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Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy

World Journal of Gastroenterology 2021年第25期27卷 3851-3862页

作者： You-Han Miao Li-Ping Mao Xiao-Juan Cai Xiao-Ying Mo qi-qi Zhu Fei-Tong Yang Mei-Hua Wang Department of Infectious Disease Nantong Third People’s HospitalNantong 226006Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignancy that results in a high rate of cancerrelated ***(DDP)-based chemotherapy is the first-line clinical treatment for GC therapy,but chemotherapy resistance remains a severe clinical *** oxide nanoparticle(ZnO-NP)has been identified as a promising anti-cancer agent,but the function of ZnO-NP in GC development is still *** To explore the effect of ZnO-NP on chemotherapy resistance during GC *** ZnO-NP was synthesized,and the effect and underlying mechanisms of ZnO-NP on the malignant progression and chemotherapy resistance of GC cells were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assays,colony formation assays,transwell assays,wound healing assays,flow cytometry,and Western blot analysis in GC cells and DDP-resistant GC cells,and by tumorigenicity analyses in nude *** Our data revealed that ZnO-NP was able to inhibit proliferation,migration,and invasion and induce apoptosis of GC ***,ZnO-NP significantly reduced the half maximal inhibitory concentration(IC50)of DDP for the inhibition of cell proliferation of DDP-resistant SGC7901/DDP cell *** was increased in DDP-resistant GC cells,as demonstrated by elevated light chain 3-like protein 2(LC3II)/LC3I and Beclin-1 expression and repressed p62 expression in SGC7901/DDP cells compared to SGC7901 ***,ZnO-NP inhibited autophagy in GC cells and treatment with DDP induced autophagy,which was reversed by ***,ZnO-NP attenuated the tumor growth of DDP-resistant GC cells in *** We conclude that ZnO-NP alleviates the chemoresistance of GC cells by inhibiting *** findings present novel insights into the mechanism by which ZnO-NP regulates the chemotherapy resistance of ***-NP may serve as a potential therapeutic candidate for GC *** potential role of ZnO-NP in the clinical treatment of GC needs clarif

关键词： Gastric cancer Progression Chemoresistance Zinc oxide nanoparticle Autophagy MTT assays

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Structural Topology Design of Container Ship Based on Knowledge-Based Engineering and Level Set Method

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China Ocean Engineering 2015年第4期29卷 551-564页

作者：崔进举王德禹史琪琪 State Key Laboratory of Ocean Engineering School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong University American Bureau of Shipping

Knowledge-Based Engineering （KBE） is introduced into the ship structural design in this paper. From the implementation of KBE, the design solutions for both Rules Design Method （RDM） and Interpolation Design Method （IDM） are generated. The corresponding Finite Element （FE） models are generated. Topological design of the longitudinal structures is studied where the Gaussian Process （GP） is employed to build the surrogate model for FE analysis. Multi-objective optimization methods inspired by Pareto Front are used to reduce the design tank weight and outer surface area simultaneously. Additionally, an enhanced Level Set Method （LSM） which employs implicit algorithm is applied to the topological design of typical bracket plate which is used extensively in ship structures. Two different sets of boundary conditions are considered. The proposed methods show satisfactory efficiency and accuracy.

关键词： Knowledge-Based Engineering (KBE) Level Set Method (LSM) Gaussian Process ( GP)

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Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth

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Signal Transduction and Targeted Therapy 2020年第1期5卷 495-507页

作者： Nan Yao Chen-Ran Wang Ming-Qun Liu Ying-Jie Li Wei-Min Chen Zheng-qiu Li qi qi Jin-Jian Lu Chun-Lin Fan Min-Feng Chen Ming qi Xiao-Bo Li Jian Hong Dong-Mei Zhang Wen-Cai Ye College of Pharmacy Jinan UniversityGuangzhouChina Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research Jinan UniversityGuangzhouChina School of Medicine Jinan UniversityGuangzhouChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina

Epidermal growth factor receptor(EGFR)activation plays a pivotal role in EGFR-driven non-small cell lung cancer(NSCLC)and is considered as a key target of molecular targeted *** tyrosine kinase inhibitors(TKIs)have been canonically used in NSCLC ***,prevalent innate and acquired resistances and EGFR kinase-independent pro-survival properties limit the clinical efficacy of EGFR ***,the discovery of novel EGFR degraders is a promising approach towards improving therapeutic efficacy and overcoming drug ***,we identified a 23-hydroxybetulinic acid derivative,namely DPBA,as a novel EGFR small-molecule *** exerted potent in vitro and in vivo anticancer activity in both EGFR wild type and mutant NSCLC by degrading *** studies disclosed that DPBA binds to the EGFR extracellular domain at sites differing from those of EGF and *** did not induce EGFR dimerization,phosphorylation,and ubiquitination,but it significantly promoted EGFR degradation and repressed downstream survival *** analyses showed that DPBA induced clathrin-independent EGFR endocytosis mediated by flotillin-dependent lipid rafts and unaffected by EGFR *** of the early and late endosome markers rab5 and rab7 but not the recycling endosome marker rab11 was involved in DPBA-induced EGFR lysosomal *** present study offers a new EGFR ligand for EGFR pharmacological degradation and proposes it as a potential treatment for EGFR-positive NSCLC,particularly NSCLC with innate or acquired EGFR TKI *** can also serve as a chemical probe in the studies on EGFR trafficking and degradation.

关键词： NSCLC EGFR positive

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World Journal of Clinical Cases 2022年第28期10卷 10186-10192页

作者： Na Chen Min-Jia qian Ru-Hui Zhang qi-qi Gao Chao-Chao He Ya-Ke Yao Jian-Ying Zhou Hua Zhou Department of Clinical Pharmacy The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Respiratory and Critical Care Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Critical Care Medicine Zhuji People’s HospitalShaoxing 311800Zhejiang ProvinceChina Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Pharmacy Yiwu Central HospitalJinhua 322000Zhejiang ProvinceChina

BACKGROUND With programmed death-1(PD-1) inhibitors becoming the standard treatment for lung cancer,PD-1-related adverse reactions and treatment have gradually become *** SUMMARY First reported case of tislelizumab-related enteritis successfully treated with adalimumab 40mg every 2 wk for 3 times in an advanced lung cancer patient who received first-line tislelizumab/pemetrexed/carboplatin for 4 *** patient continued receiving the treatment of pemetrexed/carboplatin after symptoms,abdominal computed tomography and colonoscopy improved,significant diarrhea was not *** Adalimumab can be an effective treatment option for patients with PD-1 antibody related enteritis if they do not respond well to glucocorticoid treatment.

关键词： Tislelizumab Adalimumab Enteritis Case report

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Glucose substrate in the hydrogen breath test for gut microbiota determination:A recommended noninvasive test

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World Journal of Clinical Cases 2022年第26期10卷 9536-9538页

作者： qi-qi Xie Jia-Feng Wang Yang-Fen Zhang Dong-Hui Xu Bo Zhou Ting-Hui Li Zhi-Peng Li School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina Town Hospital of Gaodu Mengyin CountyLinyi 276200Shandong ProvinceChina

Intestinal dysbiosis and small intestinal bacterial overgrowth(SIBO)are common in patients with liver *** studies have not explored the association between gut dysbiosis and *** propose some suggestions for the authors’experimental methods and concepts,and we hope these suggestions can be *** hydrogen breath test is worthy of recommendation due to its high accuracy and convenient *** suggest changing the substrate of the hydrogen breath test from lactulose to glucose to improve the accuracy of each *** is a small subset of gut dysbiosis,and we propose clarifying the concept of *** may be caused by liver cirrhosis or one of the pathogeneses of gastrointestinal ***,interference from other gastrointestinal diseases should be excluded from this study.

关键词： Glucose Hydrogen breath test Lactulose Liver cirrhosis Small intestinal bacterial overgrowth

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Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 682-697页

作者： Shuran Fan Ming qi qi qi Qun Miao Lijuan Deng Jinghua Pan Shenghui qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Medicine Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510630China The First Affiliated Hospital of Jinan University Guangzhou 510632China State Key Laboratory of Chemical Oncogenomics Guangdong Provincial Key Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.

关键词： Lymphaticmetastasis Colorectal cancer Fibroblastactivation proteinα FAPα-activated prodrug Epithelial-mesenchymal

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IFN-γ surmounts PD-L1/PD1 inhibition to CAR-T cell therapy by upregulating ICAM-1 on tumor cells

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Signal Transduction and Targeted Therapy 2021年第2期6卷 226-228页

作者： E Dong Xiao-zhu Yue Lin Shui Bin-rui Liu qi-qi Li Yun Yang Hui Luo Wei Wang Han-shuo Yang State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation Center for Biotherapy610041 ChengduChina

Dear Editor,Chimeric antigen receptor modifed T(CAR-T)cell therapy has shown potent antitumor activity against relapsed and refractory hematological ***,its efficacy in solid tumors is limited,partly because of the inhibition of PD-L1/PD-1 signaling on CAR-T cells in solid *** optimizations of CAR-T cells by disrupting PD-1 signaling have improved the anti-tumor efficacy of CAR-T cells.2 Here,we report an alternative approach that sensitizes tumor cells by interferon(IFN)-Y,but without modifying T cells;this strategy surmounts PD-1 inhibition and markedly enhances CAR-T anti-tumor activities in vitro and in vivo.

