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Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2132-2142页

作者： Xinglong Han lina qu Miao Yu Lingqun Ye Liujia Shi Guangfu Ye Jingsi Yang Yaning Wang Hao Fan Yong Wang Yingjun Tan Chunyan Wang Qi Li Wei Lei Jianghai Chen Zhaoxia Liu Zhenya Shen Yinghui Li Shijun Hu Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science State Key Laboratory of Radiation Medicine and ProtectionSuzhou Medical CollegeSoochow UniversitySuzhouChina State Key Laboratory of Space Medicine China Astronaut Research and Training CenterBeijingChina Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

During spaceflight,the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac ***,the effects and mechanisms of microgravity on cardiac morphology,physiology,metabolism,and cellular biology need to be further *** China started constructing the China Space Station(CSS)in 2021,we have taken advantage of the Shenzhou-13 capsule to send human pluripotent stem cell-derived cardiomyocytes(hPSC-CMs)to the Tianhe core module of the *** this study,hPSC-CMs subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium *** and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight,especially thiamine *** microgravity condition blocked the thiamine intake in *** decline of thiamine utilization under microgravity or by its antagonistic analog amprolium affected the process of the tricarboxylic acid *** decreased ATP production,which led to cytoskeletal remodeling and calcium homeostasis imbalance in *** importantly,in vitro and in vivo studies suggest that thiamine supplementation could reverse the adaptive changes induced by simulated *** study represents the first astrobiological study on the China Space Station and lays a solid foundation for further aerospace biomedical *** data indicate that intervention of thiamine-modified metabolic reprogramming in human cardiomyocytes during spaceflight might be a feasible countermeasure against microgravity.

关键词： programming battery modified

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台州飞龙高闸地块项目地下室防水施工工艺

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石家庄铁路职业技术学院学报 2024年第1期23卷 35-40页

作者：曲丽娜中铁十八局集团第四工程有限公司天津300350

建筑物地下室防水抗渗施工技术是保证建筑物使用功能、安全性和耐久性的一项重要工作。本文以台州飞龙高闸地块项目地下室防水施工项目为依托,根据该地下室防水设计等级,采用混凝土刚性防水层+卷材柔性防水层的两道设防。针对这两道设防... 详细信息

建筑物地下室防水抗渗施工技术是保证建筑物使用功能、安全性和耐久性的一项重要工作。本文以台州飞龙高闸地块项目地下室防水施工项目为依托,根据该地下室防水设计等级,采用混凝土刚性防水层+卷材柔性防水层的两道设防。针对这两道设防,详细介绍了地下室各部位结构的防水施工做法以及注意事项,并总结了防水工程中的质量控制技术措施。采用该防水施工工艺极大的提高地下室防水性能,有效保证地下室防水质量。

关键词：地下室施工技术防水施工技术措施

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不同金属离子条件下微生物对聚合物溶液黏度的影响及作用机制

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大庆石油地质与开发 2024年第2期43卷 108-114页

作者：卞立红曲丽娜高清河任国领胡敏张奕婷王超黑龙江省油田应用化学与技术重点实验室黑龙江大庆163712 大庆师范学院生物工程学院黑龙江大庆163712

为了减少采油过程中因为金属离子导致的聚合物黏损,从而提高原油采收率,利用从大庆油田腐蚀管道筛选出的降黏菌S,通过向聚合物培养基中添加不同种类及浓度的金属离子,将降黏菌S对聚合物黏度的影响及作用机制进行了研究。结果表明:在2 00... 详细信息

为了减少采油过程中因为金属离子导致的聚合物黏损,从而提高原油采收率,利用从大庆油田腐蚀管道筛选出的降黏菌S,通过向聚合物培养基中添加不同种类及浓度的金属离子,将降黏菌S对聚合物黏度的影响及作用机制进行了研究。结果表明:在2 000 mg/L的聚合物质量浓度下,向基础降黏培养基中加入10~50 mg/L的金属离子,Mn^(2+)、Fe^(2+)和Fe^(3+)的加入可以很大程度地提高降黏菌S的降黏率,最高黏损率分别为38.3%、35.6%、34.7%;K~+的加入对降黏菌S的降黏率影响不大;Cu^(2+)、Zn^(2+)的加入会降低菌S所引起的黏损;因此要控制采油体系中Mn^(2+)、Fe^(2+)和Fe^(3+)的含量,从而降低聚合物黏损;K~+离子含量也不宜太多。适当增加采油体系中Zn^(2+)、Cu^(2+),减少聚合物黏损,或者将6种离子均以质量浓度30 mg/L混合加入会降低聚合物黏损。研究成果对油田减少聚合物黏损,提高原油采收率提供了一定的方法和理论支撑。

