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Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance

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Bioactive Materials 2022年第10期7卷 359-371页

作者： Yumin Zhang Zujian Feng Jinjian Liu Hui Li qi su Jiamin Zhang Pingsheng Huang Weiwei Wang Jianfeng Liu Key Laboratory of Radiopharmacokinetics for Innovative Drugs Chinese Academy of Medical Sciencesand Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300192PR China Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Science and Peking Union Medical CollegeTianjin300192PR China

Radioresistance reduces the antitumor efficiency of radiotherapy and further restricts its clinical application,which is mainly caused by the aggravation of immunosuppressive tumor microenvironment(ITM).Especially tumor-associated macrophages(TAMs)usually display the tumor-promoting M2 phenotype during high-dose fractional radiotherapy mediating radiotherapy ***,the toll like receptor agonist TLR7/8a was conjugated with radiosensitive peptide hydrogel(Smac-TLR7/8 hydrogel)to regulate TAMs repolarization from M2 type into M1 type,thus modulating the ITM and overcoming the *** Smac-TLR7/8 hydrogel was fabricated through self-assembly with nanofibrous morphology,porous structure and excellent ***γ-ray radiation,Smac-TLR7/8 hydrogel effectively polarized the macrophages into M1 ***,combined with radiotherapy,TAMs repolarization regulated by Smac-TLR7/8 hydrogel could increase tumor necrosis factor secretion,activate antitumor immune response and effectively inhibit tumor ***,TAMs repolarization rebuilt the ITM and elicited the immunogenic phenotypes in solid tumors,thus enhanced the PD1-blockade efficacy through increasing tumor infiltrating lymphocytes(TILs)and decreasing Treg cells in two different immune activity tumor mice ***,this study substantiated that recruiting and repolarization of TAMs were critical in eliciting antitumor immune response and overcoming radioresistance,thus improving the efficacy of radiotherapy and immunotherapy.

关键词： Radioresistance Tumor-associated macrophage Polarization Immunosuppressive tumor microenvironment Peptide hydrogel

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Three-dimensional computed tomography mapping of posterior malleolar fractures

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World Journal of Clinical Cases 2020年第1期8卷 29-37页

作者： qi-Hang su Juan Liu Yan Zhang Jun Tan Mei-Jun Yan Kai Zhu Jin Zhang Cong Li Department of Orthopedics Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of the First Clinical Medical School Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Orthopedics Pinghu Second People’s HospitalPinghu 314200Zhejiang ProvinceChina Department of Trauma surgery Shanghai East HospitalTongji University School of MedicineShanghai 200120China

BACKGROUND Posterior malleolar fractures have been reported to occur in<40%of ankle *** To reveal the recurrent patterns and characteristics of posterior malleolar fractures by creating fracture maps of the posterior ... 详细信息

BACKGROUND Posterior malleolar fractures have been reported to occur insuperimposed to fit an ankle model template by both aligning specific biolandmarks and reducing reconstructed fracture *** lines were found and traced in order to generate an ankle fracture *** This study involved 112 patients with a mean age of 49,comprising 32 pronationexternal rotation grade IV fractures and 80 supination-external rotation grade IV fractures according to the Lauge-Hansen classification ***-dimensional maps showed that the posterior ankle fracture fragments in the supinationexternal rotation grade IV group were relatively smaller than those in the pronation-external rotation grade IV group after posterior malleolus *** addition,the distribution analyses on posterior malleolus fracture lines indicated that the supination-external rotation grade IV group tended to have higher linear density but more concentrated and orderly distribution fractures compared to the pronation-external rotation grade IV *** Fracture maps revealed the fracture characteristics and recurrent patterns of posterior malleolar fractures,which might help to improve the understanding of ankle fracture as well as increase opportunities for follow-up research and aid clinical decision-making.

