检索结果-南通市图书馆

Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution:A Trait Spectrum Exposure Pattern and Structure-Based Investigation

引用

Biomedical and Environmental Sciences 2025年第1期38卷 3-14页

作者： Zhi Li Shilin Shan Chenyang Song Chengzhe Tao Hong Qian qin yuan Yan Zhang Qiaoqiao Xu Yufeng qin Yun Fan Chuncheng Lu State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Department of Public Health Kangda College of Nanjing Medical UniversityLianyungang 222000JiangsuChina Department of Microbes and Infection School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina

Objective To investigate the associations between eight serum per-and polyfluoroalkyl substances(PFASs)and regional fat depots,we analyzed the data from the National Health and Nutrition Examination Survey(NHANES)2011-2018 *** Multiple linear regression models were developed to explore the associations between serum PFAS concentrations and six fat compositions along with a fat distribution score created by summing the concentrations of the six fat *** associations between structurally grouped PFASs and fat distribution were assessed,and a prediction model was developed to estimate the ability of PFAS exposure to predict obesity *** Among females aged 39-59 years,trunk fat mass was positively associated with perfluorooctane sulfonate(PFOS).Higher concentrations of PFOS,perfluorohexane sulfonate(PFHxS),perfluorodecanoate(PFDeA),perfluorononanoate(PFNA),and n-perfluorooctanoate(n-PFOA)were linked to greater visceral adipose tissue in this *** men,exposure to total perfluoroalkane sulfonates(PFSAs)and long-chain PFSAs was associated with reductions in abdominal fat,while higher abdominal fat in women aged 39-59 years was associated with short-chain *** prediction model demonstrated high accuracy,with an area under the curve(AUC)of 0.9925 for predicting obesity *** PFAS exposure is associated with regional fat distribution,with varying effects based on age,sex,and PFAS *** findings highlight the potential role of PFAS exposure in influencing fat depots and obesity risk,with significant implications for public *** prediction model provides a highly accurate tool for assessing obesity risk related to PFAS exposure.

关键词： Per-and polyfluoroalkyl substances Regional fat depots Obesity Structure-based NHANES

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exosome technology: A novel and effective drug delivery system in the field of cancer therapy

引用

World Journal of Gastrointestinal Oncology 2025年第3期17卷 464-469页

作者： Geng, Jia-Xin Lu, Yao-Fan Zhou, Jing-Nan Huang, Biao qin, yuan College of Life Sciences and Medicine Zhejiang Sci-Tech University Zhejiang Province Hangzhou 310018 China Zhejiang Cancer Hospital Zhejiang Province Hangzhou 310018 China

In this article, we revisit an article, which specifically focuses on the utilization of exosomes derived from human bone marrow mesenchymal stem cells (MSCs) for targeted delivery of gemcitabine in pancreatic cancer treatment. The experimental results demonstrated that the exosome-based drug delivery system derived from MSCs significantly augmented apoptosis in pancreatic cancer cells. The biocompatibility, targeting specificity, and low immunogenicity of exosomes render them as optimal carriers for drug delivery, enabling precise administration of therapeutics to diseased tissues while mitigating adverse effects, thereby achieving targeted treatment of cancer cells and significantly enhancing anti-tumor efficacy. However, the clinical application of exosome drug delivery platforms in oncology still presents challenges, necessitating further optimization to ensure their stability and efficacy. This study focuses on elucidating the advantages of exosomes as a drug delivery platform, exploring the utilization of MSC-derived exosomes in oncology therapy, and discussing their potential and future directions in cancer treatment. © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

关键词： Drug delivery Exosomes Gemcitabine Mesenchymal stem cells Tumor therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于MCDEX数据库评价抑制胃酸分泌药的药物相互作用

