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Impacts of a wind stress and a buoyancy flux on the seasonal variation of mixing layer depth in the South China Sea

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Acta Oceanologica Sinica 2013年第9期32卷 30-37页

作者： XIAO Xianjun WANG Dongxiao ZHOU Wen ZHANG Zuqiang qin yinghao HE Na ZENG Lili National Climate Center China Meteorological Administration State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of Sciences Guy Carpenter Asia-Pacific Climate Impact Centre School of Energy and EnvironmentCity University of Hong Kong National Marine Environmental Forecasting Center Beijing Meteorological Station

The seasonal variation of mixing layer depth （MLD） in the ocean is determined by a wind stress and a buoy- ance flux. A South China Sea （SCS） ocean data assimilation system is used to analyze the seasonal cycle of its MLD. It is found that the variability of MLD in the SCS is shallow in summer and deep in winter, as is the case in general. Owing to local atmosphere forcing and ocean dynamics, the seasonal variability shows a regional characteristic in the SCS. In the northern SCS, the MLD is shallow in summer and deep in winter, affected coherently by the wind stress and the buoyance flux. The variation of MLD in the west is close to that in the central SCS, influenced by the advection of strong western boundary currents. The eastern SCS presents an annual cycle, which is deep in summer and shallow in winter, primarily impacted by a heat flux on the air-sea interface. So regional characteristic needs to be cared in the analysis about the MLD of SCS.

关键词： wind stress buoyance flux mixed layer South China Sea

城市地下综合管廊PPP模式融资风险管理研究

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地下空间与工程学报 2018年第2期14卷 315-322,331页

作者：赵佳覃英豪王建波牛发阳青岛理工大学管理学院山东青岛266520 中建三局第三建设工程有限责任公司广州510275

在我国城市地下综合管廊发展探索阶段引入PPP模式融资,能够有效激发综合管廊快速发展的内在动力和外在市场。通过系统总结分析国内外综合管廊和PPP模式的发展经验和研究动态,指出风险管理是制约综合管廊PPP模式发展的关键因素,为进行有... 详细信息

在我国城市地下综合管廊发展探索阶段引入PPP模式融资,能够有效激发综合管廊快速发展的内在动力和外在市场。通过系统总结分析国内外综合管廊和PPP模式的发展经验和研究动态,指出风险管理是制约综合管廊PPP模式发展的关键因素,为进行有效的风险管理,文中采用HHM法识别出综合管廊PPP模式融资的八大主要风险因素,并利用RFRM法结合改进层析分析法、熵权法和贝叶斯决策对风险因素进行初步过滤、多视角过滤和量化过滤。根据风险因素的定性和定量过滤的结果,提出了有关完善法律政策体系、规范合同条款、重视运营管理和构建风险分担机制的风险防范和风险规避的相关建议,以期为综合管廊PPP模式的风险管理提供有益的参考。

关键词：地下综合管廊风险管理 PPP

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海上大风延伸期预报研究进展

中国农学通报 2016年第4期32卷 185-190页

作者：商舜吴萌萌秦英豪王彰贵魏立新国家海洋环境预报中心北京100081

海上大风是海洋产业的重大灾害性天气,而延伸期预报是世界性难题。目前,延伸期预报主要分成动力延伸、低频振荡、经验波传播、数理统计、气候扰动分解和集合预报等6种方法,以动力延伸中的数值模式和低频振荡中的MJO监测诊断最为流行。... 详细信息

海上大风是海洋产业的重大灾害性天气,而延伸期预报是世界性难题。目前,延伸期预报主要分成动力延伸、低频振荡、经验波传播、数理统计、气候扰动分解和集合预报等6种方法,以动力延伸中的数值模式和低频振荡中的MJO监测诊断最为流行。随着大数据时代的到来,基于大数据分析,以数值预报产品为基础的集合预报成为未来业务发展的重点方向。这6种方法都可以用于海上大风等重大灾害性天气预报,许多学者尝试较多的是气候扰动分解、低频振荡中的低频天气图等方法中的溯源技术,通过找到源头,实现重大灾害性天气的延伸期预报。

关键词：大风延伸期预报

Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart

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Bioactive Materials 2021年第12期6卷 4415-4429页

