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Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine

Nano-Micro Letters 2024年第10期16卷 576-617页

作者： Leyan Xuan Yingying Hou Lu Liang Jialin Wu Kai Fan Liming Lian jianhua qiu Yingling Miao Hossein Ravanbakhsh Mingen Xu Guosheng Tang Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436People's Republic of China School of Automation Hangzhou Dianzi UniversityHangzhou 310018People's Republic of China Department of Biomedical Engineering The University of AkronAkronOH 44325USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells or drug carriers,that are promising for tissue engineering and regenerative *** can also be aggregated into microporous scaffolds,promoting cell infiltration and proliferation for tissue *** review gives an overview of recent developments in the fabrication techniques and applications of microgels.A series of conventional and novel strategies including emulsification,microfluidic,lithography,electrospray,centrifugation,gas-shearing,three-dimensional bioprinting,*** discussed in *** characteristics and applications of microgels and microgel-based scaffolds for cell culture and delivery are elaborated with an emphasis on the advantages of these carriers in cell ***,we expound on the ongoing and foreseeable applications and current limitations of microgels and their aggregate in the field of biomedical *** stimulating innovative ideas,the present review paves new avenues for expanding the application of microgels in cell delivery techniques.

关键词： Microgels Cell delivery Scaffolds 3D bioprinting Single-cell microgels

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Translocation of telomerase reverse transcriptase coincided with ATP release in postnatal cochlear supporting cells

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Neural Regeneration Research 2024年第5期19卷 1119-1125页

作者： Yukai Zhang Keyong Tian Wei Wei Wenjuan Mi Fei Lu Zhenzhen Liu Qingwen Zhu Xinyu Zhang Panling Geng jianhua qiu Yongli Song Dingjun Zha Department of Otolaryngology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s ***,the mechanisms responsible for initiating spontaneous ATP release have not been *** previous study revealed that telomerase reverse transcriptase(TERT)is expressed in the basilar membrane during the first postnatal *** role in cochlear development remains *** this study,we investigated the expression and role of TERT in postnatal cochlea supporting *** results revealed that in postnatal cochlear Kölliker’s organ supporting cells,TERT shifts from the nucleus into the cytoplasm over *** found that the TERT translocation tendency in postnatal cochlear supporting cells in vitro coincided with that observed in *** analysis showed that TERT in the cytoplasm was mainly located in mitochondria in the absence of oxidative stress or apoptosis,suggesting that TERT in mitochondria plays roles other than antioxidant or anti-apoptotic *** observed increased ATP synthesis,release and activation of purine signaling systems in supporting cells during the first 10 postnatal *** phenomenon that TERT translocation coincided with changes in ATP synthesis,release and activation of the purine signaling system in postnatal cochlear supporting cells suggested that TERT may be involved in regulating ATP release and activation of the purine signaling *** study provides a new research direction for exploring the spontaneous electrical activity of the cochlea during the early postnatal period.

关键词： apoptosis ATP release Ca2+transients cochlea mitochondrial function reactive oxygen species spontaneous electrical activity supporting cells

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利伐沙班对股骨转子间骨折患者术后凝血功能及DVT形成的影响

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天津药学 2024年第3期36卷 33-36页

作者：邱剑华九江学院第二附属医院江西332005

目的:探讨利伐沙班与低分子肝素对股骨转子间骨折(IFF)患者术后凝血功能及下肢深静脉血栓(DVT)的影响。方法:按照随机数字表法将2021年2月—2023年2月在本院接受治疗的72例IFF患者分为两组,各36例。对照组采用低分子肝素治疗[分别于入... 详细信息

