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Ir(111)表面石墨烯中缺陷的原子结构确认

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高等学校化学学报 2020年第1期41卷 49-55页

作者：李世超刘梦溪裘晓辉中国科学院纳米标准与检测重点实验室中国科学院纳米科学卓越创新中心国家纳米科学中心北京100190 中国科学院大学北京100049

识别和解析石墨烯中缺陷的精确原子结构是研究不同类型缺陷的物化特性,实现石墨烯物性调控的前提,可以为在原子尺度研究石墨烯缺陷的构效关系提供重要的实验依据.本文结合扫描隧道显微镜(STM)和原子力显微镜(AFM)确认了在Ir(111)表面生... 详细信息

识别和解析石墨烯中缺陷的精确原子结构是研究不同类型缺陷的物化特性,实现石墨烯物性调控的前提,可以为在原子尺度研究石墨烯缺陷的构效关系提供重要的实验依据.本文结合扫描隧道显微镜(STM)和原子力显微镜(AFM)确认了在Ir(111)表面生长的石墨烯中自发形成的缺陷,以及通过离子轰击方法在石墨烯中引入的多种缺陷结构,包括单空位缺陷、非六元环拓扑结构以及石墨烯层下的基底缺陷.

关键词：扫描隧道显微镜 qPlus原子力显微镜石墨烯缺陷空位铱(111)表面

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试论图书馆网络书评的能动性作用

图书馆工作与研究 2015年第5期 24-28页

作者：邱晓辉山东省济宁市图书馆

传统的书评模式,已经逐渐被新兴的网络书评所取代。网络书评自有很大的优势,但是在现阶段也确实存在着种种不足和有待完善之处。这需要我们切合实际地分析研究,找出规律性的东西,制订出贴切的网评措施与步骤。

关键词：网络书评图书馆读者工作

Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants

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Protein & Cell 2018年第9期9卷 814-819页

作者： Lei Yang xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li East China Normal University and Shanghai Fengxian DistrictCentral Hospital Joint Center for Translational Medicine ShanghaiKey Laboratory of Regulatory Biology School of Life SciencesEast China Normal University Shanghai 200241 China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201499 China Xinhua Hospital Shanghai Jiao Tong University School ofMedicine Shanghai 200092 China School of Life Sciences Hunan Normal University Changsha 410081 China Bioray Laboratories Inc. Shanghai 200241 China Department of Molecular and Cellular Medicine The Institute of Biosciences and Technology Texas AM University Health Science Center Houston TX 77030 USA

Dear Editor, The clustered regularly interspaced short palindromic repeat （CRISPR） system has been widely adapted to genome editing to either introduce or correct genetic mutations （Wang et al., 2016）. However, due to competition with the dominant non-homologous end-joining （NHEJ） pathway, precise genome modifications through Cas9-stimulated homologous recombination （HR） is inefficient. Through fusion of cytidine deaminases, APOBEC1 （apolipoprotein B editing complex 1） or AID （activation-induced deaminase）, with Cas9 variants, several groups have developed the cytidine base editor （BE） systems （Komor et al., 2016; Li et al., 2018; Nishida et al., 2016）. The BE system achieves programmable conversion of C-G base pairs to T.A without double-stranded DNA cleavage （Zhou et al., 2017）. More recently, adenine base editors （ABEs）, which efficiently convert A-T base pairs to G-C in genomic DNA, have been developed via fusion of an engineered tRNA adenosine deaminase （ecTadA from Escherichia coh） with nCas9 （Gaudelli et al., 2017）. The ABE system has quickly been adapted to generate disease models and correction of genetic disease in mice （Ryu et al., 2017; Liu et al, 2018）. However, whether the editing efficiency and the targeting scope of ABE could be improved is largely unexplored. In this study, we describe the efficient generation of base-edi- ted mice and rats modeling human diseases through ABEs with highest efficiency up to 100%. We also demonstrate an increase of ABE activity through injection of chemically modified tracrRNA and crRNA in mouse zygotes, and the expansion of editing scope by fusion of an ecTadA mutant to SaCas9n-KKH and Casgn-VQR variants in both cells and embryos. Our study suggests that the ABE system is a powerful and convenient tool to introduce precise base conversions in rodents.