作者： Ge Guan Da Huo Yanzhao Li Xiaolin Zhao yinghao Li Zhongliang qin Dayu Sun Guanyuan Yang Mingcan Yang Ju Tan Wen Zeng Chuhong Zhu Department of Anatomy State Key Laboratory of TraumaBurn and Combined InjuryKey Lab for Biomechanics and Tissue Engineering of ChongqingArmy Medical University(Third Military Medical University)Chongqing400038China Chongqing Institute of Zhong Zhi Yi Gu Shapingba DistrictChongqing400030China Department of Cell Biology Third Military Army Medical UniversityChongqing400038China

Cell therapy has been a promising strategy for cardiac repair after myocardial infarction(MI),but a poor ischemic environment and low cell delivery efficiency remain significant *** spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI,but it is unclear whether it could be used for human pluripotent stem cell(hiPSC)cultivation and provide a proper microenvironment for cell grafts against the ischemic ***,we developed a splenic extracellular matrix derived thermoresponsive hydrogel(SpGel).Proteomics analysis indicated that SpGel is enriched with proteins known to modulate the Wnt signaling pathway,cell-substrate adhesion,cardiac muscle contraction and oxidation-reduction *** vitro studies demonstrated that hiPSCs could be efficiently induced into endothelial cells(iECs)and cardiomyocytes(iCMs)with enhanced function on *** cytoprotective effect of SpGel on iECs/iCMs against oxidative stress damage was also ***,in vivo studies revealed that iEC/iCM-laden SpGel improved cardiac function and inhibited cardiac fibrosis of infarcted hearts by improving cell survival,revascularization and *** conclusion,we successfully established a novel platform for the efficient generation and delivery of autologous cell grafts,which could be a promising clinical therapeutic strategy for cardiac repair and regeneration after MI.

关键词： Stem cell-laden splenic hydrogel hiPSC differentiation platform Antioxidant stress Myocardial infarction Cardiac repair

Over-expression of heme oxygenase-1 in peripheral blood predicts the progression and relapse risk of chronic myeloid leukemia

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Chinese Medical Journal 2014年第15期127卷 2795-2801页

作者： Wei Sixi Wang Yating Chai Qixiang Fang qin Zhang Yaming Lu yinghao Wang Jishi Hematopoietic Stem Cell Transplantation Center of GuizhouProvince Department of Hematology Affiliated Hospital of Guiyang Medical College Guiyang Guizhou550004 China Department of Clinical Biochemistry Affiliated Hospital of Guiyang Medical College Guiyang Guizhou550004 China Department of Pharmacy Affiliated Hospital of Guiyang Medical College Guiyang Guizhou550004 China

Background There are limited eligible clinical markers at present to monitor the progress of chronic myeloid leukemia （CML）.Heme oxygenase-1 （HO-1）,as one of the most important oxidation-regulating enzymes in vivo,suggests the onset and progression of cancer when highly ***,HO-1 level is related with the occurrence and development of hematological *** the relationship between HO-1 expression and progression/relapse of CML has seldom been studied *** study aimed to investigate the relationship between them to find out a new molecular marker for *** A total of 60 peripheral blood and bone marrow （BM） samples from 25 CML patients in different phases were collected respectively to detect the expressions of HO-1 and bcr/abl using real-time *** blood test was performed to detect the changes of leukocyte and platelet *** proportion of primitive cells in BM was detected by flow *** relationship between high HO-1 expression and CML progression and relapse was explored by the analysis of variance by Wilcoxon test and linear regression *** diagnostic accuracy and cutoff values were determined by receiver operating characteristic *** Relative expression of HO-1 mRNA in CML patients peripheral blood was significantly higher than that of donors （P 〈0.0001）,which were 0.57±3.78 and （1.417±1.125）×10-6,***-1 expression level in CML patients was 0.061 5±0.062 4,which decreased to 0.009 4±0.006 7 upon CMoR,and remained remarkably higher 0.016 3±0.017 5 than that of normal donors （1.417±1.125）× 10-6,P 〈*** relapse occurred,HO-1 expression significantly increased from 0.020 6±0.021 0 to 3.852±10.285 in CMoR stage and undergoing *** to progression of CML,HO-1 expression level in CML patients increased from CP （0.009 5±0.017 6） to AP （0.028 0±0.055 7） and then to BP （0.276 7± 0.447 0）.And there was a linear correlation between HO-1 expression and proportion of p