目的:探讨利伐沙班与低分子肝素对股骨转子间骨折(IFF)患者术后凝血功能及下肢深静脉血栓(DVT)的影响。方法:按照随机数字表法将2021年2月—2023年2月在本院接受治疗的72例IFF患者分为两组,各36例。对照组采用低分子肝素治疗[分别于入院至术前12 h、术后6 h采用低分子肝素钙皮下注射,4 100 IU/次],观察组采用利伐沙班治疗[于入院至术前12 h口服利伐沙班,10 mg/次,1次/d,并于术后2~12 h继续口服用药,10 mg/次,1次/d],两组均持续治疗至出院。比较两组凝血功能、DVT形成率、感染情况、术后康复情况、出血性事件以及不良反应。结果:治疗前两组活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)和D-二聚体(D-D)水平比较无统计学差异(P>0.05);治疗后两组APTT和PT较治疗前明显增长,FIB水平明显增高,D-D水平明显降低,且观察组均优于对照组(P0.05);治疗后两组WBC、IL-6、PCT和IL-6水平较治疗前降低(P0.05),观察组PCT和IL-6水平低于对照组(P0.05)。两组不良反应总发生率比较无统计学差异(P>0.05)。结论:利伐沙班与低分子肝素在IFF患者术后治疗中效果确切,二者均具有较高的安全性,但利伐沙班的整体疗效优于低分子肝素,在改善患者凝血功能、降低患者感染指标、减少DVT形成率等方面作用更为突出,值得推广。

关键词：股骨转子间骨折利伐沙班低分子肝素凝血功能下肢静脉血栓

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江汉盆地江陵凹陷复兴场背斜盐构造特征与成因

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石油实验地质 2024年第1期46卷 54-63页

作者：邱建华彭金宁唐玮潘文蕾李风勋杨帆中国石化石油勘探开发研究院无锡石油地质研究所江苏无锡214126 中国石化油气成藏重点实验室江苏无锡214126 中国石化江汉油田分公司勘探开发研究院石油开发所荆州项目部湖北荆州434020

复兴场盐背斜是江汉盆地江陵凹陷重要的含油构造,其构造演化及成因机制认识不清,制约了精细勘探。因此,对复兴场盐背斜构造演化及形成机制的分析,不仅有助于理解盐层在不同应力背景下的流动对背斜形成演化的影响,对理解油气成藏过程也... 详细信息

复兴场盐背斜是江汉盆地江陵凹陷重要的含油构造,其构造演化及成因机制认识不清,制约了精细勘探。因此,对复兴场盐背斜构造演化及形成机制的分析,不仅有助于理解盐层在不同应力背景下的流动对背斜形成演化的影响,对理解油气成藏过程也有重要意义。通过对三维地震资料的精细解析,结合关键构造层的平衡恢复技术及生长地层分析技术,研究复兴场背斜的构造特征及成因机制。结果显示,复兴场背斜为一构造特征走向上变化显著,受多期次断层改造、多种变形机制复合而成的盐背斜;背斜初始于早始新世新沟咀组沉积期—晚始新世早期的正断层作用,形成滚筒状褶皱并造成盐层的聚集;在晚始新世晚期—渐新世,沉积地层的差异负载作用驱使盐层自西向东流动,造成构造整体西倾,形成单斜构造,并在渐新世晚期抬升剥蚀;背斜定型于新近纪—第四纪,发生构造反转,演化为一挤压型盐背斜,伴生逆断层和膝折构造。复兴场背斜的形成和演化受区域应力背景、沙市组盐层、东倾正断层及盐下古构造等因素的综合作用。复兴场盐背斜形成的构造圈闭略早于烃源岩的主要排油期,并且在主要排油期,构造处于拗陷阶段,断层活动弱,有利于早期圈闭油气的成藏。

关键词：构造平衡恢复演化特征成因机制复兴场背斜江陵凹陷江汉盆地

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选择实验视角下塑料污染治理的农业生态价值评估——来自黑、豫、浙、粤、川五省的经验证据

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生态经济 2024年第8期40卷 201-207页

作者：韩灵梅游健强申洪涛邱建华河南科技大学商学院河南洛阳471000 河南中烟工业有限责任公司技术中心河南郑州450000

塑料为农业生产带来了极大的便利,但其废弃物的不当管理也造成了严重的环境问题。为了科学评估塑料污染治理的农业生态价值,合理确定污染治理措施的优先序,优化塑料污染治理投入资源配置,论文设计了一个包括源头减量、回收利用、清理整... 详细信息

