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Histone deacetylase 6 mediated NALP3 inflammasome activation contributes to dopaminergic injury in experimental models of Parkinson disease

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中国药理学与毒理学杂志 2018年第9期32卷 686-687页

作者： YAN shao-qi WEI Xin-bing JIAN Wen-cheng qiN Yue JIANG Fan LOU Hai-yan ZHANG Bin Department of Pharmacology School of Basic Medical SciencesShandong University Jinan 250012China Department of Radiology Qilu HospitalShandong University Jinan 250012China Department of Pathophysiology School of Basic Medical SciencesShandong University Jinan 250012China

OBJECTIVE To investigate the mechanisms of histone deacetylase 6(HDAC6)deacetylation activity on NALP3 inflammasome activation and explore the protective effect s of pharmacological inhibition of HDAC6 on dopaminergic *** In vitro and in vivo6-OHDA induced Parkinson disease(PD) model was *** distinguish the effect of deacetylase catalytic domains of HDAC6,we used a specific HDAC6 inhibitor tubastatin A(TBA),siRNAHDAC6,and pcDNA-HDAC6-FLAG ***,the role of pharmacological inhibition or siRNA or overexpression of HDAC6 on NALP3 inflammasome and cell death was explored by using Western blotting,TUNEL,and flow cytometric ***,the acetylation level of peroxiredoxin 2(Prx2) and the production of reactive oxygen species(ROS) in cells under different treatments was examined by using immunoprecipitation and DCFH-DA fluorescence *** effects of TBA on neuroinflammation and nigrostriatal dopaminergic system in vivo was further investigated by using Western blotting,immunohistochemistry and HPLC *** TBA remarkably inhibited 6-OHDA induced NALP3 inflammasome activation,reduced dopaminergic neurodegeneration and neuroinflammation as demonstrated by increased TH-positive neurons,striatal levels of DA and its metabolites,and decreased gliocyte *** recovered acetylation of Prx2,and reduced ROS production,which was associated with decreased NALP3 inflammasome *** HDAC6 may medicate deacetylation of Prx2 contributes to NALP3 inflammasome activation in PD pathology,suggesting that the development of specific pharmacological inhibitors of HDAC6 be required for this kind of disease.

关键词： histone deacetylase 6 NALP3 peroxiredoxin 2 reactive oxygen species

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侧沟式一体化氧化沟的生物脱氮

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华南理工大学学报（自然科学版） 2008年第12期36卷 66-69页

作者：周少奇王平华南理工大学环境科学与工程学院广东广州510006

一体化氧化沟占地面积小、工艺流程简单,因此已成为环保领域的研究热点.文中采用侧沟式一体化氧化沟技术处理生活污水,进行生物脱氮研究.试验期间,一体化氧化沟进水CODCr为200.00-400.00 mg/L,NH4^＋-N进水从1.24 mg/L迅速提高到39.72mg... 详细信息

一体化氧化沟占地面积小、工艺流程简单,因此已成为环保领域的研究热点.文中采用侧沟式一体化氧化沟技术处理生活污水,进行生物脱氮研究.试验期间,一体化氧化沟进水CODCr为200.00-400.00 mg/L,NH4^＋-N进水从1.24 mg/L迅速提高到39.72mg/L;出水CODCr保持在15.00mg/L以下,氨氮去除效果保持稳定,出水氨氮质量浓度在多数情况下保持在2.00mg/L以下.文中还分析了碱度、CODCr/NH4＋-N质量比对生物硝化作用的影响,并就如何提高反硝化效率提出了建议.

关键词：一体化氧化沟硝化反硝化生物脱氮

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Material Model Research on Rubber Vibration Isolators

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International Journal of Plant Engineering and Management 2007年第2期12卷 61-68页

作者： WANG Rui LI Shi-qi SONG shao-yun School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China

A viscohyperelastic constitutive model is proposed to describe the mechanical behaviour of vibration isolation rubber under broad-band vibration. This constitutive model comprises two parts： a component with three parameters to characterize the hyperelastic static properties of rubber materials, and the other component incorporating two relaxation time parameters, corresponding to high and low strain rates, respectively, to describe the dynamic response under vibration and impact loadings. Based on this proposed constitutive model, a series of experiments were performed on two types of rubber materials over a wide strain rate range. The results predicted from this model are in good agreement with the experimental data.

