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Synthesis and Antitumor Activity of 4-tert-Butyl-5-benzyl-2-benzyliminothiazoles

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Chemical Research in Chinese Universities 2014年第1期30卷 49-54页

作者： YE jiao qiu Shenyi HU Aixi PENG Junmei QIN Zhi College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. China

A series of novel Schiff bases including 4-tert-butyl-5-benzyl-2-benzyliminothiazoles was synthesized by reacting the aromatic aldehydes with the corresponding *** antitumor bioassay revealed that compounds 2n and 2m exhibited potent cytotoxicity against human cervix cancer（HeLa） cell line with IC50 values of 0.001 and 0.007 mmol/L,*** preliminary structure-activity relationship（SAR） investigations and the apoptosis evaluation suggest that 4-tert-butyl-5-benzyl-2-benzyliminothiazoles may be a satisfactory backbone for antitumor activity,and compound 2n can serve as an attractive candidate for the development of novel apoptosis in anticancer treatment.

关键词： 2-Aminothiazole Schiff base Antitumor activity

镉胁迫下外源壳聚糖对小麦幼苗生理特性、抗氧化能力及镉吸收的影响

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环境科学 2024年第6期45卷 3649-3660页

作者：张静静焦秋娟徐正阳范丽娜姜瑛宋佳化党领李鸽子林迪柳海涛河南农业大学资源与环境学院郑州450046 河南农业大学国家小麦工程研究中心郑州450046 河南农业大学林学院郑州450046

为探究壳聚糖(CTS)缓解小麦幼苗镉(Cd)毒害的机制,通过水培试验,以百农207小麦为试验材料,研究外源壳聚糖对Cd胁迫下小麦幼苗的生理特性、抗氧化能力和Cd积累的影响,并利用偏最小二乘(PLS)回归模型定量分析幼苗各理化指标与镉积累量间... 详细信息

为探究壳聚糖(CTS)缓解小麦幼苗镉(Cd)毒害的机制,通过水培试验,以百农207小麦为试验材料,研究外源壳聚糖对Cd胁迫下小麦幼苗的生理特性、抗氧化能力和Cd积累的影响,并利用偏最小二乘(PLS)回归模型定量分析幼苗各理化指标与镉积累量间的关系.结果表明,相较于CK,10μmol·L^(-1)和25μmol·L^(-1)Cd胁迫显著抑制了小麦幼苗的叶绿素含量(叶绿素a、叶绿素b、类胡萝卜素和总叶绿素)、光合作用和生物量的积累,使得幼苗根系变短变粗且侧根减少,同时改变了超氧化物歧化酶(SOD)和过氧化物酶(POD)活性,增加了H_(2)O_(2)和丙二醛(MDA)的积累.镉胁迫下,外源壳聚糖使小麦幼苗茎叶和根系镉含量分别降低13.22%~21.63%和7.92%~28.32%,镉积累量分别降低5.37%~6.71%和1.91%~4.09%.不同镉水平下,外源壳聚糖使小麦根系和茎叶中H_(2)O_(2)含量显著降低了38.21%~47.46%和45.81%~55.73%,MDA含量显著降低了37.65%~48.12%和29.87%~32.51%;根系中SOD和POD含量分别提高2.78%~5.61%和13.81%~18.33%.外源壳聚糖可通过提高Cd胁迫下小麦幼苗的光合特征和抗氧化酶活性的方式,降低小麦地上部和根部的Cd含量与积累量,减轻细胞膜脂质的过氧化程度,进而缓解Cd胁迫对小麦幼苗生长的毒害作用.

关键词：壳聚糖(CTS) 镉(Cd)胁迫冬小麦生理特性抗氧化系统

稀土元素铈对锌胁迫下小麦幼苗生长的缓解效应

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环境科学 2024年第2期45卷 1141-1149页

作者：张静静徐正阳焦秋娟范丽娜刘芳赵颖宋佳化党领李鸽子柳海涛河南农业大学资源与环境学院郑州450046 河南农业大学国家小麦工程研究中心郑州450046

为探究稀土元素铈(Ce)对锌(Zn)胁迫下小麦幼苗生长的缓解效应,通过水培试验,以百农307为试验材料,研究外源Ce对500μmol·L^(-1)Zn胁迫下小麦幼苗生长、Zn积累和生理特性的影响.结果表明,500μmol·L^(-1)Zn胁迫显著抑制了小麦幼苗叶绿... 详细信息

为探究稀土元素铈(Ce)对锌(Zn)胁迫下小麦幼苗生长的缓解效应,通过水培试验,以百农307为试验材料,研究外源Ce对500μmol·L^(-1)Zn胁迫下小麦幼苗生长、Zn积累和生理特性的影响.结果表明,500μmol·L^(-1)Zn胁迫显著抑制了小麦幼苗叶绿素含量(叶绿素a、叶绿素b和总叶绿素)、光合作用和生物量的积累,使得幼苗根系变短变粗、侧根减少,同时降低了超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、抗坏血酸过氧化物酶(APX)活性和可溶性蛋白含量,增加了丙二醛(MDA)的积累.外源Ce降低了根系对Zn的吸收和转运,缓解了Zn胁迫对小麦幼苗的毒害效应,具体表现为叶绿素含量和光合作用参数的升高;提高了抗氧化酶活性和可溶性蛋白含量并降低MDA质量摩尔浓度;降低脂质过氧化对细胞膜的损伤,最终表现为小麦幼苗根系和茎叶干物质量的增加.外源Ce可通过提高Zn胁迫下小麦幼苗的光合特征、抗氧化酶活性和渗透调节物质的方式,降低细胞膜脂质的过氧化程度,缓解Zn胁迫对小麦幼苗生长的毒害作用.

