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Can ＂Hybrid stent implantation＂ improve long-term safety without adversely affecting efficacy when treating multilesion coronary artery disease in the drug-eluting stent era？

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Chinese Medical Journal 2013年第9期126卷 1612-1617页

作者： ZHANG Dong XU bo DOU ke-fei YANG yue-jin CHEN Ji-lin QIAO Shu-bin wang Yang LI Jian-jun qin Xue-wen YAO Min liu Hai-bo WU Yong-jian CHEN Jue YUAN Jin-qing YOU Shi-jie LI Wei GAO Run-lin Department of Cardiology Department of Catheterization Laboratory Division of Biometrics Fu WaiHospital and Cardiovascular Institute National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences &Peking Union Medical College Beijing 100037 China

Background Though drug-eluting stent （DES） almost solved a problem of restenosis, safety issues related to stent thrombosis are still the major concern of DES. We hypothesized that hybrid stent implantation may decrease the use of DES, probably improving the long-term safety but not affecting efficacy adversely when treating multilesion coronary artery disease in the DES era. Methods From April 2004 to October 2006, 848 patients with multilesion disease underwent hybrid stent implantation. During the same period 5647 patients with multilesion coronary heart disease were treated by exclusive DES implantation in Fu Wai Hospital. According to propensity score matching, we chose 823 pairs of patients with multileison coronary artery disease for inclusion into our study. We obtained the 24-month clinical outcome including death, myocardial infarction （MI）, thrombosis, target lesion revascularization （TLR）, target vessel revascularization （TVR）, and major adverse cardiac events （MACE, the composite of death, MI, and TVR）. We used Cox＇s proportional-hazard models to assess relative risks of all the outcome measures after propensity match. Results At 24 months, patients in the hybrid stent implantation group showed a significantly higher risk of TLR （8.39% vs. 3.28%, HR2.38, 95% Cl. 1.50-3.70）, TVR （11.07% vs. 6.32%,/-/R 1.61, 95% Cl. 1.15-2.27） and MACE （13.75% vs. 8.75%, FIR 1.37, 95% Cl. 1.02-1.85）. No significant difference was apparent in terms of mortality （1.22% vs. 1.70%, HR 0.55, 95% Cl. 0.24-1.25）, MI （1.95% vs. 2.31%, HR0.73, 95% Cl. 0.37-1.42）, or thrombosis （definite＋probable）（0.73% vs. 1.58%, HR0.40, 95% Cl. 0.15-1.05）. Conclusions In patients with multilesion coronary artery disease, the exclusive DES implantation was associated with significantly lower risks of TLR, TVR and MACE, and the hybrid stent implantation did not result in any significant improvements regarding safety issues. Prospective studies are needed to confirm our results.

关键词： multilesion coronary artery disease " hybrid stent implantation " long-term safety " efficacy

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-ping Li Zhong-Rui Bai yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua jiang Xiang jiang Zhi-bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-ping Li Yuan Liang Chien-Cheng Lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su hong-Jun Su Zheng-hong Tang qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang hong-Chi wang Jian wang Jia-Ning wang Jian-Ling wang Jian-ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-qing wang Xia wang Ya-Nan wang You wang yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei hong Wu ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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基于未确知测度理论的安全生产状况评价研究

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中国安全科学学报 2010年第12期20卷 111-115页

作者：李艳强秦跃平刘宏波罗维中国矿业大学(北京)资源与安全工程学院北京100083

为研究我国省市的安全生产级别,基于未确知测度理论,建立安全生产状况评价的等级模型。根据实际情况,选取5项评价指标,建立各评价指标的未确知测度函数。利用熵确定各项指标的权重,避免人为主观性对评价的影响,根据多指标综合测度评价... 详细信息

为研究我国省市的安全生产级别,基于未确知测度理论,建立安全生产状况评价的等级模型。根据实际情况,选取5项评价指标,建立各评价指标的未确知测度函数。利用熵确定各项指标的权重,避免人为主观性对评价的影响,根据多指标综合测度评价向量和置信度识别准则进行评判。结合2009年9省市对应指标统计数据,采用未确知理论对安全生产状况进行评价,并结合实际进行分析。该理论为省、市安全生产提供了指导性的建议和依据。

