检索结果-南通市图书馆

Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling

引用

World Journal of Diabetes 2024年第2期15卷 287-304页

作者： huai-Jie Wang Li-Bin Zhang Si-Peng Sun Qing-Tao Yan Zhi-Qin Gao Fang-Ming Fu Mei-hua qu Translational Medical Center Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Endocrinology Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Pediatric Surgery Weifang People’s HospitalWeifang 261041Shandong ProvinceChina School of Bioscience and Technology Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Endocrinology Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is often accompanied by impaired glucose utilization in the brain,leading to oxidative stress,neuronal cell injury and *** studies have shown that duodenal jejunal bypass(DJB)surgery significantly improves brain glucose metabolism in T2DM rats,the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in T2DM rats remain *** To investigate the role and metabolism of DJB in improving hypothalamic oxidative stress and inflammation condition in T2DM *** A T2DM rat model was induced via a high-glucose and high-fat diet,combined with a low-dose streptozotocin injection.T2DM rats were divided into DJB operation and Sham operation *** surgical intervention was carried out on T2DM *** differential expression of hypothalamic proteins was analyzed using quantitative proteomics *** related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of T2DM rats were analyzed by flow cytometry,quantitative real-time PCR,Western blotting,and *** quantitative proteomics analysis showed significant differences in proteins related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of rats with T2DM-DJB after DJB surgery,compared to the T2DM-Sham groups of *** stress-related proteins(glucagon-like peptide 1 receptor,Nrf2,and HO-1)were significantly increased(P<0.05)in the hypothalamus of rats with T2DM after DJB *** surgery significantly reduced(P<0.05)hypothalamic inflammation in T2DM rats by inhibiting the activation of NF-κB and decreasing the expression of interleukin(IL)-1βand *** surgery significantly reduced(P<0.05)the expression of factors related to neuronal injury(glial fibrillary acidic protein and Caspase-3)in the hypothalamus of T2DM rats and upregulated(P<0.05)the expression of neuroprotective factors(C-fos,Ki67,Bcl-2,and BDNF),thereby reducing hypot

关键词： Duodenal jejunal bypass surgery Type 2 diabetes mellitus Neuron apoptosis Inflammatory Oxidative stress Hypothalamic injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical profiling of huashi Baidu prescription, an effective anti-COVID-19 TCM formula, by UPLC-Q-TOF/MS

引用

Chinese Journal of Natural Medicines 2021年第6期19卷 473-480页

作者： WEI Wen-Long WU Shi-Fei LI Hao-Jv LI Zhen-Wei qu hua YAO Chang-Liang ZHANG Jian-Qing LI Jia-Yuan WU Wan-Ying GUO De-An Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

huashi Baidu prescription(HSBDF),recommended in the Guideline for the Diagnosis and Treatment of Novel Coronavirus(2019-nCoV)Pneumonia(On Trials,the Seventh Edition),was clinically used to treat severe corona virus disease 2019(COVID-19)with cough,blood-stained sputum,inhibited defecation,red tongue *** study was aimed to elucidate and profile the knowledge on its chemical constituents and the potential anti-inflammatory effect in *** the study,the chemical constituents in extract of HSBDF were characterized by UPLC-Q-TOF/MS in both negative and positive modes,and the pro-inﬂammatory cytokines were measured by enzyme-linked immunosorbent assays(ELISA)to determine the effects of HSBDF in lipopolysaccharide(LPS)-stimulated RAW264.7 *** results showed that a total of 217 chemical constituents were tentativedly characterized in ***,HSBDF could alleviate the expression levels of IL-6 and TNF-αin the cell models,indicating that the antiviral effects of HSBDF might be associated with regulation of the inflammatory cytokines production in RAW264.7 *** hope that the results could be served as the basic data for further study of HSBDF on anti-COVID-19 effect.

关键词： huashi Baidu prescription Corona virus disease 2019 Characterization of chemical constituents ELISA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tongxinluo Capsule(通心络胶囊)for Cardiac Syndrome X：A Systematic Review and Meta-Analysis

引用

Chinese Journal of Integrative Medicine 2018年第4期24卷 296-303页

作者： MAO Hui-min LIU Mi qu hua WANG Li-qiong SHI Da-zhuo Graduate School Beijing University of Chinese Medicine Beijing 100029 China Cardiovascular Disease Center Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China