塑料为农业生产带来了极大的便利,但其废弃物的不当管理也造成了严重的环境问题。为了科学评估塑料污染治理的农业生态价值,合理确定污染治理措施的优先序,优化塑料污染治理投入资源配置,论文设计了一个包括源头减量、回收利用、清理整治与价格等属性的选择实验,以黑、豫、浙、粤、川5省487份调研数据为例,利用条件Logit模型测算塑料污染治理的边际支付意愿与塑料污染治理价值的补偿剩余。研究表明:(1)受访农业居民在塑料污染治理特征属性上的偏好为:源头减量>清理整治>回收利用,其支付意愿分别为:32.79元/人、25.27元/人、15.78元/人;(2)通过补偿剩余测算,为解决塑料污染治理难题,受访农业居民污染治理支付意愿为147.68元/人。应逐步构建起“减量化—再利用—资源化”的塑料污染全生命周期治理体系,优先考虑源头减量和清理整治方面的治理措施。

关键词：选择实验法塑料污染治理支付意愿价值评估

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The source and formation characteristics of the Zhujiadun gas reservoirs in the Yancheng Sag, Subei Basin

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能源地球科学(英文) 2023年第3期4卷 90-99页

作者： Jinning Peng Xu Liu Wenlei Pan Haihua Li jianhua qiu SINOPEC Key Laboratory of Petroleum Accumulation Mechanisms Wuxi214126China Wuxi Research Institute of Petroleum Geology SINOPECWuxi214126China

The Yancheng Sag is a favorable exploration area in the Subei Basin. However, the key geological understanding of the natural gas source and reservoir formation characteristics of the sag is still controversial. Based on a set of organic geochemical experiments conducted on natural gas and associated condensate oil of the first member of the Funing Formation (E1f1) in well YCh5 and well data analysis, the oil-gas resources and reservoir formation model in the Zhujiadun gas reservoir in the Yancheng Sag, Subei Basin, were investigated. The results of this study are as follows. (1) The natural gas in the Zhujiadun gas reservoir is dry gas with high methane content, low heavy hydrocarbon content, and high maturity. The characteristics of carbon and hydrogen isotopes in the natural gas indicate that the natural gas is oil-cracked gas, which mainly originates from the source rocks of the Permian Qixia Formation. (2) The condensate oil from well YCh5 with a high degree of maturity has a high pristane/phytane ratio, low gamma-paraffin abundance, and low tricyclic terpene abundance, indicating a mixture of the Upper Paleozoic condensate oil and Cenozoic crude oil. The saturated and aromatic hydrocarbons have similar δ13C values to the Cenozoic continental crude oil. These features suggest two sources of condensate oil. (3) Oils generated from the source rocks of the Qixia Formation were cracked into highly mature gas after deep burial, which migrated along large faults into the sandstones of the E1f1 and K1t1 members. This type of reservoir was effectively preserved beneath the overlying mudstone cap rocks. Therefore, it can be inferred that a play fairway might occur in the eastern zone of the faults connected to the Paleozoic source rocks in the Yancheng Sag since this zone has similar petroleum geological conditions to well YCh5. Therefore, this zone is a favorable area for further exploration.

关键词： Genesis of natural gas Geochemical characteristics Reservoir formation model Yancheng Sag Subei Basin

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物理化学实验思政改革的探索与实践

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大学化学 2024年第4期39卷 119-124页

作者：樊友军蔡丹丹陈卫邱建华广西师范大学化学与药学学院化学国家级实验教学示范中心(广西师范大学)广西桂林541004 中山大学化学工程与技术学院广东珠海519082

针对当前物理化学实验课程思政与实验教学脱节和融合不畅的问题,通过培养教师课程思政的意识和能力、修订物理化学实验教学目标、优化教学内容、完善教学手段和考核方式等方面的探索,将课程思政元素“润物细无声”地融合到实验教学中,... 详细信息

