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SnRK1 Phosphorylates and Destabilizes WRKY3 to Enhance Barley Immunity to Powdery Mildew

Plant Communications 2020年第4期1卷 115-128页

作者： Xinyun Han Ling Zhang lifang Zhao Pengya Xue Ting qi Chunlei Zhang Hongbo Yuan Lixun Zhou Daowen Wang Jinlong qiuand qian-Hua Shen State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesInnovation Academy for Seed DesignBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Plants recognize pathogens and activate immune responses,which usually involve massive transcriptional *** evolutionarily conserved kinase,Sucrose non-fermenting-related kinase 1(SnRK1),functions as a metabolic regulator that is essential for plant growth and stress ***,we identify barley SnRK1 and a WRKY3 transcription factor by screening a cDNA ***1 interacts with WRKY3 in yeast,as confirmed by pull-down and luciferase complementation assays.Förster resonance energy transfer combined with noninvasive fluorescence lifetime imaging analysis indicates that the interaction occurs in the barley *** expression and virus-induced gene silencing analyses indicate that WRKY3 acts as a repressor of disease resistance to the Bgh *** plants overexpressing WRKY3 have enhanced fungal microcolony formation and *** assays show that SnRK1 phosphorylates WRKY3 mainly at Ser83 and Ser112 to destabilize the repressor,and WRKY3 non-phosphorylation-null mutants at these two sites are more stable than the wild-type ***1-overexpressing barley plants display enhanced disease resistance to *** expression of SnRK1 reduces fungal haustorium formation in barley cells,which probably requires SnRK1 nuclear localization and kinase ***,these findings suggest that SnRK1 is directly involved in plant immunity through phosphorylation and destabilization of the WRKY3 repressor,revealing a new regulatory mechanism of immune derepression in plants.

关键词： SnRK1 phosphorylation WRKY transcription factor immunity powdery mildew fungus

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金亚蓓运用齐氏脐针治疗青少年身高增长缓慢的临床体会

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浙江中医药大学学报 2024年第7期48卷 823-827页

作者：姚莎娜郑利芳金亚蓓浙江中医院大学第二临床医学院杭州310053 浙江省中西医结合医院

[目的]总结浙江省名中医金亚蓓教授运用齐氏脐针治疗青少年身高增长缓慢的临床经验与体会。[方法]通过临床跟诊、整理、回顾、分析的方式,从病因病机、辨证论治和特色选穴等方面总结金师运用脐针治疗青少年身高增长缓慢的临床经验,并附... 详细信息

[目的]总结浙江省名中医金亚蓓教授运用齐氏脐针治疗青少年身高增长缓慢的临床经验与体会。[方法]通过临床跟诊、整理、回顾、分析的方式,从病因病机、辨证论治和特色选穴等方面总结金师运用脐针治疗青少年身高增长缓慢的临床经验,并附验案两则。[结果]金师认为,青少年身高增长缓慢内在核心病机为“脾虚不运,五脏不坚”,与“肾虚不充,骨髓化生乏源”“肝失疏泄,横克脾土”关系密切。临床常将患者分为脾肾两虚型和肝郁脾虚型两类,脾肾两虚型患者的脐针治疗以“震位、巽位、离位、坤位”为主方,肝郁脾虚型则以“左升四针”为主,治疗过程中注重调畅情志,随证调整针方。文末所举验案中,其一患者属脾肾两虚型,用脐针益气健脾、补肾培元为治,兼顾患者负面情绪,辅以疏肝、祛邪、固脱,邪去正复后改为“左升四针”助阳升发而使身高得长;其二患者属肝郁脾虚型,系学业压力重大、肝失疏泄、横克脾土所致,以“左升四针”疏肝解郁、升发阳气,辅以宣肺理气,最终五脏调和而身高自长。[结论]金师运用齐氏脐针治疗青少年身高增长缓慢,严谨辨证,分型论治,关注患者心理状态,注重调畅情志,临床特色鲜明,治疗效果显著,其经验值得推广学习。

