检索结果-南通市图书馆

World Journal of Diabetes 2024年第6期15卷 1070-1073页

作者： Xiao-Tian Lei Dan-Lan Pu geng Shan qi-Nan Wu department of Endocrinology The First Affiliated Hospital of the Third Military Medical University(Army Medical University)Chongqing 400038China department of Endocrinology Chongqing Yubei District People's HospitalChongqing 400030China department of Endocrinology Dazu Hospital of Chongqing Medical UniversityThe People's Hospital of DazuChongqing 402360China

In this editorial,we commented on the article published in the recent issue of the World Journal of *** cardiomyopathy(DCM)is characterized by myocardial fibrosis,ventricular hypertrophy and diastolic dysfunction in diabetic patients,which can cause heart failure and threaten the life of *** pathogenesis of DCM has not been fully clarified,and it may involve oxidative stress,inflammatory stimulation,apoptosis,and *** is lack of effective therapies for DCM in the clinical *** have been widely used in the clinical practice for years mainly to reduce cholesterol and stabilize arterial plaques,and exhibit definite cardiovascular protective *** have shown that statins also have anti-inflammatory and antioxidant *** were particularly concerned about the recent findings that atorvastatin alleviated myocardial fibrosis in db/db mice by regulating the antioxidant stress and antiinflammatory effects of macrophage polarization on diabetic myocardium,and thereby improving DCM.

关键词： Diabetic cardiomyopathy Statins Macrophage Oxidative stress

A　SIMPLE　ESTIMATOR　FOR　AN　EXPONENTIAL　TAIL　COEFFICIENT

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Systems Science and Mathematical Sciences 1996年第2期9卷 151-156页

作者： qi Yongcheng(department of Probability and Statistics, peking university, beijing 100871, china) 北京大学概率统计系北京

ＡＳＩＭＰＬＥＥＳＴＩＭＡＴＯＲＦＯＲＡＮＥＸＰＯＮＥＮＴＩＡＬＴＡＩＬＣＯＥＦＦＩＣＩＥＮＴＱＩＹｏｎｇｃｈｅｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＰｒｏｂａｂｉｌｉｔｙａｎｄＳｔａｔｉｓｔｉｃｓ，ＰｅｋｉｎｇＵｎｉｖｅｒ... 详细信息

ＡＳＩＭＰＬＥＥＳＴＩＭＡＴＯＲＦＯＲＡＮＥＸＰＯＮＥＮＴＩＡＬＴＡＩＬＣＯＥＦＦＩＣＩＥＮＴＱＩＹｏｎｇｃｈｅｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＰｒｏｂａｂｉｌｉｔｙａｎｄＳｔａｔｉｓｔｉｃｓ，ＰｅｋｉｎｇＵｎｉｖｅｒｓｉｔｙ，Ｂｅｉｊｉｎｇ１００８７...

关键词： Exponential tail regular variation estimator.

liMIT LAWS OF liFETIME FOR A CONSECUTIVE K-WITHIN-M-OUT-OF-N SYSTEM

在线全文

学校读者我要写书评

暂无评论

Systems Science and Mathematical Sciences 1994年第1期7卷 82-88页

作者： qi Yongcheng(department of Probobility and Statistics, peking university, beijing 100871, china)

ＬＩＭＩＴＬＡＷＳＯＦＬＩＦＥＴＩＭＥＦＯＲＡＣＯＮＳＥＣＵＴＩＶＥＫ－ＷＩＴＨＩＮ－Ｍ－ＯＵＴ－ＯＦ－ＮＳＹＳＴＥＭ￥ＱＩＹｏｎｇｃｈｅｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＰｒｏｂｏｂｉｌｉｔｙａｎｄＳｔａｔｉｓｔｉｃｓ... 详细信息

ＬＩＭＩＴＬＡＷＳＯＦＬＩＦＥＴＩＭＥＦＯＲＡＣＯＮＳＥＣＵＴＩＶＥＫ－ＷＩＴＨＩＮ－Ｍ－ＯＵＴ－ＯＦ－ＮＳＹＳＴＥＭ￥ＱＩＹｏｎｇｃｈｅｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＰｒｏｂｏｂｉｌｉｔｙａｎｄＳｔａｔｉｓｔｉｃｓ，ＰｅｋｉｎｇＵｎｉｖｅｒｓｉｔｙ...

关键词： limit types reliability consecutive k-within-m-out-of-n system.