关键词： viscohyperelastic constitutive model rubber vibration isolator material model

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A Two-stage Pathway-based Association Analysis Highlighting the Importance of DNA Repair Pathways in Nasopharyngeal Carcinoma

A Two-stage Pathway-based Association Analysis Highlighting ...

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第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： Ke Liu Yan Liu shao-qi Rao Department of Biomedical Engineering Zhongshan School of MedicineSun Yat-Sen University Institution of Medical Systems Biology and School of Public Health Guangdong Medical College

Background:Nasopharyngeal Carcinoma(NPC) is one of the highest mortal malignancies around the world,and its etiology involves a number of sophisticated biological *** repair related pathways are widely recognized as essential components in the etiology of NPC,yet few studies have systematically evaluated their *** this study, we proposed to use a two-stage association analysis for systematically assessing the relevance of DNA repair pathways with NPC. Methods:755 NPC cases and 755 controls of Cantonese population were recruited by Sun Yat-Sen University Cancer Center(SYSUCC).A total of 676 SNPs for 88 genes belonging to seven DNA repair related pathways were *** preprocessing the data based on Hardy-Weinberg equilibrium test,minor allele frequency and missing rate,587 SNPs were remained for subsequent *** avoid missing genes with moderate to small effects, we applied a two-stage approach that combines Fisher’s combination test and hypergeometric test to summarize the gene- and pathway-level association signals,respectively. Results:In the first stage,24 DNA repair related genes were identified associated with NPC(a=0.05),of which 17 genes were missed by the traditional single-SNP association *** the second stage,we found that two DNA repair pathways,Nucleotide Excision Repair(NER:P=0.0026) and Mismatch Repair(MMR,P= 0.0068) are significantly associated with NPC,in which association between MMR and NPC has not been reported previously. Conclusions:Our study demonstrates that the proposed two-stage approach,geneand pathway-level analysis,is able to capture genes with moderate to small effect,hence increasing the power to identify disease-relevant pathways.

关键词： Nasopharyngeal Carcinoma(NPC) DNA repair pathway pathway-based analysis

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Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway

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Neural Regeneration Research 2016年第2期11卷 345-351页

作者： qing-rong Li Zhuo Wang Wei Zhou Shou-rui Fan Run Ma Li Xue Lu Yang Ya-shan Li Hong-li Tan qi, ng-hua shao Hong-ying Yang Second Affiliated Hospital of Kunming Medical University Department of Clinical Laboratory Kunming Yunnan Province China Third People's Hospital of Yunnan Province Kunming Yunnan Province China

Epalrestat is a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy. This study assumed that epalrestat had a protective effect on diabetic peripheral nerve injury by suppressing the expression of aldose reductase in peripheral nerves of diabetes mellitus rats. The high-fat and high-carbohydrate model rats were established by intraperitoneal injection of streptozotocin. Peripheral neuropathy occurred in these rats after sustaining high blood glucose for 8 weeks. At 12 weeks after streptozotocin injection, rats were intragastrically administered epalrestat 100 mg/kg daily for 6 weeks. Transmission electron microscope revealed that the injuries to myelinated nerve fibers, non-myelinated nerve fibers and Schwann cells of rat sciatic nerves had reduced compared to rats without epalrestat administuation. Western blot assay and immunohistochemical results demonstrated that after intervention with epalrestat, the activities of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase gradually increased, but aldose reductase protein expression gradually diminished. Results confirmed that epalrestat could protect against diabetic peripheral neuropathy by relieving oxidative stress and suppressing the polyol pathway.

关键词： nerve regeneration peripheral nerve injury streptozotocin reactive oxygen species diabetic neuropathy oxidative stress aldosereductase antioxidant enzymes polyol pathway aldose reductase inhibitor superoxide dismutase catalase glutathione peroxidase rats NSFCgrant neural regeneration

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Low Field-Induced Electron Emission Phenomenon Observed from the Carbon Containing Thin Films

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Chinese Physics Letters 1997年第12期14卷 949-952页

作者： CHEN Jun WEI Ai-xiang ZHANG Hai-yan LU Yong ZHENG Xin-guo MO Dang PENG shao-qi XU Ning-sheng Department of Physics Zhongshan UniversityGuangzhou 510275

Stable cold-cathode electron emission at fields as low as 3 MV/m has been observed from two types of carbon-containing thin film of thickness in submicron scale,i.e.,non-doped fullerene C60 and amorphous diamond films.A transparent anode imaging technique was used to record the spatial distribution of individual sites and the total emission current-voltage characteristic of the *** is found that supplemental measurements of optical spectra and electrical conductivity of the films can provide important evidence useful for understanding the differences in emission behaviour between two types of film.