Objective： To evaluate the efficacy and safety of Tongxinluo Capsule（通心络胶囊, TXL） for patients with cardiac syndrome X（CSX）. Methods： Randomized controlled trials（RCTs） regarding TXL in the treatment of CSX were searched in Chinese Biomedicine Literature Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Database, Pub Med, EMBASE, Cochrane Central Register of Controlled Trial, websites of the Chinese and International Clinical Trial Registry platform up to June 30, 2015. The intervention was either TXL alone or TXL combined with conventional treatment, while the control intervention was conventional treatment with or without placebo. Data extraction, methodological quality assessment and data analyses were performed according to the Cochrane criteria. The primary outcome was a composite event of death, acute myocardial infarction（AMI）, angina requiring hospitalization, revascularization, and heart failure. The secondary outcome measures were angina symptom improvement, electrocardiograph（ECG） improvement, and serum endothelin-1（ET-1） level. The adverse events were also recorded. RevMan 5.3 software was applied for data analyses. Results： Twelve RCTs（696 patients） were included. Compared with conventional treatment, the addition of TXL to conventional treatment showed some benefits on relieving angina symptoms [risk ratio（RR）： 1.46, 95% confidence interval（CI）（1.25, 1.71）, P〈0.01], and improving ECG [RR： 1.45, 95% CI（1.21, 1.74）, P〈0.01]. The pooled result did not support a benefit of TXL on reducing the incidence of primary outcome [RR： 0.20, 95% CI（0.02, 1.61）, P=0.13]. In addition, TXL decreased serum ET-1 concentration of CSX patients [standardized mean number： –1.63, 95% CI（–2.29, –0.96）, P〈0.01]. No serious adverse events were reported. Conclusions： TXL documents potential benefits on attenuating angina symptoms, improving ECG and decreasing serum ET-1 level for CSX patients. However, more rigorous RCTs with high qual

关键词： Tongxinluo Capsule cardiac syndrome X randomized controlled trial systematic review Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

当前我国教育服务产品需求分析

引用

未来与发展 2006年第8期27卷 47-52页

作者：瞿华中山大学中国第三产业研究中心

1992年中共中央、国务院发布的《关于加快发展第三产业的决定》把教育列为“对国民经济发展具有全局性、先导性影响的基础产业”。教育产业（部门）的主要产品是教育服务产品（简称教育服务），即教育工作者提供的用于培养、提高和改善... 详细信息

1992年中共中央、国务院发布的《关于加快发展第三产业的决定》把教育列为“对国民经济发展具有全局性、先导性影响的基础产业”。教育产业（部门）的主要产品是教育服务产品（简称教育服务），即教育工作者提供的用于培养、提高和改善人类的智力素质的非实物劳动成果。包括教师的备课、讲课、辅导、批改作业等一系列“传道、授业、解惑”的教育服务。当教育服务产品为交换而生产时，它就成为商品，具有价值，并通过市场价格表现其价值。对个人而言．接受教育既可提高素质、增进知识和能力。为在竞争日益激烈的社会获得理想的职业岗位创造条件。从而满足物质生活消费需求，又可增加生活情趣。提高精神文化消费的水平。正如马克思所说．作为劳动产物的教育服务产品．具有“特殊效用”．就是“训练……劳动能力。使劳动能力改变形态……使劳动能力具有专门性”。“直接把劳动能力本身生产、训练、发展……出来”，使受教育者发展自己的才智。或是“学会赚钱的本领”。

关键词：产品需求分析教育服务劳动能力国民经济发展智力素质教育工作者第三产业基础产业教育产业市场价格

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

平行照明多目视觉检测技术

引用

红外与激光工程 2010年第2期39卷 339-345页

作者：赵阳曲兴华天津大学精密仪器与光电子工程学院天津300072

多目视觉检测技术是通过多个不同位置的视觉传感器,从不同角度获取同一目标的图像,并对所得图像进行目标匹配、差分相减等,最终清晰提取出目标信息的一种视觉测量技术。相比单目视觉方法,利用多个传感器能搜集更多的目标物信息,且在检... 详细信息

多目视觉检测技术是通过多个不同位置的视觉传感器,从不同角度获取同一目标的图像,并对所得图像进行目标匹配、差分相减等,最终清晰提取出目标信息的一种视觉测量技术。相比单目视觉方法,利用多个传感器能搜集更多的目标物信息,且在检测系统中又融入了平行光照明方式下,对称式多角度的图像采集方法,可以使不同显现力的被测物平面信息通过极高的对比度显现出来,再结合多幅图像匹配、差分规则,最终可以得到效果更佳的缺陷或轮廓信息。描述了遵照该检测方法设计的实验装置,并通过成组实验证明了其可行性。基于平行光照明的多目视觉检测方法提高了系统的抗干扰能力,使系统从根本上提高了图像处理结果的精度,相比以往软件除噪、滤波等方法更加便捷、快速、稳定,适用范围也更广。提出了利用大功率LED芯片构造平行光源的思路,该平行光源设计准直度更好,非平行杂光干扰更小。

