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Alpine vegetation responses to snow phenology in the Chinese Tianshan mountainous region

Journal of Mountain Science 2022年第5期19卷 1307-1323页

作者： ZHANG Bo LI Xue-mei LI Chao NYIRANSENGIYUMVA Christine qin qi-yong Faculty ofGeomatics Lanzhou Jiaotong UniversityLanzhou 730070China Gansu Provincial Engineering Laboratory for National Geographic State Monitoring Lanzhou 730070China National-Local Joint Engineering Research Center of Technologies and Applications for National Geographic State Monitoring Lanzhou 730070China College of Urban and Environmental Science Northwest UniversityXian 710127China

Investigating the interrelation between snow and vegetation is essential to explain the response of alpine ecosystems to climate *** on the MOD10 A1 daily cloud-free snow product and MOD13 A1 NDVI(normalized difference vegetation index)data,this study analysed the spatial and temporal patterns of snow phenology including snow onset date,snow end date,snow cover days,and vegetation phenology including the start of growing season,the end of growing season and the length of growing season in the Chinese Tianshan Mountainous Region(CTMR)from 2002 to 2018,and then investigated the snow phenological effects on the vegetation phenology among different ecogeographic zones and diverse vegetation *** results indicated that snow onset date was earlier at higher elevations and later at lower elevations,while snow end date showed opposite spatial distribution *** end of growing season occurred later on the northwest slope of the CTMR and the Yili *** earliest end of growing season was in the middle part of the CTMR.A long growing season was mainly distributed along the northern slope and the Yili Valley,while a short growing season was concentrated in the middle part of the *** response of vegetation phenology to changes in snow phenology varied among vegetation types and ecogeographic *** effect of snow phenology on vegetation phenology was more significant in IID5(Yili Valley)than in the other ecogeographic zones.A negative correlation was observed between the start of growing season and snow end date in nearly 54.78%of the study area,while a positive correlation was observed between the start of growing season and the snow end date in 66.85%of the study *** sensitivity of vegetation phenology to changes in snow cover varied among different vegetation *** onset date had the greatest effect on the start of growing season in the four vegetation cover types(alpine meadows,alpine steppes,shrubs,and alpine sparse vegetati

关键词： Snow phenology Vegetation phenology Climate change Response mechanism Grey correlation analysis Chinese Tianshan Mountainous Region

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Syntheses and Biological Activities of Novel Benzotriazole Compounds Containing a Thioamide Group

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Chemical Research in Chinese Universities 2006年第5期22卷 574-576页

作者： XU Liang-zhong ZHAI Zhi-wei YU Guan-ping qin yong-qi YANG Ya-xun College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

（E） -2- （ 1H-Benzo [ d ] [ 1,2,3 ] trlazol-1-yl） -3- （4-chlorophenyl） -3 -hydroxy-N-phenylprop-2 -enethioamide （ compound 1 ） and （E） -2- （ 1H-benzo [ d ] [ 1,2,3 ] trlazol-1-yl ） -3 -hydroxy-N, 3 -diphenylprop-2-enethioamide （ compound 2） were synthesized and their structures were confirmed by means of IR, MS, ^1H NMR, and elemental analysis. The structure of compound 1 was determined with single-crystal X-ray diffraction analysis. The results of the biological test show that the two compounds have a certain antifungal activity.

关键词： Benzotriazole Thioamide Crystal structure Biological activities

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Structure and Biological Activities of 2-(1,3-Dithiolan-2-ylidene)-1-phenyl-2-(1,2,4-triazol-1-yl)ethanone

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Chemical Research in Chinese Universities 2005年第5期21卷 528-530页

作者： XU Liang-zhong LI Wei-hua YU Guan-ping qin yong-qi YANG Shuang-hua HOU Bao-rong College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China College of Chemistry and Chemical Engineering Ocean University of China Qingdao 266033 P. R. China Institute of Oceanology Chinese Academy of Sciences Qingdno 266071 P. R. China

In order to find leading compounds with an excellent fungicidal activity, the title compound 2-（ 1,3-dithiolan-2- yl-idene）-1-phenyl-2-（ 1,2,4-tfiazol-1-yl） ethanone was synthesized according to the biological isosterism and its structure was confirmed by means of IR, MS, ^1 H NMR and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test shows that the synthesized compound exhibits some biological activities.

关键词： 1H-1 2 4-Triazole 1,3-Dithiolan Crystal structure Biological activity

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Hydrothermal Synthesis, Crystal Structure and Thermal Property of a Coordination Polymer Constructed by Ce(Ⅲ) and Succinate Ions

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Chinese Journal of Structural Chemistry 2019年第3期38卷 376-383页

作者： ZHANG Zai-Chao ZHAO Pu-Su qin yong-qi ZHU Feng-Xia ZHU Chang-Lei HU Xin-Ming LI Rong-qing Jiangsu Key Laboratory for the Chemistry of Low-dimensional Materials Huaiyin Normal University Institute of Applied Chemistry Lvliang University

A new three-dimensional coordination polymer [Ce_2(C_4H_4O_4)_3(H_2O)_2]_n·3.2 nH_2 O, constructed by Ce(Ⅲ) ion and succinate ion and lattice water molecules has been synthesized under hydrothermal conditions. It crystallizes in triclinic system, space group P1 with a = 7.8865(6), b = 12.0260(8), c = 12.2598(9) ?, α = 112.456(2)o, β = 90.046(2)o, γ = 100.423(2)o, Mr = 722.14, V = 1053.73(13) ?~3, Z = 2, Dc = 2.276 g/cm^3, μ = 4.35/mm, F(000) = 696, GOF = 1.029, R = 0.0203 and w R = 0.0570. The asymmetric unit contains two Ce^(3+) cations and both of them are nine-coordinated and their coordination geometries can be described as two distorted monocapped square antiprisms. In the title compound, a three-dimensional coordination network with one-dimensional hexagon honeycomb-like channels along the a axis is generated. TG measurement has been carried out, and its result analysis along with the powder XRD determination indicates the residue to be CeO_2.

