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钨冶炼酸法萃取工艺含钨废水综合治理

福建冶金 2024年第1期53卷 44-46页

作者：杜庆华陈志刚黄建华厦门钨业股份有限公司湿法冶金研究所福建厦门361026

研究了钨冶炼酸法萃取工艺产生的含钨废水治理,回收钨、降低废水中COD,回收废水中有机相和酸的方法,考察了大孔丙烯酸树脂、煤炭和大孔芳香族树脂、阴离子均相膜对废水中钨、有机相和酸的回收及降低COD的效果。结果表明:通过大孔丙烯酸... 详细信息

研究了钨冶炼酸法萃取工艺产生的含钨废水治理,回收钨、降低废水中COD,回收废水中有机相和酸的方法,考察了大孔丙烯酸树脂、煤炭和大孔芳香族树脂、阴离子均相膜对废水中钨、有机相和酸的回收及降低COD的效果。结果表明:通过大孔丙烯酸树脂处理,吸附流量为1~5 BV/h,回收钨达到99%,经煤炭和大孔芳香族树脂处理,吸附流量为1~5 BV/h,实现废水中COD降低了91%以上,最后利用阴离子均相膜装置处理,硫酸综合回收率达到80%以上,最终实现废水合格排放。

关键词：废水治理废水COD 回收酸树脂吸附

SIRT2 interacts with DDX24 to promote nasopharyngeal carcinoma growth

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BIOCELL 2023年第11期47卷 2445-2452页

作者： HAIYING YUE CHUNHUI WANG HUIJUN ZHU qinghua du JIAN LI XUE OU XIANGDE LI QIULU ZHONG YITING XIE DANJING LUO YIHE LI CHUNXIAO LIANG XUEMEI XU SONGNAN du WENQI LIU Department of Radiotherapy The Second Affiliated Hospital of Guangxi Medical UniversityNanningChina

Background:Nasopharyngeal carcinoma(NPC)is one of the most prevalent cancers in Southeast *** 2(SIRT2)is a member of the NAD+-dependent deacetylase family and has been shown to play important roles in numerous biological ***,Its function in NPC remains *** primary aim of this study is to clarify the role of SIRT2 in ***:In this research,we examined the effect of SIRT2 silencing on NPC cell proliferation and colony formation using vitro NPC cell ***-immunoprecipitation and mass spectrometry was applied to identify SIRT2-interacting proteins in NPC ***:In comparison to nasopharyngeal epithelial NP69 cells,SIRT2 was up-regulated in multiple NPC cell lines,particularly in CNE2 ***2 knockdown abrogated CNE2 cell proliferation and colony formation,whereas SIRT2 overexpression promoted HNE1 cell proliferation and colony *** SIRT2-interacting proteins were gathered in gene expression and regulation processes including RNA processing and *** the SIRT2-interacting proteins,there were multiple DEAD-box(DDX)family *** note,silencing of DDX24 phenocopied the effect of SIRT2 knockdown on NPC *** of DDX24 restored SIRT2-depleted CNE2 cells to proliferative and colony ***:Our study indicates that SIRT2 can interact with DDX24 to enhance NPC *** clinical relevance of SIRT2 and DDX24 in NPC warrants further investigation.

关键词： Nasopharyngeal carcinoma Sirtuin 2 DDX24 Proliferation

Material basis and pharmacodynamic mechanism of YangshenDingzhi granules in the intervention of viral pneumonia:Based on serum pharmacochemistry and network pharmacology

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Animal Models and Experimental Medicine 2024年第3期7卷 259-274页

作者： Huirong Xu Meiyue Dong Ruikun du Chengcheng Zhang Zinuo Chen Guangyu Tian qinghua Cui Kejian Li College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinanChina Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanChina Qingdao Academy of Chinese Medical Sciences Shandong University of Traditional Chinese MedicineQingdaoChina College of Pharmacy Shandong University of Traditional Chinese MedicineJinanChina