针对当前物理化学实验课程思政与实验教学脱节和融合不畅的问题,通过培养教师课程思政的意识和能力、修订物理化学实验教学目标、优化教学内容、完善教学手段和考核方式等方面的探索,将课程思政元素“润物细无声”地融合到实验教学中,使学生“亲其师,信其道”,品尝到含有思政元素“盐”的“美味佳肴”。

关键词：物理化学实验课程思政改革探索实践

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乡村振兴战略下运动休闲特色小镇体育产业发展研究

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冰雪体育创新研究 2024年第5期 13-15页

作者：邱建华陈荣项建民张林宝余奂上饶师范学院体育学院江西上饶334001 华东交通大学体育与健康学院江西南昌330013

运动休闲特色小镇以其“特而强”“聚而合”“小而美”“新而活”等特点赢得消费者的好评,为发展体育产业营造了有利的态势。然而由于现阶段还存在体育产业发展定位不精准、基础设施建设不完善等劣势问题,使得运动休闲特色小镇发展受到... 详细信息

运动休闲特色小镇以其“特而强”“聚而合”“小而美”“新而活”等特点赢得消费者的好评,为发展体育产业营造了有利的态势。然而由于现阶段还存在体育产业发展定位不精准、基础设施建设不完善等劣势问题,使得运动休闲特色小镇发展受到制约,无法为更多的消费者提供多样化的项目体验。对此该文对运动休闲特色小镇的体育产业发展机遇和挑战进行思考及改进策略研究,期望能起到参考作用。

关键词：乡村振兴运动休闲特色小镇体育产业

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DYNAMIC CHARACTERISTICS OF LARGE FLOW RATING ELECTROHYDRAULIC PROPORTIONAL CARTRIDGE VALVE

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Chinese Journal of Mechanical Engineering 2008年第6期21卷 57-62页

作者： FU Linjian WEI jianhua qiu Minxiu State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

A kind of cartridge servo proportional valve is discussed, which can be used for controlling large flow rate with high performance. By analyzing the structure principle of the valve, the transfer fimction of the valve is derived. With the transfer function, some structure elements that may affect its performance are investigated. Through the numerical simulation and test study, some principles of optimality and effective methods for improving the dynamic performance of the valve are proposed. The test results conform to the results of the theoretical analysis and simulation, which proves the correctness of the study and simulation works. The paper provides theoretical basis for engineering applications and series expanding design works

关键词： Large flow rate electro-hydraulic proportional cartridge valve Dynamic characteristics

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Simultaneous removal of 1,2-dichlorobenzene and furan over Mn-Ce-Fe oxide catalyst:Catalytic activity and product analysis

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Journal of Rare Earths 2024年第5期42卷 972-979,I0006页

作者： Juan qiu Minghui Tang Yaqi Peng Xuanhao Guo Shengyong Lu jianhua Yan Taizhou Institute of Zhejiang University Taizhou 318000China State Key Laboratory for Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China

The Mn-Ce-Fe mixed oxide(MCFe)was prepared by co-precipitation and the catalytic performance was tested by using 1,2-dichlorobenzene(1,2-DCB)and furan as model molecules of PCDD/*** effect of O_(2)concentration,SO_(2) and NO on the catalytic activity was *** 270℃,the MCFe oxide catalyst presents significant simultaneous removal efficiency of 75.25%and 100%for 1,2-DCB and furan,***-Emmett-Teller(BET)method(BET),X-ray diffraction(XRD),scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectroscopy(FTIR),H_2-temperature programmed reduction(H_(2)-TPR),NH_(3)-temperature programmed desorption(NH_3-TPD)and O_(2)-TPD were used to characterize the catalysts before and after the *** tests suggest that the oxidation behavior of furan occurred prior to that of 1,*** to the intermediate products detected by gas chromatography-mass spectrometry(GC-MS),the by-products include chlorinated hydrocarbons,long-chain hydrocarbons,ketone,*** catalytic oxidation reaction paths are proposed.

关键词： 1 2-dichlorobenzene Furan Catalytic oxidation Product analysis Rare earths

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