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A genetic variant study of bortezomib-induced peripheral neuropathy in Chinese multiple myeloma patients

Oncology Research 2024年第5期32卷 955-963页

作者： YAN ZHANG HEYANG ZHANG JING WANG XIN WEI yi qu FENG XU LIJUN ZHANG Department of Hematology The First Affiliated Hospital of China Medical UniversityShenyang110001China

Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response varies among individuals.Genetic factor may play an important role in BIPN.Methods:A nextgeneration sequencing(NGS)panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy.mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR(RT-qPCR).Serum homocysteine(Hcy)levels were detected in 40 samples by chemiluminescent microparticle immunoassay(CMIA).Results:Compared with the non-BIPN group(n=89),a total of 8 significantly associated single nucleotide polymorphisms(SNPs)were identified in the BIPN group(n=115):MTHFR(rs1801131,rs1801133,rs17421511),EPHX1(rs1051740),MME(rs2016848),ALDH1A1(rs6151031),HTR7(rs1935349)and CYP2A6(rs8192720).The mRNA expression level of MTHFR in newly diagnosed patients with peripheral neuritis after treatment(NP group)was lower than that of newly diagnosed patients without peripheral neuritis after treatment(NnP group)(1.70±0.77 vs.2.81±0.97,p=0.009).Serum Hcy levels were significantly higher in BIPN group than in non-BIPN group(11.66±1.79μmol/L vs.8.52±3.29μmol/L,p=0.016)and healthy controls(11.66±1.79μmol/L vs.8.55±2.13μmol/L,p≤0.001).Conclusion:CYP2A6,EPHX1,MTHFR,ALDH1A1,HTR7,MME and BIPN are linked in Chinese MM patients.BIPN is more likely to occur in patients with lower MTHFR mRNA expression,which might result in higher serum Hcy levels.

关键词： Multiple Myeloma Peripheral neuropathy Bortezomib Bortezomib-induced peripheral neuropathy Next-generation sequencing MTHFR Serum Hcy

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基于边缘强化的无监督单目深度估计

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系统工程与电子技术 2024年第1期46卷 71-79页

作者：曲熠陈莹江南大学轻工过程先进控制教育部重点实验室江苏无锡214122

为解决无监督单目深度估计边缘深度估计不准确的问题,提出了一种基于边缘强化的无监督单目深度估计网络模型。该模型由单视图深度网络和姿态网络两部分构成,均采用编解码结构,其中单视图深度网络编码器使用高分辨率网络(high-resolution... 详细信息

为解决无监督单目深度估计边缘深度估计不准确的问题,提出了一种基于边缘强化的无监督单目深度估计网络模型。该模型由单视图深度网络和姿态网络两部分构成,均采用编解码结构,其中单视图深度网络编码器使用高分辨率网络(high-resolution net,HRNet)作为骨干网络,在整个过程中保持高分辨率表示,有利于提取精确空间特征;单视图深度网络解码器引入条状卷积,细化深度边缘附近的深度变化,同时利用经典的高斯拉普拉斯算子增强边缘细节,最终充分利用深度边缘信息提高深度估计质量。在KITTI数据集中进行的实验结果表明:所提模型具有较好的深度估计性能,能够使深度图中的目标边缘更加清晰,细节更加丰富。

关键词：单目深度估计无监督学习条状卷积边缘增强

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从“苦行”到“思惟”——“释迦思惟出山像”诸问题考

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南京艺术学院学报（美术与设计） 2024年第2期 141-148页

作者：曲艺南京艺术学院设计学院江苏南京210013

海内外博物馆藏有大量元及以后支单腿、双手相叠伏于支腿膝盖上,另一腿弯曲置于身前,人物呈低目凝思状的坐像。此类坐像刻画的是释迦牟尼经过六年苦行后思惟出山的阶段,可被命名为“释迦思惟出山像”。它是区别于传统佛教“思惟像”的... 详细信息

海内外博物馆藏有大量元及以后支单腿、双手相叠伏于支腿膝盖上,另一腿弯曲置于身前,人物呈低目凝思状的坐像。此类坐像刻画的是释迦牟尼经过六年苦行后思惟出山的阶段,可被命名为“释迦思惟出山像”。它是区别于传统佛教“思惟像”的中国化形式,受到禅宗观念的影响,也丰富了禅宗艺术的图像类型。