关键词： markedly PD1 CAR

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The role of urethral pressure profile on treating premature ejaculation by tamsulosin

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Asian Journal of Andrology 2014年第5期16卷 792-793页

作者： Hui-Rong Chen Fu-Jun Zhao Xiao-Hai Wang qi Jiang qi Zhang Ban-Ming Han Jun Lu Shu-Jie Xia Department of Urology Shanghai First People's Hospital Shanghai Jiao Tong University Shanghai China

Dear Editor, I am Dr. Hui-Rong Chen, from the Department of Urology in Shanghai First People＇s Hospital at Shanghai Jiao Tong UnNersity, Shanghai, China. Premature ejaculation （PE） is a common sexual dysfunction, affecting approximately 20%-30% of sexually active men. According to intravaginal ejaculatory latency time （IELT） of l min, the incidence is approximately 1%-3%.1 PE is significantly associated with many personal and negative consequences, such as distress, frustration, and avoidance of sexual intimacy due to the inability of successful delayed ejaculation, α1-adrenergic blockers were effective in delaying ejaculation in approximately 50%-67% of the cases.2,3 Recently, abnormal ejaculation, an adverse infrequent side effect associated with the use of α1A-adrenergic blockers such as silodosin or tamsulosin, has drawn significant attention. Clinical studies suggested that this represents a relative anejaculation rather than a retrograde ejaculation. We present here the study to investigate the role of urethral pressure profile （UPP） on treating PE by tamsulosin.

关键词： The role urethral pressure

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Rehabilitation care of patients with neurogenic bladder after spinal cord injury:A literature review

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World Journal of Clinical Cases 2023年第1期11卷 57-64页

作者： Lei Xiang Han Li qi-qi Xie Ching Sin Siau Zhi Xie Meng-Ting Zhu Bo Zhou Zhi-Peng Li Shuai-Bin Wang Centre for Community Health Studies Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Department of Rehabilitation Medicine First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina College of Biology&Pharmacy Three Gorges UniversityYichang 443002Hubei ProvinceChina Department of Urology The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

This article reviews the research progress of rehabilitation treatment and nursing care of patients with neurogenic bladder after spinal cord injury,in order to provide reference for the rehabilitation treatment and nursing care of *** reviewed recent medical literature on patients with neurogenic bladder,focusing on neurogenic bladder caused by spinal cord *** analyzed 30 recent of publications in patients with neurogenic bladder after spinal cord injury,in addition to reviewing and evaluating the commonly used rehabilitation nursing methods for neurogenic *** counseling is a vital aspect which cannot be neglected in the process of neurogenic bladder ***,the commonly used drug and surgical treatments may have negatively impacted the mental health of patients in varying ***,in clinical practice,applying intermittent catheterization in patients who have neurogenic bladder with spinal cord injury may help improve patients’life quality,mitigate psychological burden,and reduce negative emotions.

关键词： Neurogenic bladder Anxiety Psychological burden Spinal cord injury Nursing

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锥形构象含氟杯芳烃衍生物对铜离子的高选择性识别（英文）

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无机化学学报 2019年第7期35卷 1301-1311页

作者：齐琪李星宁波大学材料科学与化学工程学院浙江省光电探测材料及器件重点实验室

合成了具有锥形构象的含氟功能基团的杯芳烃衍生物1~3,并用单晶X射线衍射和核磁共振证实了其锥形构象。在混合溶剂中,研究了杯芳烃衍生物1~3对多种金属离子的识别行为。测试了化合物1~3的紫外-可见吸收光谱和荧光发射光谱,结果显示铜离... 详细信息

合成了具有锥形构象的含氟功能基团的杯芳烃衍生物1~3,并用单晶X射线衍射和核磁共振证实了其锥形构象。在混合溶剂中,研究了杯芳烃衍生物1~3对多种金属离子的识别行为。测试了化合物1~3的紫外-可见吸收光谱和荧光发射光谱,结果显示铜离子对化合物1~3具有明显的荧光猝灭特性,而其它金属离子(如Na^+,K^+,Cs^+,Mg^2+,Ca^2+,Ba^2+,Fe^3+,Cd^2+,Mn^2+,Co^2+,Ni^2+,Zn^2+)对化合物1~3的紫外-可见吸收光谱和荧光发射强度无显著的影响,表明化合物1~3对铜离子的识别具有高选择性。

关键词：杯芳烃识别选择性含氟衍生物

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