关键词：安全生产未确知测度置信度识别准则熵权评价指标

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong Li Shao-Lin Xiong Yan-Qiu Zhang Yang Su Wei Chen Yi Zhao Xiao-bo Li Jia-Cong liu Wen-Xi Peng Rui Qiao Xin-Qiao Li Xiang-Yang Wen Li-Ming Song Shi-Jie Zheng Xin-Ying Song Xiao-Yun Zhao yue Huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen Yan-Qi Du Min Gao ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-Hui Li Lu Li qing-Xin Li Yan-Guo Li Jing Liang Xiao-Hua Liang Jin-Yuan Liao Xiao-Jing liu Ya-qing liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-Li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-Li Tuo Chen-Wei wang Hui wang Jin wang Jin-Zhou wang ping wang Wen-Shuai wang hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu wang-Chen Xue Sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-yue Zhang Da-Li Zhang Fan Zhang Fei Zhang hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou yue Zhu key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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Two-year clinical outcome after successful implantation of drug-eluting and bare metal stents in diabetic patients： results from a real-world single center registry

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Chinese Medical Journal 2009年第6期122卷 612-616页

作者： DOU ke-fei XU bo YANG yue-jin CHEN Ji-lin QIAO Shu-bin LI Jian-jun qin Xue-wen liu Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun GAO Run-lin Department of Cardiology Cardiovascular Institute and Fu Wai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Background Drug-eluting stents （DES） have revolutionized the field of interventional cardiology by dramatically improving clinical and angiographic outcomes. Patients with diabetes mellitus （DM） are associated with an increased risk of adverse clinical outcomes after a percutaneous coronary intervention （PCI）. Available information on the efficacy and safety of DES and bare metal stent （BMS） in diabetic patients remains scarce. Methods From April 2004 to October 2006, 1565 patients with diabetes, who successfully underwent elective stenting at Fu Wai Hospital in Beijing, China, were enrolled in this study. All enrolled patients were assigned to a drug eluting stent group and a bare metal stent group. We obtained follow-up data： death, myocardial infarction （MI）, thrombus, target lesion revascularization （TLR）, and target vessel revascularization （TVR） at 30 days and 12 and 24 months, as defined by the Academic Research Consortium （ARC）. We calculated and compared all the unadjusted cumulative frequencies of the various adverse events in the two groups. Cox＇s proportional-hazards models adjusted with the propensity score were used to assess the relative risks of all the outcome measures at 24 months. Results At 24 months, all ARC defined stent thrombosis in the two groups were similar; at 30 days, a more definite thrombosis was found in the BES group （0.08% vs 0.81%, P=0.016）. Patients treated with DES showed a significant lower risk of TLR （3.88% vs 10.89%; hazard ratio （HR） 0.159 （95% CI： 0.151-0.444）, P 〈0.001）, TVR （5.48%vs 11.69%; HR 0.383 （95% CI： 0.232-0.633）, P 〈0.001）, and any revascularization （12.47% vs 18.55%; HR 0.555 （95% CI： 0.370-0.831）, P=0.0004） at 24 months. No significant difference was apparent in terms of all-cause mortality, MI, and all-cause mortality/MI. Conclusions In contemporary society＇s large, diabetic population, the use of DES is associated with long-term significant reductions in the risks of TLR, TVR, and any revascularization.

关键词： clinical outcome diabetes drug-eluting stent bare metal stent

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当归补血汤物质基础研究进展

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中草药 2020年第21期51卷 5658-5663页

作者：胡静李科李爱平刘月涛秦雪梅山西大学中医药现代研究中心山西太原030006 地产中药功效物质研究与利用山西省重点实验室山西太原030006

当归补血汤出自金代名医李东垣的《内外伤辨惑论》,由黄芪和当归5∶1配伍而成,是补气生血的经典名方,现代临床主要用于治疗贫血、调节免疫功能、保护心脑血管系统、抗肿瘤等。本文查阅中外文献,通过基于传统植物化学分离分析、药物代谢... 详细信息

