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Synthesis,Spectra,X-ray Diffraction and Thermal Studies of New Zn(Ⅱ) Compounds Based on Dibenzoylmethane

Chinese Journal of Structural Chemistry 2016年第10期35卷 1582-1592页

作者： FARZIN Marandi NASTARAN Shahinpour quah ching kheng HOONG KUN Fun Department of Chemistry Payame Noor University X-ray Crystallography Unit School of PhysicsUniversity Sains Malaysia

Two new zinc（Ⅱ） compounds with dibenzoylmethane and N-donor ancillary ligands,[Zn（μ-pyz）（dbm）_2]_n（1） and [Zn（dbm）_2（μ-bpe）Zn（dbm）_2]（2）（Hdbm = dibenzoylmethane,pyz = pyrazine and bpe = 1,2-bis（4-pyridyl）ethane）,have been prepared and characterized using elemental analysis,IR,~1H NMR and 13 C NMR spectroscopy,and studied by thermal gravimetric analysis as well as single-crystal X-ray diffraction. The crystal and molecular structures of 1 and 2 have been solved by X-ray diffraction and they turned out to be a one-dimensional coordination polymer with linear dispositions of metal atoms and binuclear compound,respectively. These one-dimensional polymers are further connected to form a 3D supramolecular network by C–H···O（only in 2） and π-π interactions.

关键词： dibenzoylmethane 1 2-bis(4-pyridyl)ethane pyrazine zinc(Ⅱ)

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Synthesis, Spectral Characterization and Crystal Structure of 2-((3-Aminophenyl)(phenyl)methylene) hydrazinecarboxamide

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Journal of Crystallization Process and Technology 2013年第2期3卷 64-68页

作者： Yi-Chen Chan Abdussalam Salhin Mohamed Ali Melati Khairuddean ching-kheng quah School of Chemical Sciences Universiti Sains Malaysia Penang Malaysia X-ray Crystallography Unit School of Physics Universiti Sains Malaysia Penang Malaysia

A benzophenone substituted semicarbazone, 2-((3-aminophenyl)(phenyl)methylene)hydrazinecarboxamide (APHC) had been synthesized in good yield by the condensation of 3-aminobenzophenone and semicarbazide hydrochloride. The title compound was elucidated by elemental analysis (CHN), FTIR, 1H and 13C-NMR, 1H-1H COSY, TGA and single crystal X-ray diffraction. The compound crystallized in the orthorhombic crystal system with space group of Pccn, Z = 32, V = 10375.1 (2) ?3, and lattice constants a = 12.3855 (1) ?, b = 34.5746 (5) ?, c = 24.2283 (3) ??and γ = β = α = 90°. The molecular view shows that APHC contains four molecules of each species in the asymmetric unit, with similar geometries. However, there is no intramolecular hydrogen bond found in the crystal structure of the synthesized compound. X-ray diffraction also reveals that the molecule of the semicarbazone exists as a Z isomer with respect to the C=N.

关键词： Semicarbazone Aminobenzophenone Benzophenone Hydrazone

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NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B

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World Journal of Stem Cells 2018年第4期10卷 34-42页

作者： Jianbiao Zhou Jing-Yuan Chooi Ying Qing ching Jessie Yiying quah Sabrina Hui-Min Toh Yvonne Ng Tuan Zea Tan Wee-Joo Chng Cancer Science Institute of Singapore National University of Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of Singapore Department of Hematology-Oncology National University Cancer Institute

AIM To examine whether nuclear factor kappa B(NF-κB) activity regulates LIN28 B expression and their roles in leukemia stem cell(LSC)-like properties. METHODS We used pharmacological inhibitor and cell viability assays to examine the relation between NF-κB and LIN28 B. Western blot and q RT-PCR was employed to determine their protein and m RNA levels. Luciferase reporter was constructed and applied to explore the transcriptional regulation of LIN28 B. We manipulated LIN28 B level in acute myeloid leukemia(AML) cells and investigated LSC-like properties with colony forming and serial replating assays. RESULTS This study revealed the relationship between NF-κB and LIN28 B in AML cells through drug inhibition and overexpression experiments. Notably,inhibition of NF-κB by pharmacological inhibitors reduced LIN28 B expression and decreased cell proliferation. We demonstrated that NF-κB binds to the-819 to-811 region of LIN28 B promoter,and transcriptionally regulates LIN28 B expression. LIN28 B protein was significantly elevated in NFκB1 transfected cells compared to vector control. Importantly,ectopic expression of LIN28 B partially rescued the self-renewal capacity impaired by pharmacological inhibition of NF-κB activity. CONCLUSION These results uncover a regulatory signaling,NF-κB/LIN28 B,which plays a pivotal role in leukemia stem cell-like properties and it could serve as a promising intervening target for effective treatment of AML disease.

关键词： Nuclear factor kappa B LIN28B Leukemia stem cell Acute myeloid leukemia

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