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The differential effects of prostate stromal cells derived from different zones on prostate cancer epithelial cells under the action of sex hormones

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Asian Journal of Andrology 2011年第6期13卷 798-805页

作者： qi jiang bang-min han fu-jun zhao yan hong shu-jie xia Department of Urology Shanghai First People＇s Hospital Institute of Urology Shanghai Jiao Tong University Shanghai 200080 China

It is well known that prostate cancer （PCa） occurs predominantly in the peripheral zone （PZ）, whereas benign prostatic hyperplasia （BPH） typically develops in the transition zone. To identify possible mechanisms underlying zonal differences, we compared the effects of prostate stromal cells derived from the peripheral zone （PZsc） and the transition zone （TZsc） on a PCa epithelial cell line （PC3） in the presence of sex hormones. First, we observed that androgen receptor （AR） mRNA was more highly expressed in PZsc than TZsc when the cells were treated with dihydrotestosterone （DHT） and β-oestradiol （E2）（P〈0.05）. By ELISA, we looked for differences in the secretion of peptide growth factors from PZsc and TZsc. We found that keratinocyte growth factor （KGF） secretion increased with increasing concentrations of DHT （P〉0.01） and was higher in PZsc than TZsc. Under treatment with DHT plus E2, PZsc secreted more transforming growth factor-β1 （TGF-β1） than TZsc, but this pattern was reversed when the cells were treated with E2 only. With increasing concentrations of DHT, insulin-like growth factor-1 （IGF-1） secretion increased in PZsc but decreased in TZsc. To further characterize the effects of PZsc and TZsc on PC3 cells, we developed a coculture model and performed MTT assays, Western blot analysis and real-time RT-PCR. We found that PZsc promoted PC3 cell proliferation and progression better than TZsc, particularly when treated with 10 nmoll^- 1 DHT plus 10 nmoll^-1 E2. In conclusion, our data suggest that PZsc may have a greater capacity to induce PCa development and progression than TZsc via growth factors regulated by sex hormones. These findings provide possible mechanisms underlying zonal differences in prostate diseases, which may aid the search for novel therapeutic targets for PCa.

关键词： androgen growth factor oestrogen prostate cancer stromal cell

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Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cells

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Asian Journal of Andrology 2009年第1期11卷 119-126页

作者： Yue-qing Tang bang-min han Xin-Quan Yao yan hong yan Wang fu-jun zhao Sheng-qiang Yu xiao-Wen Sun shu-jie xia Department of Urology Shanghai First People＇s Hospital Institute of Urology Department of Urology Wujiang Third People＇s Hospital Suzhou 215228 China Department of Immunology Shanghai Jiao Tong University Shanghai 200025 China

Post-translational degradation of protein plays an important role in cell life. We employed chimeric molecules （dihydrotestosterone-based proteolysis-targeting chimeric molecule [DHT-PROTAC]） to facilitate androgen receptor （AR） degradation via the ubiquitin-proteasome pathway （UPP） and to investigate the role of AR in cell proliferation and viability in androgen-sensitive prostate cancer cells. Western blot analysis and immunohistochemistry were applied to analyse AR levels in LNCaP cells after DHT-PROTAC treatment. Cell counting and the 3-（4,5-dimethylthiazol-2-yl）-2,5- diphenyl tetrazolium bromide （MTT） cell viability assay were used to evaluate cell proliferation and viability after AR elimination in both LNCaP and PC-3 cells. AR was tagged for elimination via the UPP by DHT-PROTAC, and this could be blocked by proteasome inhibitors. Degradation of AR depended on DHT-PROTAC concentration, and either DHT or an ALAPYIP-（arg）8 peptide could compete with DHT-PROTAC. Inhibition of cell proliferation and decreased viability were observed in LNCaP cells, but not in PC-3 or 786-0 cells after DHT-PROTAC treatment. These data indicate that AR elimination is facilitated via the UPP by DHT-PROTAC, and that the growth of LNCaP cells is repressed after AR degradation.

关键词： androgen receptor LNCaP prostate cancer proteolysis ubiquitin

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Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-Wei yang Yong-Hao Chen Rong Liu bang-Jiao Ye jie Wen Hai-Rui Guo Zi-jie han qi-Ping Chen Zhong-Wei Wen Wei-Li Sun han Yi Xing-yan Liu Tao Ye jiang-Bo Bai qi An jie Bao Yu Bao Ping Cao Hao-Lei Chen Zhen Chen Zeng-qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing Gao xiao-Long Gao min-Hao Gu Chang-Cai han Guo-Zhu He Yong-Cheng He yang hong Yi-Wei Hu han-Xiong Huang Xi-Ru Huang Hao-Yu jiang Wei jiang Zhi-jie jiang han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li qiang Li xiao Li yang Li jie Liu shu-Bin Liu Ze Long Guang-Yuan Luan Chang-jun Ning Meng-Chen Niu Bin-Bin qi jie Ren Xi-Chao Ruan zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-Yu Tang Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang zhao-Hui Wang xiao-Guang Wu Xuan Wu Li-Kun Xie xiao-Yun yang Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang qi-Wei Zhang xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

