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Distribution of Traditional Chinese Medicine syndromes in diabetic kidney disease chronic kidney disease 1-5: a correlation study

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Journal of Traditional Chinese Medicine 2024年第3期44卷 572-580页

作者： LI Shuang DUAN Shuwei DONG Zheyi QU Yilun LUO Yayong KE Jianghua WANG conghui PENG Yangzhi ZHOU Xuefeng CHEN Xiangmei Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People's Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease Research School of Clinical Medicine Guangdong Pharmaceutical University Basic Medical College Chengdu University of Traditional Chinese Medicine

OBJECTIVE: To analyze the distribution of Traditional Chinese medicine(TCM) syndromes in patients with diabetic kidney disease(DKD) and its related factors.METHODS: We enrolled 435 patients with DKD, who were not undergoing dialysis, admitted to the Department of Nephrology, First Medical Center, Chinese PLA General Hospital from April 2020 to August 2021.Analysis of their TCM syndromes and related factors was carried out.RESULTS: The 435 patients included 109, 117, 86, and 123 chronic kidney disease(CKD) 1-2, CKD3, CKD4, and CKD5 cases, respectively. With the progression of CKD1-5, the proportion of Yin deficiency and dry heat syndrome,and that of qi and Yin deficiency syndrome showed a downward trend, whereas the proportion of spleen-kidney Yang deficiency, blood deficiency, blood stasis, water stagnation, and phlegm turbidity syndromes showed an upward trend; the differences were statistically significant(P qi and Yin deficiency syndrome was positively correlated with albumin(OR = 1.056, P < 0.001)and eGFR(OR = 1.008, P = 0.022) but negatively correlated with age(OR = 0.977, P = 0.023). Liver-kidney Yin deficiency syndrome was positively correlated with age(OR = 1.028, P = 0.021) and glycosylated hemoglobin(OR = 1.223, P = 0.007) but negatively correlated with total cholesterol(OR = 0.792, P = 0.006).Spleen-kidney Yang deficiency syndrome was negatively correlated with hemoglobin(OR = 0.977, P < 0.001),albumin(OR = 0.891, P < 0.001), and eGFR(OR = 0.978,P < 0.001) but positively correlated with high density lipoprotein(OR = 3.376, P = 0.001). CONCLUSION: With CKD1-5 progression, TCM syndromes changed from Yin deficiency and dry heat syndrome to syndrome of deficiency of both

关键词： albumins correlation of data diabetic nephropathies glomerular filtration rate hemoglobins syndrome and complex

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信用交易会放大个人投资者的卖出行为偏差吗

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财贸经济 2024年第3期45卷 93-109页

作者：胡聪慧亓婧宇徐鑫北京师范大学经济与工商管理学院 100875 广东财经大学金融学院 510320

信用交易缓解了投资者的资金约束,但提高了交易的复杂性和不确定性,有可能加剧投资者的行为偏差。本文利用某全国性券商2011—2015年个人投资者的脱敏账户交易数据,研究信用交易对投资者卖出行为的影响。研究发现,引入信用交易不仅降低... 详细信息

信用交易缓解了投资者的资金约束,但提高了交易的复杂性和不确定性,有可能加剧投资者的行为偏差。本文利用某全国性券商2011—2015年个人投资者的脱敏账户交易数据,研究信用交易对投资者卖出行为的影响。研究发现,引入信用交易不仅降低了投资者亏损时的卖出倾向,而且更大幅度地降低了盈利时的卖出倾向,进而导致以“盈亏时卖出倾向之差”度量的处置效应降低。进一步地,本文对盈利和亏损状态下的影响机制进行了检验,发现盈利时受赌资效应和过度自信的影响,亏损时受损失厌恶和后悔厌恶的影响,信用交易者的卖出倾向都会更大幅度地降低。本文的研究表明,信用交易会放大投资者卖出时的行为偏差,而且在盈利和亏损情形下具有不同的影响机制,这对深入理解处置效应、有针对性地开展投资者教育具有重要参考价值。

关键词：信用交易处置效应赌资效应过度自信损失厌恶

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Comparative study on skin temperature response to menstruation at acupuncture points in healthy volunteers and primary dysmenorrhea patients

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Journal of Traditional Chinese Medicine 2017年第2期37卷 220-228页

