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Effects of telbivudine and entecavir for HBeAg-positive chronic hepatitis B: A meta-analysis

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World Journal of Gastroenterology 2012年第43期18卷 6290-6301页

作者： qi-Min su Xiao-Guang Ye Department of Infectious Diseases the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina

AIM:To compare the effects of telbivudine (LDT) and entecavir (ETV) in treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B by meta-analysis. METHODS:We conducted a literature search using PubMed, MEDLINE, EMBASE, the China National Knowledge Infrastructure, the VIP database, the Wanfang database and the Cochrane Controlled Trial Register for all relevant articles published before April 1, 2012. Randomized controlled trials (RCTs) comparing LDT with ETV for treatment of HBeAg-positive chronic hepatitis B were included. The data was analyzed with Review Manager Software 5.0. We used relative risk (RR) as an effect measure, and reported its 95% CI. Meta-analysis was performed using either a fixedeffect or random-effect model, based on the absence or presence of significant heterogeneity. Two reviewers assessed the risk of bias and extracted data indepen- dently and in duplicate. The analysis was executed using the main outcome parameters including hepatitis B virus (HBV) DNA undetectability, alanine aminotransferase (ALT) normalization, HBeAg loss, HBeAg seroconversion, drug-resistance, and adverse reactions. Meta-analysis of the included trials and subgroup analyses were conducted to examine the association between pre-specified characteristics with the therapeutic effects of the two agents. REsuLTS:Thirteen eligible trials (3925 patients in total) were included and evaluated for methodological quality and heterogeneity. In various treatment durations of 4 wk, 8 wk, 12 wk, 24 wk, 36 wk, 48 wk, 52 wk, 60 wk and 72 wk, the rates of HBV DNA undetectability and ALT normalization in the two groups were similar, without statistical significance. At 4 wk and 8 wk of the treatment, no statistical differences were found in the rate of HBeAg loss between the two groups, while the rate in the LDT group was higher than in the ETV group at 12 wk, 24 wk, 48 wk and 52 wk, respectively (RR 2.28, 95% CI 1.16, 7.03, P = 0.02; RR 1.45, 95% CI 1.16, 1.82, P = 0.001; R

关键词： Telbivudine Entecavir Hepatitis B e antigen-positive chronic hepatitis B Randomized controlled trials Meta-analysis

Development of Alfalfa (Medicago sativa L.) Regeneration System and Agrobacterium-Mediated Genetic Transformation

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Agricultural Sciences in China 2010年第2期9卷 170-178页

作者： ZHANG He HUANG qi-man su Jin Biotechnology Research Institute Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

The regeneration ability of four alfalfa （Medicago sativa L.） cultivars, Xinjiang Daye, Longdong, Gannong 1 and Gannong 3, was studied, and the effects of various cultivars, explant sources and medium recipes on regeneration were compared. The better callus forming frequency obtained from hypocotyls of Xinjiang Daye is 88.5% and regeneration frequency is 9.8% in our initial experiments. To further optimize regeneration system for genetic transformation, we therefore changed concentrations of plant growth regulators and supplemented with glutamine into callus-induction and shoot-regeneration media. Callus forming frequency and shoot differentiation frequency were increased to 100%. The time taken to generate transgenic plants （16 weeks） was shorter than that for previouse procedure （25 weeks） and regeneration frequency was promoted to 15.1%. The results show that addition of glutamine is particularly important for shortening period of regeneration and promoting regeneration frequency. For study of genetic transformation of alfalfa, Agrobacterium tumefaciens-mediated transformation of Xinjiang Daye was developed based on this optimized regeneration system. The plant expression vector carrying two glutamine synthetases （GS 1 and GS2） and △1-pyrroline-5-carboxylate synthetase （P5CS） gene was used for alfalfa in vitro transformation. Six transgenic alfalfa plantlets with resistance to PPT were obtained. The introduction of foreign genes into plants was assessed in the transformants by PCR analysis and Southern hybridizations.

关键词： alfalf glutamine synthetases △1-pyrroline-5-carboxylate synthetase Agrobacterium tumefaciens-mediated transformation transgenic alfalfa

Late Quaternary Tectonic Activity and Slip Rates of Active Faults in the Western Hexi Corridor,NW China

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Journal of Earth Science 2020年第5期31卷 968-977页

作者： Xingwang Liu Daoyang Yuan qi su Bo Zhang Lanzhou National Observatory of Geophysics、Lanzhou 730000 China L anzhou Institute of Geotechnique and Earthquake China Earthquake AdministrationLanzhou 730000China School of Earth Science and Engineering Nanjing UniversityNanjing 210046China

The Yinwashan and Xinminpu faults are located in the Jiuxi Basin in the western end of the Hexi Corridor. The determination of their activity and slip rates is of great significance for understanding the eastward extension of the Altyn Tagh fault. Based on geological and geomorphologic field survey, trench excavation, optically stimulated luminescence dating, we define the fault geometry and kinematic properties of the two faults. Based on fault scarps measurement using differential GPS and 10 Be surface exposure dating, we determined vertical slip rate of 0.09±0.01 mm/yr for the Yinwashan fault and 0.1±0.02 mm/yr for the Xinminpu fault. Using the dips observed in trenches and natural sections, we estimated horizontal shortening rates of 0.05±0.03 and 0.23±0.06 mm/yr, respectively. No significant strike slip motion is observed on these two faults, and we infer that this region was dominated by horizontal shortening in the Late Quaternary. Although the shortening rate is quite low on each individual fault, together with other faults in this area, these two faults have an essential role in transferring slip from the eastern end of the Altyn Tagh fault and in accommodating the northeastward growth of Tibetan Plateau.

