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Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 76-93页

作者： Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng rong-quan He Bang-Teng Chi Lei Wang Qian Lin Qin-Yan Su Yi-Wu Dang Gang Chen Jia-Liang Wei Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of Surgery Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant ***,there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma(HCC).AIM To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC *** This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues,along with immunohistochemical scores from 383 HCC and adjacent tissues,to assess PSMD6 overexpression in *** regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell *** enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in *** sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC *** The results of 41 external and two internal datasets showed that PSMD6 mRNA(SMD=0.26,95%CI:0.09-0.42,P<0.05)and protein(SMD=2.85,95%CI:1.19-4.50,P<0.05)were significantly overexpressed in HCC *** integrated analysis results showed that PSMD6 had a significant overexpression pattern in HCC tissues(SMD=0.40,95%CI:0.15-0.66,P<0.05).PSMD6 knockout inhibited HCC cell growth(chronos scores<-1).Functional enrichment implicated ribosome biogenesis and RNA *** enrichment of signalling pathways such as RNA degradation,ribosomes,and chemical carcinogenesis—reactive oxygen *** sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323,sepantronium bromide,and *** PSMD6 effectively distinguished HCC tissues(AUC=0.75,95%CI:0.71-0.79).CONCLUSION This study was the first to discover that PSMD6 was overexpressed in HCC ***6 is essential for the growth of HCC cell

关键词： Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing

Circulant Double Coverings of a Circulant Graph of Valency Five

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Acta Mathematica Sinica,English Series 2007年第1期23卷 23-28页

作者： rong quan FENG Jin Ho KWAK LMAM School of Mathematical Sciences Peking University Beijing 100871 P. R. China Mathematics Pohang University of Science and Technology Pohang 790-784 Korea

Enumerating the isomorphism classes of several types of graph covering projections is one of the central research topics in enumerative topological graph theory. A covering of G is called circulant if its covering graph is circulant. Recently, the authors [Discrete Math., 277, 73-85 （2004）1 enumerated the isomorphism classes of circulant double coverings of a certain type, called a typical covering, and showed that no double covering of a circulant graph of valency three is circulant. Also, in [Graphs and Combinatorics, 21,386 400 （2005）], the isomorphism classes of circulant double coverings of a circulant graph of valency four are enumerated. In this paper, the isomorphism classes of circulant double coverings of a circulant graph of valency five are enumerated.

关键词： graph covering voltage assignment Cayley circulant graph

Risk preferences and the low-carbon agricultural technology adoption:Evidence from rice production in China

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Journal of Integrative Agriculture 2023年第8期22卷 2577-2590页

作者： MAO Hui quan Yu-rong FU Yong Northwest Institute of Historical Environment and Socio-Economic Development Shaanxi Normal UniversityXi'an 710119P.R.China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095P.R.China

Climate change which is mainly caused by carbon emissions is a global problem affecting the economic development and well-being of human ***-carbon agriculture is of particular significance in slowing down global warming and reaching the goal of“carbon peak and carbon neutrality”.Therefore,taking straw incorporation as an example,this paper aims to investigate the impact of risk preferences on farmers’low-carbon agricultural technology(LCAT)*** on a two-phase micro-survey data of 1038 rice farmers in Jiangsu,Jiangxi,and Hunan provinces,this paper uses experimental economics methods to measure farmers’risk aversion and loss aversion to obtain the real risk preferences information of the *** also explore the data to examine the actual LCAT adoption behavior of *** results revealed that both risk aversion and loss aversion significantly inhibit farmers’LCAT adoption:more risk-averse or more loss-averse farmers are less likely to adopt *** is further found that crop insurance,farm scale and governmental regulations can alleviate the negative impact of risk aversion and loss aversion on farmers’LCAT ***,we propose that local governments need to promote low-carbon agricultural development by propagating the benefits of LCAT,extending crop insurance,promoting appropriate scale operations,and strengthening governmental regulations to promote farmers’LCAT adoption.

关键词： risk preferences crop insurance farm scale governmental regulations low-carbon agricultural technology

Typical Frobenius Coverings

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2209-2214页

作者： Yan WANG rong quan FENG Jaeun LEE Department of Mathematics Yah Tai University Yah Tai 264005 P. R. China LMAM School of Mathematical Sciences Peking University Beijing 100871 P. R. China Department of Mathematics Yeungnam University Kyongsan 712-749 Korea

A covering p from a Cayley graph Cay（G, X） onto another Cay（H, Y） is called typical Frobenius if G is a Frobenius group with H as a Frobenius complement and the map p ： G →H is a group epimorphism. In this paper, we emphasize on the typical Frobenius coverings of Cay（H, Y）. We show that any typical Frobenius covering Cay（G, X） of Cay（H, Y） can be derived from an epimorphism /from G to H which is determined by an automorphism f of H. If Cay（G, X1） and Cay（G, X2） are two isomorphic typical Frobenius coverings under a graph isomorphism Ф, some properties satisfied by Фare given.