关键词： GENOMIC DNA CRISPR-CAS9

Investigation and Analysis of Nutrition Components of Wild Chives Collected from Hezhang County of Guizhou Province

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Asian Agricultural Research 2018年第4期10卷 93-98页

作者： Haiping WANG Yang qiu Fangwei LI Jiangping SONG xiaohui ZHANG Xixiang LI Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China Bureau of Agriculture and Animal husbandry of Hezhang Bijie 553200China

Guizhou Province is an important distribution area of wild onion resources,and a large area of wild( Chinese) chives are distributed in Hezhang County. In order to understand and study the distribution of wild chives,the geographical distribution,habitats and climate of wild chives in Hezhang County were investigated,and the main nutrition components of wild chives were analyzed. The results indicated that there were mainly three kinds of wild chives distributed in Hezhang County, including Allium wallichii Kunth., Allium ovalifolium Hand.-Mazz.( tentatively named),and Allium hookeri Thwaites( tentatively named). Among the 17 kinds of amino acids,except for proline,the content of other amino acids in wild chives was higher than that of the cultivated chives( Allaum tuberosum Rottler ex Spreng.). The sugar content of wild chives was significantly lower than the cultivated chives. Among nine trace elements,the manganese,zinc and iron content of A. ovalifolium Hand.-Mazz. were significantly higher than that of the cultivated chives and other wild chives. Among the four kinds of heavy metals,cadmium content in the three kinds of wild chives exceeded the limitation of the national standard,and cadmium content in A. ovalifolium Hand.-Mazz. was significantly higher than that of the others. Arsenic,mercury and lead content in A. ovalifolium Hand.-Mazz. also exceeded the limitation of the national standard. Vitamin C content in leaves and stalk of A. wallichii Kunth. in the original habits was higher than that of the cultivated chives. The biological characteristics and nutrition components of the wild chives from Hezhang County were significantly different from that of the cultivated chives. The collection and preservation of these resources are of great significance to the enriching of diversity of Chinese chive resources and has great development and utilization value to the improvement of nutritional quality of Chinese chives.

关键词： Wild chives Cultivate chives Nutrition component

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论服务主导型数字图书馆

图书馆学研究 2009年第4期 43-45页

作者：仇晓惠武汉大学信息管理学院2008级硕士研究生

根据数字图书馆建设的基点、体系形成和所解决的关键任务等,数字图书馆计划和项目大致可分为:资源主导型数字图书馆、技术主导型数字图书馆、服务主导性数字图书馆。就目前数字图书馆的这三种研究类型,作者认为为用户服务是数字图书馆... 详细信息

根据数字图书馆建设的基点、体系形成和所解决的关键任务等,数字图书馆计划和项目大致可分为:资源主导型数字图书馆、技术主导型数字图书馆、服务主导性数字图书馆。就目前数字图书馆的这三种研究类型,作者认为为用户服务是数字图书馆的根本任务,应当坚持数字图书馆发展的人文主义价值取向,并指出服务主导型数字图书馆是未来数字图书馆的发展方向。

关键词：数字图书馆服务主导以人为本

乡镇总体规划中的“囚徒困境”及脱困之道——兼论乡镇总体规划逻辑系统还原与重构

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城市发展研究 2017年第4期24卷 1-6页

作者：陈小辉邱白嫣福州大学建筑学院

从"城市规划"到"城乡规划"的变革推动了乡镇规划的发展,为乡镇总体规划带来机遇,但也逐渐暴露出对城乡二元差异认知不足、技术路线偏差、实施统筹低效等"囚徒困境"。针对这些困境,尝试从认识层面探明造成困境的成因并提出相应的脱困之... 详细信息

从"城市规划"到"城乡规划"的变革推动了乡镇规划的发展,为乡镇总体规划带来机遇,但也逐渐暴露出对城乡二元差异认知不足、技术路线偏差、实施统筹低效等"囚徒困境"。针对这些困境,尝试从认识层面探明造成困境的成因并提出相应的脱困之道。首先还原乡镇总体规划的逻辑系统;然后在剖析其演变来源、适用条件及思维模式的基础上探讨逻辑系统的合理性和可行性,并从中揭示引发困境的根源:乡镇总规逻辑系统误用了城市总规逻辑系统的目标导向思维模式导致乡镇总规逻辑系统失范;最后提出脱困之道:修补城乡二元差异认知的缺失,转换思维模式,利用问题导向思维模式重构乡镇总体规划逻辑系统,将制约乡镇发展的三大困境作为系统的逻辑起点,创新编制思路,从用地、资金和实施三个维度协调乡镇总体规划的各项内容,进而提升规划的科学性和实效性,消除"囚徒困境"。

关键词：乡镇总体规划囚徒困境逻辑系统思维模式还原重构

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基于雷达成像的熵函数优化方法(英文)