关键词：释迦思惟出山六年苦行禅宗艺术坐像

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高等职业技术教育机构类型分化:国际历史考察、趋势分析与实践启示

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黑龙江高教研究 2024年第6期42卷 133-140页

作者：曲艺辽宁大学辽宁沈阳110136

高等职业技术教育机构是现代高等教育体系的重要组成部分,是培养高层次技术技能人才的主要组织形式。对高等职业技术教育机构在高等教育体系中类型分化的国际历史进行考察,可见其作为行业法人团体、专门职业学校、应用技术院校与非大学... 详细信息

高等职业技术教育机构是现代高等教育体系的重要组成部分,是培养高层次技术技能人才的主要组织形式。对高等职业技术教育机构在高等教育体系中类型分化的国际历史进行考察,可见其作为行业法人团体、专门职业学校、应用技术院校与非大学高等教育机构的组织形式,并与普通学术教育机构共同发展的历程。在分化过程中,高等职业技术教育机构出现了教学活动专业化、职普制度协同化和科学研究融合化的趋势。基于国际历史考察与发展趋势分析,启示我国高等职业技术教育机构要进一步强化专业教师队伍建设,探索职普融通的制度体系,深化机构的研究职能。

关键词：高等教育职业技术教育机构分化

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Analyzing the potential mechanism of Buyang Huanwu decoction for the treatment of salt-sensitive hypertension based on network pharmacology and in vivo experiments

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Traditional Medicine Research 2024年第7期9卷 49-61页

作者： Jian-Bo Wang yi qu Ren-Jun Yu Guo-Rui Xu Ya-Nan Xue Jia-Hao Zhang Yong-Gang Ma Li-De Zhang Traditional Chinese Medicine Innovation Engineering Technology Center Liaoning University of Traditional Chinese MedicineShenyang 110847China. Key Laboratory of Visceral Image Theory and Application of Traditional Chinese Medicine Ministry of EducationShenyang 110847China. Center for Research and Evaluation of Higher Traditional Chinese Medicine Education Liaoning University of Traditional Chinese MedicineShenyang 110847China. Emergency Department Nanjing Lishui District Hospital of Traditional Chinese MedicineJiangsu 211200China. College of Acupuncture and Moxibustion Liaoning University of Traditional Chinese MedicineShenyang 110847China. Department of Rehabilitation the Second Affiliated Hospital of Liaoning University of Chinese MedicineShenyang 110034China. College of Integrated Chinese and Western Medicine Liaoning University of Traditional Chinese MedicineShenyang 110847China.

Background:Buyang Huanwu decoction(BHD)is a traditional Chinese medicine herbal formula used for treating hypertension,particularly in the later stages of hypertension when it is associated with intracerebral hemorrhage.This study aims to investigate the treatment mechanism of BHD to provide a basis for its clinical application in hypertension treatment.Methods:Network pharmacology analysis and cell culture experiments were performed to explore the potential proteins and mechanisms of action of BHD against hypertension.Bioactive compounds related to BHD were screened,and relevant targets associated with hypertension and BHD were retrieved.Molecular docking technology was used to identify the effective signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network cores.Lastly,the effects and mechanisms of BHD on salt-sensitive hypertensive endothelial cells were investigated.Results:Ninety-three potential therapeutic targets for BHD and salt-sensitive hypertension were found to be closely associated with the PI3K/Akt/eNOS signaling pathway and oxidative stress.Cell experiments further indicated the pivotal role of endothelial cells in hypertension,and validation analysis showed that BHD significantly preserved cell morphology,suppressed oxidative stress reactions,activated the PI3K/Akt/eNOS signaling pathways,preserved normal endothelial cell function,and reduced cell apoptosis.Conclusion:BHD effectively activates the PI3K/Akt/VEGF signaling pathway,attenuates oxidative stress-induced injury in endothelial cells exposed to high salt levels,and mitigates apoptosis,supporting the use of traditional Chinese medicine BHD in the treatment of salt-sensitive hypertension.

