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生物安全型手套箱式隔离器的研制

暖通空调 2019年第6期49卷 135-140页

作者：张宗兴祁建城吴金辉衣颖张恩雷张金明军事科学院卫勤保障技术研究所国家生物防护装备工程技术研究中心天津市河东区军事科学院卫勤保障技术研究所 300161

依据相关标准对高等级隔离操作设备的要求,综合考虑气密传递和消毒功能的实际需求,对手套箱式隔离器的结构进行设计并对工艺技术进行了攻关。手套箱式隔离器综合集成通风过滤系统、物品传递系统、自控系统与消毒连接系统,经过第三方检测... 详细信息

依据相关标准对高等级隔离操作设备的要求,综合考虑气密传递和消毒功能的实际需求,对手套箱式隔离器的结构进行设计并对工艺技术进行了攻关。手套箱式隔离器综合集成通风过滤系统、物品传递系统、自控系统与消毒连接系统,经过第三方检测,其技术指标达到了国家标准要求。该手套箱式隔离器适用于对高致病性病原微生物进行隔离操作,可满足我国生物安全实验室开展相关研究的现实需求。

关键词：生物安全手套箱负压隔离器气密传递消毒

Catalytic Hydrogenation of Acetic Acid to Acetaldehyde: Synergistic Effect of Bifunctional Co/Ce-Fe Oxide Solid Solution Catalysts

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Chinese Journal of Chemistry 2019年第7期37卷 709-719页

作者： Naixu Li qi Zhang Rehana Bibi Quanhao Shen Richard Ngulube Yunyi Liu jiancheng Zhou School of Chemistry and Chemical Engineering Southeast University Nanjing Jiangsu 211189 China Jiangsu Key Laboratory for Biomass Energy and Material Nanjing Jiangsu 210042 China Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research Southeast University Nanjing Jiangsu 211189 China

The large-scale industrial production of acetic acid (HAc) from carbonylation of methanol has enabled intense research interest from direct hydrogenation of HAc to acetaldehyde (AA).Herein,a series of cerium-iron oxide solid solution supported metallic cobalt catalysts were prepared by modified sol-gel method and were applied in gas-phase hydrogenation of HAc to AA.A synergistic effect between the hydrogenation metal cobalt and Ce-Fe oxide solid solution is ***,oxygen vacancies provide the active sites for adsorption of HAc,while highly uniformly dispersed metallic Co adsorbs H2 and activates the reduction of HAc into ***,the metallic Co can also assist the cyclical conversion between Fe3+/Fe2+ and Ce3+/Ce4+ on the surface of ***2-δ *** unique effect substantially enhances the ability of the support material to rapidly capture oxygen atoms from *** is found that the catalyst of 5% Co/Ce0.8Fe0.2O2-δ with the highest concentration of oxygen vacancy presents the best catalytic performance (*** yield reaches 49.9%) under the optimal reaction conditions (i.e.623 K and H2 flow rate =10 mL/min).This work indicates that the Co/Ce-Fe oxide solid solution catalyst can be potentially used for the selective hydrogenation from HAc to *** synergy between the metallic Co and Ce1-xFexO2-δ revealed can be extended to the design of other composite catalysts.

关键词： Acetic Acid Acetaldehyde Oxide Solid Solution Catalysts

Spatial structure of turbulent mixing of an anticyclonic mesoscale eddy in the northern South China Sea

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Acta Oceanologica Sinica 2020年第11期39卷 69-81页

作者： Yongfeng qi Chenjing Shang Huabin Mao Chunhua qiu Changrong Liang Linghui Yu jiancheng Yu Xiaodong Shang State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Shenzhen Key Laboratory of Marine Bioresources and Eco-environmental Science College of Life Science and OceanographyShenzhen UniversityShenzhen 518060China Ocean College Zhejiang UniversityZhoushan 316021China The Center for Coastal Ocean Science and Technology School of Marine SciencesSun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China

Upper turbulent mixing in the interior and surrounding areas of an anticyclonic eddy in the northern South China Sea(SCS)was estimated from underwater glider data(May 2015)in the present study,using the Gregg-HenyeyPolzin parameterization and the Thorpe-scale *** observations revealed a clear asymmetrical spatial pattern of turbulent mixing in the anticyclonic eddy *** diffusivity(in the order of 10–3 m2/s)was found at the posterior edge of the anticyclonic mesoscale eddy;on the anterior side,diffusivity was one order of magnitude lower on *** asymmetrical pattern was highly correlated with the eddy kinetic *** shear variance on the posterior side,which is conducive to the triggering of shear instability,may be the main mechanism for the elevated *** addition,the generation and growth of sub-mesoscale motions that are fed by mesoscale eddies on their posterior side may also promote the occurrence of strong mixing in the studied *** results of this study help improve our knowledge regarding turbulent mixing in the northern SCS.