关键词： hydrothermal synthesis crystal structure thermal property cerium(Ⅲ) complex

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丙硫菌唑的工艺改进

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农药 2017年第4期56卷 250-252页

作者：秦永其吕梁学院应用化学研究所山西吕梁033001

[目的]对丙硫菌唑的合成路线进行优化,优化后的制备工艺更加简便、高效。[方法]以1-氯环丙基甲酸乙酯、邻氯苯乙酸乙酯和1-硫-3-氮杂环丁烷并[2,3,e]-1,2,4-三氮唑为原料,经过2步反应合成丙硫菌唑,优化条件下总收率达76.8%。[结果]目标... 详细信息

[目的]对丙硫菌唑的合成路线进行优化,优化后的制备工艺更加简便、高效。[方法]以1-氯环丙基甲酸乙酯、邻氯苯乙酸乙酯和1-硫-3-氮杂环丁烷并[2,3,e]-1,2,4-三氮唑为原料,经过2步反应合成丙硫菌唑,优化条件下总收率达76.8%。[结果]目标化合物经~1H NMR光谱进行确认。[结论]该方法操作简单、反应条件温和、丙硫菌唑的收率高,适合工业化生产。

关键词：丙硫菌唑杀菌剂合成

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Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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Risk factors and incidence of acute pyogenic cholangitis

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 650-654页

作者： Yun-Sheng qin, qi-yong Li, Fu-Chun Yang , Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation Zhejiang Province, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Division of Hepatobiliary and Pancreatic Surgery Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health and Key Laboratory of Organ Transplantation Zhejiang Province First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

BACKGROUND: Acute cholangitis varies from mild to severe form. Acute suppurative cholangitis (ASC), the severe form of acute cholangitis, is a fatal disease and requires urgent biliary decompression. Which patients are at a high risk of ASC and need emergency drainage is still unclear. The present study aimed to identify the factors for determining early-stage ASC and distinguishing ASC from acute cholangitis. METHODS: We analyzed 359 consecutive patients with acute cholangitis who had been admitted to the First Affiliated Hospital, Zhejiang University School of Medicine from January 2004 to May 2011. Emergency endoscopic retrograde cholangiopancreatography (ERCP) was carried out in all patients to decompress or clear the stones by experienced endoscopists Clinical and therapeutic data were collected, and univariate and multivariate analyses were performed to identify the potential risk factors of ASC. RESULTS: Of the 359 patients, 1 was excluded because of failure of ERCP drainage. Of the remaining 358 patients with an average age of 62.7 years (range 17-90), 162 were diagnosed with ASC, and 196 with non-ASC. ENBD catheters were placed in 343 patients (95.8%), of whom 182 patients had stones removed at the same time, and plastic stent was placed in 25 patients (7.0%) Clinical conditions were improved quickly after emergency biliary drainage in all patients. Complications were identified in 11 patients (3.1%): mild pancreatitis occurred in 8 patients and hemorrhage in 3 patients. There was no mortality. Univariate analysis showed that several variables were associated with ASC: age, fever, decreased urine output, hypotension, tachycardia abnormal white blood cell count (WBC), low platelet, high C reactive protein (CRP), and duration of the disease. Multivariateanalysis revealed that advanced age, hypotension, abnormal WBC, high CRP, and duration of the disease were independent risk factors for ASC. CONCLUSIONS: This study demonstrates that advanced age, hypotension,

关键词： acute cholangitis suppurative endoscopic retrograde cholangiopancreatography

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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衰老相关分泌表型在乳腺癌进展中的作用

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中国肿瘤 2018年第5期27卷 364-368页

作者：褚玉新胡钦勇宋启斌武汉大学人民医院

细胞衰老在乳腺癌的发生发展中起重要作用,包括复制性细胞衰老、癌基因诱导细胞衰老、治疗诱导的细胞衰老。细胞衰老具备特异性表型,如特征性的形态变化,SA-β-gal染色阳性,形成衰老相关异染色质集落,以及产生衰老相关分泌表型。肿瘤细... 详细信息

细胞衰老在乳腺癌的发生发展中起重要作用,包括复制性细胞衰老、癌基因诱导细胞衰老、治疗诱导的细胞衰老。细胞衰老具备特异性表型,如特征性的形态变化,SA-β-gal染色阳性,形成衰老相关异染色质集落,以及产生衰老相关分泌表型。肿瘤细胞衰老相关分泌表型具有双面性,既可抑制肿瘤又可促进肿瘤进展。肿瘤细胞衰老相关分泌表型也有双向调节作用,在癌变早期主要发挥正性调节作用,而在肿瘤晚期主要发挥负性调节作用。不同类型的乳腺癌产生不同程度的衰老相关分泌表型,重塑肿瘤微环境,促进乳腺癌进展。鉴定靶向乳腺癌中衰老相关分泌表型的特异性药物将是一种很有前景的抗肿瘤策略。

关键词：乳腺癌衰老分泌表型

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