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Evaluation of 3D crustal seismic velocity models in southwest China:Model performance,limitation,and prospects

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Science China Earth Sciences 2024年第2期67卷 604-619页

作者： Xin WANG Ling CHEN qi-fu CHEN Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China

Southwest China is a tectonically and seismically active region,witnessing strong deformation due to the collision between the Indian and Eurasian *** the subsurface velocity structure of this region is thus important in understanding the tectonics and geodynamic processes of continental collision and in mitigating seismic *** studies have provided various 3D seismic velocity models in southwest ***,discrepancies exist among these models,and less effort has been made to quantify the reliability and accuracy of these existing velocity *** this study,we use regional 3D waveform simulation to evaluate the performance of various regional crustal 3D velocity models in reproducing observed *** particularly focus on two recent earthquake sequence in the region,the 2021 Yunnan Yangbi MS_(6.4) earthquake sequence and the 2022 Sichuan Luding MS_(6.8) earthquake *** tested 3D velocity models include the Southwest China Community Velocity model V1.0,the Unified Seismic Tomography Models for Continental China Lithosphere V2.0,the adjoint full waveform tomography model of the crustal and upper mantle beneath Eastern Tibetan Plateau,and the shallow seismic structure model beneath continental *** results show that the tested 3D velocity models generally capture well long-period(full-waveform tomography model shows a slighter better performance than the other models,especially for the body-waves,highlighting the advantages

关键词： Southwest China Seismic tomography models Shallow Structures Waveform simulation Model evaluation

Differences and identification on multi-time hydrocarbon generation of carboniferous-permian coaly source rocks in the Huanghua Depression,Bohai Bay Basin

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Petroleum Science 2024年第2期21卷 765-776页

作者： Jin-Jun Xu Xian-Gang Cheng Shu-Nan Peng Jun-Cai Jiang qi-Long Wu Da Lou fu-qi Cheng La-Mei Lin National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina PetroChina Dagang Oilfield Company Tianjin300280China

Coal is a solid combustible mineral,and coal-bearing strata have important hydrocarbon generation potential and contribute to more than 12%of the global hydrocarbon ***,the deposition and hydrocarbon evolution process of ancient coal-bearing strata is characterized by multiple geological times,leading to obvious distinctions in their hydrocarbon generation potential,geological processes,and production,which affect the evaluation and exploration of hydrocarbon resources derived from coaly source rocks *** study aimed to identify the differences on oil-generated parent macerals and the production of oil generated from different coaly source rocks and through different oil generation *** with the analysis of previous tectonic burial history and hydrocarbon generation history,high-temperature and high-pressure thermal simulation experiments,organic geochemistry,and organic petrology were performed on the Carboniferous-Permian(C-P)coaly source rocks in the Huanghua Depression,Bohai Bay *** oil-generated parent macerals of coal's secondary oil generation process(SOGP)were mainly hydrogen-rich collotelinite,collodetrinite,sporinite,and cutinite,while the oil-generated parent macerals of tertiary oil generation process(TOGP)were the remaining small amount of hydrogen-rich collotelinite,sporinite,and cutinite,as well as dispersed soluble organic matter and unexhausted residual *** with coal,the oil-generated parent macerals of coaly shale SOGP were mostly sporinite and *** part of hydrogen-poor vitrinite,lacking hydrocarbon-rich macerals,and macerals of the TOGP,in addition to some remaining cutinite and a small amount of crude oil and bitumen from SOGP contributed to the oil *** results indicated that the changes in oil yield had a good junction between SOGP and TOGP,both coal and coaly shale had higher SOGP aborted oil yield than TOGP starting yield,and coaly shale TOGP peak oil yield was low

关键词： Thermal simulation Multi-time oil generation processes Coaly source rock Carboniferous-permian Huanghua Depression

Magnetic properties and magnetocaloric effects in Eu(Ti,Nb,Mn)O_(3) perovskites

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Journal of Rare Earths 2024年第8期42卷 1560-1567,I0006页

作者： Junfeng Wang Huicai Xie Quanyi Liu Zhihong Hao Zhaojun Mo qi fu Xinqiang Gao Jun Shen Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou341000China School of Rare Earth and New Materials Engineering Gannan University of Science and TechnologyGanzhou341000China Department of Energy and Power Engineering School of Mechanical EngineeringBeijing Institute of TechnologyBeijing100081China