关键词： heme oxygenase-1 chronic myeloid leukemia progression relapse receiver operating characteristic curve

The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance

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Molecular Plant 2017年第9期10卷 1224-1237页

作者： Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun Shanxi Acad Agr Sci Inst Crop Germplasm Resources Res Taiyuan 030031 Shanxi Peoples R China Minist Agr Key Lab Crop Gene Resources & Germplasm Enhanceme Taiyuan 030031 Shanxi Peoples R China Shanxi Key Lab Genet Resources & Genet Improvemen Taiyuan 030031 Shanxi Peoples R China Chinese Acad Sci Inst Genet & Dev Biol State Key Lab Plant Genom Beijing 100101 Peoples R China Univ Chinese Acad Sci Coll Life Sci Beijing 100049 Peoples R China Shanxi Agr Univ Coll Agron Taiyuan 030801 Shanxi Peoples R China Chinese Acad Sci Inst Microbiol State Key Lab Microbial Resources Beijing Peoples R China South China Agr Univ Coll Marine Sci Guangzhou 510642 Guangdong Peoples R China

Tartary buckwheat （Fagopyrum tataricum） is an important pseudocereal crop that is strongly adapted to growth in adverse environments. Its gluten-free grain contains complete proteins with a well-balanced composition of essential amino acids and is a rich source of beneficial phytochemicals that provide significant health benefits. Here, we report a high-quality, chromosome-scale Tartary buckwheat genome sequence of- 489.3 Mb that is assembled by combining whole-genome shotgun sequencing of both Illumina short reads and single-molecule real-time long reads, sequence tags of a large DNA insert fosmid library, Hi-C sequencing data, and BioNano genome maps. We annotated 33 366 high-confidence protein-coding genes based on expression evidence. Comparisons of the intra-genome with the sugar beet genome revealed an independent whole-genome duplication that occurred in the buckwheat lineage after they diverged from the common ancestor, which was not shared with rosids or asterids. The reference genome facilitated the identification of many new genes predicted to be involved in rutin biosynthesis and regulation, aluminum stress resistance, and in drought and cold stress responses. Our data suggest that Tartary buckwheat＇s ability to tolerate high levels of abiotic stress is attributed to the expansion of several gene families involved in signal transduction, gene regulation, and membrane transport. The availability of these genomic resources will facilitate the discovery of agronomically and nutritionally important genes and genetic improvement of Tartary buckwheat.

关键词： tartary buckwheat de novo genome assembly rutin biosynthesis aluminum resistance abiotic stress,whole genome duplication

A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases

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Science China(Life Sciences) 2023年第10期66卷 2380-2398页

作者： yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang State Key Laboratory of Common Mechanism Research for Major Diseases Department of BiochemistryInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Key Laboratory of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of ChinaEngineering Research Center of Chinese Medicine Resource of Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Department of Traditional Chinese Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100005China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of OxfordOxford OX37FZUK Chinese Academy of Medical Sciences(CAMS) CAMS Oxford Institute(COI)Nuffield Department of MedicineUniversity of OxfordOxfordOX37FZUK Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Target Discovery Institute Centre for Medicines DiscoveryNuffield Department of MedicineUniversity of OxfordOxfordOX37FZUK Department of Electrical Engineering and Computer Science and Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbia MO 65211USA

Cross-kingdom herbal mi RNA was first reported in *** a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique *** constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://***),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s *** profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi *** software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal *** established roadmaps for oligonucleotide drugs development and optimization of TCM ***,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical *** propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic *** Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine.