Background:YangshenDingzhi granules(YSDZ)are clinically effective in preventing and treating *** present study elucidates the underlying mechanism of YSDZ intervention in viral pneumonia by employing serum pharmacochemistry and network ***:The chemical constituents of YSDZ in the blood were examined using ultraperformance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry(UPLC-Q-Exactive Orbitrap MS).Potential protein targets were obtained from the SwissTargetPrediction database,and the target genes associated with viral pneumonia were identified using GeneCards,DisGeNET,and Online Mendelian Inheritance in Man(OMIM)*** intersection of blood component-related targets and disease-related targets was determined using Venny ***-protein interaction networks were constructed using the STRING *** Metascape database was employed to perform enrichment analyses of Gene Ontology(GO)functions and Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathways for the targets,while the Cytoscape 3.9.1 software was utilized to construct drug-component-disease-target-pathway ***,in vitro and in vivo experiments were performed to establish the therapeutic effectiveness of YSDZ against viral ***:Fifteen compounds and 124 targets linked to viral pneumonia were detected in *** these,MAPK1,MAPK3,AKT1,EGFR,and TNF play significant *** vitro tests revealed that the medicated serum suppressed the replication of H1N1,RSV,and SARS-CoV-2 ***,in vivo testing analysis shows that YSDZ decreases the viral load in the lungs of mice infected with RSV and ***:The chemical constituents of YSDZ in the blood may elicit therapeutic effects against viral pneumonia by targeting multiple proteins and pathways.

关键词： network pharmacology pharmacodynamical material basis serum pharmacochemistry viral pneumonia YangshenDingzhi granules

IL-17 induces radiation resistance of B lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis

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Cellular & Molecular Immunology 2015年第3期12卷 366-372页

作者： Qingshan Li Xin Xu Weijie Zhong qinghua du Bizhen Yu Huabao Xiong Department of Hematology Guangzhou First People's Hospital Guangzhou Medical University Guangzhou China lmmunology Institute Mount SinaiSchool of Medicine New York NY USA Department of Hematology &Oncology Guangzhou First People's Hospital Guangzhou Medical UniversityGuangzhou China

p53 is a well-known tumor suppressor. However, the regulatory mechanism（s） for p53 expression in B lymphoma cells, and the possible role of p53 in the development of the radioresistance in tumor cells are largely unknown. A human B lymphoma cell line, Karpas1106 （k1106）, was used as a model of radioresistance. Apoptosis of k1106 cells was determined using flow cytometry. Expression of p53 was assessed using real time RT-PCR and western blotting. The results showed that irradiation at 8 Gy induced apoptosis in up to 40% of k1106 cells. At the same time, the irradiation markedly increased IL-6 production of the k1106 cells. When k1106 cells were cocultured with regulatory T cells （Tregs） and irradiated, the rate of apoptotic k1106 cells was significantly reduced, indicating an acquired resistance to irradiation. IL-6 derived from the irradiation-treated k1106 cells induced IL-17 expression in Tregs. The IL- 17＋Foxp3＋ T cells suppressed p53 expression in k1106 cells. Collectively, irradiated k1106 cells induce the expression of IL-17 in Tregs, which interferes with the expression of p53 protein in k1106 cells and thereby represses irradiation-triggered apoptosis in k1106 cells.

关键词： interleukin-17 irradiation lymphoma p53 protein regulatory T cells

Uncertain knowledge graph embedding:an effective method combining multi-relation and multi-path

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Frontiers of Computer Science 2024年第3期18卷 73-89页

作者： Qi LIU qinghua ZHANG Fan ZHAO Guoyin WANG Key Laboratory of Tourism Multisource Data Perception and Decision Ministry of Culture and TourismChongqing University of Posts and TelecommunicationsChongqing 400065China Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Chongqing Key Laboratory of Big Data Intelligent Computing Chongqing University of Posts and TelecommunicationsChongqing 400065China

