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A deep learning-based global tropical cyclogenesis prediction model and its interpretability analysis

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Science China Earth Sciences 2024年

作者： Bin MU Xin WANG Shijin YUAN Yuxuan CHEN Guansong WANG bo qin Guanbo ZHOU School of Software Engineering Tongji University Department of Atmospheric and Oceanic Sciences & Institute of Atmospheric Sciences Fudan University National Meteorological Center Shanghai Typhoon Institute China Meteorological Administration

Tropical cloud clusters (TCCs) can potentially develop into tropical cyclones (TCs),leading to significant casualties and economic *** prediction of tropical cyclogenesis (TCG) is crucial for early *** traditional deep learning methods applied to TCG prediction rely on predictors from a single time point,neglect the ocean-atmosphere interactions,and exhibit low model *** study proposes the Tropical Cyclogenesis Prediction-Net (TCGP-Net) based on the Swin Transformer,which leverages convolutional operations and attention mechanisms to encode spatiotemporal features and capture the temporal evolution of *** model incorporates the coupled ocean-atmosphere interactions,including multiple variables such as sea surface ***,causal inference and integrated gradients are employed to validate the effectiveness of the predictors and provide an interpretability analysis of the model’s decision-making *** model is trained using GridSat satellite data and ERA5 reanalysis *** results demonstrate that TCGP-Net achieves high accuracy and stability,with a detection rate of 97.9%and a false alarm rate of 2.2%for predicting TCG 24 hours in advance,significantly outperforming existing *** indicates that TCGP-Net is a reliable tool for tropical cyclogenesis prediction.

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E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 25-35页

作者： Cuicui Xiao Jiao Gong Yusheng Jie Weicheng Liang Yan Tai Wei qin Tongyu Lu Yutian Chong Ziqing Hei bo Hu Qi Zhang Biotherapy Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Anesthesiology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Key Laboratory of Liver Disease of Guangdong Province Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Laboratory Medicine Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Cell-Gene Therapy Translational Medicine Research Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and Aims:As a subunit of the condensin complex,NCAPG has an important role in maintaining chromosome condensation,but its biological function and regulatory mechanism in hepatocellular carcinoma(HCC)remains ***:The prognostic ability of NCAPG in HCC patients was examined by univariate and multivariate Cox regression *** curves were plotted to compare the predictive ability of NCAPG and *** luciferase reporter system,and ChIP were used to investigate transcriptional potential of E2F1 to *** was observed by scanning electron *** expression of NCAPG,E2F1,and major proteins constituting NLRP3 inflammasome was determined by western blotting and *** in vivo tumor formation assay was conducted to verify the in vitro ***:Up-regulated NCAPG was identified in HCC tissues compared with adjacent tissue and high NCAPG was positively correlated with poor *** NCAPG mRNA level was a prognostic factor in HCC patients and also a diagnostic factor with higher predictive ability compared with AFP[AUROC 0.766(95%CI:0.650–0.881)vs.0.649(95%CI 0.506–0.793)].HBx transfection resulted in concomitant up-regulation of E2F1 and NCAPG.E2F1 significantly increased the activity of luciferase reporter fused with NCAPG reporter,and the interaction of E2F1 and NCAPG gene was confirmed by *** of E2F1 resulted in significant down-regulation of *** of NCAPG promote pyroptosis mediated by NLRP3 inflammasome activation in multiple HCC cell lines and also suppressed tumorigenesis in ***:We identified a novel role of NCAPG in the regulation of NLRP3 inflammasome-mediated pyroptosis,which was regulated by its upstream transactivator,*** role of E2F1-NCAPG-NLRP3 regulation of pyroptosis network may be a potential target in HCC treatment.

关键词： NCAPG Hepatocellular carcinoma Pyroptosis NLRP3 inflammasome Serum marker circulating RNA.

Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer

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World Journal of Gastroenterology 2024年第2期30卷 158-169页

作者： Yue-Hao Luo Zhe-Cheng Yan Jia-Ying Liu Xin-Yi Li Ming Yang Jun Fan bo Huang Cheng-Gong Ma Xiao-Na Chang xiu Nie Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Tumor budding(TB)has emerged as a promising independent prognostic biomarker in colorectal cancer(CRC).The prognostic role of TB has been extensively studied and currently affects clinical decision making in patients with stage I and II ***,existing prognostic studies on TB in stage III CRC have been confined to small retrospective cohort ***,this study investigated the correlation among TB categories,clinicopathological features,and prognosis in stage III-IV CRC to further enhance the precision and individualization of treatment through refined prognostic risk *** To analyze the relationship between TB categories and clinicopathological characteristics and assess their prognostic value in stage III-IV CRC to further refine the prognostic risk stratification of stage III-IV *** The clinical data of 547 CRC patients were collected for this retrospective *** at the front edge of the tumor buds was counted according to the 2016 International Tumor Budding Consensus Conference *** Multivariate Cox proportional hazards regression analysis demonstrated that chemotherapy(P=0.004),clinical stage IV(Pboth in the tumor stroma and its invasive *** TB has an independent predictive prognostic value in patients with stage III-IV *** is recommended to complete the TB report of stage III-IV CRC cases in the standardized pathological report to further refine risk stratification.

关键词： Tumor budding Tumor infiltrating lymphocytes Colorectal cancer Survival analysis Prognosis

Electronic property and topological phase transition in a graphene/CoBr_(2) heterostructure

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Chinese Physics B 2024年第2期33卷 498-505页

作者：秦元秀李胜世纪维霄张昌文 School of Physics and Technology Institute of SpintronicsUniversity of JinanJinan 250022China

Recently,significant experimental advancements in achieving topological phases have been reported in van der Waals(vdW)heterostructures involving ***,using first-principles calculations,we investigate graphene/CoBr_(2)(Gr/CoBr_(2))heterostructures and find that an enhancement of in-plane magnetic anisotropy(IMA)energy in monolayer CoBr_(2) can be accomplished by reducing the interlayer distance of the vdW *** addition,we clarify that the enhancement of IMA energy primarily results from two factors:one is the weakness of the Co-d_(xy) and Co-d_(x^(2)-y^(2)) orbital hybridization and the other is the augmentation of the Co-d_(yz) and Co-d_(z)2 orbital ***,calculation results suggest that the Kosterlitz–Thouless phase transition temperature(TKT)of a 2D XY magnet Gr/CoBr_(2)(23.8 K)is higher than that of a 2D XY monolayer CoBr_(2)(1.35 K).By decreasing the interlayer distances,the proximity effect is more pronounced and band splitting ***,by taking into account spin–orbit coupling,a band gap of approximately 14.3 meV and the quantum anomalous Hall effect(QAHE)are attained by decreasing the interlayer distance by 1.0 *** by the above conclusions,we design a topological field transistor device *** results support that the vdW interlayer distance can be used to modulate the IMA energy and QAHE of materials,providing a pathway for the development of new low-power spintronic devices.

关键词： van der Waals heterostructure in-plane magnetic anisotropy energy quantum anomalous Hall effect

Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

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World Journal of Gastroenterology 2024年第26期30卷 3229-3246页