引用

现代药物与临床 2025年第1期40卷 206-210页

作者：袁勤孙嘉婧邹清梅杨彪崇州市人民医院都江堰市人民医院药学部

目的评价抑制胃酸分泌药的药物相互作用（DDI）。方法在MCDEX数据库药物相互作用版块中检索抑制胃酸分泌药的DDI，并对其进行归纳分析。结果 28种抑制胃酸分泌药在MCDEX数据库中提示存在3 607对DDI，其中禁忌合用、不推荐合用、谨慎... 详细信息

目的评价抑制胃酸分泌药的药物相互作用（DDI）。方法在MCDEX数据库药物相互作用版块中检索抑制胃酸分泌药的DDI，并对其进行归纳分析。结果 28种抑制胃酸分泌药在MCDEX数据库中提示存在3 607对DDI，其中禁忌合用、不推荐合用、谨慎合用、关注、可以合用的分别有50、168、2 214、979、196对。H2受体阻滞剂类抑酸药DDI最多，其中西咪替丁的DDI达777对。结论抑制胃酸分泌药物较易与其他药物发生相互作用，主管医师和临床药师应对其药物治疗方案进行整理和优化，避免因DDI引起药物不良反应或导致疗效降低。

关键词：抑制胃酸分泌药药物相互作用安全用药 H2受体阻滞剂质子泵抑制剂西咪替丁

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Coupled effect of climate change and human activities on the restoration/degradation of the qinghai-Tibet Plateau grassland

引用

Journal of Geographical Sciences 2021年第9期31卷 1299-1327页

作者： yuan qin yuan Quanzhi REN Ping Institute of Geography and Resources Science Sichuan Normal UniversityChengdu 610101China Sustainable Development Research Center of Resources and Environment of Western Sichuan Sichuan Normal UniversityChengdu 610066China Key Laboratory of Land Resources Evaluation and Monitoring in Southwest Ministry of EducationSichuan Normal UniversityChengdu 610066China

Climate change(CC)and human activities(HA)are the main reasons for the restoration/degradation of the qinghai-Tibet Plateau(QTP)*** related studies have been conducted thus far,but the impact mechanism of CC coupled with HA on QTP remains *** summarized the two main coupling factors in recent years(specifically,in the past five years)and obtained the following conclusions.(1)CC and HA have positive and negative effects on the QTP grassland *** primarily affects grassland ecology through temperature,humidification,and extreme climate,and HA mainly affects ecosystems through primary,secondary,and tertiary industries and restoration measures.(2)CC coupled with HA affects soil,plants,animals,and fungi/*** makes the snow line rise by increasing the temperature,which expands the zone for *** also restricts HA through hydrological changes,extreme climate,and outbreak of pikas and ***,measures are implemented through HA to control and adapt to ***,the grassland ecosystem is comprehensively influenced by CC and HA.(3)The grassland ecosystem dynamically adapts to the disturbance caused by CC and HA by changing its physiological characteristics,distribution range,diet structure,community structure,and physical ***,it responds to environmental changes through desertification,poisonous weeds,rodent outbreak,release of harmful gases,and other *** work can be used as a reference for the sustainable development of the QTP grassland.

关键词： qinghai-Tibet Plateau geochemistry soil organic carbon net primary productivity pikas pests Cordyceps sinensis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boosting multi-features with prior knowledge for mini unmanned helicopter landmark detection

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 256-261页

作者： qin-yuan REN Ping LI Bo HAN The State Key Laboratory of Industrial Control Technology Zhejiang University Hangzhou 310027 China

Without sufficient real training data,the data driven classification algorithms based on boosting method cannot solely be utilized to applications such as the mini unmanned helicopter landmark image *** this paper,we propose an approach which uses a boosting algorithm with the prior knowledge for the mini unmanned helicopter landmark image *** stage forward stagewise additive model of boosting is analyzed,and the approach how to combine it with the prior knowledge model is *** approach is then applied to landmark image detection,where the multi-features are boosted to solve a series of problems,such as rotation,noises affected,*** of real flight experiments demonstrate that for small training examples the boosted learning system using prior knowledge is dramatically better than the one driven by data only.