关键词： Electron transparent behaviour

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中国-东盟相互贸易依存度与建立东亚货币区的路径选择

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国际贸易问题 2007年第4期292卷 60-64页

作者：齐绍洲武汉大学世界经济系

本文在最优货币区理论的框架下,通过对中国与东盟人均GDP最高的6个成员国之间相互贸易依存度的回归分析和趋势预测,对比欧元区的历史经验得出,在目前和今后一段时期内尚不具备建立整个东亚货币区的条件下,东亚货币区的建设值得考虑的路... 详细信息

本文在最优货币区理论的框架下,通过对中国与东盟人均GDP最高的6个成员国之间相互贸易依存度的回归分析和趋势预测,对比欧元区的历史经验得出,在目前和今后一段时期内尚不具备建立整个东亚货币区的条件下,东亚货币区的建设值得考虑的路径应该是:第一,首先推动中国的内地、香港、澳门和台湾四大经济体的经济与货币一体化;第二,在中国—东盟自由贸易区的基础上推动中国和东盟人均GDP最高的6个国家组成“1+6”货币区;第三,“1+6”货币区再分阶段吸引韩国、日本和其他4个东盟成员国加入,从而最终促成东亚货币区的形成。

关键词：相互贸易依存度东亚货币区路径中国-东盟

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树形多体Hamilton系统的Lyapunov指数计算方法

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北京航空航天大学学报 2001年第2期27卷 230-232页

作者：金俐王琪陆启韶北京航空航天大学理学院

研究了树形多体Hamilton系统Lyapunov指数的数值方法 .利用多体Hamilton系统的正则方程和辛算法 ,给出了多体Hamilton系统Lyapunov指数的计算方法 ,该算法具有较好的计算精度和通用性 .利用该算法可对系统的运动稳定性进行分析 .最后用... 详细信息

研究了树形多体Hamilton系统Lyapunov指数的数值方法 .利用多体Hamilton系统的正则方程和辛算法 ,给出了多体Hamilton系统Lyapunov指数的计算方法 ,该算法具有较好的计算精度和通用性 .利用该算法可对系统的运动稳定性进行分析 .最后用算例说明了该算法的有效性 .

关键词：哈密顿方程计算方法多体系统 Lyapunov指数 Hamilton系统动力学方程树形多体

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A New Calibration Method for Microphone Array with Gain, Phase, and Position Errors

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Journal of Electronic Science and Technology of China 2007年第3期5卷 248-251页

作者： Hua Xiao Huai-Zong shao qi-Cong Peng wilh School of Communication and Information Engineering University of Eleclxonic Science and Technology of China （UESTC） Chengdu 610054 China

Microphone array can be used in sound source localization and separation. But gain, phase, and position errors can seriously influence the performance of localization algorithms such as multiple signal classification （MUSIC） algorithm. In this paper, a new calibration method for microphone array with gain, phase, and position errors is proposed. Unlike traditional calibration methods for antenna array, the proposed method can be used in the broadband and near-field signal model such as microphone array with arbitrary sensor geometries in one plane. Computer simulations are presented and simulation results show the new method having good performance.

关键词： Calibration microphone array multiple signal classification (MUSIC).

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Nonexistence of Positive Solutionsto a Quasilinear Elliptic SystemAnd Blow-up Estimates for a Non-Newtonian Filtration System

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河南师范大学学报（自然科学版） 2001年第4期29卷 122-123页

作者： YANG Zuo－dong LU qi－shao DepartmentofAppliedMathematics BejingUniversityofAeronauticsBeijing100083 EditorialDepartmentofJourn

Recently,reaction-diffusion systems of the Fujita typeut=Δu+u m1vn1vt=Δv+um2vn2，(x,t)∈Ω×(0,T)[ JY〗(A)as well as the related elliptic system-Δu=um1v n1，-Δv=um2vn2，x∈Ω(B)with Ω∈RN，mi,ni0,i=1,2 were studied by a number of *** p roblem concerning (A) includes global existence and global existence numbers,blo w -up,blow-up rates,and blow-up sets,uniqueness and nonuniqueness,etc. For (B) there are problems such as existence and nonexistence,uniqueness and nonuniquene ss,and so

关键词：非牛顿滤清系统准线性椭圆系统破坏估计不稳定流体

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