检索结果-南通市图书馆

Biomedical and Environmental Sciences 2024年第1期37卷 122-126页

作者： HE La Gu LIANG Yun Lai YANG Lu qi yuan Hua Min Medical laboratory Department Hunan Prevention and Treatment Institute for Occupational DiseasesChangsha 410000HunanChina Laboratory Medicine Department Xiangya HospitalCentral South UniversityChangsha 410013HunanChina

Pneumoconiosis is a group of heterogeneous fibrotic lung diseases caused by inorganic mineral dust and includes coal workers’pneumoconiosis and *** involves diffuse or nodular interstitial pulmonary fibrosis caused by exposure to asbestos or silica *** is thought to have the highest number of silicosis cases,with 6,000 new cases reported annually^([1]).Currently,the clinical diagnosis and monitoring of silicosis relies mainly on a history of occupational exposure and radiological abnormalities^([2]).Therefore,determining further indicators is crucial to reflect the severity of silicosis.

关键词： diagnosis lung diseases

One-step hydrothermal synthesis of few-layered metallic phase MoS2 for high-performance supercapacitors

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2024年第2期34卷 429-436页

作者： Jing Xu Xulong yuan Yujie Zhao Shaoqi Rui qingling Jia Han Li Shun Lu bing Li Yongxing Zhang Xuebin Zhu Anhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation Anhui Province Key Laboratory of Intelligent Computing and Applications Anhui Province Industrial Generic Technology Research Center for Alumics Materials Huaibei Normal University Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Key Laboratory of Materials Physics Institute of Solid State Physics HFIPS Chinese Academy of Sciences

In recent years,molybdenum disulfide（MoS2） has gained significant attention in the scientific *** MoS2demonstrates unique properties and potential ***,the synthesis of few-layered and high-purity 1T-MoS2is still a *** this study,we successfully employed a hydrothermal method to synthesize few-layered and high-purity *** purity of the material is controlled by a combination of sodium borohydride and ***,the few-layered 1T-MoS2exhibits exceptional performance as a supercapacitor,including the high specific capacitance(250.3 F g-1at a current density of 1 A g-1) and excellent long-trem cycling stability（90.7 % after 5000 cycles）.Meanwhile,the asymmetric device assembled by 6-FL-1TMoS2and active carbon on carbon cloths exhibits excellent flexibility and high energy and power density(23.1μWh cm-2at 600 μW cm-2,55 μWh cm-2at 12000 μW cm-2).This work provides valuable insights into the synthesis of few-layered and high-purity 1T-MoS2,opening up new avenues for further research and applications.

关键词： 1T-MoS2 Few-layered High-purity One-pot hydrothermal method Supercapacitor

microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第9期51卷 911-921页

作者： Xinghan Chen Yueru Shen Zheng Song Xinliang Wang Huaitong Yao yuan Cai Zi-Ang Zhao bing Hu Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefeiAnhui 230026China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China

MicroRNAs(miRNAs)play a significant role in axon regeneration following spinal cord ***,the functions of numerous miRNAs in axon regeneration within the central nervous system(CNS)remain largely ***,we elucidate the positive role of microRNA-2184(miR-2184)in axon regeneration within zebrafish Mauthner cells(M-cells).The upregulation of miR-2184 in a single M-cell can facilitate axon regeneration,while the specific sponge-induced silencing of miR-2184 leads to impeded *** show that syt3,a downstream target of miR-2184,negatively regulates axon regeneration,and the regeneration suppression modulated by syt3 depends on its binding to Ca2+.Furthermore,pharmacological stimulation of the cAMP/PKA pathway suggests that changes in the readily releasable pool may affect axon *** data indicate that miR-2184 promotes axon regeneration of M-cells within the CNS by modulating the downstream target syt3,providing valuable insights into potential therapeutic strategies.

