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Molecular dynamics of de novo telomere heterochromatin formation in budding yeast

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Journal of Genetics and Genomics 2016年第7期43卷 451-465页

作者： Yi-Min Duan Bo-O.zhou Jing Peng xia-Jing Tong Qiong-di Zhang Jin-qiu zhou The State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China School of Life Science and Technology Shanghai Tech University 100 Haike Road Shanghai 200031 China

In the budding yeast Saccharomyces cerevisiae, heterochromatin structure is found at three chromosome regions, which are homothallic mating-type loci, rDNA regions and telomeres. To address how telomere heterochromatin is assembled under physiological conditions, we employed a de novo telomere addition system, and analyzed the dynamic chromatin changes of the TRPI reporter gene during telomere elongation. We found that integrating a 255-bp, but not an 81-bp telomeric sequence near the TRP1 promoter could trigger Sir2 recruitment, active chromatin mark（s）＇ removal, chromatin compaction and TRP1 gene silencing, indicating that the length of the telomeric sequence inserted in the internal region of a chromosome is critical for determining the chromatin state at the proximal region. Interestingly, Rill but not Rif2 or yKu is indispensable for the formation of intra-chromosomal silent chromatin initiated by telomeric sequence. When an internal short telomeric sequence （e.g., 81 bp） gets exposed to become a de novo telomere, the herterochromatin features, such as Sir recruitment, active chromatin mark（s）＇ removal and chromatin compaction, are detected within a few hours before the de novo telomere reaches a stable length. Our results recapitulate the molecular dynamics and reveal a coherent picture of telomere het- erochromatin formation.

关键词： Telomere Heterochromatin Nucleosome positioning Siry Ku

The velocity structure of the Yinggehai Basin and its hydrocarbon implication

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Chinese Science Bulletin 1998年第24期43卷 2047-2054页

作者： kanyuan xia di zhou Daquan Su E. Flueh Sanyu Ye Hanyi He Weidong Chen Yuhong Xie Guixian Wang Saijun Liu et al. Chinese Acad Sci S China Sea Inst Oceanol Guangzhou 510301 Peoples R China Univ Kiel Res Ctr Marine Geosci D-24098 Kiel Germany China Offshore Oil Nanhai W Corp Zhanjiang 524057 Peoples R China Seismol Bur Hainan Prov Haikou 570003 Peoples R China Seismol Bur Fujian Prov Fuzhou 350003 Peoples R China

Two profiles of refraction and wide_angle reflection were completed in the Yinggehai Basin using ocean bottom hydrophones (OBHs) as receiver. These profiles reveal a low velocity layer (LVL) to the west of No. 1 Fault in the basin, with velocity of 3.0-3.5 km/s. Its upper interface lies at 3.5 km below the sea bottom at the NE end of the profiles, and deepens southwestward to 4 6 km near the axis of the basin. It coincides with the top of a gas_bearing, high_pressure layer defined by well logging. This suggests that the LVL is a layer of less_compacted and gas_charged sediments. The lower interface of the LVL is about 9 km in depth. Sediments above the LVL have velocity varying from 2 0 to 4 1 km/s. The acoustic basement is found only east of No. 1 Fault, with velocity of 5 8-6 2 km/s. A NNW_SSE_running OBH seismic profile across the Xisha Trough was completed on the same cruise. Moho and other deep interfaces are clearly visible in the profile.

关键词： seismic refraction wide_angle reflection low velocity layer Yinggehai Basin.

Two-dimensional materials for future information technology: status and prospects

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Science China(Information Sciences) 2024年第6期67卷 1-147页