关键词： Frobenius group typical Frobenius covering isomorphic

NUMERICAL RESEARCHES ON INTERACTION BETWEEN PROPELLERS IN UNIFORM FLOW

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Journal of Hydrodynamics 2012年第5期24卷 675-683页

作者： FENG Xue-mei LU Chuan-jing WUQiong CAI rong-quan School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240China Marine Design and Research Institute of China Shanghai 200011 China

Numerical simulations of the flow around two bidirectional staggered propellers are conducted in uniform flow. The computed open water performance of the fore-propeller is compared with the corresponding experimental results, and the influence of the fore-propeller on the aft one is carefully investigated. It is found that the inflow around the aft propeller close to the side of the fore is especially affected by the fore one, leading to abnormal circumferential distribution of force on the blade in the shade region. For either forces or velocity distributions, the abnormal changes behave contrarily for cases with the rotating speed larger or smaller than the idle. Moreover, the more the rotating speed of the fore differs from the idle, the larger the abnormal values become.

关键词： numerical simulation interaction propellers open water performance

Constructions of 11/2-designs from Symplectic Geometry over Finite Fields

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Acta Mathematica Sinica,English Series 2015年第9期31卷 1367-1378页

作者： Zhao CHAI rong quan FENG Li Wei ZENG LMAM School of Mathematical Sciences Peking University

In this paper, we construct some 1 1/2-designs, which are also known as partial geometric designs, using totally isotropic subspaces of the symplectic space and generalized symplectic graphs. Furthermore, these 1^-des... 详细信息

关键词： 1 1/2-design totally isotropic subspace generalized symplectic graph directed strongly reg-ular graph

Hydrodynamic Performance of An Integrated System of Breakwater and A Multi-Chamber OWC Wave Energy Converter

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China Ocean Engineering 2024年第4期38卷 543-556页

作者： NING De-zhi ZHANG Xiang-yu WANG rong-quan ZHAO Ming State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Dalian Key Laboratory of Offshore Renewable Energy Dalian University of TechnologyDalian 116024China School of Computing Engineering and MathematicsUniversity of Western SydneyPenrith NSW 2751Australia

A multi-chamber oscillating water column wave energy converter(OWC-WEC)integrated to a breakwater is *** hydrodynamic characteristics of the device are analyzed using an analytical model based on the linear potential flow theory.A pneumatic model is employed to investigate the relationship between the air mass flux in the chamber and the turbine *** effects of chamber width,wall draft and wall thickness on the hydrodynamic performance of a dual-chamber OWC-WEC are *** results demonstrate that the device,with a smaller front wall draft and a wider rear chamber exhibits a broader effective frequency *** device with a chamber-width-ratio of 1:3 performs better in terms of power ***,results from the analysis of a triplechamber OWC-WEC demonstrate that reducing the front chamber width and increasing the rearward chamber width can improve the total performance of the *** the number of chambers from 1 to 2 or 3 can widen the effective frequency bandwidth.

关键词： oscillating water column power extraction efficiency potential flow theory wave energy converter multi-chamber

The wave absorption efficiency of multi-layer vertical perforated thin plates

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Journal of Hydrodynamics 2018年第5期30卷 898-907页

作者： Bao-lei Geng rong-quan Wang De-zhi Ning National Engineering Laboratory for Port Hydraulic Construction Technology Tianjin Research Institute for Water Transportation EngineeringTianjin 300456China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

This paper analyzes the wave absorption efficiency of multi-layer perforated plates in an ideal fluid, based on the linear potential flow theory. The influence of the thickness, the porosity and the layout form of the plates on the wave absorptivity is studied on the assumption that all perforated plates are composed of the same materials and have the same thickness and porosity. The calculation results indicate that the larger the number of layers of the perforated plate set, the better the wave absorption efficiency, however, when the layer number exceeds a certain value, the efficiency of the plates is not significantly increased. For the case of porosity ？= 0.2, thickness b= 0.07 m and 4 layers of perforated plates with a distance l= 1.0 m between the layers, 90% of the energy of the wave within the incident wave period between 1.6 s and 4.4 s can be absorbed.

关键词： Wave absorptivity multi-layer vertical plate porous structure analytic method

Dysprosium Modification of Cobalt Ferrite Ionic Magnetic Fluids

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Journal of China University of Mining and Technology 2005年第4期15卷 354-356页

作者： JIANG rong-li LIU Yong-chao GENG quan-rong ZHAO Wen-tao School of Chemical Engineering and Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Dysprosium composite cobalt ferrite ionic magnetic fluids were prepared by precipitation in the presence of Tri-sodium citrate. Influence of dysprosium modification on magnetic property is studied. The result shows that magnetic response toward exterior magnetic field can be improved by adding Dy3+. Studies also show that the increase of reaction temperature may improve the modification effect of dysprosium. By adding dysprosium ions, the average diameter of the magnetic nanoparticles will be decreased evidently. It is clear that the particles appear as balls. Cobalt ferrite with sizes of 12-15 nm, rare earth composite cobalt ferrite with sizes of 6-8 nm.

关键词： cobalt ferrite magnetic fluids dysprosium modification mechanism magnetic property