关键词： Boosting Prior knowledge model Landmark detection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于物联网技术的大直径泥水平衡盾构电气系统能耗监测

引用

自动化应用 2025年第2期66卷 239-241,244页

作者：段崧黄圣秦元上海城建隧道装备有限公司上海200137

为提高电气系统能耗监测结果的可靠性,引进物联网技术,开展大直径泥水平衡盾构电气系统能耗监测方法的设计研究。布置传感器,设计基于物联网技术的盾构电气系统连接,实现电气系统关键参数的实时监测;采用信道编码的方式,进行数据的初步... 详细信息

为提高电气系统能耗监测结果的可靠性,引进物联网技术,开展大直径泥水平衡盾构电气系统能耗监测方法的设计研究。布置传感器,设计基于物联网技术的盾构电气系统连接,实现电气系统关键参数的实时监测;采用信道编码的方式,进行数据的初步处理与传输干扰屏蔽处理;引进自编码器AE,利用完成处理的采样信号数据,进行大直径泥水平衡盾构电气系统能耗监测。对比实验结果表明,设计的方法应用效果良好,可以满足大直径泥水平衡盾构电气系统能耗监测需求。

关键词：物联网技术能耗监测电气系统盾构泥水平衡大直径

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

From signaling to function: how strigolactones regulate plant development

引用

Science China(Life Sciences) 2020年第11期63卷 1768-1770页

作者： Baoyuan Qu yuan qin Yang Bai State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China CAS center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100039China CAS-JIC Centre of Excellence for Plant and Microbial Sciences Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100039China

Strigolactones (SLs) are a class of plant hormones first discovered based on their ability to stimulate germination of the root parasite witchweed (Striga lutea Lour.) and regulate symbiosis between arbuscular mycorrhiza fungi and their host plants. Recent studies have identified diverse functions of SLs in shoot branching, leaf development, root architecture, and the responses to environment stress (GomezRoldan et al., 2008;Umehara et al., 2008;Brewer et al.,2013).

关键词： plant branching function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Loop Algebra and Its Corresponding Multi-component Integrable Hierarchy

引用

Communications in Theoretical Physics 2006年第3期45卷 385-388页

作者： YAO Yu-qin CHEN Deng-yuan Department of Mathematics Shanghai University Shanghai 200444 China

A type of new loop algebra GM is constructed by making use of the concept of cycled numbers. As its application, an isospectral problem is designed and a new multi-component integrable hierarchy with multi-potential f... 详细信息

关键词： cycled numbers loop algebra multi-component integrable hierarchy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

长三角生态工业园区分布时空演化及其影响因素研究

引用

生态与农村环境学报 2025年第1期41卷 22-31页

作者：芮菡艺朱沁园苏秋克苏敬张晨杰朱琳生态环境部南京环境科学研究所江苏南京210042 昆山经济技术开发区安全生产监督管理和环境保护局江苏苏州215300

生态文明建设示范区(生态工业园区)(以下简称示范园区)是新质生产力地理格局形成的关键推动者,把握其演进规律对于优化资源配置、深化园区绿色低碳发展具有重要意义。以长三角地区经正式命名的44个示范园区为研究对象,在明晰2007—2022... 详细信息

生态文明建设示范区(生态工业园区)(以下简称示范园区)是新质生产力地理格局形成的关键推动者,把握其演进规律对于优化资源配置、深化园区绿色低碳发展具有重要意义。以长三角地区经正式命名的44个示范园区为研究对象,在明晰2007—2022年示范园区建设发展历程的基础上,系统分析示范园区在3个发展阶段的总体空间格局、集聚形态演化及空间方向迁移特征以及影响因素。结果表明:(1)示范园区发展历程具有明显的阶段性特征。(2)示范园区空间分布呈集聚特征,但均衡性总体增强,集聚形态由“一主两副”3个集聚中心逐渐演变为以苏锡常沪为集聚带的“一带多点”空间格局,分布范围呈向南北两端、向西偏移趋势,主要分布走势与京杭运河走向有较高一致性。(3)最佳参数识别可以显著提升组合分类的科学性,增强影响因素的解释力,工业产业基础、经济实力基础和政府引资力度是影响示范园区空间布局的核心因素,其后依次为环保基础设施投入、科研创新投入、科研技术水平和人力资源投入。建议充分重视影响因素的促进效应,强化示范带动作用,深化生态文明建设实践,驱动高质量发展。