作者： Hao qiu Zhihao YU Tiange ZHAO Qi ZHANG Mingsheng XU Peifeng LI Taotao LI Wenzhong BAO yang CHAI Shula CHEN Yiqi CHEN Hui-Ming CHENG Daoxin DAI Zengfeng di Zhuo DONG Xidong DUAN Yuhan FENG Yu FU Jingshu GUO Pengwen GUO Yue HAO Jun HE xiao HE Jingyi HU Weida HU Zehua HU Xinyue HUANG Ziyang HUANG Ali IMRAN Ziqiang KONG Jia LI Qian LI Weisheng LI Lei LIAO Bilu LIU Can LIU Chunsen LIU Guanyu LIU Kaihui LIU Liwei LIU Sheng LIU Yuan LIU Donglin LU Likuan MA Feng MIAO Zhenhua NI Jing NING Anlian PAN Tian-Ling REN Haowen SHU Litao SUN Yue SUN Quanyang TAO Zi-Ao TIAN Dong WANG Hao WANG Haomin WANG Jialong WANG Junyong WANG Wenhui WANG Xingjun WANG Yeliang WANG Yuwei WANG Zhenyu WANG Yao WE... School of Electronic Science and Engineering Nanjing University School of Integrated Circuits Interdisciplinary Research Center for Future Intelligent Chips (Chip-X)Nanjing University School of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences School of Physics and Key Lab of Quantum Materials and Devices of the Ministry of Education School of Electronic Science & EngineeringSoutheast University College of Integrated Circuits State Key Laboratory of Silicon and Advanced Semiconductor MaterialsZhejiang University Suzhou Laboratory State Key Laboratory of Integrated Chips and Systems School of MicroelectronicsFudan University Shaoxin Laboratory Department of Applied Physics The Hong Kong Polytechnic University Key Laboratory for Micro-Nano Physics and Technology of Hunan Province College of Materials Science and EngineeringHunan University College of Integrated Circuits Zhejiang University Shenzhen Geim Graphene Center Shenzhen Key Laboratory of Layered Materials for Value-Added ApplicationsTsinghua-Berkeley Shenzhen Institute & Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua University State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZijingang CampusZhejiang University National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics (SINANO)Chinese Academy of Sciences College of Chemistry and Chemical Engineering Hunan University Key Laboratory of Quantum State Construction and Manipulation (Ministry of Education) Department of PhysicsRenmin University of China School

Over the past 70 years, the semiconductor industry has undergone transformative changes,largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensional(2D) materials like transition metal dichalcogenides(TMDs) and graphene are pivotal in overcoming the limitations of silicon-based technologies, offering innovative approaches in transistor design and functionality, enabling atomic-thin channel transistors and monolithic 3D integration. We review the important progress in the application of 2D materials in future information technology, focusing in particular on microelectronics and optoelectronics. We comprehensively summarize the key advancements across material production, characterization metrology, electronic devices, optoelectronic devices, and heterogeneous integration on silicon. A strategic roadmap and key challenges for the transition of 2D materials from basic research to industrial development are outlined. To facilitate such a transition, key technologies and tools dedicated to 2D materials must be developed to meet industrial standards, and the employment of AI in material growth, characterizations, and circuit design will be essential. It is time for academia to actively engage with industry to drive the next 10 years of 2D material research.

关键词： two-dimensional (2D) materials information technology production technology standardization of characterization microelectronicdevices optoelectronic devices multi-functional integration

Mental health and preventive behaviour of pregnant women in China during the early phase of the COVID-19 period

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Infectious diseases of Poverty 2021年第2期10卷 80-81页

作者： Qian Wang Phoenix K.H.Mo Bo Song Jiang-Li di Feng-Rong zhou Juan Zhao Ying-Lan wu Hong Tian Li-Qian qiu Jianhong xia Lan Wang Fen Li Lin-Hong Wang National Center for Chronic and Noncom municable disease Control and Prevention Chinese Center for Disease Control and Prevention13#Rd NanweiXichengBeijingChina 不详

Background:The COVID-19 has caused significant toll over the *** women are at risk of *** present study examined the frequency of washing hands with soap and wearing face mask when going out,prevalence of depression and anxiety,and identified their associated factors among pregnant women during the early phase of COVID-19 outbreak in China.

关键词： COVID-19 Personal preventive behaviour Depression Anxiety Mental health Pregnant women China

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

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Science China(Life Sciences) 2020年第9期63卷 1413-1416页

作者： Jingfang Mu Jiuyue Xu Leike Zhang Ting Shu di wu Muhan Huang Yujie Ren Xufang Li Qing Geng Yi Xu yang qiu Xi zhou State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of Sciences(CAS)Wuhan 430071China Joint Laboratory of Infectious diseases and Health Wuhan Institute of Virology&Wuhan Jinyintan HospitalCASWuhan 430023China The University of Chinese Academy of Sciences Beijing 100049China Center for Translational Medicine Wuhan Jinyintan HospitalWuhan 430040China Center for Precision Translational Medicine of wuhan Institute of Virology and Guangzhou Women and Children’s Medical Center Guangzhou Women and Children’s Medical CenterGuangzhou 510120China Department of Thoracic Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Dear Editor,Coronaviruses (Co Vs) are large enveloped non-segmented positive-strand RNA viruses that broadly distribute among humans and other animal species, including bats, mice and birds. SARS-Co V-2 infections can cause diseases, named the 2019 novel coronavirus disease (COVID-19). The symptoms of COVID-19 range from mild symptoms to severe respiratory syndromes, including pneumonia, and even death(Chen et al., 2020b;Jiang and shi, 2020;xia et al., 2020).