Uncertain Knowledge Graphs(UKGs)are used to characterize the inherent uncertainty of knowledge and have a richer semantic structure than deterministic knowledge *** research on the embedding of UKG has only recently begun,Uncertain Knowledge Graph Embedding(UKGE)model has a certain effect on solving this ***,there are still unresolved *** the one hand,when reasoning the confidence of unseen relation facts,the introduced probabilistic soft logic cannot be used to combine multi-path and multi-step global information,leading to information *** the other hand,the existing UKG embedding model can only model symmetric relation facts,but the embedding problem of asymmetric relation facts has not be *** address the above issues,a Multiplex Uncertain Knowledge Graph Embedding(MUKGE)model is proposed in this ***,to combine multiple information and achieve more accurate results in confidence reasoning,the Uncertain ResourceRank(URR)reasoning algorithm is ***,the asymmetry in the UKG is *** embed asymmetric relation facts of UKG,a multi-relation embedding model is ***,experiments are carried out on different datasets via 4 tasks to verify the effectiveness of *** results of experiments demonstrate that MUKGE can obtain better overall performance than the baselines,and it helps advance the research on UKG embedding.

关键词： knowledge representation uncertain knowledge graph multi-relation embedding uncertain reasoning

数字孪生技术在轨道交通车辆全寿命周期管理中的应用思路

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城市轨道交通研究 2023年第4期26卷 131-134页

作者：都青华中车长春轨道客车股份有限公司国家轨道客车工程研究中心长春130113

为将数字孪生技术应用于轨道交通车辆全寿命周期管理各业务,实现作业效率和作业质量的进一步提升,结合数字孪生在其它产业的应用情况,从数字孪生的定义、特征、关键支撑技术出发,阐述了数字孪生技术在轨道交通车辆行业产品研发、工艺设... 详细信息

为将数字孪生技术应用于轨道交通车辆全寿命周期管理各业务,实现作业效率和作业质量的进一步提升,结合数字孪生在其它产业的应用情况,从数字孪生的定义、特征、关键支撑技术出发,阐述了数字孪生技术在轨道交通车辆行业产品研发、工艺设计、采购物流、生产制造及检修运维等业务板块的应用场景。对于建立理想状态的轨道交通车辆数字孪生体,从开展MBD(基于模型的工程定义)技术的协同应用、产品构型管理、产品健康管理,以及构建多物理场、多学科的协同仿真等方面提出建议。

关键词：轨道交通数字孪生技术全寿命周期管理

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Quaternary Activity Characteristics and Regional Tectonic Significance of the Jiulong Fault in Jiujiang,Jiangxi Province,China

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Journal of Earth Science 2024年第4期35卷 1107-1117页

作者： Xin Qi Yuyong Jiao qinghua Li Bin Li Faculty of Engineering China University of GeosciencesWuhan430074China Wuhan Center China Geological SurveyWuhan430205China Institute of Geological Survey China University of GeosciencesWuhan430074China

Obtaining geological and landform dislocation features,as well as the measured stratigraphic activity age,provides direct evidence to evaluate fault activity,which is more difficult to do in areas with low tectonic activity,such as eastern and central China.A detailed investigation of the fault activity,trenching,drilling joint geological profile,geological survey,and chronological analysis were used to obtain the spatial geometry,fault kinematics,and activity chronology of the Jiulong *** conclusions are as follows:(1)The Jiulong fault was a fracture zone composed of four branch faults,with a width of around 30–40 m and good extendibility,while the maximum surface rupture length was 373 m.(2)The Jiulong fault has many strata dislocations,and the dislocation distance decreased from bottom to top,demonstrating synsedimentary structure characteristics,with a maximum stratigraphic dislocation distance of 18.2 m.(3)Preliminary analysis suggested the Jiulong fault as a secondary fracture of the Xiangfan-Guangji fault zone and provided evidence of the southeastward extension of the Xiangfan-Guangji fault.A preliminary hypothesis purported the Xiangfan-Guangji fault as the seismogenic fault of the Ms 5.0 magnitude earthquake in 1911.(4)According to OSL and ESR dating analyses,the upper breakpoint of the Jiulong fault cuts into the Late Pleistocene Xingang Formation(Qp3x)strata,and the latest active age of the Jiulong fault was 57.6 *** chronology analysis confirmed an active fault from the Late Pleistocene and identified a weak tectonic in Jiujiang Province,which represents the largest active fault outcrop uncovered in the area so *** study provides evidence and research materials for the evaluation of fault activity and seismic stability in this region.

