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Erythropoietin reduces apoptosis of brain tissue cells in rats after cerebral ischemia/reperfusion injury:a characteristic analysis using magnetic resonance imaging

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Neural Regeneration Research 2016年第9期11卷 1450-1455页

作者： Chun-juan jiang Zhong-juan Wang Yan-jun Zhao Zhui-yang Zhang Jing-jing Tao jian-yong Ma Department of Radiology Wuxi Second People's Hospital Affiliated to Nanjing Medical University

Some in vitro experiments have shown that erythropoietin （EPO） increases resistance to apoptosis and facilitates neuronal survival follow- ing cerebral ischemia. However, results from in vivo studies are rarely reported. Perfusion-weighted imaging （PWI） and diffusion-weighted imaging （DWI） have been applied successfully to distinguish acute cerebral ischemic necrosis and penumbra in living animals; therefore, we hypothesized that PWI and DWI could be used to provide imaging evidence in vivo for the conclusion that EPO could reduce apoptosis in brain areas injured by cerebral ischemia/reperfusion. To validate this hypothesis, we established a rat model of focal cerebral ischemia/ reperfusion injury, and treated with intra-cerebroventricular injection of EPO （5,000 U/kg） 20 minutes before injury. Brain tissue in the ischemic injury zone was sampled using MRI-guided localization. The relative area of abnormal tissue, changes in PWI and DWI in the ischemic injury zone, and the number of apoptotic cells based on TdT-mediated dUTP-biotin nick end-labeling （TUNEL） were assessed. Our findings demonstrate that EPO reduces the relative area of abnormally high signal in PWI and DWI, increases cerebral blood volume, and decreases the number of apoptotic cells positive for TUNEL in the area injured by cerebral ischemia/reperfusion. The experiment pro- vides imaging evidence in vivo for EPO treating cerebral ischemia/reperfusion injury.

关键词： nerve regeneration nerve protection cerebral ischemia/reperfusion erythropoietin magnetic resonance imaging diffusion-weightedimaging apparent diffusion coefficient perfusion-weighted imaging cerebral blood volume mean transit time apoptosis neural regeneration

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Continuous-Wave Operation of Terahertz Quantum Cascade Lasers at 3.2 THz

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Chinese Physics Letters 2013年第6期30卷 102-105页

作者： WANG Tao LIU jun-Qi CHEN jian-Yan LIU Ying-Hui LIU Feng-Qi WANG Li-jun WANG Zhan-Guo Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083

We demonstrate continuous-wave(cw)operation of terahertz(THz)quantum cascade lasers emitting at 3.2 THz based on bound-to-continuum active region and semi-insulating surface-plasmon waveguide *** power of 62 mW with a threshold current density of 285 A/cm^(2)is obtained at 10 K from a 130-μm-wide and 1.5-mm-long laser in cw *** cw operation temperature is up to 60 *** pulsed mode,peak optical power more than 100 mW at 10 K and 2.1 mW at 85 K are observed from a 230-μm-wide and 2-mm-long device.

关键词： waveguide Lasers Quantum

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Comparison of Murraya exotica and Murraya paniculata by fingerprint analysis coupled with chemometrics and network pharmacology methods

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Chinese Journal of Natural Medicines 2021年第9期19卷 713-720页

作者： LIANG Hai-Zhen DU Zhi-Yong YUAN Shuo LU Meng-qiu XING jian-Yong MA Qing HAN Zheng-Zhou TU Peng-Fei jianG Yong State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China China Resources Sanjiu Medical&Pharmaceutical Co.Ltd. Shenzhen 518110China

There are two source plants for the traditional Chinese medicine Murrayae Folium et Cacumen(MFC)in Chinese Pharmacopoeia,*** exotica *** ***(L.)***,a chemical comparison of *** and *** by high performance liquid chromatography(HPLC)fingerprint analysis coupled with chemometrics and network pharmacology was *** main peaks in the fingerprints were identified by liquid chromatography coupled with ion trap/time-of-flight mass spectrometry(LC-IT-TOF-MS)and authenticated by *** chemometrics results showed that the HPLC fingerprints of these two species were clearly divided into two categories using hierarchical cluster analysis(HCA)and principal component analysis(PCA),and a total of 13 significantly differentiated markers were screened out by orthogonal partial least squares-discriminant analysis(OPLS-DA).However,the following network pharmacology analysis showed that these discriminated markers were found to act via many common targets and metabolic pathways,indicating the possibly similar pharmacological effects and mechanisms for *** and *** above results provide valuable evidence for the equivalent use of these two plants in clinical ***,the chromatographic fingerprint analysis coupled with chemometrics and network pharmacology supplies an efficient approach for the comparative analysis of multi-source TCMs like MFC.

