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Salsola imbricata *** acetic acid-induced inflammatory bowel disease by modulating dysregulated antioxidant enzyme system and cytokine signaling pathways in mice

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 527-534页

作者： Faraza Javed qaiser jabeen Department of Pharmacology Faculty of PharmacyThe Islamia University of BahawalpurPakistan

Objective:To explore the protective effect of the crude extract of Salsola imbricata against acetic acid-induced inflammatory bowel disease in mice and its mechanism of ***:Ethanolic crude extract of Salsola imbricata was characterized by *** imbricata extract at different doses was administered and ulcerative colitis was induced by 200μL,7.5%acetic acid and macroscopic parameters were evaluated to assess the homeostatic condition of intestinal mucosa along with hematological and biochemical *** levels of malondialdehyde,glutathione peroxidase 1,superoxide dismutase,and catalase were determined in colon *** cytokines including interleukin(IL)-1β,IL-6,and tumor necrosis factor-α(TNF-α)were quantified by *** extent of tissue damage was assessed by histological ***:Phytochemical analysis confirmed the presence of phytochemicals including quercetin,gallic acid,syringic acid,benzoic acid and chlorogenic acid in the crude *** crude extract of Salsola imbricata(300 and 500 mg/kg)markedly decreased malondialdehyde and nitric oxide(P<0.01)and increased antioxidant activities of glutathione peroxidase 1(P<0.001)and superoxide dismutase(P<0.001).Moreover,it decreased the levels of IL-1β,IL-6 and TNF-αsignificantly(P<0.001)and reduced the damage to the colon mucosa,promoting tissue healing and ***:Salsola imbricata extract restores the colonic epithelial layers by maintaining mucosal homeostasis and cell integrity by modulating antioxidant defense system and inflammatory cytokine signaling in ulcerative colitis mice.

关键词： Salsola imbricata Acetic acid Antioxidant enzymes Cytokines Inflammation Reactive oxygen species

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