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CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN qinghua song HUA LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

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3D Cohesive Finite Element Minimum Invasive Surgery Simulation Based on Kelvin‑Voigt Model

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 161-173页

作者： Yonghang Jiang qinghua song Xichun Luo Centre for Precision Manufacturing Department of Design Manufacturing&Engineering ManagementUniversity of StrathclydeGlasgow G11XJUK Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationSchool of Mechanical EngineeringShandong UniversityJinan 250013China

Minimally invasive surgery is an important technique used for cytopathological ***,multiple studies have been conducted on a three-dimensional(3D)puncture simulation model as it can reveal the internal deformation state of the tissue at the micro *** this study,a viscoelastic constitutive equation suitable for muscle tissue was ***,a method was developed to define the fracture characteristics of muscle tissue material during the simulation *** fracture of the muscle tissue in contact with the puncture needle was simulated using the cohesive zone model and a 3D puncture finite element model was established to analyze the deformation of the muscle *** stress nephogram and reaction force under different parameters were compared and analyzed to study the deformation of the biological soft tissue and guide the actual operation process and reduce pain.

关键词： Minimally invasive surgery Constitutive model 3D simulation Cohesive zone model

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Constrained layer damping treatment of a model support sting

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Chinese Journal of Aeronautics 2021年第8期34卷 58-64页

作者： Jiahao PAN Zhanqiang LIU Xiping KOU qinghua song School of Mechanical Engineering Shandong UniversityJi'nan 250061China Key National Demonstration Center for Experimental Mechanical Engineering Education/Key Laboratory of High Efficiency and Clean Mechanical Manufacture of MOE Ji'nan 250061China High Speed Aerodynamics Institute China Aerodynamics Research and Development CenterMianyang 621000China

In transonic wind tunnel tests,the pulsating airflow is prone to induce the first order resonance of the sting support *** resonance limits the wind tunnel test envelope,makes the test data inaccurate,and brings potential security *** this paper,a model support sting with constrained layer damping(CLD)treatment is proposed to reduce the first order resonance *** CLD treatment mainly consists of material selection and geometric optimization *** damping performance of the optimized CLD sting is compared with an AISI 1045 steel sting with the identical diameter in *** frequency response curves of the CLD sting support system and the AISI 1045 steel sting support system are obtained by sine sweep *** test results show that the first order resonance response of the CLD sting support system is 37.3%of that of the AISI 1045 steel sting support *** first order damping ratios are calculated from the frequency response curves by half power point *** is found that the first order damping ratio of the CLD sting support system is approximately 2.6 times that of the AISI 1045 steel sting support system.

关键词： Constrained layer damping Model supports Vibration control Viscoelastic materials Wind tunnels

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A novel stability prediction approach for thin-walled component milling considering material removing process

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Chinese Journal of Aeronautics 2017年第5期30卷 1789-1798页

作者： Jiahao SHI qinghua song Zhanqiang LIU Xing AI Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of Education Shandong University Ji'nan 250061 China School of Mechanical Engineering Shandong University Ji'nan 250061 China

The milling stability of thin-walled components is an important issue in the aviation manufacturing industry, which greatly limits the removal rate of a workpiece. However, for a thin-walled workpiece, the dynamic characteristics vary at different positions. In addition, the removed part also has influence on determining the modal parameters of the workpiece. Thus,the milling stability is also time-variant. In this work, in order to investigate the time variation of a workpiece＇s dynamic characteristics, a new computational model is firstly derived by dividing the workpiece into a removed part and a remaining part with the Ritz method. Then, an updated frequency response function is obtained by Lagrange＇s equation and the corresponding modal parameters are extracted. Finally, multi-mode stability lobes are plotted by the different quadrature method and its accuracy is verified by experiments. The proposed method improves the computational efficiency to predict the time-varying characteristics of a thin-walled workpiece.