关键词：脐针青少年身高增长缓慢脾肾两虚肝郁脾虚名医经验医案金亚蓓

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Modulation of first-passage time for gene expression via asymmetric cell division

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International Journal of Biomathematics 2019年第5期12卷 97-114页

作者： Kunwen Wen lifang Huang qi Wang Jianshe Yu School of Mathematics Jiaying University Meizhou 514015P.R.China Center for Applied Mathematics Guangzhou University Guangzhou 510006P.R.China School of Statistics and Mathematics Guangdong University of Finance and Economics Guangzhou 510320 P.R.China

How to balance the size of exponentially growing cells has always been a focus of *** experiments have uncovered that the cell is divided into two daughter cells only when the level of time-keeper protein reaches a fixed threshold and cell divi-sion in prokaryote is not completely *** timing of cell division is essentially random because gene expression is stochastic,but cells seen to manage to have precise timing of cell division *** the inter cellular variability of gene expression has attracted much attention,the randomness of event timing has been rarely *** our analysis,the timing of cell division is formulated as the first-passage time (denoted hy FPT) for time-keeper protein’s level to cross a critical threshold firstly,we derive exact analytical formulae for the mean and noise of FPT based on stochastic gene expression model with asymmetric cell *** results of numerical simulation show that the regulatory factors (division rate,newborn cell size,exponential growth rate and threshold) have significant influence on the mean and noise of *** also show that both the increase of division rate and newborn cell size could reduce the mean of FPT and increase the noise of FPT,the larger the exponential growth rate is,the smaller the mean and noise of FPT will be;and the larger the threshold value is,the higher the mean of FPT is and the lower the noise *** addition,compared with symmetric divi sion,asymmetric division can reduce the mean of FPT and improve the noise of *** summary,our results provide insight into the relationship between regulatory factors and FPT and reveal that asymmetric division is an effective mechanism to shorten the mean of FPT.

关键词： Asymmetric cell division first-passage time mean and noise

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Two Confirmed Patients of Anthrax—Binzhou City,Shandong Province,China,August 2021

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China CDC weekly 2021年第38期3卷 808-810页

作者： Xiaolin Yu lifang Zhang Ming Fang Hao Liang qi Zhang Xiusheng Yin Zengqiang Kou Wenwu Yin Zhong Li Enmin Zhang Shujun Ding Shandong Center for Disease Control and Prevention JinanShandongChina Binzhou Center for Disease Control and Prevention BinzhouShandongChina Shandong University JinanShandongChina Chinese Center for Disease Control and Prevention BeijingChina.

As of August 15,2021,2 confirmed cases of anthrax were reported to Shandong CDC,one of which was a 14-year-old student(Patient A)and the other was a 35-year-old man(Patient B)engaging in the slaughter of *** A died on August 6,and Patient B has been transferred to an infectious disease hospital for isolation and *** Shandong CDC formed a joint investigation team to determine the source of infection and prevent any further spread.

关键词： treatment. Shandong fir

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王樟连运用针刺治疗妊娠剧吐经验介绍

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新中医 2024年第14期56卷 124-128页

作者：郝萍萍陈利芳王樟连(指导) 杭州方回春堂三墩中医门诊部浙江杭州310013 浙江中医药大学附属第三医院浙江杭州310009

介绍王樟连教授运用针刺疗法治疗妊娠剧吐的临床经验。王樟连教授认为,妊娠剧吐一般由脾胃虚弱、肝气犯胃、痰湿阻滞导致,病机主要为孕后经血不泻,血聚养胎,以致冲气上逆,胃失和降。治疗以调气和中、降逆止呕为主。临证注重整体调理,主... 详细信息

介绍王樟连教授运用针刺疗法治疗妊娠剧吐的临床经验。王樟连教授认为,妊娠剧吐一般由脾胃虚弱、肝气犯胃、痰湿阻滞导致,病机主要为孕后经血不泻,血聚养胎,以致冲气上逆,胃失和降。治疗以调气和中、降逆止呕为主。临证注重整体调理,主穴选用百会、太阳、阳白、印堂、风池、内关、中脘、下脘、足三里;配穴辨证选用,脾胃虚弱者加地机,肝胃不和者加太冲,痰湿阻滞者加丰隆。兼以手法,补泻得当,故能获效。