关键词：聚合物溶液降黏菌金属离子黏损作用机制

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长期模拟失重后直立性紫癜与心血管、血液和尿液指标关联性分析

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载人航天 2024年第4期30卷 456-463页

作者：李铠卢亮石宏志元艳宏王林杰李志利徐冲曲丽娜李莹辉中国航天员科研训练中心航天医学全国重点实验室北京100094

针对航天飞行后或模拟失重生理效应实验后会出现直立性紫癜的问题,开展心血管、血液和尿液等表型指标关联性研究。在地星二号90 d头低位卧床模拟失重实验中,招募36位志愿者,头低位实验结束后发现7名志愿者发生了直立性紫癜现象。通过26... 详细信息

针对航天飞行后或模拟失重生理效应实验后会出现直立性紫癜的问题,开展心血管、血液和尿液等表型指标关联性研究。在地星二号90 d头低位卧床模拟失重实验中,招募36位志愿者,头低位实验结束后发现7名志愿者发生了直立性紫癜现象。通过261个表型组指标与直立性紫癜的关联分析,研究了与直立性紫癜发生显著相关的表型指标。结果表明:单核细胞绝对值(校正后P=0.0064)、单核细胞百分比(校正后P=0.0452)及血小板计数变化(校正后P=0.0100)等指标与直立性紫癜的形成有显著相关性。

关键词：模拟失重头低位卧床实验表型组直立性紫癜

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Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata(Desv.)Spring against inflammatory bowel disease

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Journal of Pharmaceutical Analysis 2024年第2期14卷 177-195页

作者： Haochen Hui Zhuoya Wang Xuerong Zhao lina Xu Lianhong Yin Feifei Wang Liping qu Jinyong Peng Department of Pharmaceutical Analysis College of PharmacyDalian Medical UniversityDalianLiaoning116044China Innovation Materials Research and Development Center Botanee Research InstituteYunnan Botanee Bio-technology Group Co.Ltd.Kunming650106China Department of Traditional Chinese Medicine Pharmacology School of PharmacyAnhui University of Chinese MedicineHefei230012China

Inflammatory bowel disease(IBD)is a serious disorder,and exploration of active compounds to treat it is *** acidic polysaccharide named SUSP-4 was purified from Selaginella uncinata(Desv.)Spring,which contained galacturonic acid,galactose,xylose,arabinose,and rhamnose with the main chain structure of→4)-α-d-GalAp-(1→and→6)-β-d-Galp-(1→and the branched structure of→5)-α-l-Araf-(1→.Animal experiments showed that compared with Model group,SUSP-4 significantly improved body weight status,disease activity index(DAI),colonic shortening,and histopathological damage,and elevated occludin and zonula occludens protein 1(ZO-1)expression in mice induced by dextran sulfate sodium salt(DSS).16S ribosomal RNA(rRNA)sequencing indicated that SUSP-4 markedly downregulated the level of Akkermansia and *** results confirmed that SUSP-4 obviously elevated thiamine levels compared with Model mice by adjusting thiamine metabolism,which was further confirmed by a targeted metabolism *** transplantation experiments showed that SUSP-4 exerted an anti-IBD effect by altering the intestinal flora in mice.A mechanistic study showed that SUSP-4 markedly inhibited macrophage activation by decreasing the levels of phospho-nuclear factor kappa-B(p-NF-κB)and cyclooxygenase-2(COX-2)and elevating NF-E2-related factor 2(Nrf2)levels compared with Model *** conclusion,SUSP-4 affected thiamine metabolism by regulating Akkermania and inhibited macrophage activation to adjust NF-κB/Nrf2/COX-2-mediated inflammation and oxidative stress against *** is the first time that plant polysaccharides have been shown to affect thiamine metabolism against IBD,showing great potential for in-depth research and development applications.

关键词： Gut microbiota Inflammatory bowel disease Polysaccharide Selaginella uncinata(Desv.)Spring Thiamine metabolism

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Preparation and characterization of 3-(triethoxysilyl) propyl isocyanate self-assembled monolayer on surface of chip

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Chinese Science Bulletin 2009年第5期54卷 738-742页

作者： XIE Yao GENG lina qu Feng LUO AiQin DENG YuLint School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China

Monolayer of 3-(triethoxysilyl) propyl isocyanate was prepared on the slide by self-assembled tech-nique. X-ray photoelectron spectroscopy (XPS) was employed to analyze the elementary composition of the film. Contact angle of distilled water was measured to characterize the surface state. It was shown that 3-(triethoxysilyl) propyl isocyanate had been successfully assembled on the slide. The in-crease of contact angle to 80° demonstrated that the hydrophobicity of the surface of chip was in-creased significantly. Moreover, further self-assembly of bovine serum albumin (BSA) on 3-(trietho- xysilyl) propyl isocyanate was also carried out with the advantages such as simple and convenient preparation. Therefore, the potential of broader applications in the modification of micro-channel in the μ-TAS system, the immobilization of protein or peptide and the surface modification of materials are all expectative.

