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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia qin Lingyan Liang Yichen Wei qingping Zhang Xiaocheng Li Haixia qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

不同灌水量对寒富苹果叶片几种糖类物质含量影响

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北方园艺 2009年第4期 37-39页

作者：秦嗣军张玉龙吕德国杨宝铭沈阳农业大学园艺学院辽宁沈阳110161 沈阳农业大学土地与环境学院辽宁沈阳110161

以盆栽寒富苹果为试材,研究了不同灌水量对植株叶片几种糖类物质含量的影响。结果表明:寒富苹果叶片中山梨醇含量最高,是最重要的渗透调节物质。水分胁迫条件下山梨醇含量及其所占可溶性糖的比例均明显增加,而蔗糖含量及其所占可溶性糖... 详细信息

以盆栽寒富苹果为试材,研究了不同灌水量对植株叶片几种糖类物质含量的影响。结果表明:寒富苹果叶片中山梨醇含量最高,是最重要的渗透调节物质。水分胁迫条件下山梨醇含量及其所占可溶性糖的比例均明显增加,而蔗糖含量及其所占可溶性糖比例下降,是寒富苹果叶片适应干旱环境的正常表现。每3d灌1.5L水可满足盆栽2a生寒富苹果生长发育,较饱和灌水可节省1/4用水量。

关键词：灌水量寒富苹果糖类物质

三种土壤处理方式对华红苹果光合性能及土壤有机碳行为的影响

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土壤通报 2017年第5期48卷 1197-1202页

作者：秦嗣军周恩达齐边斌吕德国沈阳农业大学园艺学院辽宁省果树品质发育与调控重点实验室辽宁沈阳110866 大兴安岭农业林业科学研究院黑龙江165000

以砧穗组合为华红/M26/山定子的2年生苹果苗为试材,通过测定植株光合作用、土壤酶活性、土壤微生物群落功能多样性及土壤有机质含量等指标,研究生草、施有机肥、埋秸秆及清耕对幼龄苹果树生长和果园土壤有机碳变化特征的影响。结果表明... 详细信息

以砧穗组合为华红/M26/山定子的2年生苹果苗为试材,通过测定植株光合作用、土壤酶活性、土壤微生物群落功能多样性及土壤有机质含量等指标,研究生草、施有机肥、埋秸秆及清耕对幼龄苹果树生长和果园土壤有机碳变化特征的影响。结果表明,与清耕对照相比,三种不同土壤处理方式均能提高华红苹果叶片的净光合速率,在果实膨大期促进作用尤为明显;各处理提高了土壤纤维素酶、蔗糖酶和β-葡萄糖苷酶的活性,丰富了土壤微生物群落结构多样性,同时还能提高土壤微生物量碳和土壤有机质的含量。

关键词：苹果光合作用土壤酶活性土壤微生物土壤有机质

Effects of surface fluoride modification on TiO_(2)for the photocatalytic oxidation of toluene

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Journal of Environmental Sciences 2025年第1期147卷 561-570页

作者： Shaoyu Yuan Min Chen Xiaoxiao qin Xueyan Chen Jianghao Zhang Changbin Zhang State Key Joint Laboratory of Environment simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

In the present study,we investigated the influence of surface fluorine(F)on TiO_(2)for the photocatalytic oxidation(PCO)of ***_(2)modified with different F content was prepared and *** was found that with the increasing of F content,the toluene conversion rate first increased and then ***,CO_(2)mineralization efficiency showed the opposite *** on the characterizations,we revealed that F substitutes the surface hydroxyl of TiO_(2)to form the structure of≡*** presence of the appropriate amount of surface≡Ti-F on TiO_(2)greatly enhanced the separation of photogenerated carriers,which facilitated the generation of·OH and promoted the activity for the PCO of *** was further revealed that the increase of only·OH promoted the conversion of toluene to ring-containing intermediates,causing the accumulation of intermediates and then conversely inhibited the·OH generation,which led to the decrease of the CO_(2)mineralization *** above results could provide guidance for the rational design of photocatalysts for toluene oxidation.