关键词：妊娠剧吐针刺疗法王樟连

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A survey of routing techniques for satellite networks

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Journal of Communications and Information Networks 2016年第4期1卷 66-85页

作者： qi Xiaogang MA Jiulong WU Dan LIU lifang HU Shaolin School of Mathematics and Statistics Xidian UniversityXi'an 710126China School of Computer Science and Technology Xidian UniversityXi'an 710071China Key Laboratory of Spacecraft Faults Diagnosis and Maintance Xi'an 710043China

Satellite networks have many advantages over traditional terrestrial ***,it is very difficult to design a satellite network with excellent *** paper briefly summarizes some existing satellite network routing technologies from the perspective of both single-layer and multilayer satellite constellations,and focuses on the main ideas,characteristics,and existing problems of these routing *** single-layer satellite networks,two routing strategies are discussed,virtual node strategy and virtual topology ***,considering the deficiency of existing multilayer satellite network routing,we discuss the topic ***,the challenges and problems faced by the satellite network are analyzed and the trend of future development is predicted.

关键词： satellite network routing technology virtual node virtual topology invulnerability

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超声提取法测定复合肥料和有机肥料中氯离子

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生态产业科学与磷氟工程 2024年第5期39卷 35-37页

作者：赵丽芳齐云徐楠刘鹏飞王东岳康兆广孙文丹张娟山东省产品质量检验研究院

目前复合肥料和有机肥料中氯离子含量测定时通过沸水提取肥料样品中水溶性氯离子，耗时长、操作步骤烦琐。采用超声提取法快速提取复合肥料和有机肥料中氯离子，分别采用容量法和自动电位滴定法测定氯离子含量，并将测定结果与标准方法... 详细信息

目前复合肥料和有机肥料中氯离子含量测定时通过沸水提取肥料样品中水溶性氯离子，耗时长、操作步骤烦琐。采用超声提取法快速提取复合肥料和有机肥料中氯离子，分别采用容量法和自动电位滴定法测定氯离子含量，并将测定结果与标准方法进行对比。超声提取法室温条件下提取时间只需5 min，且不需要冷却，大大缩短了检测时间；同时方法准确度高，重现性好，适合大批量样品的检测。

关键词：复合肥料有机肥料氯离子含量超声提取测定

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基于“一气周流”理论探讨帕金森病病机及论治

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辽宁中医药大学学报 2024年第8期26卷 128-132页

作者：张寒杨丽芳刘玉梅田宁广州中医药大学广东广州510405 安徽中医药大学安徽合肥230001 广东省中西医结合医院广东佛山528000

清代名医黄元御精读中国古代医学经典和自然哲学著作,在“天人相应”和“气一元论”的基础上提出了“土枢四象,一气周流”的学术理论,呈现为左升右降、中焦斡旋的气机运转模式,“中焦为轴,四象为轮”,枢轴运转,则阴平阳秘,脏腑调和。帕... 详细信息

清代名医黄元御精读中国古代医学经典和自然哲学著作,在“天人相应”和“气一元论”的基础上提出了“土枢四象,一气周流”的学术理论,呈现为左升右降、中焦斡旋的气机运转模式,“中焦为轴,四象为轮”,枢轴运转,则阴平阳秘,脏腑调和。帕金森病(Parkinson's disease,PD)作为全球第二大神经系统退行性病变,病情呈缓慢性进展,现代医学对本病暂无有效的治疗方法,探索新的治疗方法意义重大。该文将运用黄元御的“一气周流”理论,从整体动态的角度去探讨帕金森病的病机及治则,提出帕金森病的病机以中土失运为根本,乙木下陷、肾水下寒、肺金右滞为关键,共同引起全身气机周流阻滞;并提出了运用黄芽汤加减健运脾胃、斡旋中焦,桂枝苓胶汤加减疏肝解郁、清风泄热,天魂汤加减温肾助阳、燥湿解郁,下气汤加减收敛肺气、调达肝气,以达到恢复全身气机周转的目的,从而为帕金森病提供新的治疗思路。