关键词： BHD salt-sensitive hypertension network pharmacology oxidative stress

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城镇化背景下土地利用转型的环境与经济效应耦合研究框架构建

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地理科学进展 2024年第4期43卷 799-809页

作者：曲艺龙花楼曹林森江苏师范大学地理测绘与城乡规划学院江苏徐州221116 广西大学公共管理学院南宁530004 中国科学院地理科学与资源研究所北京100101

城镇化是经济社会发展过程的必经阶段,当前快速的城镇化进程推进了土地利用转型,也由此引发了多种正面抑或负面的环境与经济效应。开展城镇化背景下土地利用转型的环境与经济效应耦合研究,旨在基于土地利用转型这一独特视角,分析土地利... 详细信息

城镇化是经济社会发展过程的必经阶段,当前快速的城镇化进程推进了土地利用转型,也由此引发了多种正面抑或负面的环境与经济效应。开展城镇化背景下土地利用转型的环境与经济效应耦合研究,旨在基于土地利用转型这一独特视角,分析土地利用转型与环境代价和经济产出间的交互作用规律,以探索通过管控土地利用转型实现区域环境保护与经济发展的可能途径。论文梳理了现有研究在土地利用转型及其环境效应、经济效应方面的重要进展,探索了多维空间中土地利用转型的概念,提出了转型效应耦合研究中“耦合”的含义及测度途径。从学科前沿看,土地利用转型环境与经济效应耦合研究,其本质是人文与自然过程的耦合研究,如何借助土地利用转型调控好这一过程,是新时期人地关系研究的重要内容,也是推进新型城镇化的重大战略研究主题。

关键词：土地利用转型环境效应耦合研究研究框架

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全民终身学习教育体系的制度比较——兼论中国体系的构想

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成人教育 2024年第7期44卷 78-85页

作者：曲艺罗燕辽宁大学高等教育研究所辽宁沈阳110136 清华大学教育研究院北京100084

终身学习理念及其教育实践在国际社会得到了广泛传播与接纳。我国也确立了构建全民终身学习教育体系的目标,但其制度路径仍有待厘清、制度实践尚需拓展和完善。基于新制度主义社会学分析框架,世界主要国家终身教育体系建构的制度比较与... 详细信息

终身学习理念及其教育实践在国际社会得到了广泛传播与接纳。我国也确立了构建全民终身学习教育体系的目标,但其制度路径仍有待厘清、制度实践尚需拓展和完善。基于新制度主义社会学分析框架,世界主要国家终身教育体系建构的制度比较与分析可提供一定借鉴。研究发现,各国终身学习教育体系的构建,均根植于其国家的价值传统,且生发于不同的制度领域。因此,我国构建服务全民的终身学习教育体系,可从我国的价值传统出发,在制度路径和运行机制方面展开制度设计。

关键词：全民终身学习教育体系制度比较制度构想

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Association between low ambient temperature during pregnancy and adverse birth outcomes: A systematic review and meta-analysis

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中华医学杂志(英文版) 2023年第19期136卷 2307-2315页

作者： Ruan Tiechao Yue Yan Lu Wenting Zhou Ruixi Xiong Tao Jiang yin ying Junjie Tang Jun Shi Jing Wang Hua Xiao Guoguang Li Jinhui qu yi Mu Dezhi Department of Pediatrics West China Second University Hospital Sichuan University Chengdu Sichuan China Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education Sichuan University Chengdu Sichuan China Department of General Practice West China Hospital Sichuan University Chengdu Sichuan China