关键词： Hexi Corridor qilian Shan slip rate crustal shortening active fault

Transferring quantum entangled states between multiple single-photon-state qubits and coherent-state qubits in circuit QED

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Frontiers of physics 2021年第6期16卷 99-108页

作者： qi-Ping su Hanyu Zhang Chui-Ping Yang Department of Physics Hangzhou Normal UniversityHangzhou 311121China Quantum Information Research Center Shangrao Normal UniversityShangrao 334001China

We present a way to transfer maximally-or partially-entangled states of n single-photon-state(SPS)qubits onto ncoherent-state(CS)qubits,by employing 2nmicrowave cavities coupled to a superconducting flux *** two logic states of a SPS qubit here are represented by the vacuum state and the single-photon state of a cavity,while the two logic states of a CS qubit are encoded with two coherent states of a *** of using only one superconducting qutrit as the coupler,the circuit architecture is significantly *** operation time for the state transfer does not increase with the increasing of the number of *** the dissipation of the system is negligible,the quantum state can be transferred in a deterministic way since no measurement is ***,the higher-energy intermediate level of the coupler qutrit is not excited during the entire operation and thus decoherence from the qutrit is greatly *** a specific example,we numerically demonstrate that the high-fidelity transfer of a Bell state of two SPS qubits onto two CS qubits is achievable within the present-day circuit QED ***,it is worthy to note that when the dissipation is negligible,entangled states of n CS qubits can be transferred back onto n SPS qubits by performing reverse *** proposal is quite general and can be extended to accomplish the same task,by employing a natural or artificial atom to couple 2nmicrowave or optical cavities.

关键词： entangled state single-photon-state qubit coherent-state qubit circuit QED

Research and Development of Electro‑hydraulic Control Valves Oriented to Industry 4.0:A Review

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Chinese Journal of Mechanical Engineering 2020年第2期33卷 5-24页

作者： Bing Xu Jun Shen Shihao Liu qi su Junhui Zhang State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Electro-hydraulic control valves are key hydraulic components for industrial applications and aerospace,which controls electro-hydraulic *** the development of automation,digital technology,and communication technology,electro-hydraulic control valves are becoming more digital,integrated,and intelligent in order to meet the requirements of Industry *** paper reviews the state of the art development for electro-hydraulic control valves and their related *** review paper considers three aspects of state acquisition through sensors or indirect acquisition technologies,control strategies along with digital controllers and novel valves,and online maintenance through data interaction and fault *** main features and development trends of electro-hydraulic control valves oriented to Industry 4.0 are discussed.

关键词： Hydraulic valves Electro-hydraulic technology Sensor Control Digital hydraulic Fault diagnosis

Effects of entecavir and lamivudine for hepatitis B decompensated cirrhosis: Meta-analysis

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World Journal of Gastroenterology 2013年第39期19卷 6665-6678页

作者： Xiao-Guang Ye qi-Min su Department of Infectious Diseases the SecondAffiliated Hospital of Guangzhou Medical University

AIM:To compare the effects of entecavir(ETV)and lamivudine(LAM)for the treatment of hepatitis B decompensated cirrhosis using a ***:We conducted a literature search for all eligible studies published prior to May 30,2013 using PUBMED,MEDLINE,EMBASE,the China National Knowledge Infrastructure(CNKI),the VIP database,the Wanfang database and the Cochrane Controlled Trial *** controlled trials(RCTs)comparing ETV with LAM for the treatment of hepatitis B decompensated cirrhosis were *** data were analyzed with Review Manager Software *** used RR as an effect measure,and reported its95%*** meta-analysis was performed using either a fixed-effect or random-effect model,based on the absence or presence of significant *** reviewers assessed the risk of bias and extracted data independently and in *** analysis was executed using the main outcome parameters including hepatitis B virus(HBV)DNA undetectability,HBV DNA level,hepatitis B e antigen(HBeAg)seroconversion,alanine aminotransferase(ALT)level,albumin level,total bilirubin(TBIL)level,prothrombin time activity(PTA)level,Child-Turcotte-Pugh(CTP)score,mortality,drugresistance,and adverse ***-analysis of the included trials and subgroup analyses were conducted to examine the association between pre-specified characteristics and the therapeutic effects of the two ***:Thirteen eligible trials(873 patients in total)were included and evaluated for methodological quality and *** these studies,all had baseline comparability,12 of them reported baseline values of the two treatment groups in *** various treatment durations(12,24,36,48 and>48 wk),both ETV and LAM significantly reduced HBV DNA level,however,reductions were greater in the ETV group(MD=-0.66,95%CI:-0.83-0.50,P<0.00001),(MD=-0.93,95%CI:-1.36-0.51,P<0.0001),(MD=-1.4,95%CI:-1.78-1.01,P<0.00001),(MD=-1.18,95%CI:-1.90-0.46,P=0.001),(MD=-0.14,95%CI:-0.17-0.