关键词： mesoscale eddy turbulent mixing South China Sea GHP parameterization Thorpe-scale method

Identification of inhibitor of apoptosis specific DNase in Xenopus egg extract

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Chinese Science Bulletin 2001年第17期46卷 1449-1453页

作者： Zhigang Lu Wei Yang qi Cao Wei Tao jiancheng Hu Zhonghe Zhai Beijing Univ Coll Life Sci Beijing 100871 Peoples R China

When added with cytochrome c, Xenopus laevis egg extract XS-150 can induce exogenous nuclei undergoing apoptosis. Apoptosis specific DNase XAD was activated during this process, and cut chromatin between nucleosome, leading to DNA Ladder in electrophoresis. Our results showed that an inhibitor of XAD, IXAD, exists abundantly in normal egg extract, its molecular weight is about 40 ku. Normally, IXAD exists either in the form of dimmer or in complex with XAD. It was degraded during apoptosis, releasing active XAD. The results of Western assay and cross-inhibition showed that IXAD was likely homologous to DFF45 in structure and function. At the same time, these results also indicated that the pathway in apoptosis was conserved in evolution.

关键词： Xenopus laevis apoptosis IXAD XAD DNA Ladder cytochrome c cell-free system.

Review of the characteristics and graded utilisation of coal gasification slag

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Chinese Journal of Chemical Engineering 2021年第7期34卷 92-106页

作者： Xiaodong Liu Zhengwei Jin Yunhuan Jing Panpan Fan Zhili qi Weiren Bao jiancheng Wang Xiaohui Yan Peng Lv Lianping Dong State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan 030024China Institute of Coal Chemical Industry Technology National Energy Group Ningxia Coal Industry Co.Ltd.Yinchuan 750411China China Energy Investment Group Co. Ltd.Beijing 100011China State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan 750021China College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China

The characteristics of the energy structure of rich coal,less oil and less gas,coupling with a high external dependence on oil and natural gas and the emphasis on the efficient and clean utilisation of coal,have brought opportunities for coal chemical ***,with the large-scale popularisation of coal gasification technology,the production and resulting storage of coal gasification slag continue to increase,which not only result in serious environmental pollution and a waste of terrestrial resources,but also seriously affect the sustainable development of coal chemical ***,the treatment of coal gasification slag is extremely *** this paper,the production,composition,morphology,particle size structure and water holding characteristics of coal gasification slag are introduced,and the methods of carbon ash separation of gasification slag,both domestically and abroad,are *** addition,the paper also summarises the research progress on gasification slag in building materials,ecological restoration,residual carbon utilisation and other high-value utilisation,and ultimately puts forward the idea of the comprehensive utilisation of gasification *** large-scale consumption to solve the environmental problems of enterprises and achieve high-value utilisation to increase the economic benefits of enterprises,it is urgent to zealously design a reasonable and comprehensive utilisation technologies with simple operational processes,strong adaptability and economic benefits.

关键词： Coal gasification slag Morphological characteristics Dehydration Separation Comprehensive utilisation

A Prognostic Model to Predict Recovery of COVID-19 Patients Based on Longitudinal Laboratory Findings

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Virologica Sinica 2020年第6期35卷 811-819页

作者： Suyan Tian Xuetong Zhu Xuejuan Sun Jinmei Wang qi Zhou Chi Wang Li Chen Shanji Li jiancheng Xu Division of Clinical Research First Hospital of Jilin UniversityChangchun 130021China Department of Laboratory Medicine First Hospital of Jilin UniversityChangchun 130021China Department of Laboratory Medicine Changchun Infectious Disease HospitalChangchun 130123China Department of Laboratory Medicine Siping Infectious Disease HospitalSiping 136099China Department of Pediatrics First Hospital of Jilin UniversityChangchun 130021China Department of Internal Medicine College of MedicineUniversity of KentuckyLexingtonKY 40536USA Department of Laboratory Medicine Jilin Infectious Disease HospitalJilin 132011China