关键词： Three-dimensional imaging Maps Ankle fractures Computed tomography

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基于相干态光场的连续变量测量设备无关Cluster态量子通信

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电子与信息学报 2020年第2期42卷 307-314页

作者：王宇苏琦密码科学技术国家重点实验室

由于量子通信协议理论上可以发现任何窃听者的攻击行为,因此其天然具有抗量子计算机攻击的能力。高斯相干态光场相较于纠缠态光场更容易制备和实现,利用其实现量子通信网络更具经济价值和实用价值。该文提出一种利用连续变量(CV)相干态... 详细信息

由于量子通信协议理论上可以发现任何窃听者的攻击行为,因此其天然具有抗量子计算机攻击的能力。高斯相干态光场相较于纠缠态光场更容易制备和实现,利用其实现量子通信网络更具经济价值和实用价值。该文提出一种利用连续变量(CV)相干态光场就可以实现的测量设备无关(MDI)Cluster态量子通信网络协议。在此网络上可以方便地执行量子秘密共享(QSS)协议和量子会议(QC)协议。该文提出了线型Cluster态实现任意部分用户间QSS协议、星型Cluster态四用户QSS协议和QC协议,并利用纠缠模型分析了选用对称和非对称网络结构时,每种协议密钥率和传输距离之间的变化关系。结论为在量子网络中利用相干态实现QSS和QC协议提供了理论依据。

关键词：量子通信相干态连续变量测量设备无关 Cluster态

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Theirregularbrokenwaveforcesonverticalwall

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Acta Oceanologica Sinica 1998年第3期17卷 387-398页

作者： Li Yucheng, Liu Dazhong, qi Guiping ,su Xiaojun (Received April 21 , 1997, accepted July 2, 1997) Department of Civil Engineering Dalian University of Technology Dalian 116023 China

A method for the calculation of total horizontal wave forces by irregular broken waves on vertical wall is developed, which is based on physical model test. Dimensionless analysis and assessment of real construction. The method for the determination of pressure distribution of horizontal forces on vertical wall as well as uplift forces on the bottom of the wall is also recommended. The results calculated by this method well accord with samples of real construction.

关键词： Irregular waves broken waves wave forces.

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考虑双参数的公路隧道易损性及概率地震损失

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振动与冲击 2023年第13期42卷 235-241页

作者：苏琪范进南京理工大学理学院南京210094

研究高速公路隧道基于双地震动强度参数的易损性及概率地震经济损失,对震前抗震防灾及震后急救修复意义重大。建立高速公路隧道设计基准期内概率地震经济损失评估框架,引入双地震动强度参数,采用增量动力法进行易损性分析,得到的易损性... 详细信息

研究高速公路隧道基于双地震动强度参数的易损性及概率地震经济损失,对震前抗震防灾及震后急救修复意义重大。建立高速公路隧道设计基准期内概率地震经济损失评估框架,引入双地震动强度参数,采用增量动力法进行易损性分析,得到的易损性曲面与经验易损性曲线进行对比,验证了所建模型及易损性曲面的合理性;以此为基础,评估隧道设计基准期内的概率地震经济损失。结果表明,建立的基于双地震动强度参数下的易损性曲面能更准确地反映结构损伤,在高速公路隧道设计基准期内,轻微损伤造成的概率地震经济损失占比最大,中等损伤次之。该隧道概率地震经济损失评估框架可对高速公路隧道地震经济损失评估提供参考。

关键词：高速公路隧道地震动强度参数增量动力分析易损性曲面概率地震经济损失

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Relationship between survivin expression and recurrence,and prognosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第46期13卷 6264-6268页

作者： Chao-Ping Ye Cheng-Zhi qiu Zhong-Xin Huang qi-Chen su Wei Zhuang Rui-Lan Wu Xin-Feng Li Department of Hepatobiliary surgery Second Affiliated Hospitalof Fujian Medical University Quanzhou 362000 Fujian ProvinceChina Departmentof Pathology Second Affiliated Hospital of Fujian MedicalUniversity Quanzhou 362000 Fujian Province China