关键词： Axon regeneration Axon ablation miR-2184 syt3 Readily releasable pool

Precipitating thermally reinforcement phase in aluminum alloys for enhanced strength at 400℃

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第5期172卷 71-82页

作者： Xiang Su yuan Lei Yang Chen Hongjie Qu Zhixiang qi Gong Zheng Xu Liu Henggao Xiang Guang Chen National Key Laboratory of Advanced Casting Technologies MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials TechnologyEngineering Research Center of Materials Behavior and DesignMinistry of EducationNanjing University of Science and TechnologyNanjing 210094China School of Aviation and Mechanical Engineering Changzhou Institute of TechnologyChangzhou 213032China

Heat-resistant aluminum alloys are widely used in aerospace and automotive fields for manufacturing hot components due to their advantages in lightweight design and energy ***,the high-temperature strength of existing cast aluminum alloys is always limited to about 100 MPa at 350℃due to coarsening and transformation of strengthening ***,we reveal that the yield strength and ultimate tensile strength of the T6 state Al-8.4Cu-2.3Ce-1.0Mn-0.5Ni-0.2Zr alloy at 400◦C increase by 34%and 44%after re-aging at 300℃for 100 h,and its thermal strength exhibits distinguished ad-vantage over traditional heat-resistant aluminum *** enhanced elevated-temperature strength is attributed to the reprecipitation of the Ni-bearing T-Al_(20)Cu_(2)Mn_(3)phase,whose number density increases over one *** significant segregation of Ni,Ce,and Zr elements at the interfaces helps improve the thermal stability of the T *** thermostable T phase effectively strengthens the matrix by in-hibiting dislocation ***,a highly interconnected 3D intermetallic network along the grain boundaries can still remain after long-term re-aging at 300℃,which is conducive to imposing a drag on the grain boundaries at high *** finding offers a viable route for enhancing the elevated-temperature strength of heat-resistant aluminum alloys,which could provide expanded opportunities for higher-temperature applications.

关键词： Aluminum alloys Precipitation Thermally reinforcement phase Re-aging treatment High-temperature strength

Highly Conductive Ag/pCF/MVQ Composite Rubber for Efficient Electromagnetic Interference Shielding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第6期42卷 864-873页

作者： Yang Chen Xiao-Ming Shao Liang He Yi-Nuo Xu qi-yuan Yao Ding Feng Wen-Cai Wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Key Laboratory of Beijing City for Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing100029China Sino-german School of Engineering Qingdao University of Science and TechnologyQingdao266400China

In this study,flexible and highly conductive composite rubber at low filler content was successfully prepared through polydopamine-assisted electroless silver plating plus mechanical ***,carbon fibers(CF)were activated by polydopamine(PDA)to improve the surface activity by self-polymerization ***,because of the metal chelating ability of PDA,silver layer was firmly deposited on the surface of CF through a facile electroless silver plating ***,flexible silver-plated carbon fibers(Ag/pCF)silicone rubber composites prepared by mechanical *** using X-ray photoelectron spectroscopy(XPS)and X-ray diffraction(XRD),the chemical composition and crystal structure of Ag/pCF were examined,and scanning electron microscopy(SEM)was used to assess the surface morphology of the Ag/*** results showed that a uniform and dense silver layer was formed on the surface of the CF,and the conductivity of the Ag/pCF could reach 7885 S/*** was noteworthy that the composite rubber filled with only 45 phr Ag/pCF had a high electromagnetic interference shielding effectiveness(100 dB)due to the low density and high aspect ratio of Ag/*** composite rubber has excellent potential for application in the field of electromagnetic interference shielding.