关键词：铈(Ce) 锌(Zn)胁迫小麦幼苗生理特性缓解效应

Dual-Band Terahertz Left-Handed Metamaterial with Fishnet Structure

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Chinese Physics Letters 2011年第1期28卷 90-93页

作者： DU qiu-jiao LIU Jin-Song WANG Ke-Jia YI Xu-Nong YANG Hong-Wu Wuhan National Laboratory for Optoelectronics School of Optoelectronic Science and Engineering Huazhong University of Science and Technology Wuhan 430074 School of Mathematics and Physics China University of Geosciences Wuhan 430074 School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074

We present the design of a dual-band left-handed metamaterial with fishnet structure in the terahertz regime. Its left-handed properties are described by the retrieved effective electromagnetic parameters. We introduce an equivalent circuit which offers a theoretical explanation for the left-handed behavior of the dual-band fishnet metamaterial, and investigate its losses receiving- higher figure of mcrit, The design is beneficial to the development of frequency agile and broadband THz materials and devices＇. The dual-band fishnet metamaterial can be extended to infrared and optical frequency ranges by regulating the structural parameters.

关键词： Accelerators beams and electromagnetism Condensed matter: electrical magnetic and optical Optics quantum optics and lasers

The Concept of Agricultural Productivity on Ecosystem Scale and Its Measurement

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Agricultural Sciences in China 2006年第9期5卷 707-712页

作者： ZHU Wan-bin qiu Hua-jiao CHANG Xin CHENG Xu College of Resources and Environment China Agricultural University Beijing 100094 P.R.China College of Agronomy and Biotechnology China Agricultural University Beijing 100094 P.R.China

What is the connotation and the extension of the productivity concept and how to calculate it are the core problems in evaluating an agricultural-production process. The attributes of agricultural production processes have changed greatly in the last 100 years, and the methods to describe and measure the productivity failed to keep in pace with the production processes, resulting in a totally vague, incomplete evaluation of the production processes. Sometimes the serious problem of pollution is ignored in the race to shortdated money making, thus leading to a blooming and flooding pollution; sometimes the great ecological benefits are ignored and the corresponding production processes suffer drastically from “economic deficit”. With the old agricultural productivity indices, no prediction can be made of the ultimate effects of agroecosytem on mankind-pollution or welfare. A new concept, agricultural productivity on ecosystem scale （APES） and the related indices are defined here to solve these problems. Emergy and exergy are introduced to help the measurement of the indices. Emergy is the memory of energy, which can be used to measure the total cost, including natural capital and social capital. APES of the agroecosystem is the aggregated contributions of all components to mankind and its habitat in uniformed dimensions, it may be expressed in material, energy, information, organization, pollution and damage, etc., positive or negative, and are calculated based on exergy methods. And a related index agroecological coupling degree （ACD） shows sustainability.

关键词： agroecosystem productivity emergy exergy

Analysis and Design of Agricultural Sustainability Indicators System

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Agricultural Sciences in China 2007年第4期6卷 475-486页

作者： qiu Hua-jiao ZHU Wan-bin WANG Hai-bin CHENG Xu College of Agriculture and Biotechnology China Agricultural University Beijing 100094 P.R.China

The development and characteristic of agricultural sustainability indicators system （Sis）, at home and abroad, was reviewed. It was pointed out that the existing domestic methods of sustainability evaluation can not be accepted by foreign scholars, and their scientific basis is inadequate. The experience and shortcomings of the previous studies on the indicators selection and evaluation methods were analyzed, also with the significance for practice. Finally, a new SIs for agriculture development evaluation was proposed, together with the corresponding calculation and evaluation methods. The farmer development index indicator was proposed to embody the viewpoint that the development of people is the ultimate aim; the dynamic weight calculation method was designed to reflect the various significance of the different indicators when their values were changing; and new indicators integrate methods were also explored.

