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Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma

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World Journal of Clinical Oncology 2024年第1期15卷 62-88页

作者： Jie-Zhuang Huang Jian-Di Li Gang Chen rong-quan He Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Transcatheter arterial embolisation(TACE)is the primary treatment for intermediate-stage hepatocellular carcinoma(HCC)patients while some HCC cases have shown resistance to TACE.AIM To investigate the key genes and potential mechanisms correlated with TACE refractoriness in HCC.METHODS The microarray datasets of TACE-treated HCC tissues,HCC and non-HCC tissues were collected by searching multiple public databases.The respective differentially expressed genes(DEGs)were attained via limma R package.Weighted gene co-expression network analysis was employed for identifying the significant modules related to TACE non-response.TACE refractoriness-related genes were obtained by intersecting up-regulated TACE-associated and HCC-associated DEGs together with the genes in significant modules related to TACE nonresponse.The key genes expression in the above two pairs of samples was compared respectively via Wilcoxon tests and standard mean differences model.The prognostic value of the key genes was evaluated by Kaplan-Meier curve.Multivariate analysis was utilised to investigate the independent prognostic factor in key genes.Single-cell RNA(scRNA)sequencing analysis was conducted to explore the cell types in HCC.TACE refractoriness-related genes activity was calculated via AUCell packages.The CellChat R package was used for the investigation of the cell–cell communication between the identified cell types.RESULTS HCC tissues of TACE non-responders(n=66)and TACE responders(n=81),HCC(n=3941)and non-HCC(n=3443)tissues were obtained.The five key genes,DLG associated protein 5(DLGAP5),Kinesin family member 20A(KIF20A),Assembly factor for spindle microtubules(ASPM),Kinesin family member 11(KIF11)and TPX2 microtubule nucleation factor(TPX2)in TACE refractoriness-related genes,were identified.The five key genes were all up-regulated in the TACE non-responders group and the HCC group.High expression of the five key genes predicted poor prognosis in HCC.Among the key genes,TPX2 was an independent prognostic factor.Four cel

关键词： Hepatocellular carcinoma Transcatheter arterial embolisation refractoriness Weighted gene co-expression network analysis Single-cell RNA sequencing AUCell CellChat

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Explosion of research on psychopathology and social media use after COVID-19:A scientometric study

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World Journal of Psychiatry 2024年第5期14卷 742-759页

作者： Meng-Di Zhang rong-quan He Jia-Yuan Luo Wan-Ying Huang Jing-Yu Wei Jian Dai Hong Huang Zhen Yang Jin-Liang Kong Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Psychology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Division of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Despite advances in research on psychopathology and social media use,no comprehensive review has examined published papers on this type of research and considered how it was affected by the coronavirus disease 2019(COVID-19)outbreak.AIM To explore the status of research on psychopathology and social media use before and after the COVID-19 outbreak.METHODS We used Bibliometrix(an R software package)to conduct a scientometric analysis of 4588 relevant studies drawn from the Web of Science Core Collection,PubMed,and Scopus databases.RESULTS Such research output was scarce before COVID-19,but exploded after the pandemic with the publication of a number of high-impact articles.Key authors and institutions,located primarily in developed countries,maintained their core positions,largely uninfluenced by COVID-19;however,research production and collaboration in developing countries increased significantly after COVID-19.Through the analysis of keywords,we identified commonly used methods in this field,together with specific populations,psychopathological conditions,and clinical treatments.Researchers have devoted increasing attention to gender differences in psychopathological states and linked COVID-19 strongly to depression,with depression detection becoming a new trend.Developments in research on psychopathology and social media use are unbalanced and uncoordinated across countries/regions,and more indepth clinical studies should be conducted in the future.CONCLUSION After COVID-19,there was an increased level of concern about mental health issues and a changing emphasis on social media use and the impact of public health emergencies.

关键词： Psychopathology Social media Bibliometrics Web of Science PubMed Scopus

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《莲华净土实胜寺碑》初探

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内蒙古社会科学（蒙文版） 2024年第1期44卷 31-37页

作者：全荣不详

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《敕修奴儿干永宁寺碑记》考释

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中国蒙古学（蒙文） 2024年第1期 131-140页

作者：全荣不详

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TM9SF1 promotes bladder cancer cell growth and infiltration

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World Journal of Clinical Oncology 2024年第2期15卷 302-316页

作者： Long Wei Shi-Shuo Wang Zhi-Guang Huang rong-quan He Jia-Yuan Luo Bin Li Ji-Wen Cheng Kun-Jun Wu Yu-Hong Zhou Shi Liu Sheng-Hua Li Gang Chen Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Bladder cancer(BC)is the most common urological tumor.It has a high recur-rence rate,displays tutor heterogeneity,and resists chemotherapy.Furthermore,the long-term survival rate of BC patients has remained unchanged for decades,which seriously affects the quality of patient survival.To improve the survival rate and prognosis of BC patients,it is necessary to explore the molecular mechanisms of BC development and progression and identify targets for treatment and intervention.Transmembrane 9 superfamily member 1(TM9SF1),also known as MP70 and HMP70,is a member of a family of nine transmembrane superfamily proteins,which was first identified in 1997.TM9SF1 can be expressed in BC,but its biological function and mechanism in BC are not clear.AIM To investigate the biological function and mechanism of TM9SF1 in BC.Overexpression of TM9SF1 increased the in vitro proliferation,migration,and invasion of BC cells by promoting the entry of BC cells into the G2/M phase.Silencing of TM9SF1 inhibited in vitro proliferation,migration,and invasion of BC cells and blocked BC cells in the G1 phase.CONCLUSION TM9SF1 may be an oncogene in BC.

