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Chinese Journal of Integrative Medicine 2021年第1期27卷 31-38页

作者： XIA Tian-shuang LIN Liu-yue ZHANG Qiao-yan JIANG Yi-ping LI Chang-hui LIU Xiao-yan qin lu-ping XIN Hai-liang Department of Pharmacognosy School of PharmacySecond Military Medical UniversityShanghai(200433)China Schoolof Pharmacy Fujian University of Traditional Chinese MedicineFuzhou(350108)China School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou(310053)China

Objective:To systematically evaluate the protective effects of Humulus lupulus ***(HLE)on osteoporosis ***:In vivo experiment,a total of 3512-week-old female ICR mice were equally divided into 5 groups:the sham control group(sham);the ovariectomy with vehicle group(OVX);the OVX with estradiol valerate[EV,0.2 mg/(kg·d)];the OVX with low-or high-dose HLE groups[HLE,1 g/(kg·d)and 3 g/(kg·d)],7 in each *** began 1 week after the ovariectomized surgery and lasted for 12 *** mass and trabecular bone mircoarchitecture were evaluated by micro computed tomography,and bone turnover markers in serum were evaluated using enzyme-linked immunosorbent assay(ELISA)*** vitro experiment,osteoblasts and osteoclasts were treated with HLE at doses of 0,4,20 and 100μg/*** for bone formation in osteoblasts and bone resorption in osteoclasts were ***:Compared with the OVX group,HLE exerted bone protective effects by the increase of estradiol(Plular matrix mineralization(both Plusion:HLE may protect against bone loss,and have potentials in the treatment of osteoporosis.

关键词： Humulus lupulus L. osteoporosis ovariectomy-induced mice osteoblasts osteoclasts

Rubus chingii Hu: an overview of botany, traditional uses,phytochemistry, and pharmacology

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Chinese Journal of Natural Medicines 2020年第6期18卷 401-416页

作者： SHENG Jia-Yun WANG Si-Qi LIU Kao-Hua ZHU Bo ZHANG Qiao-Yan qin lu-ping WU Jian-Jun School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou 310053China

Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits(Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate the presence of terpenoids, flavonoids, steroids, alkaloids, phenylpropanoids, phenolics, and organic acids. Extracts or active substances from this plant are reported to have various pharmacological properties, including antioxidant, anti-inflammatory, antitumor, antifungal, antithrombotic, antiosteoporotic, hypoglycemic, and central nervous system-regulating effects. This review provides up-to-date information on the botanical characterizations, traditional usages, chemical constituents, pharmacological activities, toxicity,and quality control of R. chingii. Possible directions for future research are also briefly proposed. This review aims to supply fundamental data for the further study of R. chingii and contribute to the development of its clinical use.

关键词： Rubus chingii Hu Botany Traditional uses Phytochemistry Pharmacology Review

Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology

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Chinese Journal of Natural Medicines 2015年第3期13卷 163-182页

作者： SU Chun-Yan MING Qian-Liang RAHMAN Khalid HAN Ting qin lu-ping Department of Pharmacognosy School of Pharmacy Second Military Medical University Institute of Medicinal Plant Development Chinese Academy of Medical Science and Peking Union Medical College Department of Pharmacognosy School of Pharmacy Third Military Medical University Faculty of Science School of Pharmacy and Biomolecular Sciences Liverpool John Moores University

Salvia miltiorrhiza Bunge(SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy.

关键词： Danshen Cardiovascular diseases Antitumor Side effect Review

基于中医传承辅助平台探索含延胡索-川楝子药对方剂的组方规律

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中草药 2020年第18期51卷 4704-4711页

作者：赵婉璐秦路平张璐浙江中医药大学浙江杭州310053

目的通过对《中华人民共和国卫生部药品标准——中药成方制剂》(《中药部颁标准》)含延胡索-川楝子药对(简称"延胡索-川楝子")方剂组方规律的研究,以期为临床应用及方剂的后续产品开发提供理论依据。方法收集整理《中华人民共和国卫生... 详细信息