AIM： To study the expression of the inhibitor of apoptosis protein survivin in hepatocellular carcinoma （HCC）, and its correlation with clinicopathological factors, cell proliferation, recurrence and prognosis after hepatectomy. METHODS： Immunohistochemical staining of survivin and Ki-67 was performed by the standard streptavidin- peroxidase technique on paraffin sections of 55 cases of HCC. REsuLTS： The positive rate of survivin in HCC was 52.7% （29/55）. Significant correlation was found between survivin expression with portal vein thrombi and intrahepatic matastasistic nodes （P 〈 0.05）. The recurrent rate in survivin-positive HCC was significantly higher than that in survivin-negative HCC after hepatectomy, the 1- and 3-year survival rate in patients with survivin-positive tumors was significantly lower than that in patients with survivin-negative tumors （58.62 and 10.34% vs 76.92 and 30.77%, P 〈 0.05, log-rank test）. The proliferation index （Ki-67） in survivin-positive HCC （33.83% ± 18.90%） was significantly higher than that in survivin-negative HCC （19.60% ± 19.35%）（P 〈 0.05）. CONCLUSION： survivin may play an important role in progression of HCC by promoting cell proliferation, and may be positively correlated with high risk of disease recurrence and poor prognosis in HCC. Its expression may serve as a prognostic factor for patients with HCC after hepatectomy.

关键词： Hepatocelluar carcinoma survivin Proliferation index Prognosis Immunohistochemistry

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Equilibrium analysis of networked game under best-response dynamics

Equilibrium analysis of networked game under best-response d...

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第43届中国控制会议

作者： Yu Xia qi su Department of Automation Shanghai Jiao Tong University Key Laboratory of System Control and Information Processing Ministry of Education of China

Both coordination,a behavioral pattern where individuals adopt the same behavior as the majority,and anticoordination,a behavioral pattern where individuals choose a behavior different from the majority,are prevalent in social and engineering *** include the spread of social norms or innovations for coordination and the division of labor and traffic congestion for *** the large-scale interacting systems driven by coordination and anticoordination is of great significance in understanding,predicting,and optimizing the evolutionary *** existing studies have primarily focused on analyzing the convergence of networked systems and evaluating the time to reach equilibrium,our investigation delves into all possible states of a networked system and scrutinizes all equilibrium ***,we observe that the number of equilibrium states increases exponentially with the network *** for network structure properties,homogeneous networks exhibit more equilibrium states than heterogeneous ***,for specific behavioral switching thresholds,the number of equilibrium states is surprisingly higher than at neighboring switching *** work reveals the intricate interplay between evolutionary dynamics,system structure,and behavioral switching thresholds.

关键词： Best-response dynamics Complex networks Game theory Equilibrium analysis

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A numerical forecasting model of offshore-SST anomaly

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Acta Oceanologica Sinica 2000年第1期19卷 25-34页

作者： Wang Sizhen Li Xuhua qi Jianhua and su Yusong (1. Ocean University of qingdao, qingdao 266003, China.) Ocean University of qingdao Qingdao 266003 China

An SST model which is good at predicting offshore-SST anomaly (O-SSTA) has been developed. It is composed of three parts: equations of dynamics, equations of model's physics and equations of affecting factors of O-SSTA. Initial field of SST is prepared for a case of O-SSTA on last decade of July 1994, in which there are a center of warm anomaly in the Huanghai Sea and a center of cold anomaly in the East China Sea to be developing simultaneously. Using the Observed atmospheric forcing, the (decade) experiment forecast is made. Forecasting accuracy of warm (cold) anomaly is 32/44 (29/33 )' the ensemble accuracy reaches R = 91% and AMD = 0. 67 t. The chief affecting factors of O-SSTA for this case are shown, for warm anomaly: (1 ) afar radiation (weight is 64 % ), (2) the convergence of warm water (9% ), (3 ) shallow-water effects; and for cold anomaly: (l) pumping of typhoon (44 % ), (2) entrainment of storm (24 % ), (3) latent heat (19 % ), respectively. It is identified that the formation of warm (cold) anomaly is a slower (faster) process.