THE WEAK LAW OF LARGE NUMBERS WHEN EXTREME TERMS ARE EXCLUDED FROM SUMS

在线全文

学校读者我要写书评

暂无评论

Systems Science and Mathematical Sciences 1996年第1期9卷 83-92页

作者： qi Yongcheng(department of Probability and Statistics, peking university,beijing 100871,china) 北京大学概率统计系北京

ＴＨＥＷＥＡＫＬＡＷＯＦＬＡＲＧＥＮＵＭＢＥＲＳＷＨＥＮＥＸＴＲＥＭＥＴＥＲＭＳＡＲＥＥＸＣＬＵＤＥＤＦＲＯＭＳＵＭＳ￥ＱＩＹｏｎｇｃｈｅｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＰｒｏｂａｂｉｌｉｔｙａｎｄＳｔａｔｉｓｔｉｃｓ... 详细信息

ＴＨＥＷＥＡＫＬＡＷＯＦＬＡＲＧＥＮＵＭＢＥＲＳＷＨＥＮＥＸＴＲＥＭＥＴＥＲＭＳＡＲＥＥＸＣＬＵＤＥＤＦＲＯＭＳＵＭＳ￥ＱＩＹｏｎｇｃｈｅｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＰｒｏｂａｂｉｌｉｔｙａｎｄＳｔａｔｉｓｔｉｃｓ，ＰｅｋｉｎｇＵｎｉｖｅｒｓｉｔｙ...

关键词： Weak law of large numbers trimmed sums order statistics.

Epigenetic modification in liver fibrosis:Promising therapeutic direction with significant challenges ahead

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1009-1029页

作者： Runping liu Yajing li qi Zheng Mingning Ding Huiping Zhou Xiaojiaoyang li School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102400China School of life Sciences Beijing University of Chinese MedicineBeijing 102400China department of Microbiology and Immunology Virginia Commonwealth UniversityRichmondVA 22460USA

liver fibrosis,characterized by scar tissue formation,can ultimately result in liver ***’s a major cause of morbidity and mortality globally,often associated with chronic liver diseases like hepatitis or alcoholic and non-alcoholic fatty liver ***,current treatment options are limited,highlighting the urgent need for the development of new *** a reversible regulatory mechanism,epigenetic modification is implicated in many biological processes,including liver *** the epigenetic mechanisms involved in liver fibrosis could provide valuable insights into developing new treatments for chronic liver diseases,although the current evidence is still *** review provides a comprehensive summary of the regulatory mechanisms and critical targets of epigenetic modifications,including DNA methylation,histone modification,and RNA modification,in liver fibrotic *** potential cooperation of different epigenetic modifications in promoting fibrogenesis was also ***,available agonists or inhibitors regulating these epigenetic mechanisms and their potential application in preventing liver fibrosis were *** summary,elucidating specific druggable epigenetic targets and developing more selective and specific candidate medicines may represent a promising approach with bright prospects for the treatment of chronic liver diseases.

关键词： liver fibrosis Epigenetics regulation DNA methylation Histone acetylation Histone methylation mRNA methylation Non-coding RNA Drug development

A NOVEL PHOTO-INITIATING SYSTEM FOR ATOM TRANSFER RADICAL POLYMERIZATION OF STYRENE

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2001年第5期19卷 441-445页

作者： Shu-hui qin Dong-qi qin Kun-yuan qiu department of Polymer Science and Engineering College of Chemistry and Molecular Engineering peking university beijing 100871, china beijing Univ Dept Polymer Sci & Engn Coll Chem & Mol Engn Beijing 100871 Peoples R China

A novel photo-induced initiating system, 2,2-dimethoxy-2-phenylacetophenone (DMPA)/ferric tri(NN-diethyldithiocarbamate) [Fe(DC)(3)], was developed and used for the atom transfer radical polymerization (ATRP) of styrene in toluene. The polymerization proceeds with DMPA as photo-initiator, Fe(DC)(3) as catalyst and DC as a reversible transfer group, while the halogen and ligands are free. Well-defined PSt was prepared and the polymerization mechanism revealed by end group analysis belongs to a reverse ATRP. Block copolymer was prepared by using thus obtained PSt as macroinitiator and Fe(DC)(2) as catalyst under UV light irradiation via a conventional ATRP process.