关键词： TM9SF1 Bladder cancer Biological function Cell function assay Oncogene

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机械自动化技术在汽车制造中运用概述

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时代汽车 2024年第1期 138-140页

作者：权荣兰州城市学院甘肃省兰州市730070

在汽车制造行业中应用机械自动化技术,不但能够提升产品质量与生产效率,缩短生产周期和降低人力成本,增强企业竞争力,还能够降低人为因素对产品质量的影响,提升产品的一致性与稳定性。但是,在应用中也会带来一定的问题,例如环境污染问题... 详细信息

在汽车制造行业中应用机械自动化技术,不但能够提升产品质量与生产效率,缩短生产周期和降低人力成本,增强企业竞争力,还能够降低人为因素对产品质量的影响,提升产品的一致性与稳定性。但是,在应用中也会带来一定的问题,例如环境污染问题,所以,需要们在实际应用中,不断进行技术创新和分析,制定科学的技术方案。

关键词：机械自动化技术汽车制造运用分析

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补充营养和微量元素对烟蚜茧蜂寄生能力及生长发育相关酶的影响

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昆虫学报 2024年第2期67卷 203-212页

作者：赖荣泉韩梦顾钢周挺张榜赖宇飞杨晨福建农林大学植物保护学院生物防治研究所闽台作物有害生物生态防控国家重点实验室福州350002 中国烟草总公司福建省公司福州350003 山东农业大学植物保护学院泰安271018

【目的】烟蚜茧蜂Aphidius gifuensis作为烟蚜Myzus persicae的一种优势寄生蜂,被广泛用于生产,但在烟蚜茧蜂大规模扩繁的过程中,饲养多代后常常会出现寄生能力下降、体型变小等问题。本研究旨在通过测定分析补充不同浓度营养成分和微... 详细信息

【目的】烟蚜茧蜂Aphidius gifuensis作为烟蚜Myzus persicae的一种优势寄生蜂,被广泛用于生产,但在烟蚜茧蜂大规模扩繁的过程中,饲养多代后常常会出现寄生能力下降、体型变小等问题。本研究旨在通过测定分析补充不同浓度营养成分和微量元素对退化烟蚜茧蜂成蜂寄生烟蚜时的寄生率、子代成蜂体型和子代成蜂中生长发育相关酶(酚氧化酶和羧酸酯酶)含量与活性的影响,筛选出复壮效果最好的复壮方式。【方法】室内挑选饲养至10代后出现明显种群退化的烟蚜茧蜂成蜂饲喂不同浓度(5%, 10%和20%)营养成分(蜂蜜、葡萄糖和蔗糖)及不同浓度(0.25, 0.5, 1, 2和4 mg/L)的微量元素(Cu, Fe, Zn, Mn和Co)溶液,测定寄生率、子代成蜂体型及子代成蜂羧酸酯酶和酚氧化酶的含量和活性。【结果】在补充营养试验中,10%蜂蜜溶液对烟蚜茧蜂的复壮效果最好,使寄生率比对照组(纯净水)提高了28.00%,但对烟蚜茧蜂子代成蜂体型的影响不显著;饲喂10%葡萄糖组烟蚜茧蜂子代成蜂羧酸酯酶含量最高,比对照组提高了38.00%;饲喂10%蔗糖组烟蚜茧蜂子代成蜂羧酸酯酶活性最高,是对照组的3倍;饲喂10%蔗糖组烟蚜茧蜂子代成蜂酚氧化酶含量最高,比对照组提高了56.00%;饲喂10%葡萄糖组烟蚜茧蜂子代成蜂酚氧化酶活性最高,是对照组的1.3倍。补充微量元素试验中,补充1 mg/L Fe对烟蚜茧蜂的复壮效果最好,使寄生率比对照组提高了25.33%,但对其子代成蜂体型的影响不显著;烟蚜茧蜂子代成蜂羧酸酯酶含量也最高,比对照组提高了50.00%。各微量元素饲喂组烟蚜茧蜂子代成蜂羧酸酯酶的活性均低于对照组;饲喂1 mg/L Zn组烟蚜茧蜂子代成蜂酚氧化酶含量最高,和对照组相比提高了29.31%;饲喂1 mg/L Mn组子代成蜂酚氧化酶活性最高,是对照组的1.51倍。【结论】生产上可对退化的烟蚜茧蜂种群补充饲喂10%蜂蜜水或补充1 mg/L Fe来提高烟蚜茧蜂对烟蚜的寄生能力,达到复壮烟蚜茧蜂种群的目的。

