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Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene

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World Journal of Gastroenterology 2011年第14期17卷 1895-1902页

作者： Xiao-Bo Guo chang-qing Jing le-Ping Li Li Zhang Yu- Long Shi Jin-Shen Wang Jing-lei Liu Chen-Sheng Li Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong University 324 Jingwu Weiqi Road Jinan 250021 Shandong Province China

AIM:To evaluate the biological and clinical characteristics of miR-622 in gastric cancer. METHODS:We analyzed the expression of miR-622 in 57 pair matched gastric neoplastic and adjacent non-neoplastic tissues by quantitative real-time polymerase chain reaction. Functional analysis of miR-622 expression was assessed in vitro in gastric cancer cell lines with miR-622 precursor and inhibitor. The roles of miR-622 in tumorigenesis and tumor metastasis were analyzed using a stable miR-622 expression plasmid in nude mice. A luciferase reporter assay was used to assess the effect of miR-622 on inhibitor of growth family,member 1 (ING1) expression. RESULTS:Expression of miR-622 was down-regulated in gastric cancer. MiR-622 was found involved in differentia-tion and lymphatic metastasis in human gastric cancer. Ectopic expression of miR-622 promoted invasion,tumorigenesis and metastasis of gastric cancer cells both in vitro and in vivo. ING1 is a direct target of miR-622. CONCLUSION:These findings help clarify the molecular mechanisms involved in gastric cancer metastasis and indicate that miR-622 modulation may be a bona fide treatment of gastric cancer.

关键词： MicroRNA MiR-622 Gastric cancer Metastasis Inhibitor of growth family member 1

Mercury emission and pollution in Chongqing City, China

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Journal of Environmental Sciences 2000年第S1期12卷 19-21页

作者： MOU Shu\|sen, qing chang\|le (Southwest Agricultural University, Chongqing 400716, China)

Investigation showed that mercury emission in Chongqing City, China is about 2.1 t/a, 70% of which came from coal *** in many water bodies have been detected, in vegetables and milk had exceeded the food standard val... 详细信息

关键词： China Mercury emission and pollution in Chongqing City

Preventing Hg Transference from Soil to Terrestrial Food Chain

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Pedosphere 1993年第1期3卷 67-73页

作者： qingchang－le MOUSHU－SEN SouthwestAgriculturalUniversity Chaingqing630716（China） SouthwestAgriculturalUniversity Chaingqing630

Hg in acid soil could be activited by liming and become available to plant, if excessive or insufficient amount of lime was applied. The changes of Hg activity in acid soil with different rates of CaCO3 amendment Were studied by a pot experiment. To predict the adequate amount of lime application, a simple method using the pH (EDTA) as an indicator was suggested. The suitable range of lime application was the amount of lime addition when the pH of soil-EDTA system *** to 4.0-4.3.

关键词： food chain mercury terrestrial transference

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腐殖酸对矿物结合汞植物活性的影响

中国环境科学 2000年第3期20卷 215-219页

作者：姚爱军青长乐牟树森西南农业大学资源与环境学院

以植物水培试验就腐殖酸（富里酸、棕色胡敏酸和灰色胡敏酸）对矿物结合汞（CaCO3－Hg，Fe2O3-Hg，MnO2-Hg，膨润土-Hg，高岭土-Hg）的植物活性的影响进行了探讨，并以土壤作印证试验.结果表明，溶解态无机汞是最有效的植物可吸收形态... 详细信息

以植物水培试验就腐殖酸（富里酸、棕色胡敏酸和灰色胡敏酸）对矿物结合汞（CaCO3－Hg，Fe2O3-Hg，MnO2-Hg，膨润土-Hg，高岭土-Hg）的植物活性的影响进行了探讨，并以土壤作印证试验.结果表明，溶解态无机汞是最有效的植物可吸收形态．腐殖酸对土壤、矿物结合汞的植物活性的影响，与其对矿物汞的络合溶解能力以及所形成的络合汞向无机汞转化的能力有关；矿物结合汞在不同环境条件下存在的稳定性及释放汞的潜力则是制约腐殖酸效应的内在因素.反应时间决定着二者作用进展的程度.