The temporal change patterns of laboratory data may provide insightful clues into the whole course of *** study aimed to evaluate longitudinal change patterns of key laboratory tests in patients with COVID-19,and identify independent prognostic factors by examining the associations between laboratory findings and outcomes of *** multicenter study included 56 patients with COVID-19 treated in Jilin Province,China,from January 21,2020 to March 5,*** laboratoryfindings,epidemiological characteristics and demographic data were extracted from electronic medical *** average value of eosinophils and carbon dioxide combining power continued to significantly increase,while the average value of cardiac troponin I and mean platelet volume decreased throughout the course of the *** average value of lymphocytes approached the lower limit of the reference interval for the first 5 days and then rose slowly *** average value of thrombocytocrit peaked on day 7 and slowly declined *** average value of mean corpuscular volume and serum sodium showed an upward trend from day 8 and day 15,***,sex,lactate dehydrogenase,platelet count and globulin level were included in the final model to predict the probability of *** above parameters were verified in 24 patients with COVID-19 in another area of Jilin *** risk stratification and management of patients with COVID-19 could be improved according to the temporal trajectories of laboratory tests.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Platelet count Lactate dehydrogenase Globulin

关于ABSL-3实验室分类、设计要求的分析、探讨

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洁净与空调技术 2007年第4期 15-21,28页

作者：祁建城李艳菊吕京吴东来王宏伟田克恭鹿建春国家生物防护装备工程技术研究中心中国合格评定国家认可委员会中国农业科学院哈尔滨兽医研究所中国动物疫病预防控制中心军事医学科学院微生物流行病研究所

结合国家标准GB19489-2004《实验室生物安全通用要求》的修订工作,参考了相关国外实验室生物安全指南和动物生物安全实验室的建设经验,在对ABSL-3实验室的危害评估及平面布局、围护结构、气流组织、压力梯度、高效空气过滤单元、过滤器... 详细信息

结合国家标准GB19489-2004《实验室生物安全通用要求》的修订工作,参考了相关国外实验室生物安全指南和动物生物安全实验室的建设经验,在对ABSL-3实验室的危害评估及平面布局、围护结构、气流组织、压力梯度、高效空气过滤单元、过滤器检漏、室外风口的布置、自动控制与报警系统等进行综合分析的基础上,提出了我国ABSL-3实验室分类和设计要求的建议,以期为标准GB19489-2004的修订和我国ABSL-3实验室的建设提供参考。

关键词： ABSL-3实验室分类设计要求

新冠肺炎疫情下生物安全尸检和病理平台的应急创建与应用

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中华医学科研管理杂志 2021年第2期34卷 100-105页

作者：赵鹏南姚小红张宗兴祁建成黄学全何志承陈萍韩黎徐迪雄张思兵卞修武张宏雁陆军军医大学第一附属医院重庆400038 军事科学院工程研究院卫勤保障技术研究所北京100000 陆军特色医学中心重庆400042 解放军疾控中心北京100000 解放军总医院北京100000 空军军医大学西安710000

目的通过火神山医院生物安全尸检病理平台的创建与应用,分析生物安全尸检病理平台的可行性和运用效果.方法通过设计布局、筹措仪器设备、检验检测方法和效果评估等方法来分析生物安全尸检病理平台的可行性和运用效果.结果生物安全尸检... 详细信息

目的通过火神山医院生物安全尸检病理平台的创建与应用,分析生物安全尸检病理平台的可行性和运用效果.方法通过设计布局、筹措仪器设备、检验检测方法和效果评估等方法来分析生物安全尸检病理平台的可行性和运用效果.结果生物安全尸检病理平台共完成26例系统尸检和微创尸检(穿刺)8例,无一人感染.病理原创性发现包括新型冠状病毒肺炎与SARS病理特征的鉴别、呼吸衰竭机制的新认识与救治意义、新型冠状病毒的全身分布与播散机制、“炎症风暴”的病理基础、某些肿瘤标志物升高的细胞来源以及转阴患者肺部病理与纤维化特点等,对新型冠状病毒肺炎的临床诊治起到了重要指导作用.结论尸检病理研究对于新发传染病疫情的防控具有重要意义,需要及早介入.推进生物安全尸检平台规范建设是新突发传染病病理学研究的关键.病理研究需和临床诊治互促结合,才能发挥两者的最大作用.

关键词：生物安全尸检病理平台

生物安全实验室通风系统HEPA过滤器原位消毒及检漏方案

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暖通空调 2011年第5期41卷 79-84页

作者：吕京王荣祁建城钱军张宗兴曲凤宏李文京田克恭冯昕张益昭吴东来关云涛中国合格评定国家认可中心军事医学科学院北京国际医药促进会中国动物疫病预防控制中心中国建筑科学研究院中国农业科学研究院哈尔滨兽医研究所

结合我国高等级生物安全实验室建设的现状及相关标准要求,介绍了HEPA过滤器扫描检漏法、效率检漏法及气体消毒法,探讨了室外箱式HEPA过滤器单元、室内HEPA过滤器单元及风口型HEPA过滤器单元的原位消毒及检漏技术方案。

关键词：生物安全实验室 HEPA过滤器原位消毒原位检漏