳辉漆松涛冯文峰方陆雄彭玉平中国人民解放军第一军医大学南方医院神经外科广东广州510515

目的 :评价丙戊酸钠在脑肿瘤术后的临床疗效。方法 :对 15 0例脑肿瘤病人随机分成丙戊酸钠治疗组 (丙戊酸钠组 ,n =77)和对照组 (n =73) ,观察手术后病人的生命体征、癫痫发作、颅内压和脑水肿变化情况。结果 :脑肿瘤术后丙戊酸钠组病... 详细信息

目的 :评价丙戊酸钠在脑肿瘤术后的临床疗效。方法 :对 15 0例脑肿瘤病人随机分成丙戊酸钠治疗组 (丙戊酸钠组 ,n =77)和对照组 (n =73) ,观察手术后病人的生命体征、癫痫发作、颅内压和脑水肿变化情况。结果 :脑肿瘤术后丙戊酸钠组病人癫痫发生率 (5 % )、颅内压显著升高 (8% )和重度脑水肿 (4 % )与对照组 (分别为 19% ,2 2 % ,16% )比较差异有显著和非常显著意义 (P <0 .0 5或P <0 .0 1)。 2组治疗后 3wk病人恢复情况比较差异有显著意义 (P <0 .0 5 ) ,致残率 (5 % )明显低于对照组 (15 % ) (P <0 .0 5 )。结论 :脑肿瘤术后早期应用丙戊酸钠可以降低癫痫发生率 ,减轻脑水肿 ,降低颅内压升高幅度 ,减少致残率。

关键词：丙戊酸钠脑肿瘤癫痫药物治疗临床应用外科手术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肝硬化并发上消化道出血的危险因素及其Hp感染基因型与Foxp3和RORγt基因表达水平

引用

中华医院感染学杂志 2023年第12期33卷 1814-1818页

作者：钟玉福林明强冯奇桃林亚发符名勇海口市第四人民医院急诊科海南海口571199 海南医学院第二附属医院急诊科海南海口570216 海口市第四人民医院重症医学科海南海口571199

目的探讨肝硬化患者上消化道出血(UGH)的危险因素及其幽门螺杆菌(Hp)感染基因型与叉头翼状螺旋转录因子(Foxp3)、维甲酸相关孤核受体γt(RORγt)基因表达水平。方法选取2020年7月-2022年7月海口市第四人民医院收治的96例肝硬化合并UG... 详细信息

目的探讨肝硬化患者上消化道出血(UGH)的危险因素及其幽门螺杆菌(Hp)感染基因型与叉头翼状螺旋转录因子(Foxp3)、维甲酸相关孤核受体γt(RORγt)基因表达水平。方法选取2020年7月-2022年7月海口市第四人民医院收治的96例肝硬化合并UGH的患者为研究组;另选取同期于医院接受治疗的单纯肝硬化患者96例为对照组。收集两组临床资料,归纳肝硬化患者UGH的危险因素;检测Hp感染情况及其基因型,分析Hp感染与未感染患者外周血Foxp3、RORγt mRNA表达水平、血清转化生长因子-β1(TGF-β1)、白细胞介素-2(IL-2)、IL-10、IL-17水平。结果 Child-Pugh分级、食管静脉曲张分级、Hp感染阳性是肝硬化患者UGH的危险因素(P<0.05);肝硬化合并UGH患者Hp感染基因型以cagA、iceA为主,vacA、baba2两种基因型占比较少;Hp感染阳性、阴性的肝硬化合并UGH患者,其在出血原因差异有统计学意义(P<0.05),Hp感染阳性患者的溃疡性出血发生率(54.90%)高于阴性患者(P<0.05);与Hp感染阴性患者相比,Hp感染阳性患者的外周血Foxp3、RORγt mRNA升高,血清TGF-β1、IL-10及IL-17均升高,IL-2下降(P<0.05)。结论高Hp感染率与肝硬化患者UGH的发生相关,且其可能与干扰Foxp3、RORγt基因及其相关细胞因子表达,影响免疫微环境有关。

关键词：幽门螺杆菌感染肝硬化上消化道出血叉头翼状螺旋转录因子维甲酸相关孤核受体γt

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：