关键词： Murraya exotica Murraya paniculata Multi-source TCM HPLC fingerprint Chemometrics Network pharmacology

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A Mechanoelectrical Coupling Model of Neurons under Stretching

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医用生物力学 2019年第A1期34卷 171-172页

作者： Jin Tian Guoyou Huang Min Lin Jinbin qiu Baoyong Sha Tian jian Lu Feng Xu State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong UniversityXi'an710049China The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science andTechnologyXi’an Jiaotong UniversityXi’an 710049China Bioinspired Engineering and Biomechanics Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049China MOE Key Laboratory of Multifunctional Materials andStructures Xi’an Jiaotong UniversityXi’an 710049China Institute of Basic Medical Science School of Basic Medical ScienceXi’an Medical UniversityXi’an 710021China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Introduction Neurons are situated in a microenvironment composed of various biochemical and biophysical cues,where stretching is thought to have a major impact on *** instance,during a moderate traumatic brain impact,the injury region in axons exhibits significant longitudinal strain;and in a rat model of spinal cord injury,the most severe axonal injury is located in the largest strain *** may result in microstructural changes in neural tissue and further leading to abnormal electrophysiological ***,it is of great importance to understand the coupled mechanoelectricalbehaviors of neurons under *** spite of significant experimental efforts,the underlying mechanism remains elusive,more works are needed to provide a detailed description of the process that leads to the observed *** modeling is a powerful tool that offers a quantitative description of the underlying mechanism of an observed biological phenomenon,including mechanical and electrophysiological behaviors of ***,we developed a mechanoelectrical coupling model of neurons under stretching in this *** model The mathematical model consists of three submodels,i.e.,the mechanical submodel,the mechanoelectrical coupling submodel and the electrophysiological *** mechanical submodel deals with the relationship between stretching and the deformation of axons,which has specially considered the plastic deformation of *** electrophysiological submodel characterizes the feature of neuronal action potential(AP),which is based on the classical H-H model and the cable *** mechanoelectrical coupling submodel links the mechanical and electrophysiological submodels through strain-induced equivalent circuit parameter alteration and ion channel ***,we have discussed a more general deformation condition,where an expanded model coupling the axonal deformation and electrophysiology alteration was *** the mos

关键词： biomechanics electrophysiology H-H model cable theory neuronal injury

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The ralationship between fractional anisotropy value and tumor microarchitecture in late-stage rat glioma

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Asian Pacific Journal of Tropical Medicine 2017年第6期10卷 677-681页

作者： Xiang-Ying Li jian-Qiang Chen Yi-Kai Xu Xiang-jun Han Department of Medical Imaging Center Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Central South University Xiangya School of Medicine Affiliated Haikou Hospital/Haikou People's HospitalHaikouHainanP.R.China Department of Radiology Kangya HospitalYiyangHunanP.R.China

Objective: To explore the magnetic resonance diffusion tensor imaging(MR-DTI) features of in the late stage of Wistar rat C6 brain glioma, and the relationship between fractional anisotropy value and tumor microarchitecture. Methods: The concentration of more than 1.0×伊 106/10 μL glioma cells and complete medium were injected stereotactically into the right caudate nucleus of the experimental group(n=35) and control group(n=10), respectively. Conventional MRI, DTI, and enhanced T1 WI scans were Performed using the GE Signa HD× 3.0T MRI scanner about 3-4 weeks after implantation for the rats. Postproeessing was done using the DTI specific software Function Tool to gain FA image. Many ROIs were drawn avoiding hemorrhage, necrosis areas in tumor parenchyma, the value of FA was recorded. Each surviving rat brain was examined histologically using HE and immunohistochemical staining for VEGF and CD34. Pearson correlation analysis was used to determine the relationships between FA values and VEGF, MVD, cell density, respectively. Results: A total of 35 tumor-bearing rats were confirmed the tumor formation by the subsequent MRI and pathological examination. The mean FA values of the tumor and the contralateral brain tissue were 0.17 ± 0.03 and 0.31 ± 0.05 respectively, and the difference was statistically significant(t = 12.80, P 0.05). FA value in the late stage of Wistar rat C6 brain glioma has significant positive correlation to VEGF, MVD, cell density. The correlation coefficients between FA and VEGF, MVD, and cell density were 0.67, 0.65 and 0.71(P<0.05), respectively. Conclusions: The FA value of rat glioma tumor in the late stage can preoperatively provide an accurate, reliable and noninvasive imaging monitoring method to evaluate the microstructure of gliom

关键词： Rat Glioma Magnetic resonance diffusion tensor imaging Fractional anisotropy Immunohistochemistry

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Freestanding strontium vanadate/carbon nanotube films for long-life aqueous zinc-ion batteries

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Rare Metals 2022年第2期41卷 415-424页