当归补血汤出自金代名医李东垣的《内外伤辨惑论》,由黄芪和当归5∶1配伍而成,是补气生血的经典名方,现代临床主要用于治疗贫血、调节免疫功能、保护心脑血管系统、抗肿瘤等。本文查阅中外文献,通过基于传统植物化学分离分析、药物代谢、谱效关系、生物活性筛选/化学在线分析技术、化学敲除法和网络药理学等方法,对DBD药效物质基础的研究予以总结和分析,为当归补血汤的进一步研究及应用提供科学依据。

关键词：当归补血汤物质基础化学成分药理作用黄芪当归

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基于内切-1,3-β-葡聚糖酶水解的黄芪糖指纹图谱的建立及不同种质资源黄芪鉴别

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中草药 2018年第10期49卷 2320-2327页

作者：王迪刘磊李科李爱平刘月涛秦雪梅杜冠华张翔山西大学中医药现代研究中心山西太原030006 山西大学化学化工学院山西太原030006 中国医学科学院北京协和医学院药物研究所北京100050 美国路易斯维尔大学美国路易斯维尔40292

目的以内切-1,3-β-葡聚糖酶的最佳酶解条件对不同种质资源蒙古黄芪(移栽和野生)和膜荚黄芪(移栽和野生)多糖进行酶解,通过荧光辅助糖电泳(FACE)获得糖指纹图谱,用于黄芪的种质资源鉴别和评价。方法利用SMICA软件对数据进行主成分分析及... 详细信息

目的以内切-1,3-β-葡聚糖酶的最佳酶解条件对不同种质资源蒙古黄芪(移栽和野生)和膜荚黄芪(移栽和野生)多糖进行酶解,通过荧光辅助糖电泳(FACE)获得糖指纹图谱,用于黄芪的种质资源鉴别和评价。方法利用SMICA软件对数据进行主成分分析及t检验,获得区分不同种质资源黄芪的差异性糖组分。结果内切-1,3-β-葡聚糖酶酶解产物中五糖和六糖可以作为区分野生蒙古黄芪和野生膜荚黄芪的差异性糖片段,三糖、四糖和五糖可以作为区分移栽蒙古黄芪与移栽膜荚黄芪的差异性糖片段,五糖和六糖可以作为区分膜荚黄芪(野生和移栽)的差异性糖片段;结论内切-1,3-β-葡聚糖酶降解的多糖产物能很好地鉴别黄芪种属和生长方式。为黄芪药材的品质评价及活性寡糖的筛选奠定了基础。

关键词：内切-1,3-β-葡聚糖酶黄芪多糖指纹图谱种质资源主成分分析

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Clinical and angiographic characteristics of premenopausal women with coronary artery disease

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Chinese Medical Journal 2008年第23期121卷 2392-2396页

作者： DOU ke-fei XU bo YANG yue-jin Lü Rong QIU hong YANG Wei-xian MU Zhao-wei GAO Run-lin GAO Zhan CHEN Ji-lin QIAO Shu-bin LI Jian-jun qin Xue-wen liu Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun Department of Cardiology Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Coronary artery disease （CAD） is generally considered as a disease of middle-aged men. It is widely accepted that the risk for CAD of premenopausal women is low because of hormone protection. Based on our clinical experience, more and more premenopausal women suffer from angina and myocardial infarction without adequate concern. Even now, there are still limited detailed data to describe the characteristics, mechanism and prognosis of premenopausal CAD patients. This article aimed to analyze the clinical and angiographic characteristics of premenopausal women with CAD. Methods A total of 565 premenopausal women and 721 postmenopausal women （56-60 years old） who underwent coronary angiography for the first time from April 2004 to December 2007 were enrolled. The clinical data and coronary angiographic characteristics （presence, localization, length and severity） were compared between the premenopausal and postmenopausal CAD groups. Results Premenopausal CAD patients presented less frequently with hypertension, diabetes mellitus and dyslipidemia compared with postmenopausal CAD patients （55.0% vs 66.0%, 15.0% vs 31.5%, 23.9% vs 37.4%, respectively; all P 〈0.05）. Although we found more frequent involvement of single vessel in premenopausal CAD （43.2% vs 26.9%, P=0）, and triple vessels in postmenopausal （56-60 years old） CAD patients （33.8% vs 20.4%, P=0）, much more severe lesions （z90%） at left main （2.9% vs 1.1%, P=0.048） and proximal left anterior descending artery （LAD）（28.2% vs 16.6%, P=0） in the premenopausal CAD group were found. Conclusion Premenopausal women with chest discomfort are always found to have obvious atherosclerosis, more .inclined to be located at the left main and proximal LAD, which is a strong predictor of an adverse clinical outcome.