In perovskite EuTiO_(3),the magnetic characteristics and magnetocaloric effect(MCE) can be flexibly regulated by converting the magnetism from antiferromagnetic to *** the present work,a series of Eu(Ti,Nb,Mn)O_(3) compounds,abbreviated as ETNMO for convenience of description,was fabricated and their crystallography,magnetism together with cryogenic magnetocaloric effects were systematically *** crystallographic results demonstrate the cubic perovskite structure for all the compounds,with the space group of *** magnetic phase transitions are observed in these second-order phase transition(SOPT) *** joint substitution of elements Mn and Nb can considerably manipulate the magnetic phase transition process and magnetocaloric performance of the ETNMO *** the Mn content increases,gradually widened-ΔS_(M)-T curves are obtained,and two peaks with a broad shoulder are observed in the-ΔS_(M)-T curves for Δμ_(0)H≤0-1 *** a field change of 0-5 T,the values of maximum magnetic entropy change(-ΔS_(M)^(max)) and refrigeration capacity(RC) are evaluated to be 34.7 J/(kg·K) and 364.9 J/kg for EuTi_(0.8625)Nb_(0.0625)Mn_(0.075)O_(3), 27.8 J/(kg·K) and367.6 J/kg for EuTi_(0.8375)Nb_(0.0625)Mn_(0.1)O_(3),23.2 J/(kg·K) and 369.2 J/kg for EuTi_(0.8125)Nb_(0.0625)Mn_(0.125)O_(3),17.1 J/(kg·K) and 357.6 J/kg for EuTi_(0.7875)Nb_(0.0625)Mn_(0.15)O_(3),*** co nsiderable MCE parameters make the ETNMO compounds potential candidates for cryogenic magnetic refrigeration.

关键词： ETNMO perovskites Cryogenic refrigeration Magnetic phase transition Magnetocaloric effect Rare earths

Delay-optimal multi-satellite collaborative computation offloading supported by OISL in LEO satellite network

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Journal of Systems Engineering and Electronics 2024年第4期35卷 805-814页

作者： ZHANG Tingting GUO Zijian LI Bin FENG Yuan fu qi HU Mingyu QU Yunbo School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy Beijing Institute of TechnologyJiaxing 314000China School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China China Research and Development Academy of Machinery Equipment Beijing 100089China

By deploying the ubiquitous and reliable coverage of low Earth orbit(LEO)satellite networks using optical inter satel-lite link(OISL),computation offloading services can be provided for any users without proximal servers,while the resource limita-tion of both computation and storage on satellites is the impor-tant factor affecting the maximum task completion *** this paper,we study a delay-optimal multi-satellite collaborative computation offloading scheme that allows satellites to actively migrate tasks among themselves by employing the high-speed OISLs,such that tasks with long queuing delay will be served as quickly as possible by utilizing idle computation resources in the *** satisfy the delay requirement of delay-sensi-tive task,we first propose a deadline-aware task scheduling scheme in which a priority model is constructed to sort the order of tasks being served based on its deadline,and then a delay-optimal collaborative offloading scheme is derived such that the tasks which cannot be completed locally can be migrated to other idle *** results demonstrate the effective-ness of our multi-satellite collaborative computation offloading strategy in reducing task complement time and improving resource utilization of the LEO satellite network.

关键词： low Earth orbit(LEO)satellite network computation offloading task migration resource allocation

A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 295-299页

作者： qi fu Zhongming Lian Mengya Niu Yaru Huang Yanqiu Ai Long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan Tian Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475004China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and *** concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are *** this study,we construct a near-infrared light-activated nano-therapeutic system to meet this *** detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs *** designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone ***,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone ***,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

关键词： Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter Sorafenib Photodynamic therapy

Reconstruction of aether scalar tensor theory for variouscosmological scenarios

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Chinese Physics C 2024年第4期48卷 202-208页

作者：付启铭何梦慈眭陶陶张鑫 Institute of Physics Shaanxi University of TechnologyHanzhong 723000China College of Physics Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

In this paper,we present several explicit reconstructions for the aether scalar tensor(AeST)theory derived from the background of the Friedmann-Lemaître-Robertson-Walker cosmological *** is shown that the Einstein-Hilbert Lagrangian with a positive cosmological constant is the only Lagrangian capable of accurately replicating the exact expansion history of theΛcold dark matter(ΛCDM)universe filled solely with dust-like ***,theΛCDM-era can be produced within the framework of the AeST theory for some other fluids,including a perfect fluid with p=−(1/3)ρ,multifluids,and nonisentropic perfect ***,we demonstrate that theΛCDM-era can be replicated with no real matter field for the AeST *** cosmic evolution resulting from both the power-law and de-Sitter solutions can also be obtained.

关键词： reconstruction modified gravity cosmology

Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation

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Science China(Life Sciences) 2024年第3期67卷 504-517页

作者： qi fu Yu qian Hemin Jiang Yunqiang He Hao Dai Yang Chen Zhiqing Xia Yucheng Liang Yuncai Zhou Rui Gao Shuai Zheng Hui Lv Min Sun Kuanfeng Xu Tao Yang Department of Endocrinology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