Background: Extreme temperature events, including extreme cold, are becoming more frequent worldwide, which might be harmful to pregnant women and cause adverse birth outcomes. We aimed to investigate the association between exposure to low ambient temperature in pregnant women and adverse birth outcomes, such as preterm birth, low birth weight, and stillbirth, and to summarize the evidence herein.Methods: Relevant studies were searched in PubMed, Cochrane, and Embase electronic databases until November 2021. Studies involving low ambient temperature, preterm birth, birth weight, and stillbirth were included. The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses were followed to conduct this study risk of bias and methods for data synthesis.Results: A total of 34 studies were included. First, pregnant women exposed to low ambient temperature had an increased risk of preterm birth (risk ratio [RR] 1.08; 95% confidence interval [CI] 1.04–1.13). Subgroup analyses revealed that exposure during late pregnancy was more likely to induce preterm birth. In addition, only pregnant women exposed to <1st percentile of the mean temperature suffered increased risk of preterm birth. Moreover, pregnant women living in medium or hot areas were more prone to have preterm births than those in cold areas when exposed to low ambient temperatures. Asians and Blacks were more susceptible to low ambient temperatures than Caucasians. Second, pregnant women exposed to low ambient temperature had an increased risk of low birth weight (RR 1.07; 95% CI 1.03–1.12). Third, pregnant women had an increased risk of stillbirth while exposed to low ambient temperature during the entire pregnancy (RR 4.63; 95% CI 3.99–5.38).Conclusions: Exposure to low ambient temperature during pregnancy increases the risk of adverse birth outcomes. Pregnant women should avoid exposure to extremely low ambient temperature (<1st percentile of the mean temperature), especially in their late pregnancy. This study could provide clues

关键词： Ambient temperature Pregnancy Preterm birth Birth weight Stillbirth

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Y-branched TiO_2 nanotube arrays synthesized by anodic oxidation

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Science China(Physics,Mechanics & Astronomy) 2012年第1期55卷 14-18页

作者： YANG Xu qu yi FAN yi LIU XingYuan National Key Lab of High Power Semiconductor Lasers Changchun University of Science and Technology Changchun 130022 China Key Laboratory of Excited State Processes Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130033 China

We report a novel synthesis strategy for Y-branched TiO2 nanotubes on a pure titanium foil by electrochemical anodic oxidation in an NH4F organic electrolyte. Effects of temperature range, oxidation time, and morphology-dependent parameters of the Y-branched TiO2 nanotube arrays were investigated. We found that an optimized growth-temperature window between 20°C and 30°C resulted in Y-branched nanotubes with much better morphology and photoelectric performances. After annealing at 450°C for 1.5 h in air, a dominant crystal structure of these arrays was indexed to anatase.

关键词：纳米管阵列阳极氧化 TiO2 Y型制备碳纳米管有机电解液氧化作用

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Trachoma rapid assessment in Shandong province of China

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Chinese Medical Journal 2014年第14期127卷 2668-2671页

作者： qu yi Bi Hongsheng Wen ying Li Chaofeng Wu Hui Shandong Univ Tradit Chinese Med Jinan 250001 Shandong Peoples R China Shandong Univ Tradit Chinese Med Inst Eye Jinan 250001 Shandong Peoples R China

Background This research aims at identifying relative interventions on trachoma and testing the effectiveness of control measures adopted by assessing its prevalence and related risk factors in Shandong province of China. Methods Trachoma rapid assessment （TRA） was conducted in 6 sub-districts selected from Shandong province based on primary high risk assessment. Active trachoma in children aged 1-9 years and environmental risk factors of trachoma （unclean faces, absence of running water, and absence of flush toilets） were assessed （TRA 1）. Control measures were taken in endemic areas. A second TRA （TRA 2） was conducted after 12 months in the same 6 districts and findings of the two TRAs were compared. Results In TRA 1, we found trachoma in 3 sub-districts and the detection rate was 4% （95% CI： 0.39%-11.12%）, 6% （95% CI： 1.18%-14.17%）, and 6% （95% CI： 1.18%-14.17%） respectively. We could not find trachoma cases in TRA 2. Research data supports that children living with environmental risk factors face an increased risk to active trachoma. However, we could not find statistical evidence for this association, which may be caused by the limited data on prevalence. Conclusions This research indicates that the TRA methodology is easy to assess trachoma and its related risk factors. Based on the results of this study, we have already achieved the goal of ＂elimination of trachoma＂ in Shandong province, as the detection rate of trachomatous infiamation follicular/trachomatous inflammation intense in 1-9-year-old children was less than 5%. Chln Med J 2014;127（14）：2668-2671

关键词： trachoma prevalence trachoma rapid assessment

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