关键词： coronary artery disease premenopause coronary angiography characteristics

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高温采煤工作面采空区热风数值模拟研究

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煤矿安全 2011年第6期42卷 11-14页

作者：秦跃平刘宏波朱郴伟王翠霞刘沛林中国矿业大学(北京)资源与安全工程学院北京100083 陕西彬长矿业集团有限公司陕西咸阳712000

矿井空调必须考虑由采空区热风引起的温度升高,采空区热风是由围岩散热和氧化放热等引起的,影响因素多,关系复杂。从研究采空区热源入手,对影响采空区热风的因素进行分析。利用质量守恒定律和达西定律,建立了采空区气体流动微分方程;利... 详细信息

矿井空调必须考虑由采空区热风引起的温度升高,采空区热风是由围岩散热和氧化放热等引起的,影响因素多,关系复杂。从研究采空区热源入手,对影响采空区热风的因素进行分析。利用质量守恒定律和达西定律,建立了采空区气体流动微分方程;利用传热学理论和能量守恒定律建立了采空区温度场方程,从泛函出发,用有限单元法进行分析,用VB语言编制了数值计算软件;结合具体情况,运用数值软件解算出在不同工作面阻力、原始岩温下采空区热风的运移规律,并对解算结果进行了分析。

关键词：空调降温数学模型采空区泛函有限元分析

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益生菌辅助含左氧氟沙星的补救方案治疗幽门螺杆菌感染疗效的Meta分析

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中国抗生素杂志 2019年第4期44卷 503-509页

作者：刘沁何平曾波李月田文广重庆医科大学附属永川医院消化内科重庆402160 重庆医科大学附属永川医院感染科重庆402160

目的系统评价益生菌在辅助含左氧氟沙星补救治疗根除幽门螺杆菌(Hp)感染的疗效和安全性。方法计算机检索Pubmed、Embase、Cochrane Library、CNKI、VIP、CBM和Wan Fang Data,收集2017年3月1日前国内外公开发表的关于益生菌辅助含左氧氟... 详细信息

目的系统评价益生菌在辅助含左氧氟沙星补救治疗根除幽门螺杆菌(Hp)感染的疗效和安全性。方法计算机检索Pubmed、Embase、Cochrane Library、CNKI、VIP、CBM和Wan Fang Data,收集2017年3月1日前国内外公开发表的关于益生菌辅助含左氧氟沙星的补救方案治疗Hp感染疗效的随机对照试验,所有研究对象给予含左氧氟沙星补救治疗方案抗Hp治疗,试验组在此基础上再给予益生菌制剂辅助治疗,对照组未给予益生菌制剂治疗,随访过程并追踪结局。两名研究者独立完成文献筛选、资料提取、质量评价(采用PEDro量表进行评价)工作后,运用RevMan5.2进行统计分析。结果最终纳入6个随机对照研究,包括益生菌联合治疗组(试验组)430例,无益生菌治疗组(对照组)380例。Meta分析结果显示:益生菌组及非益生菌组Hp根除率PP分析结果(OR=2.11,95%CI=1.47~3.02,P<0.0001);益生菌组及非益生菌组Hp根除率ITT分析结果(OR=2.01,95%CI=1.43~2.81,P<0.0001);益生菌组及对照组治疗过程中出现不良反应情况(OR=0.63,95%CI=0.40~0.99,P=0.05),均有统计学意义。结论含益生菌能有效提高含左氧氟沙星补救疗法的Hp根除率,改善临床症状且减少药物的副作用。

关键词：益生菌幽门螺杆菌左氧氟沙星补救治疗 Meta分析系统评价随机对照试验

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