During the pathogenesis of type 1 diabetes(T1D) and type 2 diabetes(T2D), pancreatic islets, especially the β cells, face significant challenges. These insulin-producing cells adopt a regeneration strategy to compensate for the shortage of insulin, but the exact mechanism needs to be defined. High-fat diet(HFD) and streptozotocin(STZ) treatment are well-established models to study islet damage in T2D and T1D respectively. Therefore, we applied these two diabetic mouse models, triggered at different ages, to pursue the cell fate transition of isletβ cells. Cre-LoxP systems were used to generate islet cell type-specific(α, β, or δ) green fluorescent protein(GFP)-labeled mice for genetic lineage tracing, thereinto β-cell GFP-labeled mice were tamoxifen induced. Single-cell RNA sequencing(scRNA-seq) was used to investigate the evolutionary trajectories and molecular mechanisms of the GFP-labeled β cells in STZ-treated mice. STZ-induced diabetes caused extensive dedifferentiation of β cells and some of which transdifferentiated into α or δ cells in both youth-and adulthood-initiated mice while this phenomenon was barely observed in HFD models. β cells in HFD mice were expanded via self-replication rather than via transdifferentiation from α or δ cells, in contrast, α or δ cells were induced to transdifferentiate into β cells in STZ-treated mice(both youthand adulthood-initiated). In addition to the re-dedifferentiation of β cells, it is also highly likely that these “α or δ” cells transdifferentiated from pre-existing β cells could also re-trans-differentiate into insulin-producing β cells and be beneficial to islet recovery. The analysis of ScRNA-seq revealed that several pathways including mitochondrial function, chromatin modification, and remodeling are crucial in the dynamic transition of β cells. Our findings shed light on how islet β cells overcome the deficit of insulin and the molecular mechanism of islet recovery in T1D and T2D pathogenesis.

关键词： islet regeneration lineage tracing high fat diet(HFD) streptozotocin(STZ)

Guicao Baidu decoction in mitigating chemotherapy-induced myocardial injury:case report and mechanism investigation

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Natural Therapy Advances 2024年第3期7卷 29-36页

作者： Jia-qi fu Run-Jie Sun Man-Ya Yu Mu-Yun Wu Xing Cui The First School of Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250014China Center of Oncology and Hematology The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250001China

To observe the effects of GuiCaoBaiDu Decoction(GCBD)on chemotherapy especially doxorubicin(DOX)-induced myocardial cardiotoxicity(DIC)and explore the *** present study presents a case demonstrating the preventive and therapeutic effects of GCBD on myocardial injury following *** network pharmacology was employed to predict the targets of ***,a DOX-induced apoptosis model of H9C2 cardiomyocytes was established and co-cultured with serum containing GCBD *** viability and myocardial enzyme levels were evaluated using CCK8 assay and ELISA assay,TUNEL was using for apoptosis *** GCBD effect was confirmed by tests of ROS andα-actinin levels,evaluation of mitochondrial morphology,and BAX co-localization with ***,the expression levels of apoptosis-related molecules were determined via Western ***,a mouse model exhibiting DOX-induced cardiac functional impairment was generated and subsequently treated with *** enzyme level was tested at first,then echocardiography was tested,myocardial apoptosis in mice was observed through HE staining while related proteins were detected using *** pharmacological analyses revealed that GCBD exerts its effects on BAX,Caspase7,and other related ***,we demonstrated the effective amelioration of DIC in cardiomyocyte viability,LDH/CK levels,α-actinin and ROS levels,and apoptosis by GCBD through improvements in TUNEL test,mitochondrial morphology and *** efficacy of GCBD in enhancing cardiac function in DIC mice has been validated through animal *** together,our study showed that GCBD could significantly alleviate DOX induced myocardial injury by regulating mitochondrial *** utilization of GCBD can effectively contribute to the prevention and treatment of chemotherapy-induced myocardial injury when anthracycline chemotherapy is employed in clinical practice.

关键词： Guicao Baidu decoction chemotherapy-induced myocardial injury case report angiogenesis

技能习得模型与运动意向性——兼论德雷福斯与塞尔、麦克道尔的争论

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科学技术哲学研究 2024年第3期41卷 13-20页

作者：程瑞伏其秦山西大学科学技术哲学研究中心太原030006

德雷福斯通过批判笛卡尔主义式的人类智能解释传统模型,提出了基于熟练应对的技能习得模型。这一模型包括技能水平的五个发展阶段与熟练应对的三种层次。德雷福斯在技能习得模型中揭示出不同于传统预设的表征意向性的运动意向性,以及不... 详细信息

德雷福斯通过批判笛卡尔主义式的人类智能解释传统模型,提出了基于熟练应对的技能习得模型。这一模型包括技能水平的五个发展阶段与熟练应对的三种层次。德雷福斯在技能习得模型中揭示出不同于传统预设的表征意向性的运动意向性,以及不同于意向行动的专注应对行为,并在与塞尔、麦克道尔的争论中逐步阐释了它们的关系:人与动物共享的运动意向性与专注应对行为,始终作为表征意向性和意向行动的背景基础,在此基础上深思熟虑的意向行动对专注应对行为的撤离,是我们学习新技能或达到更高层次技能水平的必要手段。这种观点需要一种不同于笛卡尔的心灵表征、个体主义的更为丰富的存在论,并更普遍地回应技术哲学领域的困境。

关键词：德雷福斯熟练应对技能习得模型表征意向性运动意向性