关键词： Hepatitis B Decompensated cirrhosis Entecavir Lamivudine Randomized controlled trial Metaanalysis.

Comparative Studies on Mass Spectrometric Fragmentation of Linear Chiral Secondary Alcohols (R)-1-(4-Alkylphenyl) and (R)-1-(4-Alkoxyphenyl/Alkylthiophenyl) Alcohols

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Chemical Research in Chinese Universities 2006年第3期22卷 347-350页

作者： ZHANG qi-han su Xian-bin XU Jia-xi Key Laboratory of Bioorganic Chemistry and Molecular Engineering College of Chemistry and Molecular Engineering Peking University Beijing 100871 P.R. China

Mass spectrometric behaviour of （R） -1- （ 4-alkylphenyl ） alcohols, 1- （4-alkoxylphenyl） alcohols, and 1- （4-alkylthiophenyl） alcohols were studied with the aid of mass-analyzed ion kinetic energy spectrometry under electron impact ionization. All the title compounds show a tendency to eliminate a water molecule to form alkene ions and undergo an a-cleavago to produce protonated aldehyde ions by the loss of alkyl radicals. Except these two common fragment ions, they also show some different fragmentations due to with or without oxy/thioether-linkage.

关键词： 1-(4-Alkylphenyl) alcohol 1-(4-Alkoxylphenyl) alcohol 1-(4-Alkylthiophenyl) alcohol Electron impact ionization Fragmentation mechanism Mass spectrometry

Visible light response ZnO-C_(3)N_(4) thin film photocatalyst

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Rare Metals 2021年第1期40卷 96-104页

作者： Yue Zhang Shu-Man Zhao qi-Wen su Jun-Li Xu School of Science Northeastern University.Shenyang 110004China

Nanoflower-like ZnO-C_(3)N_(4) thin film with a porous net structure was successfully synthesized by a simple chemical corrosion *** prepared ZnOC_(3)N_(4) thin films presented remarkable photocatalytic activities for the degradation of methyl orange under visible light irradiation,and more than 90%methyl orange was removed from water by ZnO-C_(3)N_(4) ***,the ZnO-C_(3)N_(4) composite presented an enhanced photocatalytic *** loading content of C_(3)N_(4) had a great effect on the photocatalytic ***,the photocatalytic activities were higher in acidic media than those in alkaline *** adsorption of methyl orange was enhanced,and the recombination of photogenerated electrons and holes was suppressed with a suitable content of C_(3)N_(4).However,too much loading content of C_(3)N_(4) resulted in a poor dispersion of C_(3)N_(4) as the aggregated C_(3)N_(4) can behave as recombination *** addition,the prepared ZnO-C_(3)N_(4) thin film can be used for the water splitting in water-methanol system under simulated solar light irradiation.

关键词： ZnO-C_(3)N_(4)thin film Photodegradation Water splitting Visible light irradiation Photocatalytic stability

Efficient scheme for realizing a multiplex-controlled phase gate with photonic qubits in circuit quantum electrodynamics

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Frontiers of physics 2022年第5期17卷 125-135页

作者： qi-Ping su Yu Zhang Liang Bin Chui-Ping Yang School of Physics Hangzhou Normal UniversityHangzhou 311121China School of Physics Nanjing UniversityNanjing 210093China Quantum Information Research Center Shangrao Normal UniversityShangrao 334001China

We propose an efficient scheme to implement a multiplex-controlled phase gate with multiple photonic qubits simultaneously controlling one target photonic qubit based on circuit quantum electrodynamics(QED).For convenience,we denote this multiqubit gate as MCP *** gate is realized by using a two-level coupler to couple multiple *** coupler here is a superconducting *** scheme is simple because the gate implementation requires only one step of *** addition,this scheme is quite general because the two logic states of each photonic qubit can be encoded with a vacuum state and an arbitrary non-vacuum state|φ>(e.g.,a Fock state,a superposition of Fock states,a cat state,or a coherent state,etc.)which is orthogonal or quasi-orthogonal to the vacuum *** scheme has some additional advantages:because only two levels of the coupler are used,i.e.,no auxiliary levels are utilized,decoherence from higher energy levels of the coupler is avoided;the gate operation time does not depend on the number of qubits;and the gate is implemented deterministically because no measurement is *** an example,we numerically analyze the circuit-QED based experimental feasibility of implementing a three-qubit MCP gate with photonic qubits each encoded via a vacuum state and a cat *** scheme can be applied to accomplish the same task in a wide range of physical system,which consists of multiple microwave or optical cavities coupled to a two-level coupler such as a natural or artificial atom.

关键词： multiplex controlled phase gate circuit QED