作者： She Yanfen Ma Liangxiao Zhu Jiang qi conghui Wang Yanxia Tang Ling Li Chunhua Yuan Hongwen Liu Yuqi Song Jiashan School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine School of Acupuncture-Moxibustion and Tuina Hebei University of Chinese Medicine Department of Acupuncture Hebei Provincial General Hospital Department of Gynecology Dong Zhi Men Hospital Affiliated to Beijing University of Chinese Medicine Department of Acupuncture and Physiotherapy Beijing Electric Power HospitalCapital Medical University School of Traditional Chinese Medicine Capital Medical University Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Science Department of Acupuncture The Third Affiliated Hospital of Beijing University of Chinese Medicine

OBJECTIVE:To assess skin temperature response to menstruation at acupuncture points in primary dysmenorrhea(PD) patients and healthy volunteers so as to explore acupuncture point specificity in reflecting diseases in the light of skin temperature.METHODS:Fifty-two PD patients and 49 healthy volunteers were recruited.Skin temperature measurements were performed with a skin temperature assessment device at 10 points.Absolute difference between skin temperature of the same point on the left and right side is used as main outcome measure.RESULTS:On the first day of menstruation, when menstrual pain attacking in PD patients, a significant increase in skin temperature difference was detected at Taixi(KI 3) compared with the healthy group(P 0.05).CONCLUSION:The skin temperature difference at menstruation-relevant points in PD patients did not all change significantly more than those in women without PD.Significant difference was only found in Taixi(KI 3), the Yuan-source point of Kidney meridian.

关键词：痛经月经皮肤温度削尖 LR 6 (Zhongdu ) 削尖 KI 3 (Taixi ) 肾顶点比较学习

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Interfacial engineering of perfluoroalkyl functionalized covalent organic framework achieved ultra-long cycled and dendrite-free lithium anodes

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Nano Research 2023年第7期16卷 9289-9298页

作者： Yongxin Yang conghui Zhang Zhiyuan Mei Yongjiang Sun qi An qi Jing Genfu Zhao Hong Guo International Joint Research Center for Advanced Energy Materials of Yunnan Province Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon TechnologiesSchool of Materials and EnergyYunnan UniversityKunming 650091China

The finite lithium-ion utilization,short cycling life,and lower capacity retention caused by irreversible dendrite growth become the maximum dilemma in lithium metal batteries’(LMBs’)commercialization.Herein,a perfluoroalkyl-functionalized covalent organic framework(COF-F6)equipped with high stability and supernal proton conduction is introduced as an artificial solid electrolyte interface to stable the lithium metal anode.Benefiting from the strong electron-withdrawing effect of perfluoroalkyl,Li^(+)will be freed more by the competition of electronegative fluorine(F)and bis(trifluoromethanesulphonyl)imide anion(TFSI^(-)).The dissociation of LiTFSI and process of Li^(+)desolvation are easier to achieve.In addition,high electronegative fluorine can also regulate local electron-cloud density to induce the fast immigration of Li^(+).All the above roles contribute to improving the Li^(+)transfer number(0.7)and achieving the goal of inhibiting Li dendrite.As a result,the perfluoroalkyl COF-F6 modified LMB presents outstanding cycling stability.The symmetric batteries accomplish an overlong life-span of more than 5000 h with a lower hysteresis voltage(11 mV)at 5 mA·cm^(-2).Also,no dendrites are observed when using an in-situ optical microscope to learn the process of Li deposition.Therefore,this dendrite-free protection tactic holds broad prospects for the practical application of Li metal anodes.

关键词： perfluoroalkyl-functionalized covalent organic framework(COF-F6) artificial solid electrolyte interface strong electronwithdrawing effect dendrite-free lithium metal anode

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面向光学/精密结构的碳化硅制备和应用进展

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光学学报 2024年第4期44卷 56-77页

作者：张舸崔聪聪李伟董斌超曹琪周立勋郭聪慧张巍徐传享朱万利包建勋中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院光学系统先进制造技术重点实验室吉林长春130033 长春长光精瓷复合材料有限公司吉林长春130033

碳化硅陶瓷具有力学和热学综合性能优势,已广泛应用于光学/精密结构构件的制造。综述了应用于天/地基先进光电系统领域的碳化硅陶瓷制备技术国内外现状,对比分析了常压烧结、反应烧结、气相转化/沉积三种已获得工程化应用的致密化技术,... 详细信息