Journal of Southeast University(English Edition) 2009年第4期25卷 427-430页

作者：邱晓晖陈昊南京邮电大学通信与信息工程学院南京210003 中国矿业大学信息与电气工程学院徐州221008 东南大学毫米波国家重点实验室南京210096

对ISAR成像的最小熵自聚焦(MEA)算法进行了收敛性分析.仿真结果表明,MEA算法存在局部最优问题,作为其代价函数的ISAR像熵函数并非多维补偿相位的下凸函数.只有当该补偿相位矢量的初值选取合适,使其处于像熵函数的全局最小点附近时,MEA... 详细信息

对ISAR成像的最小熵自聚焦(MEA)算法进行了收敛性分析.仿真结果表明,MEA算法存在局部最优问题,作为其代价函数的ISAR像熵函数并非多维补偿相位的下凸函数.只有当该补偿相位矢量的初值选取合适,使其处于像熵函数的全局最小点附近时,MEA算法才能收敛到全局最优解.针对MEA算法的最优化问题,给出了一种基于雷达成像的熵函数优化方法.该方法首先采用改进的多普勒中心跟踪法估计补偿相位初值.该初值是最大似然准则下的估计结果,可以使初始相位位于最优解附近.然后,利用快速MEA算法进行局部搜索,得到全局最优解.仿真结果表明,该算法不仅实现了MEA算法的全局最优求解,还可避免步长、阈值等参数的选择与调整.

关键词：雷达信号处理逆合成孔径雷达(ISAR)成像自聚焦

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锂离子电池寿命预测研究现状

兵器装备工程学报 2023年第S1期44卷 405-413页

作者：崔帆帆曾繁琦袁晓静郭晓辉邱贺方火箭军工程大学西安710025

锂电池具有能量密度高、额定电压高、自放电率低的特点,使用不当会引起自燃、爆炸等事故。随着大容量锂电池在新能源汽车中的广泛应用,实时监测锂电池状态,确保锂电池安全稳定运行已成为近年来的研究热点。锂电池的健康状态(SOH)描述了... 详细信息

锂电池具有能量密度高、额定电压高、自放电率低的特点,使用不当会引起自燃、爆炸等事故。随着大容量锂电池在新能源汽车中的广泛应用,实时监测锂电池状态,确保锂电池安全稳定运行已成为近年来的研究热点。锂电池的健康状态(SOH)描述了其存储电量的能力。通过对锂电池状态的准确预测,可以及时调整锂电池的工作电压、充放电电流、散热效率等,以此提升锂电池使用效率。本文综述并对比了目前锂电池RUL预测的主要方法,对基于数据驱动以及基于性能的方法(支持向量机、电化学模型、多模型融合等)进行归纳总结,并介绍各种预测方法的优缺点。最后,针对目前锂电池RUL估计方法存在的问题,提出了未来的研究方向和重点领域。此项工作对未来锂电池寿命的研究可以提供一定参考。

关键词：锂离子电池剩余寿命预测支持向量机相关向量机神经网络

Classification of Hemifacial Microsomia Based on Bone Volume Ratio of the Healthy and Affected Sides of the Mandible:A Retrospective Self-control Experiment

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Chinese Journal Of Plastic and Reconstructive Surgery 2020年第1期2卷 35-39,50页

作者： xiaohui qiu Xianxian YANG Haisong XU Zin-mar AUNG Xiaojun CHEN Yan ZHANG Gang CHAI Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineChina The College of Medical Instrument Shanghai University of Medicine&Health SciencesNo.257Zhouzhu HighwayPudong DistrictShanghaiChina Department of Plastic and Reconstructive Surgery Maternal and Child Health Care Hospital of Hainan ProvinceHaikou 570206China

Objective Hemifacial microsomia(HFM),a congenital craniofacial malformation,is characterized by unilateral mandibular dysplasia.At present,the Pruzansky classification is the most common descriptive classification used clinically,which involves mandibular deformities.Although multiple classification systems have been proposed for HFM,a quantitative classification has not yet been proposed.This study intended to propose a quantitative classification for HFMaccording to the mandibular volume on the affected side.Methods Patients with HFM from January 2017 to January 2018 were included,and the A/U ratio(volume of the affected side/volume of the unaffected side)was measured.This study proposed a classification for HFM(mandibular-volume classification,MVC)according to the A/U ratio and compared the new classification system with the Pruzansky classification using consistency and correlation tests.Results A total of 48 patients were included.The results of MVC based on the A/U ratio were as follows:A/U>0.85,classified asmild;0.73-0.85,as moderate;and<0.73 assevere;the weighted kappa value of the Pruzansky and MVC classifications was 0.616(P<0.01).Conclusion The quantitative classification of HFMbased on the A/U ratio can serve asa viable evaluation index for patients withHFM and can provide a new reference index for determiningthe treatment plan.

关键词： Hemifacialmicrosomia quantitative classification mandibular volume ratio Pruzansky classification