关键词： Photocatalysis TiO_(2) Toluene Fluorine

樱桃属(Cerasus)植物根围微生物多样性

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生态学报 2008年第8期28卷 3882-3890页

作者：吕德国于翠杜国栋秦嗣军李芳东刘国成沈阳农业大学园艺学院沈阳110161

研究了樱桃属(Cerasus)5种植物本溪山樱(Cs)、大青叶(Cp)、马哈利(Cm)、考特(Cap)、早红宝石(Ca)各主要生长期根围微生物数量、种群组成、Shannom-Wiener指数(H)、丰富度(S)、Pielou均匀度指数(J)、simpson优势度(D)和优势微生物种群变... 详细信息

研究了樱桃属(Cerasus)5种植物本溪山樱(Cs)、大青叶(Cp)、马哈利(Cm)、考特(Cap)、早红宝石(Ca)各主要生长期根围微生物数量、种群组成、Shannom-Wiener指数(H)、丰富度(S)、Pielou均匀度指数(J)、simpson优势度(D)和优势微生物种群变化动态。从樱桃根围共分离到细菌18属,优势菌属主要为假单胞菌属(Pseudomonas)、芽孢杆菌属(Bacillus)和黄杆菌属(Flavobacterium);放线菌为链霉菌的12个类群,优势类群主要为白色类群(Albosporus)、吸水类群(Hygroscopicus)和黄色类群(Flavus);真菌6属,优势菌属为青霉属(Penicillium)。樱桃根围微生物的多样性指数(H)、丰富度指数(S)、均匀度指数(J)及优势度指数(D)随樱桃种类不同而发生变化,细菌的多样性和丰富度指数为Ca>Cs>Cp>Cm>Cap,放线菌为Ca>Cp>Cs>Cm>Cap,真菌为Cm>Ca>Cp>Cs>Cap。各生长期根围微生物种类与数量发生变化,新梢迅速生长期Ca、Cs、Cp和Cm根围微生物种类与数量较多,新梢停长期Cap根围微生物种类与数量较多,落叶期5种樱桃属植物根围微生物种类与数量均较少。

关键词：樱桃属植物根际微生物多样性指标

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观赏海棠新品种‘凤凰’

园艺学报 2015年第4期42卷 805-806页

作者：吕德国杜国栋秦嗣军马怀宇刘国成沈阳农业大学园艺学院沈阳110866

观赏海棠‘凤凰’是从与‘御紫’(Royalty)、‘加紫’(Jiazi)、‘雪球’(Snow Drift)、‘雪花’(Xuehua)和‘雪红’(Xuehong)等品种混栽、开放授粉的‘绚丽’(Radiant)植株上采种,并从其实生繁殖后代中选育出的新品种。树姿直立,生长势... 详细信息

观赏海棠‘凤凰’是从与‘御紫’(Royalty)、‘加紫’(Jiazi)、‘雪球’(Snow Drift)、‘雪花’(Xuehua)和‘雪红’(Xuehong)等品种混栽、开放授粉的‘绚丽’(Radiant)植株上采种,并从其实生繁殖后代中选育出的新品种。树姿直立,生长势强;成枝力强;幼叶褐红色,被绒毛,成熟叶片浓绿色;花冠粉红色,花瓣椭圆形、重叠;果实近圆形,橙红色;连续结果能力强,果实冬季不落,观赏期长。

关键词：观赏海棠品种

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不同生育期苹果园土壤氨氧化微生物丰度研究

植物营养与肥料学报 2016年第4期22卷 1149-1156页

作者：李景云秦嗣军葛鹏吕德国刘灵芝沈阳农业大学土地与环境学院沈阳110866 沈阳农业大学园艺学院/辽宁省果树品质发育与调控重点实验室沈阳110866

【目的】大量施氮引起的土壤酸化问题已严重制约苹果的安全生产。氨氧化微生物驱动的土壤硝化作用是土壤氮素循环的重要环节,探析苹果园土壤中氨氧化微生物氨单加氧酶基因(amo A)丰度与土壤硝化强度(Potential Nitrification,PN)和土壤... 详细信息