关键词： Carbon fibers Polydopamine Electroless plating Silver Electromagnetic interference shielding

Structure,ligands,and roles of GPR126/ADGRG6 in the development and diseases

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 294-305页

作者： qi Li Anran Huo Mengqi Li Jiali Wang qiao Yin Lumiao Chen Xin Chu yuan qin Yuwan qi Yang Li Hengxiang Cui qifei Cong Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases Soochow UniversitySuzhouJiangsu215123China Department of Neurology and Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Nephrology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Emergency Center The Second Affiliated Hospital of Nantong UniversityNantongJiangsu226001China Department of Neurology Huzhou Central HospitalThe Affiliated Huzhou HospitalZhejiang University School of MedicineHuzhouZhejiang 313000China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China

Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix *** adhesion GPCR Adgrg6,also known as GPR126,is one of the better-characterized ***126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and *** studies have extended our understanding of GPR126-mediated roles during develop-ment and in human *** this review,we highlighted these recent advances in GPR126 in expression profile,molecular structure,ligand-receptor interactions,and associated physiological and pathological functions in development and diseases.

关键词： Adhesion G protein-coupled receptor Function GPR126/Adgrg6 Ligand Structure

Delay-optimal multi-satellite collaborative computation offloading supported by OISL in LEO satellite network

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第4期35卷 805-814页

作者： ZHANG Tingting GUO Zijian LI Bin FENG yuan FU qi HU Mingyu QU Yunbo School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy Beijing Institute of TechnologyJiaxing 314000China School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China China Research and Development Academy of Machinery Equipment Beijing 100089China

By deploying the ubiquitous and reliable coverage of low Earth orbit(LEO)satellite networks using optical inter satel-lite link(OISL),computation offloading services can be provided for any users without proximal servers,while the resource limita-tion of both computation and storage on satellites is the impor-tant factor affecting the maximum task completion *** this paper,we study a delay-optimal multi-satellite collaborative computation offloading scheme that allows satellites to actively migrate tasks among themselves by employing the high-speed OISLs,such that tasks with long queuing delay will be served as quickly as possible by utilizing idle computation resources in the *** satisfy the delay requirement of delay-sensi-tive task,we first propose a deadline-aware task scheduling scheme in which a priority model is constructed to sort the order of tasks being served based on its deadline,and then a delay-optimal collaborative offloading scheme is derived such that the tasks which cannot be completed locally can be migrated to other idle *** results demonstrate the effective-ness of our multi-satellite collaborative computation offloading strategy in reducing task complement time and improving resource utilization of the LEO satellite network.

关键词： low Earth orbit(LEO)satellite network computation offloading task migration resource allocation

Regio-and Stereoselective Polymerization of Bio-based Ocimene by Rare-Earth Metal Catalysts

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第2期42卷 223-229,I0008页

作者： qi-yuan Wang Li-Peng Sang Zhen Zhang Yang Jiang Hui Tian Xia Zhao Xiang Guo Shi-Hui Li State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechonologyXiangyang441003China Shanxi Coal Chemical Industry Technology Research Institute Xi’an710000China Hubei Institute of Aerospace Chemotechonology Xiangyang441003China

Coordination polymerization of renewable β-ocimene has been investigated using asymmetric diiminophosphinate lutetium complex1, β-diketiminate yttrium complex 2, bis(phosphino)carbazolide yttrium complex 3, half-sandwich benzyl fluorenyl scandium complex 4 and pyridyl-methylene-fluorenyl rare-metal complexes 5a–5c. Complexes 1, 4 and 5a–5c show trans-1,2-regioselectivities and high activities, of which 5c exhibits excellent isoselectivity(mmmm>99%). Conversely, complexes 2 and 3 promote β-ocimene polymerization to produce isotactic cis-1,4-polyocimenes(cis-1,4>99%, mm>95%). Diblock copolymers cis-1,4-PIP-block-cis-1,4-POc and cis-1,4-PBD-block-cis-1,4-POc are obtained in one-pot reactions of β-ocimene with isoprene and butadiene using complex 3. Epoxidation and hydroxylation of polyocimene afford functionalized polyolefins with enhanced T_(g)(from-20 ℃ to 79 ℃ and 74 ℃) and hydrophilicity.