关键词： al. suppressor diseases

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南海南北共轭边缘伸展模型探讨

高校地质学报 2005年第1期11卷 105-110页

作者：吴世敏杨恬周蒂丘学林夏斌中国科学院边缘海重点实验室广州510301

通过对南海南北边缘地震剖面的对比,结合周边构造分析,提出南海大陆边缘的裂离经历了两期伸展作用,即早期的简单剪切和晚期的纯剪切伸展作用。简单剪切发生在晚白垩世—早始新世,其动力与太平洋板块俯冲带的后撤、太平洋板块与欧亚板块... 详细信息

通过对南海南北边缘地震剖面的对比,结合周边构造分析,提出南海大陆边缘的裂离经历了两期伸展作用,即早期的简单剪切和晚期的纯剪切伸展作用。简单剪切发生在晚白垩世—早始新世,其动力与太平洋板块俯冲带的后撤、太平洋板块与欧亚板块之间汇聚速率的降低、以及先存北倾缝合带等密切相关。纯剪切发生在中始新世—渐新世/早中新世。

关键词：南海北部陆缘伸展模型

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen shiqiang Chen Tianlu Chen Wei Chen xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio di Micco Ran ding Siqin dingl Yadong ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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2519厚板搅拌摩擦焊接工艺及组织分析

中南大学学报（自然科学版） 2006年第1期37卷 114-118页

作者：周鹏展钟掘贺地求舒霞云中南大学机电工程学院湖南长沙410083

采用搅拌摩擦焊接方法对厚度为12mm的2519铝合金板进行焊接试验。实验结果表明：在焊接速度为140mm／min，旋转速度为1800-2200r／min时，随着旋转速度的增加，焊缝强度先增加后减小；在旋转速度为2000r／min时，可以获得较好的焊接接... 详细信息

采用搅拌摩擦焊接方法对厚度为12mm的2519铝合金板进行焊接试验。实验结果表明：在焊接速度为140mm／min，旋转速度为1800-2200r／min时，随着旋转速度的增加，焊缝强度先增加后减小；在旋转速度为2000r／min时，可以获得较好的焊接接头，抗拉强度达到最大值296MPa，断裂形式为韧性和脆性的混合型断裂。光学显微镜、扫描电子显微镜和电子能谱分析结果表明：焊缝中组织的差异及晶界上粗大的富铜析出相是导致焊缝强度低于基材强度的原因；焊缝中的组织差异及晶界富铜析出相的形成是焊缝区温度沿板厚的急剧变化和搅拌力综合作用的结果。

关键词：搅拌摩擦焊 2519铝合金抗拉强度显微组织

2519厚板搅拌摩擦焊缝组织性能及断裂分析

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焊接学报 2006年第4期27卷 33-36页

作者：周鹏展钟掘贺地求舒霞云中南大学机电工程学院长沙410083

采用搅拌摩擦焊方法对厚度为20 mm的2519高强铝合金板进行了单道对接焊试验,并对焊缝的微观组织、力学性能及断裂特性进行了分析。试验结果表明,在旋转速度为1600 r/min、焊接速度为30 mm/min时,20 mm厚板焊缝的抗拉强度可达313 MPa;厚... 详细信息

采用搅拌摩擦焊方法对厚度为20 mm的2519高强铝合金板进行了单道对接焊试验,并对焊缝的微观组织、力学性能及断裂特性进行了分析。试验结果表明,在旋转速度为1600 r/min、焊接速度为30 mm/min时,20 mm厚板焊缝的抗拉强度可达313 MPa;厚板焊接时,因焊接速度较慢,厚板焊缝搅拌区的平均显微硬度在115 HV左右,出现了较大程度的软化,其软化区长度约为55 mm;其断裂形式为韧性和脆性的混合型断裂。20 mm厚板焊接时,上下板面搅拌区的温差在150℃左右,热机作用梯度沿板厚急剧变化,是厚板焊接比薄板焊接困难的原因之一。

关键词：搅拌摩擦焊 2519铝合金厚板