关键词： agriculture sustainability indicators system

Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation

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Neural Regeneration Research 2020年第11期15卷 2154-2161页

作者： Tao Pan qiu-jiao Zhu Li-Xiao Xu Xin Ding Jian-Qin Li Bin Sun Jun Hua Xing Feng Department of Neonatology Children’s Hospital Affiliated to Suzhou UniversitySuzhouJiangsu ProvinceChina Department of Critical Care Medicine Children’s Hospital Affiliated to Suzhou UniversitySuzhouJiangsu ProvinceChina Institute of Pediatrics Children’s Hospital Affiliated to Suzhou UniversitySuzhouJiangsu ProvinceChina Blood Section Children’s Hospital Affiliated to Suzhou UniversitySuzhouJiangsu ProvinceChina

Transient receptor potential melastatin 2(TRPM2) is an important ion channel that represents a potential target for treating injury caused by cerebral ischemia. However, it is unclear whether reducing TRPM2 expression can help repair cerebral injury, and if so what the mechanism underlying this process involves. This study investigated the protective effect of reducing TRPM2 expression on pheochromocytoma(PC12) cells injured by oxygen-glucose deprivation(OGD). PC12 cells were transfected with plasmid encoding TRPM2 shRNAS, then subjected to OGD by incubation in glucose-free medium under hypoxic conditions for 8 hours, after which the cells were allowed to reoxygenate for 24 hours. Apoptotic cells, mitochondrial membrane potentials, reactive oxygen species levels, and cellular calcium levels were detected using flow cytometry. The relative expression of C-X-C motif chemokine ligand 2(CXCL2), NACHT, LRR, and PYD domain–containing protein 3(NALP3), and caspase-1 were detected using fluorescence-based quantitative reverse transcription-polymerase chain reaction and western blotting. The rates of apoptosis, mitochondrial membrane potentials, reactive oxygen species levels, and cellular calcium levels in the TRPM2-shRNA + OGD group were lower than those observed in the OGD group. Taken together, these results suggest that TRPM2 knockdown reduces OGD-induced neuronal injury, potentially by inhibiting apoptosis and reducing oxidative stress levels, mitochondrial membrane potentials, intracellular calcium concentrations, and NLRP3 inflammasome activation.

关键词： apoptosis calcium caspase-1 NLRP3 mitochondrial impairment oxidative stress oxygen-glucose deprivation PC12 shRNA TRPM2

Rice Chitin Receptor OsCEBiP Is Not a Transmembrane Protein but Targets the Plasma Membrane via a GPI Anchor

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Molecular Plant 2017年第5期10卷 767-770页

作者： Gong, Ben-Qiang Xue, jiao Zhang, Nannan Xu, Lahong Yao, Xinran Yang, qiu-jiao Yu, Yang Wang, Hong-Bin Zhang, Dandan Li, Jian-Feng Sun Yat Sen Univ Sch Life Sci State Key Lab Biocontrol Guangzhou 510275 Guangdong Peoples R China Sun Yat Sen Univ Sch Life Sci Guangdong Prov Key Lab Plant Resources Guangzhou 510275 Guangdong Peoples R China

Dear Editor,Plants are sessile organisms that are constantly challenged by microbial pathogens from the habitat. The key for plants to survive is to perceive pathogens in a timely and precise manner and subsequently l... 详细信息

关键词： Rice Chitin Receptor OsCEBiP Transmembrane Protein

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栀子苷的危害评估和健康指导值推导

毒理学杂志 2024年第3期38卷 199-206页

作者：邱雪娇李强张磊李琦黄雅琳覃思包汇慧中国医学科学院食品安全创新单元(2019RU013) 国家卫生健康委员会食品安全风险评估重点实验室国家食品安全风险评估中心北京100022 湖南农业大学湖南长沙410125 丹东市振安区疾病预防控制中心辽宁丹东118003

目的根据现有毒理学资料,在系统文献检索的基础上开展栀子苷对健康影响的危害评估,并基于基准剂量(benchmark dose,BMD)法推导栀子苷的健康指导值(health-based guidance value,HBGV)。方法采用系统文献检索方法(systematic literature ... 详细信息

目的根据现有毒理学资料,在系统文献检索的基础上开展栀子苷对健康影响的危害评估,并基于基准剂量(benchmark dose,BMD)法推导栀子苷的健康指导值(health-based guidance value,HBGV)。方法采用系统文献检索方法(systematic literature search,SLS)收集栀子苷毒理学资料,利用ToxRTool工具对纳入的文献进行质量评价,选取毒理学数据评级最高的文献应用基准剂量法测算关键效应和剂量,结合不确定系数推导栀子苷的健康指导值。结果共纳入10篇栀子苷毒性文献,毒性研究集中在肝、肾毒性,经毒理学可靠性评价最终选取1篇26周大鼠经口毒性试验文献,得出栀子苷大鼠经口毒性NOAEL值为50 mg/kg·bw,以雄性大鼠血清AST活性变化为敏感指标,基于此试验剂量-反应关系经BMD模型计算得出雄性大鼠的BMDL10为38.625 mg/kg·bw。不确定系数为100,推导栀子苷的每日可耐受摄入量(tolerable daily intake,TDI)为0.386 mg/kg·bw。结论栀子苷主要表现为肝毒性,尚无证据表明栀子苷具有遗传毒性,基于危害评估得出栀子苷健康指导值为每日386μg/kg·bw。

关键词：栀子苷危害评估基准剂量法健康指导值