【目的】大量施氮引起的土壤酸化问题已严重制约苹果的安全生产。氨氧化微生物驱动的土壤硝化作用是土壤氮素循环的重要环节,探析苹果园土壤中氨氧化微生物氨单加氧酶基因(amo A)丰度与土壤硝化强度(Potential Nitrification,PN)和土壤理化性质的相关性,有助于评价土壤氨氧化微生物类群在苹果园土壤生态系统中的作用。【方法】本研究以辽宁省丹东东港地区‘寒富’苹果园土壤为研究对象,采用实时荧光定量PCR(Real-time PCR)技术,检测苹果树不同生育时期,4月28日(萌芽期)、7月24日(新梢停长期)、10月23日(落叶期)的两个苹果园(分别编号为D1和D2)的土壤理化性质、土壤硝化强度、氨氧化古菌(Ammonia-oxidizing archaea,AOA)和氨氧化细菌(Ammonia-oxidizing bacteria,AOB)的amo A基因丰度,并分析了氨氧化微生物丰度与土壤理化性质和土壤硝化强度之间的关系。【结果】不同生育时期‘寒富’苹果园土壤理化因子差异较大。所有供试土壤的硝态氮(NO-3-N)、速效磷(AP)和速效钾(AK)含量在4月份最高,铵态氮(NH+4-N)含量在7月最高,NO-3-N、NH+4-N、AP和AK含量在10月多为最低。且所有供试土壤p H值均在4.25 6.09之间。同一生育时期内,D2土壤p H均显著高于D1土壤,但其NO-3-N和NH+4-N含量则不同程度地低于D1土壤。不同采样时期的果园土壤硝化强度随季节变化表现出先降后增的趋势,除7月D2土壤硝化强度显著高于D1土壤外,4月与10月D2土壤硝化强度均显著低于D1土壤。尽管不同采样时期的土壤AOA与AOB丰度随生育期而各异,所有供试土壤中AOA丰度均显著高于AOB丰度。同一时期内,D2土壤AOA和AOB丰度均显著高于D1土壤。尽管土壤p H、NO-3-N与AOA、AOB均表现出显著相关性,土壤PN仅与AOA丰度明显正相关。【结论】长期施肥导致苹果园土壤p H值降低,p H值的改变是影响AOA与AOB丰度的重要因子,果园土壤的硝化过程主要由AOA来完成,土壤硝化强度与季节变化引起的温度和土壤环境因子等的改变密切相关。苹果园无机氮肥混合有机肥的施入,同时结合自然生草、人工刈割等管理制度,在一定程度上可改变土壤氮素的含量与种类,减缓土壤酸化。

关键词：氨氧化微生物丰度果园酸性土壤环境因子荧光定量PCR

山楂叶黄酮提取工艺优化及周年积累动态和分布特性的研究

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吉林农业大学学报 2010年第3期32卷 271-276页

作者：吕德国李志霞鲁巍巍秦嗣军沈阳农业大学园艺学院国家果树种质沈阳山楂圃沈阳110161

对山楂品种"甜水"叶片中总黄酮的超声波提取工艺及周年积累动态和分布规律进行了研究。结果表明:超声波提取山楂叶片中总黄酮的最优工艺条件为用70%乙醇在温度40℃、功率450W条件下,以料液比1∶30提取30min。年生长周期中,山楂叶总黄酮... 详细信息

对山楂品种"甜水"叶片中总黄酮的超声波提取工艺及周年积累动态和分布规律进行了研究。结果表明:超声波提取山楂叶片中总黄酮的最优工艺条件为用70%乙醇在温度40℃、功率450W条件下,以料液比1∶30提取30min。年生长周期中,山楂叶总黄酮含量总体呈上升趋势,落叶时总黄酮含量最高,确定秋季果实成熟后为最佳采叶期。生长前期营养枝上叶片黄酮含量高于结果枝叶,后期相反;不同长度枝叶片黄酮无明显的差异;整个生长期内叶片黄酮含量上位叶>中位叶>下位叶、叶柄>托叶。

关键词：山楂黄酮超声波提取工艺积累动态分布规律

Peptide-based strategies for overcoming multidrug-resistance in cancer therapy

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Chinese Chemical Letters 2025年第1期36卷 110-118页

作者： Xiaofang Luo Ye Wu Xiaokun Zhang Min Tang Feiye Ju Zuodong qin Gregory J Duns Wei-Dong Zhang Jiang-Jiang qin Xin Luan Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and BioengineeringHunan University of Science and EngineeringYongzhou 425199China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Medicinal Plant DevelopmentChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100700China

Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade *** demand for targeted therapeutics for multidrug-resistant cancer is more important than ***,as emerging alternatives to current anticancer drugs,offer exquisite versatility in facilitating the design of novel oncology drugs,with the core superiorities of good biocompatibility and a low tendency to induce drug *** review comprehensively introduces the pharmacological mechanisms of peptide-based drugs and strategies for overcoming multidrug resistance(MDR)in cancers,including inducing cell membrane lysis,targeting organelles,activating anticancer immune responses,enhancing drug uptake,targeting ATP-binding cassette(ABC)transporters,and targeting B-cell lymphoma-2(BCL-2)family ***,the current clinical applications of representative peptides in combating MDR cancers and their potential directions for medicinal chemistry research have been thoroughly *** review offers essential insights into the novel treatment approaches for MDR cancers and highlights the trends and perspectives in this field.

关键词： Drug resistance Antitumor peptides Mechanism of action Targeted therapeutics Immunotherapy Medicinal chemistry