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Pharmacokinetics and bioequivalence of ranitidine and bismuth derived from two compound preparations

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World Journal of Gastroenterology 2006年第17期12卷 2742-2748页

作者： quan Zhou Zou-rong Ruan Hong Yuan Bo Jiang Dong-Hang Xu Department of Clinical Pharmacology the 2^th Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To evaluate the bioequivalence of ranitidine and bismuth derived from two compound preparations. METHODS： The bioavailability was measured in 20 healthy male Chinese volunteers following a single oral dose （equivalent to 200 mg of ranitidine and 220 mg of bismuth） of the test or reference products in the fasting state. Then blood samples were collected for 24 h. Plasma concentrations of ranitidine and bismuth were analyzed by high-performance liquid chromatography and inductively coupled plasma-mass spectrometry （ICPMS）, respectively. The non-compartmental method was used for pharmacokinetic analysis. Log-transformed Cmax, AUC（0-t） and AUC（0-∞） were tested for bioequivalence using ANOVA and Schuirmann two-one sided t-test. Tmax was analyzed by Wilcoxon＇s test. RESULTS： Various pharmacokinetic parameters of ranitidine derived from the two compound preparations, including Cmax, AUC（0-t）, AUC（0-∞）, Tmax and T1/2, were nearly consistent with previous observations. These parameters derived from test and reference drug were as follows： Cmax（0.67 ± 0.21 vs 0.68 ± 0.22 mg/L）, AUC（0-t）（3.1 ± 0.6 vs 3.0 ± 0.7 mg/L per hour）, AUC（0-∞）（3.3 ± 0.6 vs 3.2 ± 0.8 mg/L per hour）, Tmax （2.3 ± 0.9 VS 2.1 ± 0.9 h） and T1/2 （2.8 ± 0.3 vs 3.1 ± 0.4 h）. In addition, double-peak absorption profiles of ranitidine were found in some Chinese volunteers. For bismuth, those parameters derived from test and reference drug were as follows： Cmax （11.80 ± 7.36 vs 11.40 ± 6.55 μg/L）, AUC（0-t）（46.65 ± 16.97 vs 47.03 ± 21.49 μg/L per hour）, Tmax （0.50 ± 0.20 vs 0.50 ± 0.20 h） and T1/2 （10.2 ± 2.3 vs 13.0 ± 6.9 h）. Ninety percent of confidence intervals for the test/reference ratio of Cmax, AUC（0-t） and AUC（0-∞） derived from both ranitidine and bismuth were found within the bioequivalence acceptable range of 80%-125%. No significant difference was found in Tmax derived from both ranitidine and bismuth. CONCLUSION： The two compound preparations are bioequivalent and may be prescribed intercha

关键词： Ranitidine Bismuth Compound preparation Bioequivalence Pharmacokinetics Healthy volunteers High-performanace liquid chromatography Inductively coupled plasma-mass spectrometry

Markov Chain-based Degree Distributions of Evolving Networks

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Acta Mathematica Sinica,English Series 2012年第10期28卷 1981-1994页

作者： Xiang Xing KONG Zhen Ting HOU Ding Hua SHI quan rong CHEN Qing Gui ZHAO School of Mathematics Central South University Department of Mathematics Shanghai University Department of Electronic Engineering City University of Hong KongP.R.China Department of Mathematics and Science Hunan First Normal University

In this paper, we study a class of stochastic processes, called evolving network Markov chains, in evolving networks. Our approach is to transform the degree distribution problem of an evolving network to a corresponding problem of evolving network Markov chains. We investigate the evolving network Markov chains, thereby obtaining some exact formulas as well as a precise criterion for determining whether the steady degree distribution of the evolving network is a power-law or not. With this new method, we finally obtain a rigorous, exact and unified solution of the steady degree distribution of the evolving network.