作者： Ye-Hong Du Xian-Yu Liu Xin-Yu Wang jun-Cai Sun Qiong-Qiong Lu jian-Zhi Wang Ahmad Omar Daria Mikhailova Institute of Materials and Technology Dalian Maritime UniversityDalian 116026China e-mail:wangxinyu@*** School of Chemistry and Chemical Engineering Lanzhou City UniversityLanzhou 730070China Leibniz Institute for Solid State and Materials Research(IFW)Dresden E.V Helmholtzstraße 2001069 DresdenGermany e-mail:q.lu@ifw-dresden.de Key Laboratory for Green Chemical Process of Ministry of Education School of Chemical Engineering and PharmacyWuhan Institute of TechnologyWuhan 430205China

Aqueous rechargeable zinc-ion battery(ZIB)is considered to be a potential energy storage system for large-scale applications due to its environmental friendliness,high safety,and low ***,it remains challenging to develop suitable cathode materials with high specific capacity and long-term cyclic ***,we have fabricated freestanding Sr0.19V2O51.3H2O/carbon nanotubes(SrVO/CNTs)composite films with different mass ratios by incorporating SrVO into CNTs *** synthesized SrVO possesses a large interlayer spacing of 1.31 nm,which facilitates Zn(2+)***,the SrVO/CNTs composite film with conductive network structure promotes electron transfer and ensures good contact between SrVO and CNTs during the long-term cycling *** a result,the battery based on the SrVO/CNTs composite cathode with a mass ratio of 7:3 delivers a specific capacity of 326 mAh·g^(-1)at 0.1 A·g^(-1)and 145 mAh·g^(-1)at 5 A·g^(-1),demonstrating a high capacity and excellent rate ***,the assembled ZIB shows good capacity retention of 91%even after ultra-long cycling for 7500 cycles at a high current rate of 5 Ag^(-1).More importantly,the battery also delivers a high energy density and power density,as 290 Wh·kg^(-1)at 125 W·kg^(-1)(0.1 A·g^(-1)),or 115 Wh·kg^(-1)at 6078 W·kg^(-1)(5 Ag^(-1)).The results demonstrate that the SrVO/CNTs composite is a promising cathode toward large-scale energy storage applications.

关键词： Aqueous zinc-ion battery Strontium vanadate Carbon nanotubes network Freestanding composite film Long cycle life

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Research on focal nodular hyperplasia with MSCT and postprocessing

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World Journal of Gastroenterology 2009年第38期15卷 4838-4843页

作者： Yuan-jian Liu Wei-jun Fan Zhi-Dong Yuan Peng-Cheng Liu Chun-Rong Wang Wei-Qiang Yan Su-Mei Wang jun-Hui Chen Zheng Liu Imaging Center Peking University Shenzhen HospitalShenzhen 518036 Guangdong Province China State Key Laboratory of Oncology in Southem China Imaging and Interventional Center Cancer Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China

AIM： To investigate and evaluate the pathological features and diagnostic value of focal nodular hyperplasia （FNH） with multiection spiral computed tomography （MSCT） and postprocessing. METHODS： A total of 25 patients with FNH who had undergone MSCT and postprocessing were included in the investigation. All patients had been pathologically or clinically confirmed with FNH. A number of 75 cases of hepatic carcinomas, hemangiomas and adenomas were randomly selected at a same period for a comparative study. RESULTS： There was a single focus in 22 cases and multiple foci in 3 cases. On the plain scan, 17 lesions showed hypodensity, 7 isodensity and 4 hyperdensity （the case with fatty liver）. With contrast, 28 lesions were enhanced evenly or in the nodules in the arterial phase; 13 lesions still showed hyperdensity, 11 lesions isodensity and 4 lesions hypodensity in the parenchymatous phase; in the delayed phase only 5 lesions showed hyperdensity but 9 lesions showed isodensity or slight hypodensity and 14 lesions showed hypodensity. Twelve lesions of 28 had central asteroid scars. Thickened feeding arteries in postprocessing were seen in 24 lesions, and were integrated into the parenchymatous lesions with a gradual and smooth course. On the contrary, there were no artery penetrated into the lesion found in any of comparative hepatic tumors. CONCLUSION： Doctors could make a correct diagnosis and differentiation of FNH on evaluation of the characteristic appearance on MSCT with postprocessing,

关键词： Angiography Computer-assisted imageprocessing Focal nodular hyperplasia Liver diseases X-ray Computed tomography

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输卵管和腹膜结核的MRI表现特征分析

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中国CT和MRI杂志 2024年第9期22卷 131-133页

