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Chinese Journal of Natural Medicines 2019年第3期17卷 218-226页

作者： qin wei-wei WANG Li JIAO Zheng WANG Bin WANG Cheng-Yu QIAN Li-Xuan QI wei-Lin ZHONG Ming-Kang Department of Pharmacy Huashan Hospital Fudan University Department of Cardiology Huashan Hospital Fudan University

This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate(STS) in healthy volunteers and coronary heart disease(CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic analysis was performed by nonlinear mixed-effect modeling. The final model was evaluated by bootstrap and visual predictive check. A total of 230 plasma concentrations were included, 137 from healthy volunteers and 93 from CHD patients. It was a two-compartment model with first-order elimination. The typical value of the apparent clearance(CL) of STS in CHD patients with total bilirubin(TBIL) level of 10 μmol×L^(–1) was 48.7 L×h^(–1) with inter individual variability of 27.4%, whereas that in healthy volunteers with the same TBIL level was 63.1 L×h^(–1). Residual variability was described by a proportional error model and estimated at 5.2%. The CL of STS in CHD patients was lower than that in healthy volunteers and decreased when TBIL levels increased. The bootstrap and visual predictive check confirmed the stability and validity of the final model. These results suggested that STS dosage adjustment might be considered based on TBIL levels in CHD patients.

关键词： Sodium tanshinone IIA sulfonate Nonlinear mixed-effects modeling Population pharmacokinetics Coronary heart disease Total bilirubin

FAT10 level in human gastric cancer and its relation with mutant p53 level,lymph node metastasis and TNM staging

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World Journal of Gastroenterology 2009年第18期15卷 2228-2233页

作者： Feng Ji Xi Jin Chun-Hua Jiao qin-wei Xu Zi-wei Wang Yue-Liang Chen Department of Digestive Diseases First Affiliated Hospital of Zhejiang University Medical SchoolHangzhou 310003 Zhejiang Province China

AIM:To investigate the role of FAT10 and mutant p53 in the pathogenesis,severity and prognosis of gastric ***:FAT10,mutant p53 mRNA and protein levels were measured by reverse transcription(RT)-PCR and immunohistochemistry in gastric cancer tissue(n = 62),tumoradjacent tissue(n = 62) and normal gastric tissue(n = 62).Relation of FAT10 and mutant p53 expression with clinicopathological features and clinical outcomes of gastric cancer patients were ***:The FAT10,mutant p53 mRNA and protein levels were signif icantly higher in gastric cancer than in its adjacent and normal *** FAT10 and mutant p53 levels in gastric cancer tissue were significantly correlated with lymph node metastasis and tumor,nodes,metastasis(TNM) ***,the high FAT10 level was associated with the overall survival rate of *** Cox-proportional hazards model analysis showed that mRNA and protein levels of FAT10 and mutant p53,lymph node metastasis,distant metastasis and TNM stage were the independent prognostic factors for gastric ***:FAT10 may be involved in gastric carcinogenesis,and is a potential marker for the prognosis of gastric cancer ***10 and mutant p53 may play a common role in the carcinogenesis of gastric cancer.

关键词： Gastric cancer FAT10 Mutant p53 Prognosis

Application of Computed Tomographic Colonography in Diagnosis of Colonic Polyps

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Chinese Medical Sciences Journal 2009年第1期24卷 36-40页

作者： Ming-wei qin wei-dong Pan Guan-ning Cong Yun Wang Yun-qing Zhang Ji-xiang Liang Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To assess the clinical values of computed tomographic colonography （CTC） in diagnosis of colonic polyps. Methods Forty-two patients who were clinically suspicious of colonic polyps or underwent colonic polyps screening received examinations with both CTC and conventional colonoscopy. Sixteen- or 64-slice spiral computed tomography and professional imaging processing techniques were used for evaluation. Per-polyp and per-patient results were analyzed. Those by per-polyp were subsequently divided into ≥10 mm group, 5-10 mm group, and ≤5 mm group. Sensitivity, positive predictive value （PPV）, specificity, negative predictive value （NPV）, and accuracy were calculated using statistical method for diagnostic studies, with conventional colonoscopy as a gold standard. Results Ninety and 61 polyps were found by CTC and conventional colonoscopy, respectively. The per-polyp sensitivity/PPV were 80.3%/55.6% in total, and 100%/92.9%, 93.8%/65.2%, and 68.8%/ 41.5% in the ≥10 mm group, 5-10 mm group, and ≤5 turn group, respectively. The per-patient sensitivity, PPV, specificity, NPV, and accuracy were 97.1%, 89.5%, 42.9%, 75.0%, and 88.1%, respectively. Conclusion CTC can clearly reveal the morphology of colonic polyps and be used as a routine monitoring method for the clinical diagnosis of polyps.