关键词：三乙氧基(3-异氰酸丙基)硅自组装单分子膜共价健制备

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Time-Periodic Solutions to quasilinear Hyperbolic Systems on General Networks

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 41-72页

作者： Peng qu School of Mathematical Sciences Fudan UniversityShanghai 200433China

For quasilinear hyperbolic systems on general networks with time-periodic boundary-interface conditions with a dissipative structure,the existence and stability of the time-periodic classical solutions are discussed.

关键词： Time-periodic solution quasilinear hyperbolic system General net-work Classical solution Asymptotic stability

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Flat jet electrochemical milling of TC4 alloy with tailoring backward parallel flow

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Chinese Journal of Aeronautics 2024年第4期37卷 574-592页

作者： Huanghai KONG Ningsong qu College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In flat jet electrochemical milling, the electrolyte forms a backward parallel flow after impacting the workpiece, resulting in a weak current density distribution on the workpiece. Poor surface quality usually occurs on the machined titanium alloy surface because it inevitably suffers from the weak current density. In this study, a method of flat jet electrochemical milling with tailoring the backward parallel flow was proposed to eliminate the negative effects caused by the weak current density. Multiphysics simulations are carried out to comprehend the mechanism of flat jetEC milling with tailoring backward parallel flow and better construct the novel tool *** on flat jet electrochemical milling of TC4 alloy with and without tailoring backward parallel flow are conducted. The results reveal that, compared with flat jet electrochemical milling without tailoring backward parallel flow, the recommended tool reduces the surface roughness by86% to 93%, and improves the material removal rate by 93% to 163% with different feed ***, the recommended tool is more conducive to maintaining the inherent hardness of the material. Finally, a surface with low Sa of 0.37 μm is obtained.

关键词： Flat jet electrochemical milling TC4 alloy Surface roughness Micro-hardness Material removal rate

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Pathways toward a pollution-free planet and challenges

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 3-8页

作者： Jiuhui qu Jiaping Chen School of Environment Tsinghua UniversityBeijing 100084China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

The mission of“Establishment of Zero-Pollution Earth”defined by United Nations Environment Programme aims at creation of a clean,safe and prosperous home for all human *** is of rational choice from each individual to protect our environment and demonstrates our great ambition to achieve our *** key message given in this article is that,zero pollution does not mean no discharge of pollutants and instead it can be achievable through optimizing and controlling a sound balance between pollutants discharge and capacities of decontamination through treatment and natural environmental accumulation,which can be termed as“Principle of Equilibrium”between pollution and *** on this principle,we propose and illustrate several key factors and synergistic pathways toward a pollution-free planet:quantitative determination on purification and wastewater;source control through green measures;minimization of negative side-effects;precise management through digitalized systems;and keeping sound balance between pollutants and natural *** should be noted that we would face a series of difficulties and challenges in moving forward to“Zero-Pollution Earth”.We should further develop theories,principles and tools to achieve the balance between quantity of pollutants and decontamination *** should work together to break through the bottleneck limited by“Principle of equilibrium”to establish new environmental remediation systems leading to“Zero-Pollution Earth”.

关键词： Wastewater treatment Resources Recovery Greenhouse gases Energy Pollution-free

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Facile synthesis of bimetallic N-doped carbon hybrid material for electrochemical nitrogen reduction

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Journal of Energy Chemistry 2021年第8期30卷 715-720,I0015页

作者： Linchuan Cong Kaida Yao Siqi Zhang Ziqi Zhang Zhuochen Yu Miaomiao Qian lina qu Weimin Huang College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory of Physics and Technology for Advanced Batteries of Ministry of Education Jilin UniversityChangchun 130012China

Due to the increasingly depleted limited fossil fuel resources,the development of renewable energy is the key to promote sustainable development which is an important part of the energy strategy[1].NH3 is one of most important and largest chemical productions in the world,it can be used as a feedstock for nitrogen fertilizer productions[2,3]or as a carbon-free energy carrier[4,5].

关键词： Electrocatalysis NH_(3) synthesis Co and Ru bimetal Nitrogen-doped carbon layer Ambient conditions

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