关键词：多目视觉检测平行光差分

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

余家菊的乡村教育思想探析

引用

东北师大学报（哲学社会科学版） 2013年第6期 190-193页

作者：曲铁华东北师范大学农村教育研究所吉林长春130024

在我国20世纪二三十年代,掀起了声势浩大的乡村教育运动,余家菊是其中的代表人物之一,他提出了一套比较系统的乡村教育思想,包括乡村教育目的、乡村教育学制系统、乡村教育的实施等,颇有特色,对于我国当前重视农村教育研究、大力发展农... 详细信息

在我国20世纪二三十年代,掀起了声势浩大的乡村教育运动,余家菊是其中的代表人物之一,他提出了一套比较系统的乡村教育思想,包括乡村教育目的、乡村教育学制系统、乡村教育的实施等,颇有特色,对于我国当前重视农村教育研究、大力发展农村教育具有重要的借鉴价值。

关键词：余家菊乡村教育思想价值

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于自我反思的教师缄默知识的显性化

引用

四川师范大学学报（社会科学版） 2013年第1期40卷 89-93页

作者：曲铁华东北师范大学教育学部长春130024

自我反思是教师专业发展的决定性因素,从教师的知识结构出发,将教师自我反思的意义指向教师的缄默知识。缄默知识是教师个人知识体系的重要组成部分,也是教师专业发展的知识基础。实现教师缄默知识的显性化,是教师个人成长的关键和重要... 详细信息

自我反思是教师专业发展的决定性因素,从教师的知识结构出发,将教师自我反思的意义指向教师的缄默知识。缄默知识是教师个人知识体系的重要组成部分,也是教师专业发展的知识基础。实现教师缄默知识的显性化,是教师个人成长的关键和重要条件。教师缄默知识显性化通过反思札记、教育自传、教育叙事和教师Blog来实现。

关键词：反思教师缄默知识显性化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on the Logistics Operation of Scale Farm Methane Engineering

引用

Meteorological and Environmental Research 2012年第7期3卷 8-11页

作者： qu Jian-hua CUI Yan WANG Zhen-feng Mechanical and Electrical Engineering College of Henan Agricultural University Zhengzhou 450002 China

Based on the large-scale farms methane project of logistics operation as the breakthrough point, methane project of the supply chain of the raw material supply logistics, production logistics and product sales organization of logistics and operation mode were preliminarily studied, and the methane energy company as the core was decided. The third party logistics as key support for the integration of logistics operation mode provid- ed a new train of thought for the large scale operation and implementation of methane project.

关键词： Methaneengineering -Logistics Industrial methane Supply chain China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effects of Cyclic Stretching on the Proliferation of Lung Adenocarcinoma Cells in Vitro

引用

Chinese Journal of Biomedical Engineering(English Edition) 2006年第1期15卷 31-35页

作者： qu hua WU Wen-zhou CHEN Wei-yi College of Science Taiyuan University of Technology Taiyuan 030024 China College of Science Taiyuan University of Technology Taiyuan 030024 China College of Science Taiyuan University of Technology Taiyuan 030024 China

Using FX-4000 strain unit, the prolieration in human lung adenocarcinoma A549 cells that underwent mechanical strain of different waveform、frequency and duration were studied. Image analysis revealed that cellular proliferation rate(PR) reduced significantly after cells were subjected to square wave with 0～20% elongation at frequency 30,40,50 and 60 cycles/min for 2h. The PR had no distinct difference at heart wave , triangle wave and sine wave group compared with control. It is concluded that square wave and higher frequency play an important role in inhibiting A549 cells proliferation.

关键词： Cyclic stretch, Waveform and frequency, Lung adenocarcinoma cell , Proliferation rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mitochondrial Glycerol 3-phosphate Dehydrogenase Promotes Skeletal Muscle Regeneration during Obesity and Diabetes

Mitochondrial Glycerol 3-phosphate Dehydrogenase Promotes Sk...

引用

第三届中国生物物理学会代谢生物学分会学术研讨会

作者： Yi Zheng Xiufei Liu hua qu Hongting Zheng Department of Endocrinology Translational Research Key Laboratory for DiabetesXinqiao HospitalArmy Medical University

＜正＞While adult mammalian skeletal muscle is stable due to its post-mitotic nature,muscle regeneration is still essential throughout life for maintaining functional *** certain diseases,such as the modern pandemics of obesity and diabetes,the regeneration process becomes impaired,leading to the loss of muscle function,and contributing to the global burden of these ***,the

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：