关键词： active fault regional tectonic earthquakes seismic intensity tectonics

A stable implicit nodal integration-based particle finite element method(N-PFEM)for modelling saturated soil dynamics

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2172-2183页

作者： Liang Wang Xue Zhang Jingjing Meng qinghua Lei Department of Earth Sciences ETH ZürichZürich8092Switzerland Department of Civil Engineering and Industrial Design University of LiverpoolLiverpoolL693BXUK Department of Civil Environmental and Natural Resources EngineeringLuleåUniversity of TechnologyLuleå97187Sweden Department of Earth Sciences Uppsala UniversityUppsala75105Sweden

In this study,we present a novel nodal integration-based particle finite element method(N-PFEM)designed for the dynamic analysis of saturated *** approach incorporates the nodal integration technique into a generalised Hellinger-Reissner(HR)variational principle,creating an implicit PFEM *** mitigate the volumetric locking issue in low-order elements,we employ a node-based strain smoothing *** discretising field variables at the centre of smoothing cells,we achieve nodal integration over cells,eliminating the need for sophisticated mapping operations after re-meshing in the *** express the discretised governing equations as a min-max optimisation problem,which is further reformulated as a standard second-order cone programming(SOCP)***,pore water pressure,and displacements are simultaneously determined using the advanced primal-dual interior point ***,our numerical model offers improved accuracy for stresses and pore water pressure compared to the displacement-based PFEM *** experiments demonstrate that the N-PFEM efficiently captures both transient and long-term hydro-mechanical behaviour of saturated soils with high accuracy,obviating the need for stabilisation or regularisation techniques commonly employed in other nodal integration-based PFEM *** work holds significant implications for the development of robust and accurate numerical tools for studying saturated soil dynamics.

关键词： Particle finite element method Nodal integration Dynamic saturated media Second-order cone programming(SOCP)

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一种高效的跨平台工作流优化方法

计算机工程 2022年第7期48卷 13-21,28页

作者：杜清华张凯复旦大学软件学院上海200438 复旦大学计算机科学技术学院上海200438

为了应对复杂的数据分析任务,研究人员设计开发出结合多个平台的跨平台数据处理系统。系统跨平台工作流中算子的平台选择对于系统性能至关重要,因为算子在不同平台上的实现会产生性能间的显著差异。目前多使用基于成本的优化方法来实现... 详细信息

为了应对复杂的数据分析任务,研究人员设计开发出结合多个平台的跨平台数据处理系统。系统跨平台工作流中算子的平台选择对于系统性能至关重要,因为算子在不同平台上的实现会产生性能间的显著差异。目前多使用基于成本的优化方法来实现跨平台工作流的平台选择,但现有的成本模型由于无法挖掘跨平台工作流的潜在信息而导致成本估计不准确。提出一种高效的跨平台工作流优化方法,采用GGFN模型作为成本模型,以算子特征和工作流特征作为模型输入,利用图注意力机制捕捉有向无环图型跨平台工作流的结构信息和算子邻居节点信息,同时结合门控循环单元记忆算子的运行时序信息,从而实现准确的成本估计。在此基础上,根据跨平台工作流的特点设计算子实现平台的枚举算法,利用基于GGFN的成本模型和延迟贪婪剪枝方法进行枚举操作,为每个算子选择合适的实现平台。实验结果表明,该方法可以将跨平台工作流的执行性能提升3倍,运行时间缩短60%以上。

关键词：跨平台工作流 GGFN模型图注意力机制门控循环单元枚举算法