检索结果-南通市图书馆

Chemical Research in Chinese Universities 2024年第1期40卷 145-152页

作者： WU Jun LI Yongzhi qin hanjiao GAO Ying YANG Bing SHENG Jiyao ZHANG Xuewen Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun130022P.R.China Department of Radiation Oncology the Second Hospital of Jilin UniversityChangchun130022P.R.China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun130012P.R.China

In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TPA).Furthermore,TPA-PEG2000 fluorescent nanoparticles were prepared via coating the shells with ***-PEG2000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09%,indicating a high emission *** biology experiments have confirmed its low toxicity and excellent *** cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced ***,the uptake of TPA-PEG2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

关键词： Nanoparticle Near-infrared Fluorescence Systemic treatment sensitivity Cell membrane fluidity

Brain-derived neurotrophic factor expression in dorsal root ganglion neurons in response to reanastomosis of the distal stoma after nerve grafting

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2012年第26期7卷 2012-2017页

作者： Wei Yu Jian Wang Mingzhu Xu hanjiao qin Shusen Cui Department of Hand Surgery China Japan Union Hospital Jilin University Changchun 130033 Jilin Province China Department of Orthopedics First Affiliated Hospital Wenzhou Medical College Wenzhou 325000 Zhejiang Province China Department of Nephrology China Japan Union Hospital Jilin University Changchun 130033 Jilin Province China Norman Bethune Medical College Jilin University Changchun 130021 Jflin Province China

Studies have shown that retreatment of the distal stoma after nerve grafting can stimulate nerve regeneration. The present study attempted to verify the effects of reanastomosis of the distal stoma, after nerve grafting, on nerve regeneration by assessing brain-derived neurotrophic factor expression in 2-month-old rats. Results showed that brain-derived neurotrophic factor expression in L2-4 dorsal root ganglia began to increase 3 days after autologous nerve grafting post sciatic nerve injury, peaked at 14 days, decreased at 28 days, and reached similar levels to the sham-surgery group at 56 days. Brain-derived neurotrophic factor expression in L2-4 dorsal root ganglia began to increase 3 days after reanastomosis of the distal stoma, 59 days after autologous nerve grafting post sciatic nerve injury, significantly increased at 63 days, peaked at 70 days, and gradually decreased thereafter, but remained higher compared with the sham-surgery group up to 112 days. The results of this study indicate that reanastomosis of the distal stoma after orthotopic nerve grafting stimulated brain-derived neurotrophic factor expression in L2.4 dorsal root ganglia.

关键词： sciatic nerve orthotopic nerve grafting brain-derived neurotrophic factor dorsal root ganglion distalstoma reanastomosis peripheral nerve injury neural regeneration

Precision diagnosis of hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第10期136卷 1155-1165页

作者： Zhenxiao Wang hanjiao qin Shui Liu Jiyao Sheng Xuewen Zhang Department of Hepatobiliary and Pancreatic Surgery Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Radiotherapy Second Hospital of Jilin UniversityChangchunJilin 130041China

Hepatocellular carcinoma(HCC)is the most common type of primary hepatocellular carcinoma(PHC).Early diagnosis of HCC remains the key to improve the *** recent years,with the promotion of the concept of precision medicine and more in-depth analysis of the biological mechanism underlying HCC,new diagnostic methods,including emerging serum markers,liquid biopsies,molecular diagnosis,and advances in imaging(novel contrast agents and radiomics),have emerged one after ***,we reviewed and analyzed scientific advances in the early diagnosis of HCC and discussed their application and *** review aimed to provide a reference for scientific research and clinical practice of HCC.

