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Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

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World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： qi-Long Wu Xiao-Ting Fang Xin-Xin Wan qing-Yong Ding Yan-Jun Zhang Ling Ji Yong-Liang lou Xiang Li School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors *** reports suggest that Fusobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of ***,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various *** study is designed to explore whether *** influences the onset and progression of CRC by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** affects CRC occurrence and *** Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of ***,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the effects on proliferative proteins and mitochondrial *** Our research indicates that the prevalence of *** in fecal samples from CRC patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably *** mice colonized with ***,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of *** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC ***,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the proliferation of CRC *** combined presence of *** and NaB attenuated the effects of the *** employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of CRC cell *** F.n

关键词： Colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

LD侧面抽运Nd:YAG陶瓷激光器运转条件下归一化热参数优化理论及实验研究

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物理学报 2006年第10期55卷 5221-5226页

作者：朱洪涛楼祺洪漆云凤董景星魏运荣中国科学院上海光学精密机械研究所上海201800

考虑激光提取对介质内非辐射跃迁的抑制作用,建立和完善LD侧面抽运Nd:YAG陶瓷激光器运转条件下增益介质的发热模型,通过实验测量激光器斜率效率和增益介质吸收的抽运功率来推导出归一化热参数.通过归一化热参数,讨论了影响Nd:YAG陶瓷介... 详细信息

考虑激光提取对介质内非辐射跃迁的抑制作用,建立和完善LD侧面抽运Nd:YAG陶瓷激光器运转条件下增益介质的发热模型,通过实验测量激光器斜率效率和增益介质吸收的抽运功率来推导出归一化热参数.通过归一化热参数,讨论了影响Nd:YAG陶瓷介质内热沉积的主要因素,研究结果表明:增益介质内热沉积对激光提取效率、交叠效率以及掺杂浓度的变化比较敏感.为有效减少热沉积,对所研究的掺杂原子百分比浓度为1·0%的Nd:YAG陶瓷多模激光器的输出耦合镜进行优化选择,激光提取效率提高到0·905,归一化热参数降低到0·474.研究结果可为进一步研究陶瓷激光器中热效应以及冷却方案设计等提供一定参考.

关键词：热沉积归一化热参数 Nd:YAG陶瓷

Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu qi Pan Li-Li Ding Si-Chen Li Lu-Yan Cheng Shu-qi Wang Bing-Hai lou Jun He Cui-Yun Lei Lin Cong Hao-qiang Liu Xue-Feng Wang Chun Ran Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus *** a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus *** acquisition of genomic information can provide a molecular genetic basis for effective control of ***,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of *** genome size of *** was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were *** resequencing of female and male individuals indicated that the sex chromosome system of *** is *** analysis demonstrated that *** and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely ***,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further *** high-quality genome provides an important reference for developing effective management strategies of ***.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing

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语境与生活世界:语用学发展新探

外语学刊 2011年第1期 54-58页

作者：韩冰娄奇牡丹江师范学院牡丹江157012

语境是言语交际中生成,实现并制约言语行为的相关因素的总和。不同语境对语言的使用产生不同的制约作用,并且决定语言形式的选择。本文采用例证法探讨语境与交际、语境与教学的关系,揭示语境对生活世界的实际意义。作为语用学发展的一... 详细信息

语境是言语交际中生成,实现并制约言语行为的相关因素的总和。不同语境对语言的使用产生不同的制约作用,并且决定语言形式的选择。本文采用例证法探讨语境与交际、语境与教学的关系,揭示语境对生活世界的实际意义。作为语用学发展的一个新的研究方向,语境研究会对生活世界产生更加深远的影响。

关键词：语境生活世界交际教学

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矩形边界平面问题在边界条件作用下应力解

郑州大学学报（工学版） 2011年第5期32卷 1-6页

作者：许琪楼郑州大学土木工程学院河南郑州450001

边界条件作用下平面问题应力解为双调和方程解,由通解和特解组成.应力函数通解为含有8个待定系数的双向单三角级数,与矩形边界8个边界条件相对应;级数曲线波形符合相应方向边界法向面力或法向位移固有分布特点.应力函数特解有边界法向... 详细信息

边界条件作用下平面问题应力解为双调和方程解,由通解和特解组成.应力函数通解为含有8个待定系数的双向单三角级数,与矩形边界8个边界条件相对应;级数曲线波形符合相应方向边界法向面力或法向位移固有分布特点.应力函数特解有边界法向面力、边界法向位移和边界常量剪应力3种;将任意分布的边界法向面力和边界法向位移进行格式化处理,由给定构造规则确定前2个特解.在特定边界条件下常量剪应力特解可不予考虑.随法向边界条件的变化有16种应力函数表达式,以处理256种矩形边界平面问题,推导了常见边界的特解表达式,分析了求解过程中的几个问题,并附有算例.