碳化硅陶瓷具有力学和热学综合性能优势,已广泛应用于光学/精密结构构件的制造。综述了应用于天/地基先进光电系统领域的碳化硅陶瓷制备技术国内外现状,对比分析了常压烧结、反应烧结、气相转化/沉积三种已获得工程化应用的致密化技术,以及预制体成型技术和材料性能调控方法;介绍了碳化硅陶瓷的增材制造技术,及其应用于光学/精密结构构件制备的进展;总结了超大口径、超高复杂度碳化硅陶瓷的连接技术。阐述了不同应用场景对碳化硅陶瓷的性能需求及其面临的挑战,展望了碳化硅陶瓷制备技术的发展趋势。

关键词：光学材料碳化硅陶瓷光学/精密结构构件致密化技术增材制造连接技术

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COF-based single Li^(+)solid electrolyte accelerates the ion diffusionandrestrains dendritegrowthin quasi-solid-state organic batteries

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Carbon Energy 2023年第2期5卷 171-183页

作者： Genfu Zhao Zhiyuan Mei Lingyan Duan qi An Yongxin Yang conghui Zhang Xiaoping Tan Hong Guo School of Materials and Energy Yunnan UniversityKunmingYunnanChina College of Chemistry and Chemical Engineering Yangtze Normal UniversityFulingChongqingChina

A solid-state electrolyte(SSE),which is a solid ionic conductor and electroninsulating material,is known to play a crucial role in adapting a lithium metal anode to a high-capacity cathode in a solid-state battery.Among the various SSEs,the single Li-ion conductor has advantages in terms of enhancing the ion conductivity,eliminating interfacial side reactions,and broadening the electrochemical window.Covalent organic frameworks(COFs)are optimal platforms for achieving single Li-ion conduction behavior because of wellordered one-dimensional channels and precise chemical modification features.Herein,we study in depth three types of Li-carboxylate COFs(denoted LiOOC-COFn,n=1,2,and 3)as single Li-ion conducting SSEs.Benefiting from well-ordered directional ion channels,the single Li-ion conductor LiOOC-COF3 shows an exceptional ion conductivity of 1.36×10^(-5) S cm^(-1) at room temperature and a high transference number of 0.91.Moreover,it shows excellent electrochemical performance with long-term cycling,high-capacity output,and no dendrites in the quasi-solid-state organic battery,with the organic small molecule cyclohexanehexone(C_(6)O_(6))as the cathode and the Li metal as the anode,and enables effectively avoiding dissolution of the organic electrode by the liquid electrolyte.

关键词： covalent organic frameworks quasi-solid-state organic battery single Li-ion conductor solid-state electrolyte

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基于机器学习的碳排放研究热点文献计量分析

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福建开放大学学报 2024年第1期 43-49页

作者：李聪慧黄林昊祁芳斌王慰娟张先佶福建开放大学福建福州350003

为了应对全球气候变化引发的系列生态危机,厘清机器学习算法在碳排放研究领域的应用趋势,利用Cite Space系统分析了近十年来中国知网和Web of Science两个数据库基于机器学习的碳排放研究进展,结果表明:我国发文量占国际发文总量43.74%... 详细信息

为了应对全球气候变化引发的系列生态危机,厘清机器学习算法在碳排放研究领域的应用趋势,利用Cite Space系统分析了近十年来中国知网和Web of Science两个数据库基于机器学习的碳排放研究进展,结果表明:我国发文量占国际发文总量43.74%,但研究机构的国际合作较为缺乏,领域内作者集群现象不明显;国外的相关研究涉及到经济社会发展全链联系,重点围绕神经网络的优化改进,而国内更关注产业政策及社会生活改革,需重点发力算法优化及碳排量估计和预测。总体来看,神经网络作为研究热点和趋势,将对碳排放量的估计和预测发挥有力作用,该领域的深入研究将为人类社会采取相应措施缓解全球变暖提供重要参考依据。

关键词：深度学习排碳量知识图谱趋势

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中药联合腔内理疗治疗薄型子宫内膜经验撷菁

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中华中医药杂志 2024年第2期39卷 784-787页

作者：王艺绚庞聪慧吴海萃于艺夏芳丹连方山东中医药大学济南250000 山东中医药大学附属医院中西医结合生殖与遗传中心济南250000

子宫内膜过薄可导致子宫内膜容受性下降,胚胎反复种植失败,目前已成为临床一大棘手问题。连方教授以“肾主生殖”为理论指导,认为薄型子宫内膜的病位在胞宫,肾虚精亏为基本病机,肝郁脾虚、胞脉血瘀为其主要兼证。连教授辨证论治时,注重... 详细信息