关键词： Hepatocellular carcinoma Precision medicine Serum markers Liquid biopsy Molecular diagnosis Radiomics

Astragaloside in cancer chemoprevention and therapy

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第10期136卷 1144-1154页

作者： Yaning Wang Zhuo Zhang Zhaohua Cheng Wei Xie hanjiao qin Jiyao Sheng Department of Hepatobiliary and Pancreatic Surgery Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Orthopedics China-Japan Union Hospital of Jilin UniversityChangchunJilin 13033China Department of Ophthalmology Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Radiotherapy Second Hospital of Jilin UniversityChangchunJilin 130041China

Tumor chemoprevention and treatment are two approaches aimed at improving the survival of patients with *** ideal anti-tumor drug is that which not only kills tumor cells but also alleviates tumor-causing risk factors,such as precancerous lesions,and prevents tumor *** herbal monomers are considered to be ideal treatment agents due to their multi-target *** has been shown to possess tumor chemoprevention,direct anti-tumor,and chemotherapeutic drug sensitization *** this paper,we review the effects of astragaloside on tumor prevention and treatment and provide directions for further research.

关键词： Astragaloside Carcinoma Chemoprevention Anti-tumor Tumor recurrence

Human umbilical cord mesenchymal stem cell-loaded amniotic membrane for the repair of radial nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第36期8卷 3441-3448页

作者： Zhi Li hanjiao qin Zishan Feng Wei Liu Ye Zhou Lifeng Yang Wei Zhao Youjun Li Affiliated Central Hospital of Shenyang Medical College Department of Endocrinology and Metabolism First Clinical Hospital of Norman Bethune College of Medicine Jilin University Shengjing Hospital China Medical University Department of Human Anatomy and Histoembryology Norman Bethune University of Medical Science

In this study, we loaded human umbilical cord mesenchymal stem cells onto human amniotic membrane with epithelial cells to prepare nerve conduits, i.e., a relatively closed nerve regeneration chamber. After neurolysis, the injured radial nerve was enwrapped with the prepared nerve conduit, which was fixed to the epineurium by sutures, with the cell on the inner surface of the conduit. Simultaneously, a 1.0 mL aliquot of human umbilical cord mesenchymal stem cell suspension was injected into the distal and proximal ends of the injured radial nerve with 1.0 cm intervals. A total of 1.75 x 107 cells were seeded on the amniotic membrane. In the control group, patients received only neurolysis. At 12 weeks after cell transplantation, more than 80% of patients exhibited obvious improvements in muscular strength, and touch and pain sensations. In contrast, these improvements were observed only in 55-65% of control patients. At 8 and 12 weeks, muscular electrophysiological function in the region dominated by the injured radial nerve was significantly better in the transplantation group than the control group. After cell transplantation, no immunological rejections were observed. These findings suggest that human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury.

关键词： neural regeneration stem cells peripheral nerve injury cells radial nerve amniotic membrane nerve electrophysiology motor sensory neuroregeneration human umbilical cord mesenchymal stem conduit nerve regeneration chamber

在线全文

学校读者我要写书评

暂无评论

外科4.0的进展及展望

国际外科学杂志 2021年第9期48卷 634-638页

作者：盛基尧琴瀚姣张卓吉林大学第二医院肝胆胰外科长春130041 吉林大学第二医院肿瘤科长春130041 吉林大学中日联谊医院骨科长春130031

医学与理学、工学技术的深度融合使外科4.0取得了快速的发展。以人工智能、5G通信、精准外科及手术机器人为代表的新技术,在外科疾病的诊疗工作中得到了深入的探索和广泛的应用,对普通外科的发展起到了重要的推动作用。未来随着外科4.0... 详细信息

医学与理学、工学技术的深度融合使外科4.0取得了快速的发展。以人工智能、5G通信、精准外科及手术机器人为代表的新技术,在外科疾病的诊疗工作中得到了深入的探索和广泛的应用,对普通外科的发展起到了重要的推动作用。未来随着外科4.0相关技术的不断进展、完善和推广,将极大地改变外科医师的传统工作模式,优化外科疾病的诊疗流程。

关键词：基本外科人工智能医院通信系统精准医疗机器人手术

人源性肿瘤组织异种移植模型在胰腺癌综合治疗中的应用及展望

在线全文

学校读者我要写书评

暂无评论

国际外科学杂志 2021年第6期48卷 366-370页

作者：盛基尧琴瀚姣张学文吉林大学第二医院肝胆胰外科吉林省肝胆胰疾病转化医学工程实验室长春130041 吉林大学第二医院肿瘤科长春130041

胰腺癌预后欠佳,以化疗及分子靶向治疗为代表的全身综合治疗是改善胰腺癌术后预后的关键,也是延长晚期胰腺癌生存时间的重要手段。但是由于胰腺癌细胞的耐药性、异质性等原因,目前的全身综合治疗方案仍未达到理想效果,基于精准医学的个... 详细信息