关键词： Offshore-SSTA numerical forecasting shallow-water effect

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Nutrition support in surgical patients with colorectal cancer

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World Journal of Gastroenterology 2011年第13期17卷 1779-1786页

作者： Yang Chen Bao-Lin Liu Bin Shang Ai-Shan Chen Shi-qing Liu Wei sun Hong-Zhuan Yin Jian-qiao Yin qi su Department of surgery Shengjing Hospital China Medical UniversityShenyang 110004 Liaoning Province China

AIM: To review the application of nutrition support in patients after surgery for colorectal cancer, and to propose appropriate nutrition strategies. METHODS: A total of 202 consecutive surgical patients admitted to our hospital with a diagnosis of colon cancer or rectal cancer from January 2010 to July 2010, meeting the requirements of Nutrition Risk Screening 2002, were enrolled in our study. Laboratory tests were performed to analyze the nutrition status of each patient, and the clinical outcome variables, including postoperative complications, hospital stay, cost of hospitalization and postoperative outcome, were analyzed. REsuLTS: The "non-risk" patients who did not receive postoperative nutrition support had a higher rate of postoperative complications than patients who received postoperative nutrition support (2.40 ± 1.51 vs 1.23 ± 0.60, P = 0.000), and had a longer postoperative hospital stay (23.00 ± 15.84 d vs 15.27 ± 5.89 d, P = 0.009). There was higher cost of hospitalization for patients who received preoperative total parenteral nutrition (TPN)than for patients who did not receive preoperative TPN (62 713.50 ± 5070.66 RMB Yuan vs 43178.00 ± 3596.68 RMB Yuan, P = 0.014). Applying postoperative enteral nutrition significantly shortened postoperative fasting time (5.16 ± 1.21 d vs 6.40 ± 1.84 d, P = 0.001) and postoperative hospital stay (11.92 ± 4.34 d vs 15.77 ± 6.03 d, P = 0.002). The patients who received postoperative TPN for no less than 7 d had increased serum glucose levels (7.59 ± 3.57 mmol/L vs 6.48 ± 1.32 mmol/L, P = 0.006) and cost of hospitalization (47 724.14 ± 16 945.17 Yuan vs 38 598.73 ± 8349.79 Yuan, P = 0.000). The patients who received postoperative omega-3 fatty acids had a higher rate of postoperative complications than the patients who did not (1.33 ± 0.64 vs 1.13 ± 0.49, P = 0.041). High level of serum glucose was associated with a high risk of postoperative complications of infection. CONCLUSION: Appropriate and moderate nutrition

关键词： Nutritional support Nutrition assessment Colorectal cancer surgery Prognosis

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Compound Kushen injection combined with chemotherapy in the treatment of gastric cancer: a meta-analysis of randomized controlled trials

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TMR Cancer 2019年第1期2卷 118-126页

作者： su-Tong Liu Kai-qi su Wen-Xia Zhao Department of Gastroenterology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenan450008China Department of Gastroenterology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200071China

Objective: This study aims to systematically evaluate the efficacy and safety of compound kushen injection (CKI) in combination with chemotherapy in patients with gastric cancer (GC). Methods: A comprehensive electronic search was conducted by searching PubMed, EMBASE, Cochrane Library, Chinese Biological Medical disc, China National Knowledge Infrastructure and Wanfang databases (the last update January 20, 2018). All randomized controlled trials (RCTs) of CKI plus chemotherapy versus chemotherapy alone in GC patients were identified. The quality of each study was evaluated using the Jadad’s scale, and the meta-analysis was performed using Review Manager 5.3 and STATA 14 software. Results: A total of nine studies on 688 cases were included in this study. The results showed that CKI combined with chemotherapy had a better effect on improving patients’ overall response rate (ORR) and life quality. The consequences of Egger’s and Begg’s tests showed there was no significant publication bias. Conclusion: The current evidence showed that CKI may enhance the clinical efficacy of chemotherapy, improve the quality of life and increase the safety in patients with gastric cancer.

关键词： Compound kushen injection Chemotherapy Gastric cancer Randomized controlled trials

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