关键词： Evolving network Markov chain scale-free network degree distribution

Determining role of heterogeneous microstructure in lowering yield ratio and enhancing impact toughness in high-strength low-alloy steel

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 816-825页

作者： Yi-shuang Yu Bin Hu Min-liang Gao Zhen-jia Xie Xue-quan rong Gang Han Hui Guo Cheng-jia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Institute of Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan 114021China

Here we present a novel approach of intercritical heat treatment for microstructure tailoring,in which intercritical annealing is introduced between conventional quenching and *** induced a heterogeneous microstructure consisting of soft intercritical ferrite and hard tempered martensite,resulting in a low yield ratio(YR)and high impact toughness in a high-strength low-alloy *** initial yielding and subsequent work hardening behavior of the steel during tensile deformation were modified by the presence of soft intercritical ferrite after intercritical annealing,in comparison to the steel with full martensitic *** increase in YR was related to the reduction in hardness difference between the soft and hard phases due to the precipitation of nano-carbides and the recovery of dislocations during *** excellent low-temperature toughness was ascribed not only to the decrease in probability of microcrack initiation for the reduction of hardness difference between two phases,but also to the increase in resistance of microcrack propagation caused by the high density of high angle grain boundaries.

关键词： heterogeneous microstructure yield ratio impact toughness intercritical heat treatment high-strength low-alloy steel

Nominalization and Its Implications on the Teaching of Writing

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海外英语 2013年第20期 109-110页

作者： CHEN rong-quan College of Foreign Languages Shihezi University

TESL and TEFL vary in many aspects, including learning motivation, language environment, input and output of target language and target language teachers. It is significant for college English teachers to learn these differences in setting teaching objectives, finding effective ways of teaching, adapting proper teaching methods and reaching a preferable teaching result.

关键词： written discourse stylistic differences oral-style

EXISTENCE OF AUTHENTICATION CODES

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Systems Science and Mathematical Sciences 2000年第1期13卷 108-112页

作者： FENG rong quan (School of Mathematical Sciences, Peking University, Beijing 100871, China) 北京大学数学科学院北京 100871

***,e,andMbethreenon--emptysetsandletf:Sxe--+Mbeamap;thefourtuple(S,E,M;f)iscalledanauthenticationcoded],if1)Themapf:Sxe-Missurjectiveand2)ForanymEMandeEE,ifthereisansESsatisfyingf(s,e)=m,thensuchansisuniquelydetermin... 详细信息

关键词： Authentication code Cartesian authentication code optimal existence.

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哈剌和林城始建年代考

内蒙古社会科学 2022年第1期43卷 91-97页

作者：全荣内蒙古师范大学民族学人类学学院内蒙古呼和浩特010022 内蒙古社会科学院历史研究所内蒙古呼和浩特010010

哈剌和林古城遗址位于今蒙古国境内,是著名的世界文化遗产。囿于史料阙载,学界对于哈剌和林城的名称及始建年代众说纷纭。“和林”一词系突厥语,意为“小石块、流砂”,“哈剌和林”释作“黑石、黑岩石”等较为恰当。依据《敕赐兴元阁碑... 详细信息

哈剌和林古城遗址位于今蒙古国境内,是著名的世界文化遗产。囿于史料阙载,学界对于哈剌和林城的名称及始建年代众说纷纭。“和林”一词系突厥语,意为“小石块、流砂”,“哈剌和林”释作“黑石、黑岩石”等较为恰当。依据《敕赐兴元阁碑》以及其他相关的诸种文字史料记载,哈剌和林城始建年代应早于1220年,而不是1235年。

关键词：哈剌和林古城名称释义始建年代

阿旺罗桑却丹生平叙补——以《SUBUD ERIKE》为基础史料

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内蒙古社会科学 2016年第4期37卷 79-83页

作者：全荣内蒙古社会科学院历史研究所内蒙古呼和浩特010010

二世章嘉活佛阿旺罗桑却丹不仅是一位佛教高僧,更是一位学识渊博的爱国学者。清代前期,他作为一个宗教领袖参与政治活动,推动了我国多民族国家的统一和巩固,促进了各民族之间的友好交流和沟通,对此我们应该给予充分肯定。