子宫内膜过薄可导致子宫内膜容受性下降,胚胎反复种植失败,目前已成为临床一大棘手问题。连方教授以“肾主生殖”为理论指导,认为薄型子宫内膜的病位在胞宫,肾虚精亏为基本病机,肝郁脾虚、胞脉血瘀为其主要兼证。连教授辨证论治时,注重分期论治,通过对肾阴、肾阳的调控,使机体达到阴平阳秘的稳定状态,同时根据患者临床症状随证加减。此外,在局部配合使用腔内理疗,改善宫腔环境,提高子宫内膜容受性,获得了较好的临床疗效。

关键词：薄型子宫内膜补肾调周腔内理疗连方名医经验

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经典名方华盖散的古代文献分析与现代临床应用

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中国实验方剂学杂志 2024年第5期30卷 35-45页

作者：陈巧楠苏灿钰王晨张丽萍周围王聪慧娄锡恩北京中医药大学第三临床医学院北京100029 北京中医药大学北京100029 北京中医药大学第三附属医院北京100029

目的:梳理华盖散的历史沿革、处方演变及现代临床应用情况。方法:以“华盖散”及其异名“华盖汤”为关键词,检索中医智库、中华医典、爱如生中国医学库及中国知识基础设施工程(CNKI)等数据库,根据纳入排除标准筛选,获取与“华盖散”有... 详细信息

目的:梳理华盖散的历史沿革、处方演变及现代临床应用情况。方法:以“华盖散”及其异名“华盖汤”为关键词,检索中医智库、中华医典、爱如生中国医学库及中国知识基础设施工程(CNKI)等数据库,根据纳入排除标准筛选,获取与“华盖散”有关的古籍条文信息及现代临床研究文献,系统梳理与分析华盖散的历史源流、处方组成、制法、用量、主治病证、药材基原、药材炮制方法及现代临床应用。结果:纳入华盖散相关的古籍信息198条,涉及中医古籍93种。华盖散由炒紫苏子、赤茯苓、炒桑白皮、橘红、炒苦杏仁、麻黄、炒甘草7味药组成,具有宣肺解表、祛痰止咳的功效,主治风寒束表之咳嗽上气,痰气不利等。制法建议为煮散,将七味药物粉碎成粗粒,每次用量折合为紫苏子1.27 g、赤茯苓1.27 g、桑白皮1.27 g、橘红1.27 g、苦杏仁1.27 g、麻黄1.27 g、甘草0.64 g,加水300 mL,煎取210 mL,去药渣,饭后温服。纳入临床研究文献21篇分析华盖散的现代临床应用,主要用于呼吸系统疾病肺炎、哮喘、支气管炎等治疗。结论:笔者考证并总结了经典名方华盖散的关键信息,可为其复方制剂的研发和临床运用提供详实的参考依据。

关键词：经典名方华盖散华盖汤处方考证临床应用中药煮散历史沿革

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Understanding a Single-Li-Ion COF Conductor for Being Dendrite Free in a Li-Organic Battery

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Research 2023年第1期2022卷 209-218页

作者： Yongjiang Sun Genfu Zhao Yao Fu Yongxin Yang conghui Zhang qi An Hong Guo School of Materials and Energy Yunnan UniversityNo.2Green Lake North RoadKunming 650091China

In addition to improving ion conductivity and the transference number,single-Li-ion conductors(SLCs)also enable the elimination of interfacial side reactions and concentration difference polarization.Therefore,the SLCs can achieve high performance in solid-state batteries with Li metal as anode and organic molecule as cathode.Covalent organic frameworks(COFs)are leading candidates for constructing SLCs because of the excellent 1D channels and accurate chemical-modification skeleton.Herein,various contents of lithium-sulfonated covalently anchored COFs(denoted as LiO,S-COF1 and LiO,S-COF2)are controllably synthesized as SLCs.Due to the directional ion channels,high Li contents,and single-ion frameworks,LiO,SCOF2 shows exceptional Li-ion conductivity of 5.47×10^(-5)S.cm^(-1),high transference number of 0.93,and low activation energy of 0.15eV at room temperature.Such preeminent Li-ion-transported properties of LiO_(3)S-F2 permit stable Li+plating/stripping in a symmetric lithium metal battery,effectively impeding the Li dendrite growth in a liquid cell.Moreover,the designed quasi-solid-state cell(organic anthraquinone(AQ)as cathode,Li metal as anode,and LiO_(3)S-COF2 as electrolyte)shows high-capacity retention and rate behavior.Consequently,LiO_(3)S-COF2 implies a potential value restraining the dissolution of small organic molecules and Li dendrite growth.

关键词： lithium Battery restrain

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