关键词： small RNA herbal decoction cross-kingdom regulation traditional Chinese medicine RNA oligonucleotide drug RNA therapeutics Bencao small RNA Atlas

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生物降解地膜应用与地膜残留污染防控

生物工程学报 2016年第6期32卷 748-760页

作者：严昌荣何文清薛颖昊刘恩科刘勤中国农业科学院农业环境与可持续发展研究所农业部旱作节水农业重点实验室北京100081 农业部农业生态与资源保护总站北京100125

地膜是农业生产中重要的生产资料之一,过去30多年,地膜用量和农作物覆膜面积一直稳定增长,2014年地膜用量达到了144万t,覆膜面积超过1 800万hm^2,该技术对保障我国农产品安全供给作出了重大贡献。与此同时,地膜残留污染问题越来越严重,... 详细信息

地膜是农业生产中重要的生产资料之一,过去30多年,地膜用量和农作物覆膜面积一直稳定增长,2014年地膜用量达到了144万t,覆膜面积超过1 800万hm^2,该技术对保障我国农产品安全供给作出了重大贡献。与此同时,地膜残留污染问题越来越严重,一些农田的地膜残留量超过250 kg/hm^2,在我国西北的局部区域,地膜残留已经对农田土壤、作物生长发育、农事作业等造成严重影响和危害。生物降解地膜成为替代普通PE地膜、解决地膜残留污染的一种有效措施和手段,目前生物降解地膜正处于产品研发和评价试验的关键阶段,部分生物降解地膜产品在马铃薯、花生、烟草生产上显示出良好的效果,但总体上还面临巨大挑战,主要包括需要进一步提高地膜产品质量,提高地膜产品破裂和降解可控性,改善地膜的增温保墒能力,实现满足农作物对地膜覆盖功能的要求;此外,需要降低生物降解地膜综合成本,促进生物降解地膜规模化应用。总体上,随着技术进步和农业生产环境的变化,生物降解地膜应用将具有良好的前景。

关键词：地膜残留污染生物降解地膜机遇与挑战

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甘肃省中东部农户地膜应用及回收现状

农业工程学报 2019年第15期35卷 211-216页

作者：严昌荣戚瑞敏薛颖昊董闫闫李真刘勤徐志宇中国农业科学院农业环境与可持续发展研究所/农业农村部农膜污染防控重点实验室北京100081 农业农村部农业生态与资源保护总站北京100125

为了解甘肃省中东部地区农户地膜应用、回收状况及其主要影响因素,于2019年3月26日—4月1日采用手机问卷方式,在甘肃中东部开展了地膜应用及回收情况调查。结果显示:调查区域主要种植有玉米、小麦、蔬菜和马铃薯等作物覆膜面积占种植面... 详细信息

为了解甘肃省中东部地区农户地膜应用、回收状况及其主要影响因素,于2019年3月26日—4月1日采用手机问卷方式,在甘肃中东部开展了地膜应用及回收情况调查。结果显示:调查区域主要种植有玉米、小麦、蔬菜和马铃薯等作物覆膜面积占种植面积的73.2%;种植不同作物的调查农户中,99.3%玉米种植户采用覆膜技术,28.5%、77.1%、57.9%和52.1%种植户分别对小麦、蔬菜、马铃薯和其他作物采用覆膜技术;甘肃省中东部地区地膜回收方式主要为人工捡拾,占调查对象的89.3%;回收残膜的农户中47.7%的农户将残膜交给回收网点,28.3%在地头焚烧,13.8%将其堆放田间,7.9%进行填埋处理,还有2.2%采取其他方式处理;调查作物的地膜回收作业率均在80.0%以上,其中蔬菜高达99.3%;按照人工回收作业的地膜离田率为80%和90%分别估算,2018年甘肃省中东部地区地膜回收率达74.2%和83.5%,其中蔬菜上地膜回收情况最好,分别为79.4%和89.4%。目前甘肃省中东部地区地膜回收工作仍存在回收难度大、回收机械化强度不够、回收地膜处置不当,政府支持力度不够等问题。政府和相关部门应加大地膜新国家标准宣传及执行力度,制定相关扶持和奖励机制,提高地膜回收的机械化程度,快速推动农膜回收及资源化利用工作,为合理应用地膜及农膜污染防控提供数据支撑。此外,手机调查地膜应用及回收系统的启用,能快速有效地获得一手数据,为未来全面快速获取中国地膜应用回收的基础数据提供借鉴。

关键词：地膜回收作物手机调查存在问题政策建议