关键词： Material removal effect Multi-mode Stability Thin-walled workpiece Vibration

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Partial Surface Damper to Suppress Vibration for Thin Walled Plate Milling

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Chinese Journal of Mechanical Engineering 2017年第3期30卷 632-643页

作者： Jiahao SHI qinghua song Zhanqiang LIU Xing AI key laboratory of high efficiency and clean mechanical manufacture of ministry of education shandong universityJinan 250061China school of mechanical engineering shandong universityJinan 250061China

The material removal rate and required work- piece surface quality of thin-walled structure milling are greatly limited due to its severe vibration, which is directly associated with the dynamic characteristics of the system. Therefore, the suppression of vibration is an unavoidable problem during milling. A novel partial surface damping method is proposed to modify the mode of the thin walled cantilever plate and to suppress vibration during milling. Based on classical plate theory, the design criterion is analyzed and configuration of the partial surface damper is introduced, in which viscoelastic plate and constraining plate are attached to the surface of the plate to increase the system＇s natural frequency and loss factor. In order to obtain the energy expression of the cutting system, the Ritz method is used to describe the unknown displacements. Then, with Lagrange＇s equation, the natural frequency and loss factor are calculated. In addition, the plate is divided into a finite number of square elements, and the regulation of treated position is studied based on theoretic and experimental analysis. The milling tests are conducted to verify its damping performance and the experimentalresults show that with treatment of partial surface damper, the deformation of the hare plate is reduced from 0.27 mm to 0.1 mm, while the vibration amplitude of the bare plate is reduced from 0.08 mm to 0.01 mm. The proposed research provides the instruction to design partial surface damper.

关键词： Partial surface damper Milling process Thin-walled plate

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Chatter suppression techniques in milling processes:A state of the art review

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Chinese Journal of Aeronautics 2024年第7期37卷 1-23页

作者： Zhenmin LI qinghua song Peijian JIN Zhanqiang LIU Bing WANG Haifeng MA Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061China National Demonstration Center for Experimental Mechanical Engineering Education Shandong UniversityJinan 250061China

Chatter in the machining system can result in a decrease in tool life,poor surface finish,conservative cutting parameters,*** many review papers promoting the understanding and research of this area,chatter suppression techniques are generally discussed within limited pages in the framework of comprehensive chatter-related *** recent years,the developments of smart materials,advanced sensing techniques,and more effective control strategies have led to some new progress in chatter ***,the widely used thin-walled parts present more and more severe machining challenges in their milling *** the above deficiencies,this paper summarizes the current state of the art in milling chatter *** classifications of chatter suppression techniques are proposed according to the working principle and control *** on the new classified framework,the mechanism and comparisons of different chatter suppression strategies are ***,the current challenges and potential tendencies of milling chatter suppression techniques are ***,integration,compactness,adaptability to workpiece geometry,and the collaboration of multiple control methods are predicted to be important trends in the future.

关键词： Active control Chatter suppression Damping Milling Regenerative effect

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Fiber orientation effects on grinding characteristics and removal mechanism of 2.5D C_(f)/SiC composites

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Chinese Journal of Aeronautics 2023年第12期36卷 425-441页

作者： Cheng CAO qinghua song Hui FU Hansong JI Zhanqiang LIU Liping JIANG Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061China National Demonstration Center for Experimental Mechanical Engineering Education Shandong UniversityJinan 250061China Shandong Industrial Ceramic Research&Design Institute Zibo 255020China

Carbon fiber reinforced silicon carbide(C_(f)/SiC)composites are widely used in aerospace for their excellent mechanical ***,the quality of the machined surface is poor and unpredictable due to the material heterogeneity induced by complex removal *** clarify the effects of fiber orientation on the grinding characteristics and removal mechanism,single grit scratch experiments under different fiber orientations are conducted and a three-phase numerical modelling method for 2.5D C_(f)/SiC composites is *** fiber cutting modes i.e.,transverse,normal and longitudinal,are defined by fiber orientation and three machining directions i.e.,MA(longitudinal and normal),MB(longitudinal and transverse)and MC(normal and transverse),are selected to investigate the effect of fiber orientation on grinding force and ***,a three-phase cutting model of 2.5D C_(f)/SiC composites considering the mechanical properties of the matrix,fiber and interface is *** simulations are performed to reveal the micro-mechanism of crack initiation and extension as well as the material removal mechanism under different fiber *** results indicate that the scratching forces fluctuate periodically,and the order of mean forces is MA>MC>*** tend to grow along the fiber axis,which results in the largest damage layer for transverse fibers and the smallest for longitudinal *** removal modes of transverse fibers are worn,fracture and peel-off,in which normal fibers are pullout and outcrop and the longitudinal fibers are worn and *** the stable cutting condition,the change of contact area between fiber and grit leads to different removal modes of fiber in the same cutting mode,and the increase of contact area results in the aggravation of fiber fracture.