关键词：一气周流帕金森病病机治则

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OsRFPH2-10,a RING-H2 Finger E3 Ubiquitin Ligase,Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection

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Molecular Plant 2014年第6期7卷 1057-1060页

作者： lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li qingqing qin Rui Wang Shaoyi Ji Shanshan Zhao qi Xie Chunhong Wei Can Xie Biao Ding Yi Li The State Key Laboratory of Protein and Plant Gene Research College of Life SciencesPeking UniversityBeijing 100871People’s Republic of China Peking-Yale Joint Center for Plant Molecular Genetics and Agrobiotechnology College of Life SciencesPeking UniversityBeijing 100871People’s Republic of China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101People’s Republic of China Department of Molecular Genetics and Center for RNA Biology The Ohio State UniversityColumbusOH 43210USA

Dear Editor,Rice dwarf virus(RDV),a member of the Phytoreoviurs genus,is transmitted to rice(Oryza sativa)plants by leaf-hopper(Nephotettix cincticeps)in a propagative *** by RDV results in severe stunting growth pheno-types and a dramatic reduction in grain *** genome of RDV is composed of 12-segmented double-stranded RNAs(S1-S12 based on their migration rates in agarose gel electro-phoresis).The 12 segments encode seven structural proteins(P1,P2,P3,P5,P7,P8,and P9 as the products of Sl,S2,S3,S5,S7,S8,and S9,respectively)and five nonstructural proteins(Pns4,Pns6,Pnsl0,Pns11,and Pns12 as the products of S4,S6,S10,S11,and S12,respectively).The outer capsid protein P2 is essential for RDV infection of insects and thus influences transmission of RDV by the insect vector(Omura et al.,1998;Zhou et al.,2007).P2 also contributes to the dwarf phenotype of infected rice by interfering with gibberellic acid synthesis(Zhu et al.,2005).When RDV-infected rice plants were main-tained via vegetative propagation for several years without insect transmission,they regained normal growth height due to loss of RDV P2 and Pnsl0 proteins(Pu et al.,2011).

关键词： P2 PROTEIN PHYTOREOVIRUS STRESS CELLS

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灸法在脑卒中后偏瘫肩痛患者康复护理中的应用进展

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中国医药科学 2024年第9期14卷 57-60页

作者：谢延真朱莉芳林梅娟吴燕华复旦大学附属中山医院厦门医院护理部福建厦门361015 复旦大学附属中山医院厦门医院普外科福建厦门361015

脑卒中是患者致残的重要原因之一,患者可存在不同程度的功能障碍,遗留偏瘫等后遗症。偏瘫肩痛是脑卒中后常见的并发症之一,影响患者上肢功能康复进程及最终预后,造成患者住院时间延长,严重影响其日常生活活动能力和生活质量,给家庭带来... 详细信息

脑卒中是患者致残的重要原因之一,患者可存在不同程度的功能障碍,遗留偏瘫等后遗症。偏瘫肩痛是脑卒中后常见的并发症之一,影响患者上肢功能康复进程及最终预后,造成患者住院时间延长,严重影响其日常生活活动能力和生活质量,给家庭带来巨大经济和心理负担。灸法是将艾绒或药物点燃后作用于体表穴位,通过温热刺激及药物药理作用达到疏通经络、调和气血及防治疾病作用的一种外治法。近年来,灸法在脑卒中后偏瘫肩痛患者康复护理中被广泛应用,因此,本文从脑卒中后偏瘫肩痛的病因病机、灸法治疗脑卒中后偏瘫肩痛的作用机制及选穴、常用灸法的临床应用方面进行阐述,以期为脑卒中后偏瘫肩痛患者的康复护理提供参考。

关键词：灸法脑卒中偏瘫肩痛康复护理综述

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