作者： Juan Sun Jin-xiu Zhang Meng-Shi Li Meng-Bin qin Ruo-Xi Cheng qing-Ru Wu Qiu-Ling Chen Dan Yang Cun Liao Shi-Quan Liu Jie-An Huang Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina Department of Colorectal&Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Monopolar spindle-binding protein 3B(MOB3B)functions as a signal transducer and altered MOB3B expression is associated with the development of human *** To investigate the role of MOB3B in colorectal cancer(CRC).METHODS This study collected 102 CRC tissue samples for immunohistochemical detection of MOB3B expression for association with CRC *** overexpression and knockdown of MOB3B expression were induced in CRC cell lines,changes in cell viability,migration,invasion,and gene expression were *** cell autophagy was detected using transmission electron microscopy,while nude mouse xenograft experiments were performed to confirm the in-vitro *** MOB3B expression was reduced in CRC vs normal tissues and loss of MOB3B expression was associated with poor CRC *** of MOB3B protein in vitro attenuated the cell viability as well as the migration and invasion capacities of CRC cells,whereas knockdown of MOB3B expression had the opposite effects in CRC *** the molecular level,microtubule-associated protein light chain 3 II/I expression was elevated,whereas the expression of matrix metalloproteinase(MMP)2,MMP9,sequestosome 1,and phosphorylated mechanistic target of rapamycin kinase(mTOR)was downregulated in MOB3B-overexpressing RKO *** contrast,the opposite results were observed in tumor cells with MOB3B *** nude mouse data confirmed these in-vitro findings,i.e.,MOB3B expression suppressed CRC cell xenograft growth,whereas knockdown of MOB3B expression promoted the growth of CRC cell *** Loss of MOB3B expression promotes CRC development and malignant behaviors,suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mTOR/autophagy signaling.

关键词： Colorectal cancer Monopolar spindle-binding protein 3B Mechanistic target of rapamycin kinase Autophagy Prognosis

街道尺度下北京城市公共体育设施空间配置研究

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地球信息科学学报 2024年第2期26卷 381-392页

作者：张磊窦旺胜秦波中国人民大学体育部北京100872 北京市人文北京研究基地北京100872 中国人民大学公共管理学院北京100872 中国人民大学数字政府与国家治理实验室北京100872

城市公共体育设施的分布特征与可达性、公平性等空间配置直接关系到基本公共服务的均等性与城市空间结构的完整性。本文以北京市为例,以POI数据表征城市公共体育设施,运用核密度估计、最近邻指数、改进型两步移动搜索法以及覆盖度指数... 详细信息

城市公共体育设施的分布特征与可达性、公平性等空间配置直接关系到基本公共服务的均等性与城市空间结构的完整性。本文以北京市为例,以POI数据表征城市公共体育设施,运用核密度估计、最近邻指数、改进型两步移动搜索法以及覆盖度指数等分析方法,研究北京街道尺度上城市公共体育设施的空间集聚特征及供需视角下的可达性与公平性。结果表明:(1)改进型两步移动搜索法考虑了不同等级城市公共体育设施的供给规模与“15 min生活圈”理念下的居民出行距离,适合街区级与社区级体育设施可达性分析,中心城区街区级与社区级设施空间可达性较高;(2)北京各级城市公共体育设施具有显著的空间集聚趋势,地区级设施表现为“点状集聚、面状分散”趋势,街区级总体呈现出“核心-边缘”式特征,中心城区供给数量多,周边地区配置少;社区级设施为“小集聚、大分散”模式,空间分布均匀;(3)北京社区级城市公共体育设施覆盖度高的街道最多,空间配置最为均衡,街区级设施覆盖度指数高的街道较少,覆盖范围相对有限。研究结果可为北京城市公共体育设施的规划编制与优化布局提供参考。

关键词：公共体育设施街道尺度改进型两步移动搜索法空间集聚供需视角可达性公平性北京市

Dimensional regulation in gigantic molybdenum blue wheels featuring{(W)Mo_(5)}motifs for enhanced proton conductivity

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Nano Research 2024年第9期17卷 8261-8268页