关键词：腐殖酸矿物结合汞植物活性土壤监测

Effects of atmospheric mercury pollution on terrestrial ecosystem in Chongqing, China

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Journal of Environmental Sciences 2000年第S1期12卷 31-38页

作者： WANG Ding yong, LIU De shao, YAO Ai jun, PI Guang jie, MOU Shu sen, qing chang le (College of Resources and Environment, Southwest Agricultural University, Chongqing 400716, China)

The results from investigations indicated that mercury pollution in terrestrial ecosystem was serious due to the anthropogenic mercury emission growing in Chongqing, China. The concentration of atmospheric mercury in Chongqing was 34.4±2.7 ng/m\+3 with the range of 9.2—101.5. The accumulation of mercury in surface soil was increasing with time. The mercury content of some agricultural products have exceeded the food health standard value, especially near the mercury emission sources. The mercury accumulation in soil plant system was affected by atmospheric mercury and a positive correlation between them was found. Volatilization of mercury was the most important processes with which soil mercury joined the global mercury recycling.

关键词： accumulation agricultural product atmospheric mercury pollution plant soil terrestrial ecosystem

Molecular mechanism of icariin on rat asthmatic model

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Chinese Medical Journal 2011年第18期124卷 2899-2906页

作者： XU chang-qing le Jing-jing DUAN Xiao-hong DU Wei-jing LIU Bao-jun WU Jing-feng CAO Yu-xue DONG Jing-cheng Integrative Department Huashan Hospital Affiliated to FudanUniversity Shanghai 200040 China

Background Effects of icariin on airway inflammation in asthmatic rats and the intervention of LPS induced inflammation are interfered with the machanism of icariin. Our study aimed to observe the effect of icariin on ovalbumin-induced imbalance of Th1/Th2 cytokine expression and its mechanism. Methods Sixty male SD rats were randomly divided into control group （PBS）, asthma group （ovalbumin （OVA）-induced） dexamethasone group, and OVA＋icariin low, medium and high dose groups （5, 10, 20 mg/kg, respectively）. Each group had ten rats. The model of OVA sensitization was a rat asthma model. Enzyme-linked immunosorbent assay （ELISA） method was used to observe the effects of icariin on interleukin-4 （IL-4） and inerferon y （IFN-y） in rats＇ lung tissue. Immunohistochemical staining was applied to detect the intervention effects of icadin on T cells （T-bet） and gatabinding protein 3 （GATA-3） in rat pulmonary tissue. Realtime RT-PCR was used to observe the intervention effects of icariin on T-bet and GATA-3 mRNA expression in rat pulmonary tissue and spleen lymphocytes. Western blotting was used to observe the icariin intervention effects on T-bet, GATA-3 and nuclear factor-Kappa B （NF-KB） p65 protein expressions in rat pulmonary tissue. Results The ELISA results from pulmonary tissue showed that IL-4 expression was significantly reduced （P 〈0.05）, while the IFN-y expression increased but not significantly when we compared OVA＋icariin medium and high dose groups with the asthma group. Immunohistochemical staining of pulmonary tissue showed that the GATA-3 decreased significantly while the T-bet staining did not change in the OVA＋icariin high dose group. In pulmonary tissue and spleen lymphocytes T-bet and GATA-3 mRNA expressions were significantly reduced （P 〈0.05） in icariin treatment groups compared with the asthma model group. GATA-3 and T-bet mRNA in rat spleen lymphocytes in the asthma group were higher than in the control group. GATA-3 mRNA expression in pulmonary tissue