关键词：生态工业园区时空演化最优参数地理探测器长三角

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

乳酸干预破骨细胞条件培养基促进内皮细胞血管的生成

引用

中国组织工程研究 2025年第11期29卷 2210-2217页

作者：黄宏莉聂闻麦昱颖覃媛廖红兵广西医科大学口腔医学院/附属口腔医院口腔修复科广西壮族自治区南宁市530021 广西口腔颌面修复与重建研究重点实验室广西壮族自治区南宁市530021

背景:聚乳酸作为可降解的骨组织工程支架材料被广泛用于组织再生与修复研究,在促进组织愈合与新骨形成、血管生成中具有重要作用。目的:观察聚乳酸降解终产物乳酸对破骨细胞的作用,以及乳酸干预后破骨细胞条件培养基对血管内皮细胞增殖... 详细信息

背景:聚乳酸作为可降解的骨组织工程支架材料被广泛用于组织再生与修复研究,在促进组织愈合与新骨形成、血管生成中具有重要作用。目的:观察聚乳酸降解终产物乳酸对破骨细胞的作用,以及乳酸干预后破骨细胞条件培养基对血管内皮细胞增殖、迁移和小管形成功能的影响。方法:(1)取对数生长期的小鼠单核巨噬细胞系RAW264.7,贴壁后分别加入含0,5,10,20 mmol/L乳酸的破骨诱导培养基(含核因子κB受体活化因子配体、体积分数10%胎牛血清的DMEM培养基),培养5 d后分别进行抗酒石酸酸性磷酸酶与细胞骨架纤维状肌动蛋白染色,培养24h后采用RT-PCR检测抗酒石酸酸性磷酸酶5 m RNA表达。(2)取对数生长期的RAW264.7细胞,贴壁后分2组培养:对照组加入破骨诱导培养基,实验组加入含10 mmol/L乳酸的破骨诱导培养基,培养5 d后更换为无血清DMEM培养基继续培养24 h,离心取上清液,分别与等体积含体积分数10%胎牛血清DMEM培养基混合后作用条件培养基备用。取对数生长期的人脐静脉内皮细胞,分别与对照组、实验组条件培养基共培养,通过CCK-8、Transwell、划痕、成管实验观察细胞的增殖、迁移和成管能力,通过RT-PCR和Western Blot检测血管生成相关基因和蛋白的表达。结果与结论:(1)抗酒石酸酸性磷酸酶与肌动蛋白染色结果显示,5,10 mmol/L乳酸可促进RAW264.7细胞破骨向分化,其中以10 mmol/L乳酸的促进作用更显著;RT-PCR检测结果显示,5,10,20 mmol/L乳酸均可提高酒石酸酸性磷酸酶5 m RNA的表达,其中以10 mmol/L乳酸的提高作用最显著;(2)与对照组条件培养基相比,实验组条件培养基可促进人脐静脉内皮细胞的增殖、迁移与成管能力(P<0.05),提高血管内皮生长因子、血管生成素1的m RNA和蛋白表达(P<0.05);(3)结果表明,乳酸诱导分化的破骨细胞条件培养基可促进内皮细胞的血管生成,机制可能与提高血管内皮生长因子、血管生成素1表达相关。

关键词：破骨细胞条件培养基乳酸人脐静脉内皮细胞血管生成内皮细胞

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：