关键词：弹性力学平面问题双调和方程应力函数通解应力函数特解

Effects of flue gas desulfurization gypsum and clover planting on qualities of soil and winter jujube in coastal saline-alkali orchard of north China

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Soil Ecology Letters 2024年第1期6卷 141-152页

作者： qi Shao Xuejing Xia Guihua Li Hui Li Jitong Lin Yanhong lou Quangang Yang Hui Wang Zhongchen Yang Hong Pan Yuping Zhuge National Engineering Research Centerfor Efficient Utilization of Soil and Fertilizer Resources College of Resources and EnvironmentShandong Agricultural UniversityTai'an271018China Tai'an City Management Comprehensive Service Center Tai'an 271021China

Flue gas desulfurization gypsum and clover planting alleviated the soil salinization *** pH and total phosphorus affected the bacterial *** phosphorus affected the fungal *** gas desulfurization gypsum and clover planting improved jujube *** coastal area of Shandong Province,characterized by coastal saline tidal soil,is one of the main production areas of winter jujube in ***,the low soil fertility and poor soil structure in jujube orchard restricted the development of the jujube *** objectives of this study were to 1)evaluate the effect of application of flue gas desulfurization(FGD)gypsum and clover planting on soil quality improvement and soil microbial community structure of jujube orchard;2)investigate the effects of two measures on the nutrition and quality of winter *** results showed that FGD gypsum reduced the soil total salt content by 65.6%,and clover planting increased the soil organic matter content by 30.7%,which effectively alleviated the soil salinization stress and improved the soil *** pH and total phosphorus(TP)were the main determinants influencing bacterial community composition,and TP was the dominant factor of the fungal community composition in the saline-alkali ***,FGD gypsum addition and clover planting significantly increased the sugar degree and Vc content of winter jujube,thus improved jujube quality,and further contributed to the ecological sustainable development of winter jujube industry.

关键词： saline-alkali soils winter jujube bacterial community fungal community fue gas desulfurization gypsum clover planting

长江口深水航道治理工程袋装砂堤心成型及砂被铺设施工工艺

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水运工程 2006年第B12期 74-77页

作者：楼启为上海交通建设总承包公司上海201208

袋装砂斜坡堤堤心充灌及铺设成型施工工艺的开发,实现了袋装砂水上作业、水下充灌、水下成型铺设的目标,突破了传统的袋装砂施工工艺,成功解决了河口丰砂少石地区袋装砂堤心充灌成型的技术难题,提高了工效,降低了成本,确保了工程质量。

关键词：袋装砂堤心成型砂被铺设施工工艺研制开发

Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China

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World Journal of Gastroenterology 2008年第20期14卷 3236-3241页

作者： Bing-Liang Lin Zhi-Xin Zhao Yu-Tian Chong lian-Guo Li Xing Zuo Yu Tao Tan-qi lou Zhi-Liang Gao Department of Infectious Diseases Third Affiliated Hospital of Sun Yet-Sen University Guangzhou510060 Guangdong Province China Department of Pathology First Affiliated Hospitalof Sun Yet-Sen University Guangzhou 510060 GuangdongProvince China Department of Internal Medicines Divisionof Renal Diseases Third Affiliated Hospital of Sun Yet-SenUniversity Guangzhou 510060 Guangdong Province China

AIM: To analyze the clinical presentation of venous diethylene glycol (DEG) poisoning in patients with preexisting severe liver disease and factors that correlate with DEG poisoning. METHODS: Retrospective chart review was performed to analyze the epidemiology, clinical presentation, hepatorenal functions, hemodynamics and pathological characteristics of 64 patients with severe liver disease who received intravenous armillarisin-A, the solvent of which was DEG. Comparative analyses of correlating factors and causes for poisoning were based on the presence or absence of poisoning. RESULTS: Of the 64 patients who received armillarisin-A, 15 were found to have DEG poisoning. Twelve poisoned patients died. After a mean of 5 d, the poisoned patients displayed acute renal failure. Metabolic acidosis occurred in 13 cases. BUN, Cr, and CO2 values were significantly elevated and exacerbation of digestive tract symptoms and/or symptom was noted in 11 cases. Neurological system impairment was observed in 10 cases after 2 wk. Compared to the 49 non-poisoned patients, the poisoned patients exhibited significantly lower RBC and Hb values and higher WBC count. Renal biopsy from the poisoned patientsrevealed acute tubular necrosis and interstitial nephritis. Significant differences in preexisting severe hepatitis, ascites, renal disease, and diuretic therapy were found between groups. Prior to diethylene glycol injections, the mean values for neutral granular cells, BUN, Cr, calcium and phosphorous ions differed significantly between groups. CONCLUSION: Venous diethylene glycol poisoning is characterized by oliguric acute renal failure, metabolic acidosis, digestive symptoms, nervous system impairment, and a high probability of anemia and WBC proliferation. Mortality is high. Correlative factors include preexisting severe liver disease, renal disease, and infection.

关键词： Diethylene glycol Poisoning Liver disease Clinical feature

千瓦级双包层光纤激光器冷却方案设计理论和实验研究

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物理学报 2008年第8期57卷 4966-4971页

作者：朱洪涛楼祺洪周军漆云凤董景星魏运荣中国科学院上海光学精密机械研究所

尽管双包层光纤激光器的散热性能好于传统的固体激光器的散热性能,光纤激光器中的热沉积仍然是限制提高其输出功率的重要因素.以双端抽运的400W双包层光纤激光器为实例,定量分析了光纤内的热沉积分布.根据所建立的散热模型,为了确保千... 详细信息

尽管双包层光纤激光器的散热性能好于传统的固体激光器的散热性能,光纤激光器中的热沉积仍然是限制提高其输出功率的重要因素.以双端抽运的400W双包层光纤激光器为实例,定量分析了光纤内的热沉积分布.根据所建立的散热模型,为了确保千瓦级双包层光纤激光器安全稳定的运行,抽运端附近的对流换热系数应大于2.8×10-2W·cm-2K-1.据此设计出高功率双包层光纤激光器抽运端冷却装置并成功应用在激光系统中,获得了千瓦级的激光输出.

关键词：热沉积散热双包层光纤激光器