关键词： 2.5D C_(f)/SiC composites Material removal mechanism Numerical modelling Single grit scratch experiments Surface morphology

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Three‑dimensional Modeling and Simulation of Muscle Tissue Puncture Process

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 174-186页

作者： Zongkai Lv qinghua song Fan Gao Zhanqiang Liu Yi Wan Yonghang Jiang School of Mechanical Engineering Shandong UniversityJinan 250061China Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationShandong UniversityJinan 250061China National Demonstration Center for Experimental Mechanical Engineering Education Shandong UniversityJinan 250061China Centre for Precision Manufacturing Department of DesignManufacturing and Engineering ManagementUniversity of StrathclydeGlasgow G40NTUK

Needle biopsy is an essential part of modern clinical *** puncture accuracy and sampling success rate of puncture surgery can be effectively improved through virtual *** are few three-dimensional puncture(3D)models,which have little significance for surgical guidance under complicated conditions and restrict the development of virtual *** this paper,a 3D simulation of the muscle tissue puncture process is ***,the mechanical properties of muscle tissue are *** Mooney-Rivlin(M-R)model is selected by considering the fitting accuracy and calculation ***,an accurate 3D dynamic puncture model is *** failure criterion is used to define the breaking characteristics of the muscle,and the bilinear cohesion model defines the breaking *** with different puncture speeds are carried out through the built in vitro puncture *** experimental results are compared with the simulation *** experimental and simulated reaction force curves are highly consistent,which verifies the accuracy of the ***,the model under different parameters is *** simulation results of varying puncture depths and puncture speeds are *** 3D puncture model can provide more accurate model support for virtual surgery and help improve the success rate of puncture surgery.

关键词： Puncture biopsy Muscle soft tissue 3D Puncture Simulation

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Study on an automatic multi-pin insertion system for preparing Z-pin composite laminates

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Chinese Journal of Aeronautics 2014年第2期27卷 413-419页

作者： song qinghua Li Yong Qi Junwei Wen Liwei Xiao Jun Ni Jinhui College of Material Science and Technology Nanjing University of Aeronautics and Astronautics

As a three-dimensional layer enhancement technology, the Z-pin technology is suitable for manufacturing composite prepreg laminates and can also effectively improve their interlaminar properties. In order to manufacture Z-pin composite parts efficiently, this paper proposes a transi- tional insertion system, and according to the technical requirements of the transitional insertion process and the functional requirements of the transitional insertion platform, proposes a transition insertion plan which can insert multiple Z-pins into a carrier. A prototype machine has been designed and made, and a series of function debugging and verification experiments have been car- ried out on the machine. Some problems show up during the experiments, but based on the analysis of the reasons, this paper provides lots of solutions, and finally demonstrates the feasibility and practical value of the system. The results show that the system meets all technical requirements of the Z-pin insertion process. It is capable to insert multiple Z-pins into a foam carrier; as a result, the system is as much as 5 times more efficient than existing equipment, and the deviation for the insertion distance can be controlled within 0.3 mm. This Z-pin transitional insertion platform pro- motes the use of Z-pins in national defense and lays the foundation for commercializing the Z-pin technology.

关键词： Composite materialsInsertion Multi-pin Three-dimensional Z-pin

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Novel metasurface phase-modulation mechanism

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Light(Science & Applications) 2021年第10期10卷 1816-1816页

作者： qinghua song Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518000China

Science,373(6559),1133–1137,(2021)https://***/10.1126/***3179 The past few years have witnessed exciting developments in non-Hermitian physics,showing unconventional phenomena and unique features associated with exceptional points(EPs).EPs exist in many open systems,leading to a spectral *** research team from CNRS-CRHEA in France collaborating with the University of California,Berkeley in US utilizes the topological feature around an EP to introduce a novel design in metasurface to achieve a new wavefront phase encoding technique.

关键词： technique. phase utilize

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