关键词： colonic polyp X-ray computed tomography colonoscopy

USING OF MULTISLICE HELICAL CT COLONOGRAPHY IN PATIENTS WITH MALIGNANT LESIONS OF COLON

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Chinese Medical Sciences Journal 2005年第3期20卷 171-175页

作者： Ming-wei qin wei-dong Pan Guan-ning Cong Yun Wang Yun-qing Zhang Wen-bin Mou Zheng-yu Jin Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objoctive To investigate the techniques and clinical applications ofmultislice helical computed tomography （CT） colonography in colonic lesions. Methods Fifty-nine patients with malignant lesions of colon underwent volume scanning using multislice helical CT. Four types of reconstruction including CT virtual colonoscopy （CTVC）, shaded surface display （SSD）, Raysum, and multiple planar reconstruction （MPR） were used for image post-processing. The results were compared with those of colonoscopy and pathology. Results Multislice helical CT colonography detected 54 colorectal carcinomas, 4 adenomas with focal carcinoma, 1 non-Hodgkin＇s lymphoma （NHL）. The lesions＇ number, size, location, morphology, stricture of intestinal cavity, infiltration, and metastasis were shown satisfactorily by multislice helical CT colonography. Whole colon could be shown in all patients. CT colonography displayed 4 synchronous colonic tumors, 1 ascending colon carcinoma combined with left renal carcinoma among 54 patients with colonic carcinomas. The accuracy of location of CT colonography was 100%. There were 9 cases that CT showed the tumor location was different from the finding of conventional colonoscopy, while all of the CT location were proven exact by operation. CT colonography also displayed the infiltration of serous layer and fatty tissue in 45 cases; 21 cases matched the pathological results in all the 24 cases of suspicious lymph node metastasis, the sensitivity was 87.5%, the specificity was 90.6%; 9 cases hepatic metastasis, 2 ovarian metastasis, and 1 double adrenal gland metastasis. Conclusions Multislice helical CT colonography is effective in preoperative diagnosis, location, stage, and making treatment plan of colorectal carcinoma. It can display the portion not seen during colonoscopy and may have an adjunctive role.

关键词： tomography, X-ray computed colorectal neoplasms image processing, computer assisted

高校教学支持服务的发展——国际视野与本土探索

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比较教育研究 2014年第7期36卷 25-31页

作者：秦炜炜苏州大学教育学院江苏苏州215123

随着《博耶报告》的发表,大学教学引起了国际高等教育界的广泛关注,而教学支持服务也成为各国高校提升教学质量的普遍方式。如果从1962年美国密歇根大学创建全球第一个教学支持服务中心算起,西方高校的教学支持服务实践与研究距今已有... 详细信息

随着《博耶报告》的发表,大学教学引起了国际高等教育界的广泛关注,而教学支持服务也成为各国高校提升教学质量的普遍方式。如果从1962年美国密歇根大学创建全球第一个教学支持服务中心算起,西方高校的教学支持服务实践与研究距今已有半个世纪的历史,并呈现出制度化、多元化、专业化和全球化等特征。2007年,中国海洋大学成立了国内首个教学支持中心,我国也开始更加注重这一领域的实践探索。要跨越中西方近半个世纪的历史差距,就必须在国际视野与本土实践的双重变奏中探寻中国高校教学支持服务的发展路向。

关键词：大学教学教学质量教学支持服务教学发展中心

大学教学发展的组织变革与体系构建——多伦多大学个案研究

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高等教育研究 2014年第3期35卷 54-62页

作者：秦炜炜苏州大学教育学院江苏苏州215123

现代大学热衷科研而忽视教学,于是高等教育界发出"回归大学之道"的时代呼唤。自20世纪80年代以来,多伦多大学作为世界一流大学,其教学发展组织先后经过孕育萌生、战略规划、融合发展和体系构建四个阶段,最终形成了"学校-院(系)-项目"三... 详细信息

现代大学热衷科研而忽视教学,于是高等教育界发出"回归大学之道"的时代呼唤。自20世纪80年代以来,多伦多大学作为世界一流大学,其教学发展组织先后经过孕育萌生、战略规划、融合发展和体系构建四个阶段,最终形成了"学校-院(系)-项目"三级联动的教学发展体系,成为现代大学坚守教学本位、重振教学风气的典范。同时,多伦多大学的教学发展组织在研究引领、机制创新、服务品质、技术融合与系统变革等方面积累了丰富的经验,对我国高校正在兴起的教学发展实践具有一定的借鉴意义。

关键词：大学教学教学发展组织教学支持服务教学技术多伦多大学

具记忆状态反馈的输入受限时滞系统模型预测控制器

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华南理工大学学报（自然科学版） 2012年第6期40卷 63-69页

作者：秦伟伟刘刚郑志强国防科技大学机电工程与自动化学院湖南长沙410073

针对一类具有输入约束的离散线性不确定时滞系统,提出了一种具有记忆状态反馈的模型预测控制器.首先,定义时滞系统的鲁棒性能指标,在考虑时滞状态影响的条件下设计了包含时滞状态的记忆状态反馈控制律,在线优化时将当前控制量作为独立... 详细信息

针对一类具有输入约束的离散线性不确定时滞系统,提出了一种具有记忆状态反馈的模型预测控制器.首先,定义时滞系统的鲁棒性能指标,在考虑时滞状态影响的条件下设计了包含时滞状态的记忆状态反馈控制律,在线优化时将当前控制量作为独立优化变量,与其它作为反馈控制的时域控制序列分开处理,以降低算法保守性,提高可行性.然后,给出了基于线性矩阵不等式凸优化的控制策略以及系统稳定的充分条件.最后,通过仿真实验验证了该控制算法的有效性.

关键词：不确定时滞系统记忆状态反馈控制模型预测控制线性矩阵不等式