关键词： photo atom transfer radical polymerization living radical polymerization well-defined polystyrene block copolymer

Synthesis of Macrocycles Containing Amino Acid Ester and Aryl-heterocyclic Units

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1997年第12期8卷 0-0,0-0页

作者： Yan Tao CHEN Wen Ting HUA qi Yi XING(department of Chemistry peking university beijing 100871) peking Univ Dept Chem Beijing 100871 Peoples R China

Four kinds of new macrocycles containing amino acids and nyl-heterocyclic units were synthesized by the condensation of di-esters containing Ts-amino acids units with di-halogenated compounds at room temperature. The ... 详细信息

关键词： FAB Synthesis of Macrocycles Containing Amino Acid Ester and Aryl-heterocyclic Units

SYNTHESIS AND CHARACTERIZATION OF A NOVEL BLUE liGHT EMITTING ROD-COIL DIBLOCK OliGOMER

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2002年第5期20卷 401-407页

作者： lifang Yang Haifeng He Hongqing Cao Xinhua Wan qi-feng Zhou department of Polymer Science & Engineering College of Chemistry & Molecular Engineering peking university beijing 100871, china peking Univ Coll Chem & Mol Engn Dept Polymer Sci & Engn Beijing 100871 Peoples R China

Four new rod-coil diblock molecules, which had well-defined para-phenylene oligomers (PPP, from biphenyl to quinquephenyl) as rigid segments and poly(ethylene oxide) (PEO, M-w ca. 750) as flexible segments, were synthesized. The chemical structure and the number of repeating unit in PEO coil and PPP rod were characterized by H-1-NMR and MALDI-TOF mass spectrometry. The diblock oligomers showed good solubility in common organic solvents and aggregated in water as characterized by a blue shift in UV-vis absorption spectra, a red shift in emission spectra, quenching of the fluorescence and formation of the microfibrilla and fractal-like structures. The formation of different supramolecular structures meant that this effort might lead to commercial important highly organized functional materials.

关键词： rod-coil diblock oligomer MALDI-TOF mass spectrometry microfibrilla aggregate fractal-like pattern

Relationship between the unique microstructures and behaviors of high-entropy alloys

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1350-1363页

作者： Yaqi Wu Peter Kliaw Ruixuan li Weiran Zhang Guihong geng Xuehui Yan Guiqun liu Yong Zhang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Xi’an Rare Metal Materials Institute Co.Ltd. Xi’an 710016China School of Materials Science and Engineering North Minzu UniversityYinchuan 750030China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China

High-entropy alloys(HEAs),which were introduced as a pioneering concept in 2004,have captured the keen interest of nu-merous ***,in this context,can be perceived as representing disorder and *** contrast,elemental composi-tions within alloy systems occupy specific structural sites in space,a concept referred to as *** accordance with Shannon entropy,structure is analogous to ***,the arrangement of atoms within a material,termed its structure,plays a pivotal role in dictating its *** addition to expanding the array of options for alloy composites,HEAs afford ample opportunities for diverse structural *** profound influence of distinct structural features on the exceptional behaviors of alloys is underscored by numer-ous *** features include remarkably high fracture strength with excellent ductility,antiballistic capability,exceptional radi-ation resistance,and corrosion *** this paper,we delve into various unique material structures and properties while elucidating the intricate relationship between structure and performance.

关键词： high-entropy alloys unique microstructure special properties alloy design

Safety control strategy of spinal lamina cutting based on force and cutting depth signals

在线全文

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence Technology 2024年第4期9卷 894-902页

作者： Jian Zhang Yonghong Zhang Shanshan liu Xuquan Ji Sizhuo liu Zhuofu li Baoduo geng Weishi li Tianmiao Wang School of Mechanical Engineering and Automation Beihang UniversityBeijingChina beijing Zoezen Robot Co.Ltd. BeijingChina department of Orthopaedics Peking University Third HospitalBeijingChina Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijingChina beijing Key Laboratory of Spinal Disease Research BeijingChina School of Biological Science and Medical Engineering Beihang UniversityBeijingChina department of Biology Kenyon CollegeGambierOhioUSA

Laminectomy is one of the most common posterior spinal operations. Since the lamina is adjacent to important tissues such as nerves, once damaged, it can cause serious com-plications and even lead to paralysis. In order to prevent the above injuries and com-plications, ultrasonic bone scalpel and surgical robots have been introduced into spinal laminectomy, and many scholars have studied the recognition method of the bone tissue status. Currently, almost all methods to achieve recognition of bone tissue are based on sensor signals collected by high‐precision sensors installed at the end of surgical robots. However, the previous methods could not accurately identify the state of spinal bone tissue. Innovatively, the identification of bone tissue status was regarded as a time series classification task, and the classification algorithm LSTM‐FCN was used to process fusion signals composed of force and cutting depth signals, thus achieving an accurate classi-fication of the lamina bone tissue status. In addition, it was verified that the accuracy of the proposed method could reach 98.85% in identifying the state of porcine spinal laminectomy. And the maximum penetration distance can be controlled within 0.6 mm, which is safe and can be used in practice.

关键词： artificial neural network intelligent robots robotics surgery