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Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： Jing-Yu Tang qi An jiang-Bo Bai jie Bao Yu Bao Ping Cao Hao-Lei Chen qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing Gao xiao-Long Gao min-Hao Gu Chang-Cai han Zi-jie han Guo-Zhu He Yong-Cheng He yang hong Yi-Wei Hu han-Xiong Huang Xi-Ru Huang Hao-Yu jiang Wei jiang Zhi-jie jiang han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li qiang Li xiao Li yang Li jie Liu Rong Liu shu-Bin Liu Xing-yan Liu Ze Long Guang-Yuan Luan Chang-jun Ning Meng-Chen Niu Bin-Bin qi jie Ren Zhi-Zhou Ren Xi-Chao Ruan zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang zhao-Hui Wang Zhong-Wei Wen xiao-Guang Wu Xuan Wu Li-Kun Xie xiao-Yun yang Yi-Wei yang han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang qi-Wei Zhang xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-jun Zhu 无 State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications

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Measurement of the neutron total cross section of carbon at the Back-n white neutron beam of CSNS

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Nuclear Science and Techniques 2019年第9期30卷 73-82页

作者： Xing-yan Liu Yi-Wei yang Rong Liu jie Wen Zhong-Wei Wen Zi-jie han Zhi-Zhou Ren qi An Huai-Yong Bai jie Bao Ping Cao qi-Ping Chen Yong-Hao Chen Pin-Jing Cheng Zeng-qi Cui Rui-Rui Fan Chang-qing Feng min-Hao Gu Feng-qin Guo Chang-Cai han Guo-Zhu He Yong-Cheng He Yue-Feng He han-Xiong Huang Wei-Ling Huang Xi-Ru Huang xiao-Lu Ji Xu-yang Ji Hao-Yu jiang Wei jiang han-Tao Jing Ling Kang ming-Tao Kang Bo Li Lun Li qiang Li xiao Li yang Li yang Li shu-Bin Liu Guang-Yuan Luan Ying-Lin Ma Chang-jun Ning Bin-Bin qi jie Ren Xi-Chao Ruan zhao-Hui Song hong Sun xiao-yang Sun Zhi-Jia Sun Zhi-Xin Tan hong-qing Tang Jing-Yu Tang Peng-Cheng Wang qi Wang Tao-Feng Wang yan-Feng Wang zhao-Hui Wang Zheng Wang qing-Biao Wu xiao-Guang Wu Xuan Wu Li-Kun Xie han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Jing Zhang Lin-Hao Zhang Li-Ying Zhang qing-min Zhang qi-Wei Zhang xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Ying-Tan zhao Liang Zhou Zu-Ying Zhou Dan-yang Zhu Ke-jun Zhu Peng Zhu Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics State Key Laboratory of Particle Detection and Electronics Chinese Academy of Sciences(CAS) Department of Modern Physics University of Science and Technology of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University Key Laboratory of Nuclear Data China Institute of Atomic Energy Institute of High Energy Physics Chinese Academy of Sciences(CAS) Spallation Neutron Source Science Center University of South China Northwest Institute of Nuclear Technology Department of Engineering and Applied Physics University of Science and Technology of China Beihang University Xi’an Jiaotong University

To verify the performance of the neutron total cross-sectional spectrometer, the neutron total cross section of carbon is initially measured in the energy range of 1 eV to 20 MeV using the time-of-flight method. The measurement is performed at the Back-n white neutron source with a 76-m time-of-flight path using the China Spallation Neutron Source. A multilayer fast fission chamber with 235U and 238U is employed as the neutron detector. The diameter and thickness of the natural graphite sample are 70 mm and 40 mm, respectively. Signal waveforms are collected using a data acquisition system. Off-line data processing was used to obtain the neutron time-of-flight spectra and transmissions. The uncertainty of the counting statistics is generally approximately 3% for each bin in the energy range of 1–20 MeV. It is determined that the results for the neutron total cross section of carbon obtained using ^235U cells are in good agreement with the results obtained using 238U cells within limits of statistical uncertainty. Moreover, the measured total cross sections show good agreement with the broadening evaluated data.