关键词： icariin Th1/Th2 T-bet/GATA-3 nuclear factor Kappa B p65

腐殖酸对矿物结合汞活性的影响研究──Ⅱ.腐殖酸对矿物结合汞挥发活性影响的动态特征

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土壤学报 2000年第2期37卷 202-208页

作者：姚爱军青长乐牟树森中国科学院南京土壤研究所南京210008 西南农业大学资环学院重庆400716

汞的挥发动力学表明：腐殖酸对矿物结合汞活性兼具抑制与活化的双重效应，突出表现为对矿物结合汞的挥发具有先期抑制与后期活化最后趋于稳定的动态影响特征，其效应具长期性渐变特点。不同腐殖酸针对不同矿物类型结合汞，其作用速率与... 详细信息

汞的挥发动力学表明：腐殖酸对矿物结合汞活性兼具抑制与活化的双重效应，突出表现为对矿物结合汞的挥发具有先期抑制与后期活化最后趋于稳定的动态影响特征，其效应具长期性渐变特点。不同腐殖酸针对不同矿物类型结合汞，其作用速率与强度不同。

关键词：腐殖酸矿物结合汞挥发活性动力学特征

腐殖酸对矿物结合汞活性的影响──I.腐殖酸对矿物结合汞挥发活性的影响

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土壤学报 1999年第4期36卷 477-483页

作者：姚爱军青长乐牟树森西南农业大学资环学院重庆400716

挥发试验结果表明，试验条件下，富里酸能极显著地促进Fe2O3－Hg，MnO2－Hg与高岭土结合汞的挥发，对膨润土结合汞和碳酸钙结合汞的挥发则表现抑制作用。棕色胡敏酸能促进各矿物结合汞的挥发。灰色胡敏酸影响最为微弱。腐殖酸对矿物结... 详细信息

挥发试验结果表明，试验条件下，富里酸能极显著地促进Fe2O3－Hg，MnO2－Hg与高岭土结合汞的挥发，对膨润土结合汞和碳酸钙结合汞的挥发则表现抑制作用。棕色胡敏酸能促进各矿物结合汞的挥发。灰色胡敏酸影响最为微弱。腐殖酸对矿物结合态汞挥发性的影响与其对汞的络合容量与络合稳定性，矿物对汞的吸持特性，以及矿物与腐殖酸的作用特性密切相关。

关键词：腐殖酸矿物结合汞挥发活性

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锌、镉在紫色土中的竞争吸附

中国环境科学 2006年第B7期26卷 73-77页

作者：朱波汪涛王艳强高美荣青长乐中国科学院成都山地灾害与环境研究所四川成都610041 西南大学资源环境学院重庆500716

研究了3种紫色土及2种黏土矿物对Zn、Cd的吸附特点.结果表明,中性紫色土中Zn、Cd的吸附特点相似,等温吸附符合Langmuir方程,最大吸附量分别为147.9,104.7mg/kg;其吸附动力学过程先快后慢,符合一级动力学方程与Elovich方程,快速吸附段的... 详细信息

研究了3种紫色土及2种黏土矿物对Zn、Cd的吸附特点.结果表明,中性紫色土中Zn、Cd的吸附特点相似,等温吸附符合Langmuir方程,最大吸附量分别为147.9,104.7mg/kg;其吸附动力学过程先快后慢,符合一级动力学方程与Elovich方程,快速吸附段的吸附量与易解吸量相近,且符合一级动力学方程,为交换吸附;慢速吸附段的吸附量与难解吸量相近,且满足Elovich方程,可能属于深层吸附或专性吸附,3种紫色土及2种黏土矿物对Zn、Cd的吸附量及其土壤理化性质的相关分析表明,CEC与最大吸附量显著相关,表明紫色土对Zn、Cd的吸附机理为交换吸附所控制.Zn、Cd共存时吸附速度与吸附量降低,表明二者对吸附位的竞争,竞争吸附服从质量作用定律,高浓度者占优,高浓度Zn对Cd的吸附有明显抑制,完善的土壤重金属阈限指标应包含复合污染的考虑.

关键词：吸附-解吸竞争吸附 Zn Cd 紫色土