关键词：二世章嘉活佛阿旺罗桑却丹生平事迹

Original article：A novel two-stage complete repair method for pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries

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Chinese Medical Journal 2010年第3期 259-264页

作者： MEI Ju DING Fang-bao ZHU Jia-quan BAO Chun-rong XIE Xiao ZHANG Yun-jiao Department of Cardiothoracic Surgery Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China

Background Pulmonary atresia with ventricular septal defect （PA-VSD） and major aortopulmonary collateral arteries （MAPCAs） remains a challenging complex congenital heart disease nowadays. In the present study, we aimed to develop a two-stage surgical method and to evaluate outcomes of this method in managing PA-VSD and MAPCAs. Methods Between December 2003 and December 2008, 7 female and 4 male patients between the age of 5 and 10 years who were suffering from PA-VSD and MAPCAs were selected and recruited. The native pulmonary artery trunks were absent in all patients; the lungs were solely supplied by major aortopulmonary collaterals, and the numbers of supplied lung segments ranged from 15 to 20 （17.9±1.6）. There were a total of 43 MAPCAs in all the patients （3-5 （3.9~0.7） MAPCAs per patient）. The accumulated Nakata index was （222.9＋_29.9） mm2/m2 （ranged from 182 to 272）. All the patients underwent two sequential operations. Stage one included left major aortopulmonary collateral unifocalization and modified Blalock-Taussig shunt from left posterior lateral thoracotomy; stage two comprised right unifocalization, ligation of the shunt, followed by ventricular septal defect closure and right ventricular outflow tract reconstruction assisted with cardiopulmonary bypass from midline sternotomy. Results All the patients survived the initial surgery, but one of them died of low cardiac output syndrome on the third day after the second operation. Postoperative complications included pneumonia in one case and capillary leak syndrome in another. Postoperative oxygen saturation maintained about 95%-100%, which was significantly higher than pre-operation （P 〈0.01）. During the follow-up period of 3-51 （25.4±15.2） months, there were no late death and no need for reintervention. All the patients enjoyed their lives with good conditions. Conclusions This two-stage complete repair strategy was well-tolerated and effective with good outcome, thus offering an alternative surgical a

关键词： pulmonary atresia major aortopulmonary collateral arteries unifocalization surgery congenital heart disease

Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 76-93页

作者： Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng rong-quan He Bang-Teng Chi Lei Wang Qian Lin Qin-Yan Su Yi-Wu Dang Gang Chen Jia-Liang Wei Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of Surgery Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant ***,there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma(HCC).AIM To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC *** This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues,along with immunohistochemical scores from 383 HCC and adjacent tissues,to assess PSMD6 overexpression in *** regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell *** enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in *** sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC *** The results of 41 external and two internal datasets showed that PSMD6 mRNA(SMD=0.26,95%CI:0.09-0.42,P<0.05)and protein(SMD=2.85,95%CI:1.19-4.50,P<0.05)were significantly overexpressed in HCC *** integrated analysis results showed that PSMD6 had a significant overexpression pattern in HCC tissues(SMD=0.40,95%CI:0.15-0.66,P<0.05).PSMD6 knockout inhibited HCC cell growth(chronos scores<-1).Functional enrichment implicated ribosome biogenesis and RNA *** enrichment of signalling pathways such as RNA degradation,ribosomes,and chemical carcinogenesis—reactive oxygen *** sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323,sepantronium bromide,and *** PSMD6 effectively distinguished HCC tissues(AUC=0.75,95%CI:0.71-0.79).CONCLUSION This study was the first to discover that PSMD6 was overexpressed in HCC ***6 is essential for the growth of HCC cell

关键词： Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing