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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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基于DSP的单周控制器研究

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煤矿机电 2010年第5期31卷 43-46页

作者：宋世贤覃荆伟汪玉凤双鸭山矿业集团供电公司黑龙江双鸭山155100 辽宁工程技术大学电气与控制工程学院辽宁葫芦岛125105

利用数字信号处理器(DSP)结合单周控制模型实现单周控制,其与传统单周控制器相比多了谐波信号的检测电路,但核心控制器却相对简单,而且可以修改单周控制的参数,控制算法更易实现。通过在单相有源电力滤波器中的实验,体现了DSP的单周控... 详细信息

利用数字信号处理器(DSP)结合单周控制模型实现单周控制,其与传统单周控制器相比多了谐波信号的检测电路,但核心控制器却相对简单,而且可以修改单周控制的参数,控制算法更易实现。通过在单相有源电力滤波器中的实验,体现了DSP的单周控制器的调试方便,控制系统稳定,滤波效果好的特点,为在三相有源电力滤波器中的应用提供了基础。

关键词：单周控制数字信号处理器有源电力滤波器

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Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

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World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-wei Fu Yue-jing Li Ran Yu Rui-qing Guo Li-Xia Gao Sheng-Xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect

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Neutrophils in the era of single-cell RNA sequencing: functions and targeted therapies in cancer

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Cancer Biology & Medicine 2023年第12期20卷 903-914页

作者： jing qin Feng wei Xiubao Ren National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Tianjin’s Clinical Research Center for Cancer Tianjin 300060China Key Laboratory of Cancer Prevention and Therapy Tianjin 300060China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060China Department of Immunology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute&HospitalTianjin 300060China

Introduction Neutrophils,a crucial component of the innate immune system,are the most abundant bone marrow-derived eukaryotic cell in human *** functional importance of neutrophils is often overlooked because neutrophils are short-lived,terminally differentiated,and do not *** traditionally considered anti-bacterial cells,research has demonstrated the multifaceted roles of neutrophils in *** have suggested that neutrophils with normal functions co-exist with pathologically activated neutrophils that support tumorprogression and metastasis in the context of cancer.

关键词： metastasis targeted traditionally

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钉道局部与整体固化增强椎弓根螺钉稳定性的体外比较研究

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科学技术与工程 2008年第18期8卷 5150-5154页

作者：刘达雷伟吴子祥秦为径张伟战策杨彬奎第四军医大学西京医院全军骨科研究所西安710032

为比较钉道局部固化与传统式钉道整体固化在体外强化椎弓根螺钉早期稳定性的效果,选用30个新鲜成年山羊腰椎。每一个椎体,一侧椎弓根行传统式钉道整体固化,即钉道内直接注射CSC(0.3 mL)(对照组);另一侧使行钉道局部固化,即用空心侧孔丝... 详细信息

为比较钉道局部固化与传统式钉道整体固化在体外强化椎弓根螺钉早期稳定性的效果,选用30个新鲜成年山羊腰椎。每一个椎体,一侧椎弓根行传统式钉道整体固化,即钉道内直接注射CSC(0.3 mL)(对照组);另一侧使行钉道局部固化,即用空心侧孔丝攻给予钉道局部注射CSC(0.3 mL)(实验组),24 h后,随机选取10个椎体,对其中的螺钉进行轴向拔出实验,其余20个椎体中的螺钉进行周期抗屈实验。得到螺钉最大轴向拔出力(Fmax):对照组(918.50±149.56)N,实验组(807.90±128.97)N;螺钉拔出的能量吸收值:对照组(1.835±0.320)J,实验组(1.615±0.268)J,两组间差异有均有统计学意义(P(0.05)。周期抗屈试验结果表明:与对照组相比,实验组中的螺钉发生松动时所需要的负荷更小,或者在同等负荷下所产生的位移较大。说明在使用相同剂量固化材料的前提下,钉道局部固化对螺钉早期稳定性的强化效果不如钉道整体固化方法明显。但钉道局部固化为临床上解决螺钉松动问题提供了一个新的研究方向。

关键词：椎弓根螺钉硫酸钙骨水泥最大轴向拔出力(Fmax) 周期抗屈性能

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无张力疝修补手术治疗成人腹股沟疝患者的效果及安全性

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中国当代医药 2021年第29期28卷 78-80页

作者：秦为径王斌权冬常欣刘轩解放军63750部队医院外一科陕西西安710043 解放军63750部队医院外二科陕西西安710043

目的探讨无张力疝修补手术治疗成人腹股沟疝患者的效果及安全性。方法选取2016年5月至2020年6月期间于解放军63750部队医院外一科收治的成人腹股沟疝的88例患者作为本次研究对象,根据手术适应症及患者意愿分为观察组63例与对照组25例,... 详细信息

目的探讨无张力疝修补手术治疗成人腹股沟疝患者的效果及安全性。方法选取2016年5月至2020年6月期间于解放军63750部队医院外一科收治的成人腹股沟疝的88例患者作为本次研究对象,根据手术适应症及患者意愿分为观察组63例与对照组25例,观察组采用无张力疝修补术,对照组采用腹腔镜疝修补术,比较两组患者的临床治疗效果、并发症总发生率、手术时间、术中出血量、住院时间、疼痛程度和治疗费用。结果两组患者的总有效率比较,差异无统计学意义(P>0.05);两组的并发症总发生率比较,差异无统计学意义(P>0.05);两组患者的手术时间、术中出血量、住院时间和VAS评分比较,差异无统计学意义(P>0.05);两组患者的治疗费用比较,差异无统计学意义(P>0.05)。结论与腹腔镜疝修补术比较,无张力修补术在并发症、出血量、复发率等方面无明显差异,临床效果类似,不会明显增加手术时间,患者不会有较高的治疗费用,手术操作相对简单,适合在临床特别是基层医院继续推广应用。

关键词：无张力疝修补手术腹股沟疝效果并发症发生率

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Influence of TiO2 on the melting property and viscosity of Cr-containing high-Ti melting slag

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International Journal of Minerals,Metallurgy and Materials 2020年第3期27卷 310-318页

作者： jing Ma Gui-qin Fu wei Li Miao-yong Zhu School of Metallurgy Northeastern University

A study on the melting and viscosity properties of the chromium-containing high-titanium melting slag(CaO–SiO2–MgO–Al2O3–TiO2–Cr2O3) with TiO2 contents ranging from 38.63 wt% to 42.63 wt% was conducted. The melting properties were investigated with a meltingpoint apparatus, and viscosity was measured using the rotating cylinder method. The FactSage 7.1 software and X-ray diffraction, in combination with scanning electron microscopy–energy-dispersive spectroscopy(SEM–EDS), were used to characterize the phase equilibrium and microstructure of chromium-containing high-titanium melting slags. The results indicated that an increase in the TiO2 content led to a decrease in the viscosity of the chromium-containing high-titanium melting slag. In addition, the softening temperature, hemispheric temperature, and flowing temperature decreased with increasing TiO2 content. The amount of crystallized anosovite and sphene phases gradually increased with increasing TiO2 content, whereas the amount of perovskite phase decreased. SEM observations revealed that the distribution of the anosovite phase was dominantly influenced by TiO2.

关键词： titanium dioxide Cr-containing high-titanium melting slag melting property viscosity vanadium titanomagnetite

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Mapping the landscape of gastric signet ring cell carcinoma:Overcoming hurdles and charting new paths for advancement

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World Journal of Clinical Oncology 2025年第2期16卷 94-109页

作者： Shu-Yuan Wang jing-Hang Wang Run-Kai Chen Zhen Yuan Hao Cui Bo wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from ***,there still persist some controversies regarding the associated research *** To summarize the current obstacles and potential future directions for research on *** To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this ***,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection *** analysis results were visually *** This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and *** popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC.

关键词： Gastric cancer Signet ring cell carcinoma Bibliometric analysis CiteSpace VOSviewer

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An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li jing Li Yanqi Song Sujuan qin Qiaoyan Wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

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Recent progress in constructing fluorinated solid–electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 270-291页

作者： Di Zhang Pengfei Lv wei qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of China School of Chemical Engineering Sichuan University

Lithium metal batteries(LMBs) are emerging as a promising energy storage solution owing to their high energy density and specific capacity. However, the non-uniform plating of lithium and the potential rupture of the solid–electrolyte interphase(SEI) during extended cycling use may result in dendrite growth, which can penetrate the separator and pose significant short-circuit risks. Forming a stable SEI is essential for the long-term operation of the batteries. Fluorine-rich SEI has garnered significant attention for its ability to effectively passivate electrodes, regulate lithium deposition, and inhibit electrolyte corrosion. Understanding the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode performance. This paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal anodes. It focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI performance. For instance, combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the SEI. Integrating metals with LiF significantly improves electrochemical performance at the SEI/anode interface, with a necessary focus on reducing electron tunneling risks. Additionally, incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity, though maintaining structural stability over long cycles remains a critical area for future research. Although alloys combined with LiF increase surface energy and lithium affinity, challenges such as dendrite growth and volume expansion persist. In summary, this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

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