关键词： CSNS Back-n white neutron source NTOX Neutron total cross section Carbon Multilayer fast fission chamber

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： jun Liu Dan-Dan Li Wei Dong Yu-qi Liu yang Wu Da-Xuan Tang fu-Chun Zhang Meng qiu qi Hua Jing-Yu He jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-jun jiang Bo Cui jiang-Bin Chen yang-Gan Wang Hai-Rong Wang qin Yu Jing He Yi-Lin Mao xiao-Fang Bin Yue Deng Yu-Dan Tian qing-Hua han Da-Jin Liu Li-qin Duan ming-jun zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua Li Ying xiao You-Zhi Hu xiao-Yu Huang Kun Xing Xin jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa jiang Ying yang Yao-Rong Dong Lei Zhang Guang fu Ying Li shu-Wei Huang Li-Ping Dou Lan-jun Sun Ying-qiang zhao jie Li Yun xia jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan yang Lin Ya-Bin Zhou Jian-Fei yang Guo-qing Ma Hui-jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu xiao-Jia Luo xiao-hong Bin Ya-Nan Yu Hai-xia Dang Bing Li Fei Teng Wang-min qiao xiao-Long Zhu Bing-Wei Chen qi-Guang Chen Chun-Ti Shen Yong-yan Wang Yun-Dai Chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

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不同年龄段人前列腺外周带基质细胞表型特征的研究

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中华男科学杂志 2011年第3期17卷 219-223页

作者：王永传韩邦旻王小海于胜强蒋琪赵福军洪艳夏术阶上海交通大学附属第一人民医院泌尿外科上海200080

目的:探讨体外培养的不同年龄段人前列腺外周带基质细胞的表型特征和生长特性差异,分析前列腺基质细胞微环境对老年男性前列腺癌促发的可能原因。方法:原代培养不同年龄段前列腺外周带基质细胞,利用免疫细胞化学技术分析细胞表型特征、... 详细信息

目的:探讨体外培养的不同年龄段人前列腺外周带基质细胞的表型特征和生长特性差异,分析前列腺基质细胞微环境对老年男性前列腺癌促发的可能原因。方法:原代培养不同年龄段前列腺外周带基质细胞,利用免疫细胞化学技术分析细胞表型特征、透射电镜观察细胞超微结构、琥珀酸脱氢酶法观察细胞体外增殖以及流式细胞术检测细胞凋亡情况。结果:不同年龄段前列腺基质细胞均表达成纤维细胞标记物prolyl-4-hydroxy-lase,而平滑肌肌动蛋白(α-SMA)、肌间线蛋白(desmin)的表达随年龄逐渐增加,即α-SMA的阳性表达:年轻组vs老年组=(2.56±1.81)%vs(38.89±11.22)%,(Pmin阳性表达:年轻组vs老年组=(0.89±0.93)%vs(14.89±5.97)%,(Pmin阳性细胞形态相对宽大、扁平、多形性。超微结构观察发现,前列腺基质细胞内蛋白合成有关的细胞器随着年龄的增加不断增多,主要为粗面内质网和高尔基复合体。老年组前列腺基质细胞的增殖率低于年轻组(P<0.01);而两组基质细胞凋亡率均在1%～3%之间,组间差异无统计学意义。结论:前列腺外周带基质细胞中具有活性的肌成纤维细胞随年龄不断增加可能是老年男性前列腺癌高发和恶性进展的原因之一。

关键词：前列腺外周带基质细胞表型年龄

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng zhao Gang zhao Li-Cai Deng xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu yan Cai shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning fu Peng Gao Xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua jiang xiang jiang Zhi-Bo jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li qi Li shuang Li Sha-Sha Li Xin-Nan Li yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-jun Ni zhao-xiang qi Yong-jun qi Shi-Yin Shen Huo-ming Shi Jing Song Yi-han Song Ding-qiang Su hong-jun Su Zheng-hong Tang qing-Sheng Tao Yuan Tian Dan Wang Da-qi Wang Feng-Fei Wang Guo-min Wang Hai Wang hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang jun-xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang shu-qing Wang xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei ming-Zhi Wei hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu xiao-Zheng Xing Ling-Zhe Xu Xin-qi Xu yan Xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-qin yang ming yang Zheng-qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang yan-xia Zhang Zheng-Chao Zhang ming zhao Fang Zhou Xu Zhou jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma(2022 version)

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Journal of Clinical and Translational Hepatology 2023年第7期11卷 1553-1564页