作者：邱健邹仡伟黄炳乐丁宇薛周李文华上海健康医学院附属崇明医院医学影像科上海202150 上海交通大学医学院附属新华医院放射科上海200092

目的探讨输卵管和腹膜结核的MRI表现特征。方法选21例经病理和实验室检查证实的输卵管和腹膜结核(TB)患者和27例卵巢癌(EOC)累及输卵管伴腹膜转移患者的临床和MRI及PET/CT表现进行比较分析,对病变形态、T1WI、T2WI和弥散加权成像(DWI)... 详细信息

目的探讨输卵管和腹膜结核的MRI表现特征。方法选21例经病理和实验室检查证实的输卵管和腹膜结核(TB)患者和27例卵巢癌(EOC)累及输卵管伴腹膜转移患者的临床和MRI及PET/CT表现进行比较分析,对病变形态、T1WI、T2WI和弥散加权成像(DWI)信号特点、表观弥散系数(ADC)值及强化特征进行分析研究。结果21例TB患者中,16例输卵管TB为单侧性(左侧9例,右侧7例),5例为双侧性。病变输卵管10例呈棒状,12例呈腊肠状S或L形,4例呈肿块状。病变输卵管于T1WI上呈略高信号,T2WI上呈软组织中等信号,DWI上呈高信号,ADC值测量范围为0.75-1.02×10-3mm2/s。结核性输卵管病变大小从0.7×2.2cm到1.5×4.5cm。TB性腹膜的厚度范围为1.6mm-3.2mm,呈薄层均匀平滑无结节增厚。结论输卵管呈管状、S/L形等非肿块样改变,在T1WI呈略高信号和腹膜呈薄层均匀性增厚并明显强化是输卵管和腹膜结核的特征表现。

关键词：输卵管腹膜结核磁共振成像扩散加权成像

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The Data Processing of the LAMOST Medium-resolution Spectral Survey of Galactic Nebulae(LAMOST MRS-N Pipeline)

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Research in Astronomy and Astrophysics 2022年第7期22卷 224-234页

作者： Chao-jian Wu Hong Wu Wei Zhang Yao Li Juan-Juan Ren jian-jun Chen Chih-Hao Hsia Yu-Zhong Wu Hui Zhu Bin Li Yong-Hui Hou CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyTaipaMacaoChina Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008China University of Science and Technology of China Hefei 230026China 8 Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China

The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) medium-resolution spectral survey of Galactic Nebulae(MRS-N) has conducted for more than three years since 2018 September and observed more than190 thousand nebular spectra and 20 thousand stellar ***,there is not yet a data processing pipeline for nebular *** significantly improve the accuracy of nebulae classification and their physical parameters,we developed the MRS-N *** article presented in detail each data processing step of the MRS-N Pipeline,such as removing cosmic rays,merging single exposure,fitting sky light emission lines,wavelength recalibration,subtracting skylight,measuring nebular parameters,creating catalogs and packing ***,a description of the data products,including nebular spectra files and parameter catalogs,is provided.

关键词： surveys catalogs methods:data analysis ISM:general

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Self-healed microcracks in polymer bonded explosives via thermoreversible covalent bond and hydrogen actions

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Defence Technology（防务技术） 2023年第10期28卷 183-194页

作者： Yu-bin Li Xu Zhao Ya-jun Luo Zhi-jian Yang Li-ping Pan Cheng-cheng Zeng Cong-mei Lin Xue Zheng Institute of Chemical Materials China Academy of Engineering PhysicsMianyang621900China

Polymeric materials used for the polymer bonded explosive(PBX)or other energetic composite materials(ECMs)that simultaneously possess excellent mechanical properties and high self-healing ability,convenient healing,and facile fabrication are always a huge ***,self-healing linear polyurethane elastomers(PTMEG2000-IPDI-DAPU,denoted as 2I-DAPU)with high healing efficiency and mechanical properties were facilely fabricated by constructing reversible covalent bonds and dynamic hard domains into polymer ***,a TATB-based PBX using as-prepared 2I-DAPU polymer as the binder was constructed,disclosing an excellent self-healing property to heal cracks generated during fabrication,transportation and *** damage healing manner of such a PBX sample was investigated by means of prefabricated damage through mechanical load,heal treatment via heating at high temperature,and CT-scanning the inner structure and mechanical property characterization via Brazilian *** self-healing mechanism of internal damage in PBX was preliminarily *** propose that this 2I-DAPU binder with Diels-Alder bonds could generate plentiful active surface groups resulting from damage and drive self-healing at fitting temperature and increase the slightly packed hard phase via incorporating a small amount of hydrogen *** work may offer a novel strategy for improving mechanical property and healing ability in the field of self-healing material which could help expand its applications with enhanced versatility in mechanical-enhanced functional materials.

关键词： Polymer bonded explosives Self-healing polymers Diels-alder(DA)bonds H-bond

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