胰腺癌预后欠佳,以化疗及分子靶向治疗为代表的全身综合治疗是改善胰腺癌术后预后的关键,也是延长晚期胰腺癌生存时间的重要手段。但是由于胰腺癌细胞的耐药性、异质性等原因,目前的全身综合治疗方案仍未达到理想效果,基于精准医学的个体化胰腺诊疗模式将是解决这个问题的重要途径。随着人源性肿瘤组织异种移植(PDX)模型的应用,胰腺癌的个体化治疗方案的制定将成为可能。本文将在回顾胰腺癌PDX模型建立方法的基础上,对PDX模型在胰腺癌综合治疗中的应用进展进行综述,旨在为胰腺癌的个体化治疗提供新的思路。

关键词：胰腺肿瘤异种移植模型抗肿瘤试验抗肿瘤联合化疗方案分子靶向治疗精准医疗

在线全文

学校读者我要写书评

暂无评论

不可切除肝内胆管细胞癌诊疗策略

中华肝脏外科手术学电子杂志 2021年第1期10卷 1-5页

作者：吴军琴瀚姣盛基尧张学文吉林大学第二医院肝胆胰外科长春130041 吉林大学第二医院吉林省肝胆胰疾病转化医学工程实验室长春130041 吉林大学第二医院肿瘤放射科长春130041

在过去40年里,肝内胆管细胞癌(ICC)的发病率一直在上升,其发病率从0.44/100000升至1.18/100000[1]。ICC侵袭性强,目前手术治疗是唯一可能的治愈手段,但术后复发率高达40%~80%,且大部分患者确诊时处于不可切除[2]。因此,针对不可切除ICC... 详细信息

在过去40年里,肝内胆管细胞癌(ICC)的发病率一直在上升,其发病率从0.44/100000升至1.18/100000[1]。ICC侵袭性强,目前手术治疗是唯一可能的治愈手段,但术后复发率高达40%~80%,且大部分患者确诊时处于不可切除[2]。因此,针对不可切除ICC的治疗建立新的治疗体系将成为未来主要的研究方向。

关键词：胆管肿瘤化学治疗放射治疗靶向治疗

在线全文

学校读者我要写书评

暂无评论

不同大小库尔勒香梨果实品质综合评价

北方园艺 2024年第20期 16-22页

作者：俞安炜阿不都苏甫尔·吾甫尔江温玥唐寒娇覃伟铭田嘉新疆农业大学园艺学院库尔勒千合农业开发有限公司新疆库尔勒香梨产业发展有限公司

以成熟香梨为试材，按照果实单果质量分为200 g 7个等级，对外观品质和内在品质进行测定，采用模糊综合评判等权法和模糊综合评判加权法进行综合评价，探究库尔勒香梨果实大小与品质之间的关系，以期为库尔勒香梨分级标准提供参考依据... 详细信息

以成熟香梨为试材，按照果实单果质量分为200 g 7个等级，对外观品质和内在品质进行测定，采用模糊综合评判等权法和模糊综合评判加权法进行综合评价，探究库尔勒香梨果实大小与品质之间的关系，以期为库尔勒香梨分级标准提供参考依据。结果表明：随着果实增大，硬度先减小后增大、总糖含量增大、细润度等级变差，不同果实大小总酸含量无显著差异，果形指数、总酸含量、糖酸比在不同果实大小中无显著性差异。单果质量与总糖均呈极显著正相关(P<0.01),与细润度、果点呈极显著负相关(P<0.01)。模糊综合评判等权法和模糊综合评判加权法结果较为一致，2种综合评价方法中综合评分前3位果实大小均大于140 g,综合评价表明，单果质量140～160 g果实品质最佳。

关键词：库尔勒香梨果实品质果实大小综合评价