作者： han Wang jun Chen Xin Zhang xia Sheng xiao-yan Chang jie Chen min-Shan Chen Hui Dong Guang-jie Duan He-Ping Hu Zhi-Yong Huang Wei-Dong Jia xiao-qing jiang Dong Kuang Shan-Shan Li Zeng-Shan Li Chang-Li Lu shu-Kui qin Xue-Shan qiu Li-Juan Qu Chun-Kui Shao Feng Shen Guo-ming Shi Su-Sheng Shi Yu-jun Shi Hui-Chuan Sun xiao-Dong Teng Bin Wang Zhan-Bo Wang Tian-fu Wen Jia-Mei yang qiao-qiao yang Sheng-Long Ye hong-Fang Yin Zhen-Gang Yuan Jing-Ping Yun Feng-Lin Zang hong-qi Zhang Li-hong Zhang Jing-min zhao Jian Zhou Wei-Xun Zhou Jia Fan xiao-Ping Chen Wan Yee Lau Yuan Ji Wen-ming Cong Chinese Society of Liver Cancer of Chinese Anti-Cancer Association Digestive Disease Group of Chinese Society of Pathology,Chinese Medical Association Chinese Society of Pathology of Chinese Anti-Cancer Association Hepatic Surgery Group of Chinese Society of Surgery,Chinese Medical Association Biliary Tract Tumor Committee of China Anti-Cancer Association Chinese Society of Clinical Oncology IDepartment of Pathology Eastern Hepatobilary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology the Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsuChina Department of Pathology Zhongshan HospitalFudan UniversityShanghaiChina Department of Pathology Minhang HospitalFudan Uni-versityShanghaiChina Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sci-ences and Peking Union Medical CollegeBeijingChina Department of Liver Surgery Sun Yat-Sen University Cancer CenterGuangzhouGuangdongChina Department of Pathology The First Affiliated HospitalArmy Medical UniversityChongqingChina Department of Hepatobiliary Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghaiChina Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWu-hanHubeiChina Department of General Surgery The First Affliated Hospital of USTCDivision of Life Science and Medi-cineUniversity of Science and Technology of ChinaHefeiAnhuiChina Department of Biliary Surgery I Eastern Hepatobil-iary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Pathology The First Afiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenanChina Department of Pathology Xijing Hospi-talAir Force Medical UniversityXi'anShaanxiChina Department of Pathology West China HospitalSichuan UniversityChengduSichuanChina Cancer Center of Jinling Hospital Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Pathology The First Affiliated HospitalChina Medical UniversityShenyangLiaoningChina Department of Pathology The 900 Hospital of the Chinese People's Liberation Army Joint Logistics TeamFuzhouFujianChina Department of Pathology The Third Affiliated HospitalSun Yat-Sen UniversityGuangz

Intrahepatic cholangiocarcinoma(iCCA)can originate from the large bile duct group(segment bile ducts and area bile ducts),small bile duct group(septal bile ducts and interlobular bile ducts),and terminal bile duct group(bile ductules and canals of Hering)of the intrahepatic biliary tree,which can be histopathological corresponding to large duct type iCCA,small duct type iCCA and iCCA with ductal plate malformation pattern,and cholangiolocarcinoma,*** challenge in pathological diagnosis of above subtypes of iCCA falls in the distinction of cellular morphologies,tissue structures,growth patterns,invasive behaviors,immunophenotypes,molecular mutations,and surgical *** these reasons,this expert consensus provides nine recommendations as a reference for standardizing and refining the diagnosis of pathological subtypes of iCCA,mainly based on the 5th edition of the World Health Organization Classification of Tumours of the Digestive System.

关键词： Intrahepatic cholangiocarcinoma Pathology Histological type Immunohistochemistry Molecular variation

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

引用

Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu Yue Huang Guang-Cheng xiao qing-Cui Bu Jin-Lu Qu shu Zhang shuang-Nan Zhang shu-Mei Jia Fang-jun Lu xiang Ma Lian Tao Wei Zhang Li Chen Li-ming Song Ti-Pei Li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan Liu Ce Cai Zhi Chang Gang Chen Tian-xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du min-Xue fu Guan-Hua Gao He Gao min Gao ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei han Jia Huo Lu-Hua jiang Wei-Chun jiang Jing Jin Yong-jie Jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-shun Li Wei Li xian Li xiao-Bo Li Xu-Fang Li yang-Guo Li Zheng-Wei Li xiao-Hua Liang Jing-Yuan Liao Bai-Sheng Liu Guo-qing Liu hong-Wei Liu xiao-Jing Liu Yi-Nong Liu Bo Lu Xue-Feng Lu qi Luo Tao Luo Bin Meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song Liang Sun Ying Tan You-Li Tuo Chen Wang Guo-Feng Wang Juan Wang Ling-jun Wang Weng-shuai Wang Yu-Sa Wang xiang-yang Wen Bai-yang Wu Bo-Bing Wu Mei Wu shuo xiao Shao-Lin Xiong He Xu Jia-Wei yang Sheng yang yan-Ji yang Yi-jung yang qi-Bin Yi qian-qing Yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-zhao Zhang Yi Zhang Yi-Fei Zhang Yong-jie Zhang Yuan-hang Zhang Yue Zhang zhao Zhang Zhi Zhang Zi-Liang Zhang Hai-Sheng zhao xiao-Fan zhao Shi-jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou Yu-Xuan Zhu Ren-Lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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