目的通过对《中华人民共和国卫生部药品标准——中药成方制剂》(《中药部颁标准》)含延胡索-川楝子药对(简称"延胡索-川楝子")方剂组方规律的研究,以期为临床应用及方剂的后续产品开发提供理论依据。方法收集整理《中华人民共和国卫生部药品标准——中药成方制剂》中包含延胡索-川楝子的方剂,录入中医传承辅助平台软件(V.2.5)建立数据库,统计主治病症频次、配伍药材频次、组方归经频次;采用关联规则Apriori算法对含延胡索-川楝子方剂的药材核心组合进行统计分析(设置支持度分别为10%、20%、30%,置信度为0.90);选择较高频次归经进行组方规律分析。结果共筛选出51首含延胡索-川楝子方剂,涉及主治疾病8种(频次≥2),包括胃痛、胁痛、带下病、痛经、盆腔炎、月经失调等;涉及主治证候9种(频次≥2),包括肝胃不和证、气滞血瘀证、肝郁气滞证、肝郁血虚证、胞宫血热证等;常配伍药材17味(频次≥5),包括白芍、木香、甘草、香附等;常用药材组合20种(频次≥6),其中核心药材组合包括延胡索-白芍-川楝子、延胡索-甘草-川楝子、延胡索-木香-川楝子、延胡索-香附-川楝子;组方归肝脾胃经频次较高;常与延胡索-川楝子配伍归肝经的组方核心药材有5种,包括木香、白芍、陈皮、砂仁、沉香,其中核心药材组合(频次≥7)包括延胡索-木香-川楝子、延胡索-白芍-川楝子、延胡索-陈皮-川楝子、延胡索-陈皮-白芍-木香-川楝子。常与延胡索-川楝子配伍归脾胃经的组方核心药材有3种,包括沉香、白芍、砂仁,其中核心药材组合(频次≥4)包括延胡索-沉香-川楝子、延胡索-白芍-川楝子、延胡索-砂仁-川楝子。结论《中华人民共和国卫生部药品标准——中药成方制剂》中含延胡索-川楝子方剂所用药物多理气止痛之功效,用药较为集中,组方法度清晰。此外,以3种归经组方规律的对比分析,反映了含延胡索-川楝子方剂不同归经组方的用药规律和配伍特点,为"异病同治"提供理论支持,也为延胡索-川楝子药对更好的应用于临床提供理论支持。

关键词：中医传承辅助平台延胡索川楝子药对组方规律

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卒中后认知功能障碍的临床研究进展

第二军医大学学报 2019年第10期40卷 1130-1134页

作者：秦鲁平王诺张萍邓本强海军军医大学(第二军医大学)长海医院脑血管病中心

卒中后认知障碍(PSCI)是脑卒中后残疾的重要原因,也是脑卒中研究的重点之一。PSCI发病率高,影响脑卒中后神经功能的康复,进而降低患者的生活质量。因此,在临床工作中神经科医师应警惕PSCI的发生,并指导患者积极预防PSCI以改善患者预后... 详细信息

卒中后认知障碍(PSCI)是脑卒中后残疾的重要原因,也是脑卒中研究的重点之一。PSCI发病率高,影响脑卒中后神经功能的康复,进而降低患者的生活质量。因此,在临床工作中神经科医师应警惕PSCI的发生,并指导患者积极预防PSCI以改善患者预后。本文就PSCI的发病率、影响因素、神经心理评估、影像学、预防等方面的研究进展等予以综述。

关键词：卒中认知障碍神经心理评估影像学研究

Estrogenic activity of osthole and imperatorin in MCF-7 cells and their osteoblastic effects in Saos-2 cells

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Chinese Journal of Natural Medicines 2016年第6期14卷 413-420页

作者： JIA Min LI Yuan XIN Hai-Liang HOU Ting-Ting ZHANG Nai-Dai XU Hong-Tao ZHANG Qiao-Yan qin lu-ping Department of Pharmacognosy School of Pharmacy Second Military Medical University

There is an increasing interest in phytoestrogens due to their potential medical usage in hormone replacement therapy(HRT). The present study was designed to investigate the in vitro effects of estrogen-like activities of two widespread coumarins, osthole and imperatorin, using the MCF-7 cell proliferation assay and their alkaline phosphatase(ALP) activities in osteoblasts Saos-2 cells. The two compounds were found to strongly stimulate the proliferation of MCF-7 cells. The estrogen receptor-regulated ERα, progesterone receptor(PR) and PS2 m RNA levels were increased by treatment with osthole and imperatorin. All these effects were significantly inhibited by the specific estrogen receptor antagonist ICI182, 780. Cell cycle analysis revealed that their proliferation stimulatory effect was associated with a marked increase in the number of MCF-7 cells in S phase, which was similar to that observed with estradiol. It was also observed that they significantly increased ALP activity, which was reversed by ICI182,780. These results suggested that osthole and imperatorin could stimulate osteoblastic activity by displaying estrogenic properties or through the ER pathway. In conclusion, osthole and imperatorin may represent new pharmacological tools for the treatment of osteoporosis.

关键词： Osthole Imperatorin MCF-7 Estrogenic activity Estrogen receptors Osteoblasts Alkaline phosphatase

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华中五味子藤茎的化学成分研究

中草药 2016年第19期47卷 3374-3378页

作者：黄泽豪秦路平福建中医药大学药学院福建福州350122 解放军第二军医大学药学院上海200433

目的研究华中五味子Schisandra sphenanthera藤茎的化学成分。方法运用正相硅胶柱色谱,制备TLC等方法进行分离,根据波谱数据鉴定化合物结构。结果从华中五味子藤茎95%乙醇提取物中分离得到了13个化合物,包括6个三萜,6个木脂素和1个甾... 详细信息