关键词： Biobased monomer Terpenes Ocimene Rare-earths Polymerization Regio/stereoselectivity Elastomer

Permian integrative stratigraphy,biotas,paleogeographical and paleoclimatic evolution of the qinghai-Tibetan Plateau and its surrounding areas

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第4期67卷 1107-1151页

作者： Shuzhong SHEN Yichun ZHANG Dongxun yuan Haipeng XU qi JU Hua ZHANG Quanfeng ZHENG Mao LUO Zhangshuai HOU State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Nanjing 210049China School of Resources and Geosciences China University of Mining and TechnologyXuzhou 221116China

The Permian Period was a critical time interval during which various blocks of the qinghai-Tibetan Plateau have experienced profound and complex paleogeographical *** supercontinent Pangea was formed to its maximum during this interval,hampering a global east-to-west trending equatorial warm ocean ***,a semi-closed Tethys Ocean warm pool formed an eastward-opening oceanic embayment of Pangea,and became an engine fostering the evolutions of organisms and environmental changes during the Paleozoic-Mesozoic *** and preserved fossil groups have proved extremely useful in understanding such changes and the evolutionary histories of the qinghai-Tibetan *** distributed Permian deposits and fossils from various blocks of the qinghai-Tibetan Plateau exhibited varied characteristics,reflecting these blocks’different paleolatitude settings and drifting *** Himalaya Tethys Zone south to the Yarlung Zangbo suture zone,located in the northern Gondwanan margin,yields fossil assemblages characterized by cold-water organisms throughout the Permian,and was affliated to those of the *** of the exotic limestone blocks within the Yarlung Zangbo suture zone are Guadalupian(Middle Permian)to Early Triassic in *** exotic limestone blocks bear fossil assemblages that have transitional affinities between the warm Tethys and cold Gondwanan regions,suggesting that they most probably represent seamount deposits in the Neo-Tethys *** the Asselian to Sakmarian(Cisuralian,also Early Permian),the Cimmerian microcontinents in the northern part of Gondwana preserved glacio-marine deposits of Asselian to Sakmarian,and contained typical Gondwana-type cold-water *** the middle Cisuralian(~290-280 Ma),the Cimmerian microcontinents rifted off from the Gondwanaland,and drifted northward allometrically due to the active magmatism of the Panjal Traps in the northern margin of the Indian *** slices of micro

关键词： Permian Tethys Ocean qinghai-Tibetan Plateau Biotas Paleogeography

ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 5409-5423页

作者： Ding Wang qi Jiang Ruoyu Shen Lijun Peng Wentao Zhou Tingting Meng Fuqiang Hu Jianwei Wang Hong yuan College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009China

The destruction of the intestinal barrier is likely to cause an increase in intestinal permeability and cause pathological *** studies have demonstrated that intestinal barrier function plays an important role in the occurrence and development of inflammatory bowel disease(IBD).Oral administration is the most common route for intestinal *** this study,a synergistic strategy is proposed for IBD management through active barrier repair combined with anti-inflammatory treatment,which can interrupt the pathological process of IBD,resulting in the significantly improved efficacy of existing *** on the specific pH values and high reactive oxygen species(ROS)levels in inflammatory sites of IBD,an orally administrated ROS-responsive drug delivery system targeting inflamed colon has been designed,and confirmed in vitro and in *** anti-inflammatory drug dexamethasone acetate(Dex)and the barrier function regulator LY294002 are delivered by the synthesized nanocarrier to treat IBD synergistically by inhibiting inflammation and actively repairing the intestinal barrier through tight junctions(TJs).The accumulation of nanocarriers in the inflamed colon and synergistic efficacy has been validated in mice with *** brief,a drug delivery system and a therapeutic strategy for IBD are successfully developed.

关键词： nanotechnology reactive oxygen species(ROS)-responsive targeted delivery inflammatory bowel disease(IBD) intestinal barrier combination treatment