关键词：烟蚜茧蜂烟蚜寄生能力羧酸酯酶酚氧化酶

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基于模糊层次分析法的尾矿库风险评价

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地质灾害与环境保护 2024年第1期35卷 109-116页

作者：权国荣孙军刚中国地质调查局西安矿产资源调查中心西安710100 长安大学地球科学与资源学院西安710054

尾矿库是矿山生产的重要设施,是矿企修建的环保工程,但其重力势能较高,具有溃坝风险,且尾矿砂含有害元素,对环境存在较大威胁,建立尾矿库风险评价体系迫在眉睫[1-3]。本研究以全国重点地区生态调查为背景,以河南省洛钼集团某尾矿库为例... 详细信息

尾矿库是矿山生产的重要设施,是矿企修建的环保工程,但其重力势能较高,具有溃坝风险,且尾矿砂含有害元素,对环境存在较大威胁,建立尾矿库风险评价体系迫在眉睫[1-3]。本研究以全国重点地区生态调查为背景,以河南省洛钼集团某尾矿库为例,经野外调研结合高分二号(GF-2)遥感影像,建立了库属性、库环境、地质背景、日常管理4层次16指标的尾矿库风险评价模型。运用模糊层次分析法,对不同层次进行权重比较构造判断矩阵,归一化各指标权重,并对指标因子的独立性进行一致性检验。将尾矿库风险划分为4种等级并计算其得分区间,求得各区间的隶属度情况,根据最大隶属度原则,得到各指标的归一化评价矩阵。根据归一化评价结果计算出该尾矿库最终得分为75.380,其风险评价为低风险。

关键词：尾矿库模糊层次分析法风险评价 FAHP

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Risk preferences and the low-carbon agricultural technology adoption:Evidence from rice production in China

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Journal of Integrative Agriculture 2023年第8期22卷 2577-2590页

作者： MAO Hui quan Yu-rong FU Yong Northwest Institute of Historical Environment and Socio-Economic Development Shaanxi Normal UniversityXi'an 710119P.R.China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095P.R.China

Climate change which is mainly caused by carbon emissions is a global problem affecting the economic development and well-being of human society.Low-carbon agriculture is of particular significance in slowing down global warming and reaching the goal of“carbon peak and carbon neutrality”.Therefore,taking straw incorporation as an example,this paper aims to investigate the impact of risk preferences on farmers’low-carbon agricultural technology(LCAT)adoption.Based on a two-phase micro-survey data of 1038 rice farmers in Jiangsu,Jiangxi,and Hunan provinces,this paper uses experimental economics methods to measure farmers’risk aversion and loss aversion to obtain the real risk preferences information of the farmers.We also explore the data to examine the actual LCAT adoption behavior of farmers.The results revealed that both risk aversion and loss aversion significantly inhibit farmers’LCAT adoption:more risk-averse or more loss-averse farmers are less likely to adopt LCAT.It is further found that crop insurance,farm scale and governmental regulations can alleviate the negative impact of risk aversion and loss aversion on farmers’LCAT adoption.Therefore,we propose that local governments need to promote low-carbon agricultural development by propagating the benefits of LCAT,extending crop insurance,promoting appropriate scale operations,and strengthening governmental regulations to promote farmers’LCAT adoption.

关键词： risk preferences crop insurance farm scale governmental regulations low-carbon agricultural technology

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肇庆市中心城区暴雨强度公式研究及应用

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广东气象 2024年第2期46卷 6-10页

作者：陈荣泉张聪慧肇庆市气象局广东肇庆526040 广东省肇庆学院广东肇庆526040

采用年最大值法挑选肇庆市中心城区降水样本,并尝试用皮尔逊Ⅲ型、耿贝尔型、指数分布型3种概率分布函数进行拟合试验,结果表明:皮尔逊Ⅲ型和耿贝尔型通过KS检验;耿贝尔型暴雨强度的精度误差较皮尔逊Ⅲ型为优,最终获得耿贝尔型暴雨强度... 详细信息

采用年最大值法挑选肇庆市中心城区降水样本,并尝试用皮尔逊Ⅲ型、耿贝尔型、指数分布型3种概率分布函数进行拟合试验,结果表明:皮尔逊Ⅲ型和耿贝尔型通过KS检验;耿贝尔型暴雨强度的精度误差较皮尔逊Ⅲ型为优,最终获得耿贝尔型暴雨强度公式。根据公式计算单一重现期暴雨强度发现,1h降水量达50mm的重现期为2年以内,即每年都会发生;24h降水量达暴雨量级的重现期为2年以内,即每年都会发生;特大暴雨量级的降水的重现期为50年以上。在面对超百年一遇的极端降雨时,需要完善应急管理措施;在预测有强降雨过程来临时,及时做好城市排水管道、调蓄池、行泄通道的调度。

关键词：气候学暴雨强度概率分布曲线重现期肇庆市

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