作者： Yu-Lun Wu Jing Du Hai-Ying Zhang Ming-Jun Hou Qiao-Yue Li Wei-Chao Chen Kui-Zhan Shao bo Zhu Chao qin Xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China Hebei Key Laboratory of Organic Functional Molecules National Demonstration Center for Experimental Chemistry EducationTesting and Analysis CenterCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Dimensional regulation in polyoxometalates is an effective strategy during the design and synthesis of polyoxometalates-based high proton conductors,but it is not available to ***,the precise regulation of dimensionality has been realized in an unprecedented gigantic molybdenum blue wheel family featuring pentagonal{(W)Mo5}motifs through optimizing the molar ratio of Mo/W,including[Gd_(2)Mo_(124)W_(14)O_(422)(H_(2)O)62]38-(0D-{Mo_(124)W_(14)},1),[Mo_(126)W_(14)O441(H_(2)O)51]^(70-)(1D-{Mo_(126)W_(14)}n,2),and[Mo_(124)W_(14)O_(430)(H_(2)O)50]60-(2D-{Mo_(124)W_(14)}n,3).Such important{(W)Mo5}structural motif brings new reactivity into gigantic Mo blue *** are different numbers and sites of{Mo2}defects in each wheel-shaped monomer in 1-3,which leads to the monomers of 2 and 3 to form 1D and 2D architectures via Mo-O-Mo covalent bonds driven by{Mo2}-mediated H_(2)O ligands substitution process,respectively,thus achieving the controllable dimensional *** expected,the proton conductivity of 3 is 10 times higher than that of 1 and 1.7 times higher than that of *** continuous proton hopping sites in 2D network are responsible for the enhanced proton conductivity with lower activation *** study highlights that this dimensional regulation approach remains great potential in preparing polyoxometalates-based high proton conductive materials.

关键词： polyoxometalate molybdenum blue wheels Mo/W mixed-addenda polyoxometalates dimensional regulation proton conduction

基于XGboost算法的亚热带地区生态旅游适宜性评价方法研究

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地球信息科学学报 2024年第2期26卷 303-317页

作者：黄钦谭翠杨波湖南师范大学地理科学学院长沙410081 湖南师范大学地理空间大数据挖掘与应用湖南省重点实验室长沙410081 东风高级中学十堰442011

近年来,随着公众环境保护意识的提升,追求人与自然和谐共生的生态旅游方式越来越受到人们的普遍关注。面对丰富多样的生态旅游资源及国内生态旅游的供需矛盾,如何在大保护的前提下有序开发、合理利用,将“绿水青山”科学、合理地转化为... 详细信息

近年来,随着公众环境保护意识的提升,追求人与自然和谐共生的生态旅游方式越来越受到人们的普遍关注。面对丰富多样的生态旅游资源及国内生态旅游的供需矛盾,如何在大保护的前提下有序开发、合理利用,将“绿水青山”科学、合理地转化为“金山银山”是现阶段亟需面对和解决的重大问题。本文以神农架林区为例,基于多源地理空间数据,运用XGboost算法对其生态旅游适宜性进行评估,得出如下结论:(1)基于XGboost算法的生态旅游适宜性评价模型融合了机器学习技术与数据挖掘思想并取得了良好的分类效果,模型在10折交叉验证下的整体分类精度为89.44%,同时兼有良好的召回率(89.68%),F1分数为0.874 5,兼顾了精确度和召回率,模型AUC值为0.959 3,模型整体分类性能表现优秀;(2)根据特征重要性排序结果,生态环境要素NDVI(26.86%)、年平均气温(11.61%)和社会经济因素距道路距离(8.90%)对模型贡献度最高,位列所有特征前3位;(3)生态旅游适宜性分类结果表明,神农架林区整体生态旅游资源丰富,高度适宜区、中度适宜区、边际适宜区和不适宜区的覆盖面积分别占林区总面积的44.13%、15.93%、11.89%和28.05%。本文研究方法突破了传统生态旅游适宜性评估方法主观性较强的局限,立足于数据挖掘思想和机器学习技术解决实际问题,可为区域国土空间规划、乡村振兴战略和生态旅游资源整合提供决策依据。

关键词：生态旅游适宜性评价 XGboost算法机器学习亚热带地区多源地理空间数据神农架林区可持续发展

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网络同侪互评系统的设计与实现

信息技术 2012年第12期36卷 36-40页

作者：王莉军秦秀波渤海大学辽宁锦州121013

从对网络协作学习理论和教学实践中分析,尝试通过凯利方格技术与模糊综合评价的整合提出一种符合当前网络协作学习的同侪互评模式,深入探索与分析学生作品信息,使学生学习作品的教育价值在协作学习中得以最大程度开发、利用。

关键词：网络协作学习凯利方格技术模糊综合评价同侪互评