目的研究华中五味子Schisandra sphenanthera藤茎的化学成分。方法运用正相硅胶柱色谱,制备TLC等方法进行分离,根据波谱数据鉴定化合物结构。结果从华中五味子藤茎95%乙醇提取物中分离得到了13个化合物,包括6个三萜,6个木脂素和1个甾醇,分别鉴定为华中五内酯素（1）、南五内酯（2）、五内酯E（3）、12β-羟基黑老虎酸（4）、五味子酸（5）、schisanbilactone A（6）、β-谷甾醇（7）、内消旋二氢愈创木脂酸（8）、去氧五味子素（9）、五味子酯甲（10）、五味子酚乙（11）、五味子乙素（12）和当归酰基戈米辛M1（13）。结论其中化合物1为1个新三萜类化合物,命名为华中五内酯素。化合物2～4、6、9、11、13为植物中首次分离得到。

关键词：华中五味子华中五内酯素三萜木脂素畲药

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毛鸡屎藤全草的化学成分研究

中草药 2012年第4期43卷 658-660页

作者：李洋郑承剑秦路平福建中医药大学药学院福建福州350108 第二军医大学药学院生药教研室上海200433

目的研究毛鸡屎藤Paederia scandens ***全草的化学成分。方法采用各种色谱技术进行分离纯化,通过理化常数测定和波谱技术分析进行结构鉴定。结果从毛鸡屎藤全草中分离得到10个化合物,分别鉴定为2,3-二羟基-1-甲氧基蒽醌(1)、1,4-二甲氧... 详细信息

目的研究毛鸡屎藤Paederia scandens ***全草的化学成分。方法采用各种色谱技术进行分离纯化,通过理化常数测定和波谱技术分析进行结构鉴定。结果从毛鸡屎藤全草中分离得到10个化合物,分别鉴定为2,3-二羟基-1-甲氧基蒽醌(1)、1,4-二甲氧基-2-羟基蒽醌(2)、1,3,4-三甲氧基-2-羟基蒽醌(3)、邻苯二甲酸二异丁酯(4)、反式阿魏酸(5)、邻甲基苯乙醚(6)、水杨酸(7)、β-谷甾醇(8)、熊果酸(9)、齐墩果酸(10)。结论所有化合物均为首次从毛鸡屎藤植物中分离得到。其中化合物1～7为首次从鸡屎藤属中分离得到。

关键词：鸡屎藤属毛鸡屎藤 2,3-二羟基-1-甲氧基蒽醌 1,4-二甲氧基-2-羟基蒽醌邻甲基苯乙醚

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内生菌药用新资源与道地药材的关系探讨

药学服务与研究 2009年第5期9卷 321-324页

作者：贾敏游飞秦路平第二军医大学药学院生药学教研室上海200433

内生菌广泛地存在于植物组织内部。近20年来从内生菌中发现了很多结构新颖的活性次生产物,这些内生菌及相应产物对植物及相应化学组分含量有不同程度的影响。不同产地的同种药材中各种化学组分种类以及含量存在一定差异,一直以来认为这... 详细信息

内生菌广泛地存在于植物组织内部。近20年来从内生菌中发现了很多结构新颖的活性次生产物,这些内生菌及相应产物对植物及相应化学组分含量有不同程度的影响。不同产地的同种药材中各种化学组分种类以及含量存在一定差异,一直以来认为这些差异源于气候、土壤、温度等外环境的影响,近期对于内生菌的研究表明,微生物也是影响药材质量的一个关键因素。内生菌自身产生或刺激宿主产生特定化学产物,或参与到特定物质的代谢途径中,从而影响药材的化学组分及各组分含量。本研究对内生菌作为一种药用新资源以及与植物药材质量的关系进行初步探讨。

关键词：内生菌道地药材次生代谢产物综述

黄芪-当归化学成分、药理作用及临床应用的研究进展

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中草药 2022年第7期53卷 2196-2213页

作者：向璐张巧艳赵琦明秦路平龚婉浙江中医药大学生命科学学院浙江杭州310053 浙江中医药大学药学院浙江杭州310053 浙江中医药大学基础医学院浙江杭州310053

黄芪-当归是近代中药方剂中的常见药对,二者均为益气补血常用药,经历代医家证实其临床疗效确切。黄芪-当归具有调节免疫力、改善血液循环、抗氧化、抗脏器纤维化、抗炎、抗肿瘤等作用,临床应用广泛,多用于肾脏综合征、糖尿病病变、贫血... 详细信息

黄芪-当归是近代中药方剂中的常见药对,二者均为益气补血常用药,经历代医家证实其临床疗效确切。黄芪-当归具有调节免疫力、改善血液循环、抗氧化、抗脏器纤维化、抗炎、抗肿瘤等作用,临床应用广泛,多用于肾脏综合征、糖尿病病变、贫血等的治疗,并且取得了良好的疗效,未来具有较大的研究和开发潜力。结合国内外相关文献,从化学成分、药理作用、临床应用3个方面对黄芪-当归的研究进展进行系统总结,以期为该药对的深入研究及开发应用提供科学依据。

关键词：黄芪-当归黄芪当归黄芪甲苷阿魏酸气血两虚证